USPTO Art Unit 1657 Prosecution Statistics

Art Unit Information

Art Unit: 1657
Group: 1650
Tech Center: 1600
Total Cases: 10,259
Last Active: September 2025

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
19345445METHODS AND KITS FOR PREDICTING INFUSION REACTION RISK AND ANTIBODY-MEDIATED LOSS OF RESPONSE BY MONITORING SERUM URIC ACID DURING PEGYLATED URICASE THERAPYSeptember 2025January 2026Allow310YesNo
19254402Zonal and Targeted Methods and Uses for Treating a Chronic Post-Traumatic Headache Associated with a Post-Traumatic Stress DisorderJune 2025October 2025Allow410YesNo
19208663ANTIHYPERTENSIVE PEPTIDE PROBIOTIC GOAT MILK POWDER AND PREPARATION METHOD THEREOFMay 2025December 2025Allow721NoNo
19205490TREATMENT OF FISTULA WITH BONE MARROW MESENCHYMAL STEM CELL DERIVED EXTRACELLULAR VESICLESMay 2025November 2025Allow610YesNo
19096765ENDOPHYTIC FUNGUS OF OPHIOPOGON JAPONICUS AND USE THEREOFApril 2025September 2025Allow510YesNo
19069812METHODS TO GENERATE POLYMER SCAFFOLDS HAVING A GRADIENT OF CROSSLINKING DENSITYMarch 2025February 2026Allow1111YesNo
19059018Zonal and Targeted Methods and Uses for Treating a Post-Traumatic Stress DisorderFebruary 2025June 2025Allow410YesNo
19055164Treatment for Chronic Kidney DiseaseFebruary 2025October 2025Abandon810NoNo
19032240METHOD FOR PREPARING THEAFLAVIN WITH IMMOBILIZED SUBSTRATEJanuary 2025October 2025Allow910YesNo
19021675LACTICASEIBACILLUS RHAMNOSUS AFY01 AND APPLICATION OF PRODUCT PREPARED FROM LACTICASEIBACILLUS RHAMNOSUS AFY01 IN INFLAMMATORY COLON CANCERJanuary 2025July 2025Allow610NoNo
18972671PROBIOTICS COMPOSITIONS AND METHOD OF USING THE SAME TO ENHANCE GROWTH AND SOCIAL FUNCTION IN CHILDRENDecember 2024March 2026Allow1521NoNo
18946341ASPERGILLUS ORYZAE JAAS-32 AND USE THEREOF IN PREPARATION OF LARVAL HERMETIA ILLUCENS PASTE PROTEIN PEPTIDENovember 2024June 2025Allow711NoNo
18933318COLLAGEN AND USE THEREOFOctober 2024August 2025Allow1011YesNo
18919965LACTOBACILLUS ACIDOPHILUS GOLDGUT-LA100 HAVING FUNCTIONS OF LIPID LOWERING, BLOOD GLUCOSE LOWERING AND WEIGHT LOSS AND APPLICATION THEREOFOctober 2024June 2025Allow820NoNo
18915656EVOLVED INTEGRASES AND METHODS OF USING THE SAME FOR GENOME EDITINGOctober 2024June 2025Allow821YesNo
18884680BACTERIAL COMPOSITIONS FOR TREATING AND PREVENTING HALITOSISSeptember 2024November 2025Allow1421NoNo
18846159IN CHEMICO TEST FOR TOXICITYSeptember 2024January 2026Allow1621NoNo
18815386AUTOBIOTIC COMPOSITIONS AND METHOD FOR PROMOTING HEALTHY GUT MICROBIOMEAugust 2024June 2025Allow920NoNo
18787118COMPOSITIONS AND METHODS OF PREPARING AIRWAY CELLSJuly 2024January 2026Allow1810NoNo
18786855ENGINEERING MECHANICALLY FUNCTIONAL HUMAN CARTILAGE AND METHOD OF MAKING SAMEJuly 2024March 2026Allow1910NoNo
18785008GRANULE FOR DETECTING OCCULT BLOOD IN PET URINE AND METHOD FOR PREPARING THE SAMEJuly 2024December 2024Allow501YesNo
18776537METHODS OF PROTECTING A PLANT FROM A FUNGAL PESTJuly 2024August 2025Allow1320NoNo
18756561ANTI-FATIGUE LACTOBACILLUS COMPOSITION AND METHOD OF PROMOTING ANTI-FATIGUE PERFORMANCE AFTER AEROBIC EXERCISE OF SUBJECT IN NEED THEREOF BY USING THE SAMEJune 2024October 2025Allow1620NoNo
18722480SPINOSAD HIGH-YIELD STRAIN AND USE THEREOFJune 2024July 2025Allow1320YesNo
18746808UNGLYCOSYLATED LYSOSTAPHIN VARIANT PROTEINJune 2024March 2026Allow2011NoNo
18735209METHOD FOR SELECTING AEROBIC DENITRIFYING FUNGUS AND METHOD FOR REMEDIATING WATER BODY WITH LOW CARBON-TO-NITROGEN RATIO USING AEROBIC DENITRIFYING FUNGUSJune 2024February 2025Allow811YesNo
18679906COMPOSITIONS AND METHODS FOR OBTAINING ORGANOIDSMay 2024March 2025Allow1010YesNo
18713690METHOD FOR INHIBITING BIOGENIC HYDROGEN SULFIDE IN OILFIELDSMay 2024July 2025Allow1320NoNo
18662758RPE CELL POPULATIONS AND METHODS OF GENERATING SAMEMay 2024January 2026Allow2011NoNo
18656253Perfusion Culturing Methods and Uses ThereofMay 2024April 2025Allow1110NoNo
18633352Treatment and prevention of neuropathology associated with neurodegenerative diseasesApril 2024March 2025Allow1100YesNo
18631515PROCESS FOR CONTROLLING ORGANIC ACID RATIOS IN A CARBON DIOXIDE BIOCONVERSION PROCESSApril 2024May 2025Allow1310NoNo
