USPTO Examiner CONSTANTINE CHARLES Z - Art Unit 1657

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
19032240METHOD FOR PREPARING THEAFLAVIN WITH IMMOBILIZED SUBSTRATEJanuary 2025October 2025Allow910YesNo
18785008GRANULE FOR DETECTING OCCULT BLOOD IN PET URINE AND METHOD FOR PREPARING THE SAMEJuly 2024December 2024Allow501YesNo
18582510PRODUCTION METHOD OF ENZYMATIC REACTION USING ADENOSINE INSTEAD OF ATPFebruary 2024March 2025Allow1310YesNo
18516887GRANULE FOR DETECTING OCCULT BLOOD IN PET URINE AND METHOD FOR PREPARING THE SAMENovember 2023December 2024Abandon1320NoNo
18375171COMPOSITIONS AND METHODS FOR REDUCING BLOOD ALCOHOL CONTENTSeptember 2023March 2026Abandon3011NoNo
18373763METHOD AND AGENTS FOR DETECTING LUCIFERASE ACTIVITYSeptember 2023July 2025Allow2210NoNo
18351559METHOD FOR PRODUCING TERTIARY BETA-HYDROXY-ALPHA-AMINO ACIDSJuly 2023March 2026Allow3200YesNo
18208713APPARATUS AND METHOD FOR PRETREATMENT OF MICROBIAL SAMPLESJune 2023September 2024Abandon1520NoNo
18253861METHOD FOR PREPARING NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND DERIVATIVE THEREOF BY ENZYMATIC-CHEMICAL CASCADE METHODMay 2023May 2024Allow1210YesNo
18024502STABILIZER FOR COLOR DEVELOPING AGENT AND APPLICATION THEREOF, APPLICATION OF COMPOSITION IN PREPARATION OF STABILIZER, AND KITMarch 2023August 2024Allow1730YesNo
18112871REAGENTS AND METHODS FOR SCREENING MPS I, II, IIIA, IIIB, IVA, VI, AND VIIFebruary 2023February 2026Allow3610NoNo
18015938THERAPEUTIC MICROBESJanuary 2023March 2026Abandon3801NoNo
17991991GLUCOSYL STEVIA COMPOSITIONSNovember 2022May 2025Abandon3020NoYes
18049495NICOTINAMIDE RIBOSIDE PRODUCTION IN FILAMENTOUS FUNGIOctober 2022January 2024Allow1411YesNo
17905749METHOD TO PRODUCE THE ANTI-MICROBIAL DITERPENOID LEUBETHANOL AND RELATED SERRULATANE-TYPE DITERPENESSeptember 2022March 2025Allow3101YesNo
17823530Compositions Comprising Probiotic and Prebiotic Components and Mineral Salts, with LactoferrinAugust 2022September 2023Allow1320NoNo
17894924METHODS FOR SYNTHESIZING ANTICOAGULANT POLYSACCHARIDESAugust 2022February 2023Allow510NoNo
17863024PHOTON-INDUCED ACCELERATED ENZYMES AND BIOACTIVE COMPOUNDS ACCUMULATION IN BARLEY DURING MALTINGJuly 2022June 2025Allow3520YesNo
17854325METHODS FOR TREATING LYSOSOMAL ACID LIPASE DEFICIENCY IN PATIENTSJune 2022May 2024Allow2311NoNo
17788289PROSTAGLANDIN PRODUCTION METHODJune 2022June 2024Allow2420YesNo
17806208Method for Stabilizing Colorimetric Assay for Use with Plucked Human HairJune 2022September 2025Abandon4030NoNo
17777336ENZYME MEDIATED PROCESSMay 2022January 2024Allow2001NoNo
17740547Treatment for Inflammatory Bowel Disease and Radiation-induced Intestinal InjuryMay 2022January 2026Abandon4411NoNo
17735532OPTIMAL RANGE OF SALIVARY MMP-9 CONCENTRATION FOR SCREENING RISK OF PERIODONTITIS, AND METHOD OF ITS APPLICATION FOR SCREENING RISK OF PERIODONTITISMay 2022April 2024Abandon2310NoNo
17706131Method for Online Monitoring of Mashing Processes Using Infrared SpectroscopyMarch 2022December 2023Abandon2001NoNo
