USPTO Art Unit 1681 Prosecution Statistics

Art Unit Information

Art Unit: 1681
Group: 1680
Tech Center: 1600
Total Cases: 2,320
Last Active: October 2025

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
19375973FRAGMENTING RNA:DNA HYBRIDSOctober 2025January 2026Allow300YesNo
19318311METHODS FOR DETECTING INTERCELLULAR INTERACTIONS OF CELLS IN A COMPARTMENT OF A FLUIDIC DEVICESeptember 2025January 2026Allow510YesNo
19318315METHODS FOR INCUBATING AND ANALYZING A CELL IN A COMPARTMENT OF A FLUIDIC DEVICESeptember 2025January 2026Allow510YesNo
19311988SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATIONAugust 2025March 2026Allow610NoNo
19306722METHOD OF RAPID EXTRACTION OF DNA FROM SALIVA AND QPCR AMPLIFICATION OF GROUP A STREPTOCOCCUS DNAAugust 2025February 2026Allow610NoNo
19297604Biomarker for Detecting and Treating Type II DiabetesAugust 2025February 2026Allow610NoNo
19295122NANOPORE-BASED ANALYSIS OF ANALYTESAugust 2025December 2025Allow400NoNo
19294044METHODS FOR IMAGING AND ANALYZING A CELL IN A COMPARTMENT OF A FLUIDIC DEVICEAugust 2025January 2026Allow610YesNo
19278614METHODS FOR ENCLOSING AND ANALYZING A CELL IN A FLUIDIC DEVICEJuly 2025February 2026Allow710YesNo
19268022LINKED LIGATIONJuly 2025August 2025Allow100NoNo
19249710SEQUENCING METHODS WITH PARTITIONINGJune 2025September 2025Allow310NoNo
19240880METHODS AND COMPOSITIONS FOR ISOLATING AN ANALYTEJune 2025August 2025Allow200NoNo
19230686SYSTEMS AND METHODS FOR ENCAPSULATION AND MULTI-STEP PROCESSING OF BIOLOGICAL SAMPLESJune 2025March 2026Allow920NoNo
19228005ANALYSIS OF A POLYNUCLEOTIDE VIA A NANOPORE SYSTEMJune 2025October 2025Allow410YesNo
19212481METHOD FOR MAKING A PHYSICAL MAP OF BINDING EVENTS THAT ARE ON OR ON CELLSMay 2025July 2025Allow100NoNo
19212398CHROMATIN PROFILING COMPOSITIONS AND METHODSMay 2025November 2025Allow610NoNo
19188704Nucleotide Analogs for Efficient DNA and RNA AmplificationApril 2025August 2025Allow400NoNo
19177401DEVICES AND METHODS FOR ANALYZING BIOLOGICAL SAMPLESApril 2025August 2025Allow410NoNo
19172702Products for Protein Analyte Detection Assays Using AntibodiesApril 2025December 2025Allow821YesNo
19172703Nucleic Acid Reporter Molecules for Massively Parallel DNA SequencingApril 2025October 2025Allow611YesNo
19097444METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDESApril 2025January 2026Allow1010YesNo
19091172SYSTEMS AND METHODS FOR SELECTIVE DNA MULTIPLE DISPLACEMENT AMPLIFICATION OF A DNA MIXTURE;March 2025January 2026Allow1020YesNo
19088591SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATIONMarch 2025November 2025Allow810NoNo
19083413PRIMER SET OF MYCOBACTERIUM TUBERCULOSIS BASED ON SPECIFIC HRCA ISOTHERMAL AMPLIFICATION AND AN APPLICATION THEREOFMarch 2025July 2025Allow410YesNo
19083328METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDESMarch 2025October 2025Allow720YesNo
19082509LINKED LIGATIONMarch 2025July 2025Allow400NoNo
19082485LINKED LIGATIONMarch 2025May 2025Allow200NoNo
19072459METHODS AND SYSTEMS FOR DETECTING GENETIC VARIANTSMarch 2025August 2025Allow610NoNo
19070259METHODS AND SYSTEMS FOR DETECTING GENETIC VARIANTSMarch 2025April 2025Allow210NoNo
19064793SELF-CONTAINED BIOLOGICAL ANALYSISFebruary 2025August 2025Allow510YesNo
19059102CATALYTIC DE-CROSSLINKING OF SAMPLES FOR IN SITU ANALYSISFebruary 2025September 2025Allow610NoNo
19047506PROBE-BASED ANALYSIS OF NUCLEIC ACIDS AND PROTEINSFebruary 2025July 2025Allow510NoNo
19041629CELL-FREE METHOD OF PRODUCING SYNTHETIC CIRCULAR NUCLEIC ACIDJanuary 2025September 2025Allow711YesNo
19029558METHODS AND SYSTEMS FOR ANALYZING NUCLEIC ACID MOLECULESJanuary 2025October 2025Allow910YesNo