18630584METHODS AND KITS FOR PREDICTING INFUSION REACTION RISK AND ANTIBODY-MEDIATED LOSS OF RESPONSE BY MONITORING SERUM URIC ACID DURING PEGYLATED URICASE THERAPYApril 2024August 2024Allow510YesNo
18627183PROBIOTIC COMPOSITIONS FOR TREATING AND PREVENTING COLORECTAL CANCERApril 2024February 2026Allow2231YesNo
18622012ORGANOTYPIC DRG-PERIPHERAL NERVE CULTURE SYSTEMMarch 2024March 2025Allow1110YesNo
18606318METHOD OF FORMING A MYCOLOGICAL PRODUCTMarch 2024April 2025Allow1310NoNo
18603954SYSTEMS AND METHODS FOR MONITORING TISSUE SAMPLE PROCESSINGMarch 2024September 2025Allow1811NoNo
18599428PH20 POLYPEPTIDE VARIANTS, FORMULATIONS AND USES THEREOFMarch 2024August 2024Allow530YesNo
18596683PEPTIDE BIOMARKER FOR IDENTIFYING HIPPOCAMPUS SPECIES BASED ON PEPTIDOMICS AND APPLICATION THEREOFMarch 2024April 2025Abandon1320NoNo
18595392LARGE-SCALE PRODUCTION OF MYCELIUM-BASED TEXTILES AT MUSHROOM FARM FACILITIESMarch 2024May 2025Allow1410YesNo
18594617SYNTHESIS OF BETA-HYDROXYISOVALERATE AND METHODS OF USEMarch 2024December 2025Allow2210YesNo
18686912Depolymerization of a Polyhydroxyalkanoate and Recycling of Hydroxyalkonoate Monomer Obtained Thereby Via a Metabolic ProcessFebruary 2024January 2025Allow1110NoNo
18588041CUPRIAVIDUS METALLIDURANS CML2, ITS PREPARATION, AND ITS BIOREMEDIATION METHOD FOR HEAVY METAL-CONTAMINATED ENVIRONMENTFebruary 2024September 2025Abandon1820NoNo
18583572COMPOSITIONS AND METHODS FOR TRANSPLANTATION OF COLON MICROBIOTAFebruary 2024March 2026Abandon2421NoNo
18582510PRODUCTION METHOD OF ENZYMATIC REACTION USING ADENOSINE INSTEAD OF ATPFebruary 2024March 2025Allow1310YesNo
18441106Adherent Cell Culture Substrate Sampling DeviceFebruary 2024March 2025Allow1410YesNo
18439987PRODUCTION OF RETINOLFebruary 2024October 2025Abandon2001NoNo
18440328Stable Inoculant Compositions and Methods for Producing SameFebruary 2024December 2025Allow2210YesNo
18436701LOW SHEAR MICROFLUIDIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOFFebruary 2024May 2025Abandon1510NoNo
18681293COMPOSITION FOR THE TREATMENT AND PREVENTION OF THE ESCA DISEASEFebruary 2024January 2026Allow2430NoNo
18426195ESCHERICHIA COLI K-12 MG1655 BLBYZT6 AND APPLICATION THEREOFJanuary 2024March 2025Allow1440YesNo
18421205Orally Ingestible Delivery SystemJanuary 2024April 2025Allow1410NoNo
18421866RAPID REAL TIME MULTIPOINT PROCEDURE FOR OPTIMIZING SPERM STATE FOR USE IN ASSISTED REPRODUCTIVE TECHNOLOGIESJanuary 2024October 2025Abandon2120NoNo
18419836ENZYME-ASSISTED ATRP PROCEDURESJanuary 2024April 2025Abandon1410NoNo
18416049Selection and Use of Melatonin Supporting Bacteria to Reduce Infantile ColicJanuary 2024January 2026Allow2421YesNo
18415272MECHANISM BASED QUALITY CONTROL FOR BOTANICAL MEDICINEJanuary 2024September 2025Abandon2010NoNo
18409181METHODS TO IMPROVE ORGAN VIABILITYJanuary 2024December 2024Allow1210NoNo
18406886CYTOPHERESIS CARTRIDGES AND USE THEREOFJanuary 2024July 2025Allow1810NoNo
18405102PREGABALIN ARTIFICIAL HAPTEN, ARTIFICIAL ANTIGEN AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOFJanuary 2024March 2025Allow1400YesNo
18402122BIOPLASTIC PRODUCTION METHODJanuary 2024April 2025Abandon1510NoNo
18399556RECOMBINANT ALGAE HAVING HIGH LIPID PRODUCTIVITYDecember 2023April 2025Allow1610YesNo
18541328COMPOSITION FOR TREATING OF FACIAL DYSMORPHISM IN MUCOPOLYSACCHARIDOSISDecember 2023December 2025Abandon2410NoNo
18541238MULTISTRAIN POPULATION CONTROL SYSTEMS AND METHODSDecember 2023January 2026Allow2511YesNo
18535865TREATMENT OF VASCULOPATHY WITH PROSTACYCLIN AND MESENCHYMAL STEM CELLSDecember 2023December 2024Allow1210NoNo
18535745TREATMENT OF PULMONARY ARTERIAL HYPERTENSION WITH PROSTACYCLIN-TREATED ENDOTHELIAL PROGENITOR CELLSDecember 2023January 2025Allow1410NoNo
18532631METHOD FOR PREPARING ACTIVE PROTEIN PEPTIDE AND PREPARED ACTIVE PROTEIN PEPTIDE AND USE THEREOFDecember 2023September 2024Allow1010YesNo
18526264Novel Strain of Glutamicibacter, Originating from Insects, Capable of Efficiently Degrading BifenthrinDecember 2023June 2024Allow721NoNo
18524494BACTERIAL CULTURES AND METHODS FOR PRODUCTION OF ALGINATENovember 2023March 2025Allow1511YesNo