17760705NOVEL POLYPEPTIDES FOR PRODUCING ALBICANOL AND/OR DRIMENOL COMPOUNDSMarch 2022December 2025Allow4521YesNo
17637987LACTOCOCCAL EXPRESSION OF IL-35 FOR TREATMENT OF DISEASEFebruary 2022February 2026Allow4711NoNo
17677931AMPHOTERICIN B AND BETA-1,3-GLUCANASE LOADED BI-FUNCTIONAL NANO-SYSTEM WITH BOTH TARGETS, PREPARATION METHOD AND APPLICATION THEREOFFebruary 2022July 2023Allow1710NoNo
17591171COPPER SUPPLEMENTATION FOR CONTROL OF GLYCOSYLATION IN MAMMALIAN CELL CULTURE PROCESSFebruary 2022April 2023Allow1510NoNo
17555438Triterpene ProductionDecember 2021May 2024Abandon2940NoNo
17550084REAL-TIME MONITORING OF MICROBIAL CONTAMINATION IN OILFIELD DRILLING FLUIDS AND CEMENTDecember 2021December 2023Abandon2410NoNo
17456177NOVEL SPORICHTHYACEAE MICROORGANISM AND USE THEREOFNovember 2021January 2023Allow1410NoNo
17493477COMPOSITIONS AND METHODS FOR SIMULTANEOUS INACTIVATION OF ALKALINE PHOSPHATASE AND PEROXIDASE ENZYMES DURING AUTOMATED MULTIPLEX TISSUE STAINING ASSAYSOctober 2021January 2024Allow2711NoNo
17412031AMPHOTERIC GLYCOLIPID BIOSURFACTANT AND ITS PREPARATION METHODAugust 2021August 2025Abandon4711NoNo
17376354METHODS FOR SYNTHESIZING ANTICOAGULANT POLYSACCHARIDESJuly 2021September 2022Allow1411NoNo
17422586CHIMERIC PROTEIN AND RELATED GENIC TRANSFER TECHNOLOGYJuly 2021September 2024Allow3800YesNo
17421718USE OF CELL WALL SKELETON OF ISOLATED RHODOCOCCUS RUBER FOR PREPARING HUMAN PAPILLOMAVIRUS INFECTION TREATMENT DRUGJuly 2021June 2024Allow3601YesNo
17418124COMBINATIONS OF ENGINEERED ANTIMICROBIAL PROBIOTICS FOR TREATMENT OF GASTROINTESTINAL TRACT PATHOGENSJune 2021January 2026Allow5521NoNo
17312350FAMIN Assay MethodsJune 2021September 2024Allow4010NoNo
17311835A Method for Enzymatic Resolution of Chiral SubstancesJune 2021April 2025Allow4610YesNo
17303513METHOD FOR EVALUATING METABOLIZABLE ENERGY IN GOOSE DIET BY USING A SIMULATIVE DIGESTION GROSS ENERGY TECHNIQUEJune 2021September 2023Allow2810YesNo
17296772BIOCATALYTIC TECHNIQUESMay 2021September 2023Allow2800YesNo
17206944IMMOBILIZED THERMOSTABLE TREHALOSE SYNTHASE AND METHOD FOR PRODUCING TREHALOSE AND TREHALULOSE BY USING SAMEMarch 2021January 2024Allow3421YesNo
17276820METHOD FOR THE BIOTECHNOLOGICAL PRODUCTION OF THE BLUE-GREEN FUNGUS PIGMENT XYLINDEINMarch 2021August 2023Allow2910NoNo
17167136Compositions and methods for ordered and continuous complementary DNA (cDNA) synthesis across non-continuous templatesFebruary 2021June 2024Allow4001YesNo
17164010BIOSYNTHESIS OF PREPARING NICOTINAMIDE MONONUCLEOTIDE AND DERIVATIVES THEREOFFebruary 2021October 2023Abandon3201NoNo
17159902METAL NANOPARTICLES FOR GLUCOSE DETECTION AND GLUCOSE DETECTION METHOD USING THE SAMEJanuary 2021April 2023Allow2710NoNo
17261426METHOD FOR DECONTAMINATING ENVIRONMENT POLLUTED WITH PETROLEUM-RELATED MATERIAL, AND MATERIAL USEDJanuary 2021July 2024Abandon4201NoNo
17149354COMPOSITIONS AND METHODS FOR REDUCING BLOOD ALCOHOL CONTENTJanuary 2021May 2023Allow2810NoNo
17260168ENZYMATIC PREPARATION OF GLUCOSAMINEJanuary 2021May 2024Allow4111NoNo
17144422COMPOSITIONS, DEVICES, KITS AND METHODS USEFUL FOR REMOVAL OF PHOSPHOLIPIDSJanuary 2021February 2025Abandon4931NoNo