19028873METHODS FOR SIMULTANEOUS AMPLIFICATION OF TARGET LOCIJanuary 2025October 2025Allow910NoNo
19028776METHODS FOR SIMULTANEOUS AMPLIFICATION OF TARGET LOCIJanuary 2025October 2025Allow910NoNo
19029171METHODS FOR NON-INVASIVE PRENATAL PLOIDY CALLINGJanuary 2025October 2025Allow910NoNo
19029732DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESISJanuary 2025August 2025Allow701NoNo
19025566METHODS AND SYSTEMS FOR ANALYZING NUCLEIC ACID MOLECULESJanuary 2025October 2025Allow910NoNo
19014935METHOD AND KIT FOR GENOTYPING OF MULTI-SYSTEM RED BLOOD CELL (RBC) BLOOD GROUP BASED ON NEXT-GENERATION SEQUENCING (NGS)January 2025June 2025Allow610NoNo
18986602ESTIMATING TUMOR PURITY FROM SINGLE SAMPLESDecember 2024August 2025Allow811NoNo
18969786Gene target region enrichment method and kitDecember 2024December 2025Allow1220NoNo
18965294PERSONALIZED METHODS OF DETECTING CIRCULATING TUMOR DNADecember 2024October 2025Allow1021YesNo
18961447RPA-PAND BASED ENTEROVIRUS TYPING DETECTION KIT AND DETECTION METHODNovember 2024July 2025Allow711NoNo
18958854SEQUENCING A TARGET SEQUENCE IN A CELLNovember 2024June 2025Allow610NoNo
18946611METHODS OF PREDICTING ENGRAFTMENT CAPABILITY OF DIFFERENTIATED NEURONAL PROGENITOR CELLSNovember 2024February 2025Allow300NoNo
18941885CONSTRUCTION METHOD AND APPLICATION OF MICRORNA ELECTROCHEMICAL BIOSENSORNovember 2024June 2025Allow720YesNo
18939319TEMPERATURE-SELECTABLE FRET CASSETTE SIGNALINGNovember 2024March 2026Allow1630NoYes
18939315TEMPERATURE-SELECTABLE FRET CASSETTE SIGNALINGNovember 2024June 2025Allow811NoNo
18938479PRIMER AND PROBE COMPOSITION FOR CAT BLOOD TYPE DETECTION, DETECTION METHOD, AND USENovember 2024August 2025Allow911NoNo
18936839METHODS AND SYSTEMS FOR MONITORING A RECIPIENT OF AN ALLOGRAFTNovember 2024July 2025Allow830YesNo
18936042Compositions and Methods for Analyte DetectionNovember 2024January 2026Allow1422NoNo
18930072METHODS FOR MONITORING RESIDUAL DISEASEOctober 2024February 2025Allow1310YesNo
18912947MOLECULAR MARKERS FOR GERMPLASM IDENTIFICATION AND SELECTION OF CAROTENOID-RICH BAY SCALLOPSOctober 2024August 2025Allow1020NoNo
18911297COMPOSITION AND KIT FOR DETECTING MYCOPLASMAOctober 2024June 2025Allow810YesNo
18903582HIGH THROUGHPUT SCREENING ASSAY TO IDENTIFY DNA TOPOISOMERASE INHIBITORSOctober 2024January 2025Allow310NoNo
18900948METHOD, KIT AND SYSTEM FOR END LABELING OF NUCLEIC ACIDSSeptember 2024June 2025Allow811YesNo
18899799METHODS AND MATERIALS FOR ASSESSING NUCLEIC ACIDSSeptember 2024August 2025Allow1011YesNo
18892086ASSAYS AND OTHER REACTIONS INVOLVING DROPLETSSeptember 2024May 2025Allow812YesNo
18891871Methods for Detecting and Discriminating among Microbes in Microbial Pathogen MixturesSeptember 2024November 2025Abandon1311NoNo
18889834DETECTING POLYNUCLEOTIDES WITH BARCODED OLIGONUCLEOTIDE PROBESSeptember 2024June 2025Allow930YesNo
18889399METHODS FOR ISOLATING TARGET ANALYTES FROM URINE SAMPLES USING ATPS AND MAGNETIC BEADSSeptember 2024April 2025Allow701NoNo
18889404METHODS AND KITS USEFUL FOR DIAGNOSIS OF UROGENITAL CANCERSeptember 2024April 2025Allow701NoNo
18888001SPATIAL MAPPING BY SERIAL PRIMER EXTENSIONSeptember 2024July 2025Allow1020NoNo
18887759DETERMINATION OF PROTEIN INFORMATION BY RECODING AMINO ACID POLYMERS INTO DNA POLYMERSSeptember 2024April 2025Allow721YesNo
18885331DETECTION OF METHYLATION STATUS OF A DNA SAMPLESeptember 2024May 2025Allow811YesNo
18882493METHOD FOR NUCLEIC ACID AMPLIFICATIONSeptember 2024October 2025Allow1421YesNo
18827295MICROFLUIDICS SYSTEM, DEVICE, AND METHODS FOR PERFORMING RAPID POLYMERASE CHAIN REACTION (PCR) PROTOCOLSSeptember 2024April 2025Allow801NoNo
18820804MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOFAugust 2024March 2025Allow610NoNo