18523358METHODS OF PROCESSING LIGNOCELLULOSIC BIOMASS USING SINGLE-STAGE AUTOHYDROLYSIS AND ENZYMATIC HYDROLYSIS WITH C5 BYPASS AND POST-HYDROLYSISNovember 2023May 2025Allow1810NoNo
18523103Method of Selecting Chemotherapeutic Agents for an Isolated Organ or Regional TherapyNovember 2023December 2025Abandon2431NoNo
18520265TISSUE PRESERVATION SYSTEMNovember 2023December 2024Abandon1310NoNo
18516887GRANULE FOR DETECTING OCCULT BLOOD IN PET URINE AND METHOD FOR PREPARING THE SAMENovember 2023December 2024Abandon1320NoNo
18512646Bioerodible Matrix for Tissue InvolvementNovember 2023April 2025Abandon1710NoNo
18512389BACTERIA FOR THE TREATMENT OF DISORDERSNovember 2023October 2025Allow2310NoNo
18389470ENGINEERED MATERIALS AND METHODS OF FORMINGNovember 2023July 2025Allow2010YesNo
18507533CENTRIFUGATION AND FILTRATION METHODS FOR CONCENTRATING MICROORGANISMSNovember 2023September 2025Abandon2210NoNo
18508109METHODS FOR VIRAL INACTIVATION AND OTHER ADVENTITIOUS AGENTSNovember 2023January 2025Abandon1401NoNo
18502098PROBIOTIC COMPOSITIONS AND USES THEREOFNovember 2023December 2024Allow1310YesNo
18559060EXIGUOBACTERIUM INDICUM AND APPLICATION THEREOF IN SYNTHESIS OF NANO-SELENIUMNovember 2023December 2024Allow1410NoNo
18387192METHOD OF ISOLATING MESENCHYMAL STEM CELLS FROM THE AMNIOTIC MEMBRANE OF THE UMBILICAL CORD, A MESENCHYMAL STEM CELL POPULATION ISOLATED FROM THE AMNIOTIC MEMBRANE OF THE UMBILICAL CORD AND A CELL CULTURE MEDIUM FOR ISOLATING MESENCHYMAL STEM CELLS FROM THE AMNIOTIC MEMBRANE OF THE UMBILICAL CORDNovember 2023February 2025Allow1610NoNo
18558863A Bioreactor and Process for Forming Polyhydroxybutyrate Directly from Depolymerized PolyhydroxybutyrateNovember 2023June 2025Allow1911YesNo
18500327AGENT FOR IMPROVING MITOCHONDRIAL FUNCTIONNovember 2023July 2025Abandon2020NoNo
18499761SYSTEMS AND METHODS FOR PERFORMING ANTIMICROBIAL SUSCEPTIBILITY TESTINGNovember 2023January 2025Allow1410NoNo
18498807OIL OF MICROORGANISMS RICH IN DOCOSAHEXAENOIC ACIDOctober 2023March 2025Allow1610NoNo
18493878SENSORS FOR DETECTING AND IMAGING OF CANCER METASTASISOctober 2023June 2025Abandon2001NoNo
18493590ACONITIC ACID EXPORTER (AEXA) INCREASES ORGANIC ACID PRODUCTION IN ASPERGILLUSOctober 2023May 2025Allow1820YesNo
18382410SYSTEM FOR GROWING FUNGAL MATERIALSOctober 2023April 2025Abandon1811NoNo
18382446Nutritional Formulas Comprising Medium Chain Fatty Acids or Esters Thereof and Methods Related TheretoOctober 2023January 2026Allow2710NoNo
18287028LACTOBACILLUS REUTERI AND USE, COMPOSITION, DRUG AND FOOD THEREOFOctober 2023November 2025Allow2520NoNo
18555515A composition comprising Pediococcus Pentosaceus for use in treatment and/or prevention of food and/or alcohol poisoningOctober 2023January 2025Allow1511YesNo
18286791PROCESS TO PRODUCE MONO-RHAMNOLIPIDSOctober 2023January 2025Allow1540NoNo
18485543Construction Method and Application of Microorganism Capable of Realizing High Production of Lacto-N-neotetraoseOctober 2023July 2024Allow911YesNo
18553977PROCESS FOR THE PREPARATION OF A SUGAR PRODUCT AND A FERMENTATION PRODUCTOctober 2023March 2026Allow2910NoNo
18375171COMPOSITIONS AND METHODS FOR REDUCING BLOOD ALCOHOL CONTENTSeptember 2023March 2026Abandon3011NoNo
18553487HYALURONIC ACID-PRODUCING RECOMBINANT CELLSSeptember 2023March 2026Allow2910NoNo
18373435Caproate-producing bacterium with multiple substrate utilization capabilities and its applicationsSeptember 2023July 2024Allow1011YesNo
18373763METHOD AND AGENTS FOR DETECTING LUCIFERASE ACTIVITYSeptember 2023July 2025Allow2210NoNo
18472953Treatment of Anthrax with Pegylated Capsule-Degrading EnzymeSeptember 2023April 2024Allow710NoNo
18371651COMPOSITIONS AND METHOD OF USE FOR H5 COMPETENT BIFIDOBACTERIUM LONGUM SUBSP. INFANTISSeptember 2023June 2025Allow2111YesNo
18467280METHOD FOR PREPARING A TRANSFORMED, SALMO SALAR INTERFERON GAMMA (IFNG)-PRODUCING LACTOCOCCUS LACTIS BACTERIUMSeptember 2023January 2025Allow1610YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for art-unit 1657.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
150
Examiner Affirmed
108
(72.0%)
Examiner Reversed
42
(28.0%)
Reversal Percentile
26.9%
Lower than average