17257792ENZYMATIC SYNTHESIS OF 4'-ETHYNYL NUCLEOSIDE ANALOGSJanuary 2021March 2024Allow3911NoNo
17256364Genetically Engineered Bacteria, Its Construction Method And Its Application In Producing Nad+ MethodDecember 2020September 2024Allow4521NoNo
17124740CHEMOENZYMATIC SYNTHESIS OF TREHALOSE ANALOGUESDecember 2020August 2023Allow3210NoNo
17253314METHOD OF SELECTING A POLYPEPTIDE OF INTERESTDecember 2020November 2025Allow5931NoNo
17123226Method for Producing Long-chain Glycosylated GenisteinDecember 2020October 2021Allow900YesNo
17076012Composition for Promoting Increase in Subcutaneous Tissue and Subcutaneous Adipose TissueOctober 2020February 2024Abandon4010NoNo
17074342SEPARATION OF ACETATE FROM FERMENTATION BROTHOctober 2020January 2025Abandon5121NoNo
17027997Biogas production with select macro algae and nanoparticles added to anaerobic digester feedstockSeptember 2020April 2023Abandon3010NoNo
16975894Method For Preparing Hexahydrofuro-Furanol Derivative, Intermediate Thereof And Preparation Method ThereofAugust 2020September 2022Allow2521NoNo
16983750GLUCOSYL STEVIA COMPOSITIONAugust 2020October 2023Allow3920NoNo
16945559MODIFIED HOST CELLS FOR HIGH EFFICIENCY PRODUCTION OF VANILLINJuly 2020September 2025Allow6031YesNo
16907381FAECALIBACTERIUM PRAUSNITZII STRAINS FOR TREATING AND PREVENTING GASTROINTESTINAL PAINJune 2020March 2023Allow3210YesNo
16903028COATINGS CONTAINING POLYMER MODIFIED ENZYME FOR STABLE SELF-CLEANING OF ORGANIC STAINSJune 2020March 2024Allow4521NoNo
16888779METHOD FOR EXTRACTING CITRULLINE FROM WATERMELONMay 2020September 2020Allow410NoNo
16881479METHOD FOR PRETREATMENT OF MICROBIAL CELLSMay 2020March 2023Allow3311NoNo
16855562METHOD OF PRODUCING A PECTIC POLYSACCHARIDE ISOLATE ENRICHED IN RHAMNOGALACTURONAN-IApril 2020November 2024Allow5531YesNo
16649771PRODUCTION OF TRANS-RETINALMarch 2020October 2024Abandon5531NoNo
16820845COMPOSITION FOR TREATMENT OF JOINT DISEASE AND METHOD THEREOFMarch 2020May 2022Abandon2610NoNo
16647038ONLINE BIOMASS CAPACITANCE MONITORING DURING LARGE SCALE PRODUCTION OF POLYPEPTIDES OF INTERESTMarch 2020July 2024Abandon5210NoNo
16640231METHOD FOR MEASURING CHOLESTEROL IN LOW-DENSITY LIPOPROTEIN, MEASUREMENT REAGENT, AND MEASUREMENT KITFebruary 2020September 2024Allow5521NoNo
16773304METHOD AND AGENTS FOR DETECTING LUCIFERASE ACTIVITYJanuary 2020June 2023Allow4120YesYes
16741627METHOD AND COMPOSITION FOR PRODUCING ENHANCED ANTI-INFLAMMATORY/ANTI-CATABOLIC AND REGENERATIVE AGENTS FROM AUTOLOGOUS PHYSIOLOGICAL FLUIDJanuary 2020February 2024Allow4951YesNo
16629643MICROBIAL CELLS FOR SPERMIDINE PRODUCTIONJanuary 2020June 2025Allow6051YesNo
16724682COATINGS CONTAINING ENZYME FOR STABLE SELF-CLEANING OF ORGANIC STAINSDecember 2019August 2022Allow3211NoNo
16715975CULTURE DEVICE FOR LACTIC ACID BACTERIADecember 2019March 2022Abandon2710NoNo
16622852PRODUCTION METHOD OF ENZYMATIC REACTION USING ADENOSINE INSTEAD OF ATPDecember 2019November 2023Allow4720YesNo