18813477METHODS AND SYSTEMS FOR DETECTING GENETIC VARIANTSAugust 2024February 2025Allow610NoNo
18841241CRISPR-CAS-BASED COMPOSITION FOR SALMONELLA DETECTION AND SALMONELLA DETECTION METHOD USING SAMEAugust 2024August 2025Allow1220NoNo
18812385METHODS AND SYSTEMS FOR DETECTING GENETIC VARIANTSAugust 2024February 2025Allow510NoNo
18807061DARK CYCLE SEQUENCINGAugust 2024February 2025Allow621NoNo
18803324COMPOSITION COMPRISING CELL ORIGINATION BARCODES FOR THE ANALYSIS OF BOTH GENOMIC DNA AND CDNA FROM THE SAME CELLAugust 2024October 2024Allow200NoNo
18791082NUCLEOTIDE ANALOGUESJuly 2024August 2025Abandon1221NoNo
18776193DEVICES AND METHODS FOR ANALYZING BIOLOGICAL SAMPLESJuly 2024January 2025Allow610YesNo
18770271METHODS AND SYSTEMS FOR ANALYZING NUCLEIC ACID MOLECULESJuly 2024December 2024Allow510NoNo
18770298METHODS AND SYSTEMS FOR ANALYZING NUCLEIC ACID MOLECULESJuly 2024March 2025Allow810NoNo
18769778DETECTING TUMOR INFILTRATING CELLSJuly 2024October 2025Allow1520NoNo
18724919METHOD FOR CONFIRMING THE IDENTITY OF A PRODUCT BY MEANS OF A MICROBIAL DNA TAGJune 2024January 2026Allow1911NoNo
18753991DETECTING MUTATIONS AND PLOIDY IN CHROMOSOMAL SEGMENTSJune 2024October 2025Allow1520YesNo
18753625COMPOSITIONS AND METHODS FOR NUCLEIC ACID EXTENSIONJune 2024May 2025Abandon1001NoNo
18752431CAPTURING, CONCENTRATING, AND DETECTING MICROBES IN A SAMPLE USING MAGNETIC IONIC LIQUIDS AND RECOMBINASE POLYMERASE AMPLIFICATIONJune 2024June 2025Allow1110NoNo
18741014METHODS, DEVICES AND KITS FOR PREPARING NUCLEIC ACID SAMPLES FOR STORAGE AND ANALYSISJune 2024February 2026Abandon2001NoNo
18738910SAFE SEQUENCING SYSTEMJune 2024September 2025Allow1620YesNo
18739037CHEMICALLY-ENHANCED PRIMER COMPOSITIONS, METHODS AND KITSJune 2024August 2025Abandon1410NoNo
18737828PROBE-BASED ANALYSIS OF NUCLEIC ACIDS AND PROTEINSJune 2024March 2025Abandon910NoNo
18737230SYSTEMS AND METHODS FOR SEQUENCING ERROR CORRECTION VIA DOUBLE STRAND PRESERVATIONJune 2024September 2024Allow410NoNo
18733895KIT AND METHOD FOR EMBRYO IMPLANTATIONJune 2024October 2025Abandon1611NoNo
18715913A METHOD OF CAPTURING CRISPR ENDONUCLEASE CLEAVAGE PRODUCTSJune 2024July 2025Allow1321YesNo
18679053METHOD FOR BARCODINGMay 2024September 2024Allow300YesNo
18677090SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATIONMay 2024February 2025Allow910NoNo
18677555COMPOSITION COMPRISING CELL ORIGINATION BARCODES FOR THE ANALYSIS OF BOTH PROTEIN AND NUCLEIC ACID FROM THE SAME CELLMay 2024August 2024Allow300YesNo
18677070DETERMINATION OF PROTEIN INFORMATION BY RECODING AMINO ACID POLYMERS INTO DNA POLYMERSMay 2024March 2026Allow2120NoNo
18675708LABELED NUCLEOTIDE ANALOGS, REACTION MIXTURES, AND METHODS AND SYSTEMS FOR SEQUENCINGMay 2024May 2025Allow1210NoNo
18673376METHOD FOR SCREENING LACTOBACILLUS CASEI FERMENTATION AGENTMay 2024October 2024Allow510NoNo
18672154Adenosine triphosphatase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 (ATP2A2) gene-based molecular marker for identifying chicken feed efficiency trait, and identification method and use thereofMay 2024March 2025Allow1010NoNo
186701073'-O-MODIFIED NUCLEOTIDE ANALOGUES WITH DIFFERENT CLEAVABLE LINKERS FOR ATTACHING FLUORESCENT LABELS TO THE BASE FOR DNA SEQUENCING BY SYNTHESISMay 2024November 2025Abandon1810NoNo
18663889METHODS AND DEVICES FOR SEQUENCING NUCLEIC ACIDS IN SMALLER BATCHESMay 2024January 2026Allow2021NoNo
18656534OSCILLATING AMPLIFICATION REACTION FOR NUCLEIC ACIDSMay 2024July 2025Allow1420NoNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for art-unit 1681.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
27
Examiner Affirmed
10
(37.0%)
Examiner Reversed
17
(63.0%)
Reversal Percentile
96.9%
Higher than average