What This Means

With a 28.0% reversal rate, the PTAB affirms the examiner's rejections in the vast majority of cases. This reversal rate is below the USPTO average, indicating that appeals face more challenges here than typical.

Strategic Value of Filing an Appeal

Total Appeal Filings
920
Allowed After Appeal Filing
235
(25.5%)
Not Allowed After Appeal Filing
685
(74.5%)
Filing Benefit Percentile
17.5%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 25.5% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

⚠ Appeals to PTAB face challenges. Ensure your case has strong merit before committing to full Board review.

⚠ Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Art Unit 1657 - Prosecution Statistics Summary

Executive Summary

Art Unit 1657 is part of Group 1650 in Technology Center 1600. This art unit has examined 10,259 patent applications in our dataset, with an overall allowance rate of 57.5%. Applications typically reach final disposition in approximately 36 months.

Comparative Analysis

Art Unit 1657's allowance rate of 57.5% places it in the 13% percentile among all USPTO art units. This art unit has a significantly lower allowance rate than most art units at the USPTO.

Prosecution Patterns

Applications in Art Unit 1657 receive an average of 1.94 office actions before reaching final disposition (in the 54% percentile). The median prosecution time is 36 months (in the 26% percentile).

Strategic Considerations

When prosecuting applications in this art unit, consider the following:

  • The art unit's allowance rate suggests a more challenging examination environment compared to the USPTO average.
  • With more office actions than average, plan for relatively streamlined prosecution.
  • The median prosecution time is longer than average and should be factored into your continuation and client communication strategies.
  • Review individual examiner statistics within this art unit to identify examiners with particularly favorable or challenging prosecution patterns.

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.