16705720METHOD FOR EVALUATION OF DRUG EFFICACY OF A MEDICINE HAVING A THERAPEUTIC OR PREVENTIVE EFFECT AGAINST A DISEASE RELATED TO EL ACTIVITY AND A METHOD FOR SCREENING AN INHIBITOR OF EL ACTIVITYDecember 2019March 2022Abandon2810NoNo
16616633Use of Terminal Transferase Enzyme in Nucleic Acid SynthesisNovember 2019January 2024Allow4920NoNo
16615865Enzymatic DNA Synthesis Using the Terminal Transferase Activity of Template-Dependent DNA PolymerasesNovember 2019February 2024Abandon5121NoNo
16613663METHOD OF PRODUCING 2'-FUCOSYLLACTOSE USING FUCOSYLTRANSFERASE DERIVED FROM PSEUDOPEDOBACTER SALTANSNovember 2019September 2021Allow2300YesNo
16612065IMPROVED METHODS FOR PRODUCING lSOBUTENE FROM 3-METHYLCROTONIC ACIDNovember 2019February 2024Allow5211YesNo
16605993METHOD AND ENZYME FOR PREPARATION OF ENZYME-MODIFIED STEVIA SUGAR AND USE OF ENZYME-MODIFIED STEVIA SUGAROctober 2019February 2022Allow2801YesNo
16599496FOOD COMPOSITION AND PHARMACEUTICAL COMPOSITION WITH STRAINS OF LACTIC ACID BACTERIA AND METHOD FOR MODULATING BLOOD GLUCOSEOctober 2019November 2022Allow3720NoNo
16500497REGIOSELECTIVE HYDROXYLATION OF ISOPHORONEOctober 2019March 2024Allow5421NoNo
16589933SYSTEMS AND METHODS FOR CULTIVATING AND DISTRIBUTING AQUATIC ORGANISMSOctober 2019August 2022Allow3410YesNo
16495435METHOD FOR DETECTING ATP BY USING PERSONAL BLOOD GLUCOSE METERSeptember 2019April 2023Abandon4330NoNo
16563260PROCESSES FOR OBTAINING MICROBIAL OIL FROM MICROBIAL CELLSSeptember 2019May 2024Allow5731NoYes
16543433REGULATION OF POLYMERASE USING COFACTOR OXIDATION STATESAugust 2019February 2023Allow4211YesNo
16539961MICROBIAL ELECTRO-PHOTOSYNTHESISAugust 2019October 2019Allow200YesNo
16464459AGLYCONE PRODUCTION PROMOTERAugust 2019December 2022Abandon4320YesNo
16482608NOVEL 5'-INOSINIC ACID DEHYDROGENASE AND METHOD OF PREPARING 5'-INOSINIC ACID USING THE SAMEJuly 2019March 2021Allow1900YesNo
16515415Method for Producing Heparosan Compound Having Isomerized Hexuronic Acid ResidueJuly 2019January 2023Allow4211YesNo
16467805GLUCOSYL STEVIA COMPOSITIONSJune 2019December 2022Abandon4310NoNo
16424230GLUCOSYL STEVIA COMPOSITIONMay 2019May 2023Allow4851YesNo
16462899AMYOTROPHIC LATERAL SCLEROSIS DIAGNOSTIC COMPOSITION USING ACID SPHINGOMYELINASE, AND METHOD FOR DETECTING DIAGNOSTIC MARKERSMay 2019August 2022Allow3910YesNo
16341734Novel Plant-Growth Promoting Bacteria and the Use ThereofApril 2019January 2023Abandon4521YesNo
16381654PROTEIN MODIFICATION OF LIVING CELLS USING SORTASEApril 2019June 2022Allow3801NoNo
16369939METHOD TO SCREEN COMPOUNDS FOR ANTIFUNGAL ACTIVITY AND PHARMACEUTICAL COMPOSITIONS AND METHODS TO TREAT FUNGAL DISEASES BY INHIBITING SPORE GERMINATIONMarch 2019January 2024Allow5721NoNo
16337688COMPOSITION FOR PRODUCTION OF GINSENOSIDE COMPOUND K COMPRISING HIGH TEMPERATURE alpha-L-ARABINOFURANOSIDASE, AND METHOD FOR PREPARING GINSENDOSIDE COMPOUND KMarch 2019June 2022Abandon3821NoNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner CONSTANTINE, CHARLES Z.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
4
Examiner Affirmed
3
(75.0%)
Examiner Reversed
1
(25.0%)
Reversal Percentile
37.8%
Lower than average

What This Means

With a 25.0% reversal rate, the PTAB affirms the examiner's rejections in the vast majority of cases. This reversal rate is below the USPTO average, indicating that appeals face more challenges here than typical.

Strategic Value of Filing an Appeal

Total Appeal Filings
21
Allowed After Appeal Filing
7
(33.3%)
Not Allowed After Appeal Filing
14
(66.7%)
Filing Benefit Percentile
50.6%
Higher than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 33.3% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is above the USPTO average, suggesting that filing an appeal can be an effective strategy for prompting reconsideration.

Strategic Recommendations

Appeals to PTAB face challenges. Ensure your case has strong merit before committing to full Board review.

Filing a Notice of Appeal is strategically valuable. The act of filing often prompts favorable reconsideration during the mandatory appeal conference.

Examiner CONSTANTINE, CHARLES Z - Prosecution Strategy Guide

Executive Summary

Examiner CONSTANTINE, CHARLES Z works in Art Unit 1657 and has examined 466 patent applications in our dataset. With an allowance rate of 58.2%, this examiner allows applications at a lower rate than most examiners at the USPTO. Applications typically reach final disposition in approximately 34 months.

Allowance Patterns

Examiner CONSTANTINE, CHARLES Z's allowance rate of 58.2% places them in the 18% percentile among all USPTO examiners. This examiner is less likely to allow applications than most examiners at the USPTO.

Office Action Patterns

On average, applications examined by CONSTANTINE, CHARLES Z receive 1.79 office actions before reaching final disposition. This places the examiner in the 40% percentile for office actions issued. This examiner issues fewer office actions than average, which may indicate efficient prosecution or a more lenient examination style.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by CONSTANTINE, CHARLES Z is 34 months. This places the examiner in the 42% percentile for prosecution speed. Prosecution timelines are slightly slower than average with this examiner.

Interview Effectiveness

Conducting an examiner interview provides a +51.7% benefit to allowance rate for applications examined by CONSTANTINE, CHARLES Z. This interview benefit is in the 94% percentile among all examiners. Recommendation: Interviews are highly effective with this examiner and should be strongly considered as a prosecution strategy. Per MPEP § 713.10, interviews are available at any time before the Notice of Allowance is mailed or jurisdiction transfers to the PTAB.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 26.1% of applications are subsequently allowed. This success rate is in the 42% percentile among all examiners. Strategic Insight: RCEs show below-average effectiveness with this examiner. Carefully evaluate whether an RCE or continuation is the better strategy.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 39.8% of cases where such amendments are filed. This entry rate is in the 61% percentile among all examiners. Strategic Recommendation: This examiner shows above-average receptiveness to after-final amendments. If your amendments clearly overcome the rejections and do not raise new issues, consider filing after-final amendments before resorting to an RCE.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 133.3% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 85% percentile among all examiners. Strategic Recommendation: Pre-appeal conferences are highly effective with this examiner compared to others. Before filing a full appeal brief, strongly consider requesting a PAC. The PAC provides an opportunity for the examiner and supervisory personnel to reconsider the rejection before the case proceeds to the PTAB.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 78.9% of appeals filed. This is in the 71% percentile among all examiners. Of these withdrawals, 73.3% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner shows above-average willingness to reconsider rejections during appeals. The mandatory appeal conference (MPEP § 1207.01) provides an opportunity for reconsideration.

Petition Practice

When applicants file petitions regarding this examiner's actions, 65.0% are granted (fully or in part). This grant rate is in the 70% percentile among all examiners. Strategic Note: Petitions show above-average success regarding this examiner's actions. Petitionable matters include restriction requirements (MPEP § 1002.02(c)(2)) and various procedural issues.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 1.1% of allowed cases (in the 68% percentile). This examiner makes examiner's amendments more often than average to place applications in condition for allowance (MPEP § 1302.04).

Quayle Actions: This examiner issues Ex Parte Quayle actions in 0.7% of allowed cases (in the 58% percentile). This examiner issues Quayle actions more often than average when claims are allowable but formal matters remain (MPEP § 714.14).

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Prepare for rigorous examination: With a below-average allowance rate, ensure your application has strong written description and enablement support. Consider filing a continuation if you need to add new matter.
  • Prioritize examiner interviews: Interviews are highly effective with this examiner. Request an interview after the first office action to clarify issues and potentially expedite allowance.
  • Request pre-appeal conferences: PACs are highly effective with this examiner. Before filing a full appeal brief, request a PAC to potentially resolve issues without full PTAB review.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.