What This Means

With a 63.0% reversal rate, the PTAB has reversed the examiner's rejections more often than affirming them. This reversal rate is in the top 25% across the USPTO, indicating that appeals are more successful here than in most other areas.

Strategic Value of Filing an Appeal

Total Appeal Filings
222
Allowed After Appeal Filing
83
(37.4%)
Not Allowed After Appeal Filing
139
(62.6%)
Filing Benefit Percentile
77.6%
Higher than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 37.4% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the top 25% across the USPTO, indicating that filing appeals is particularly effective here. The act of filing often prompts favorable reconsideration during the mandatory appeal conference.

Strategic Recommendations

✓ Appeals to PTAB show good success rates. If you have a strong case on the merits, consider fully prosecuting the appeal to a Board decision.

✓ Filing a Notice of Appeal is strategically valuable. The act of filing often prompts favorable reconsideration during the mandatory appeal conference.

Art Unit 1681 - Prosecution Statistics Summary

Executive Summary

Art Unit 1681 is part of Group 1680 in Technology Center 1600. This art unit has examined 2,320 patent applications in our dataset, with an overall allowance rate of 88.7%. Applications typically reach final disposition in approximately 39 months.

Comparative Analysis

Art Unit 1681's allowance rate of 88.7% places it in the 87% percentile among all USPTO art units. This art unit has a significantly higher allowance rate than most art units at the USPTO.

Prosecution Patterns

Applications in Art Unit 1681 receive an average of 2.38 office actions before reaching final disposition (in the 82% percentile). The median prosecution time is 39 months (in the 16% percentile).

Strategic Considerations

When prosecuting applications in this art unit, consider the following:

  • The art unit's allowance rate suggests a more favorable examination environment compared to the USPTO average.
  • With more office actions than average, plan for multiple rounds of prosecution.
  • The median prosecution time is longer than average and should be factored into your continuation and client communication strategies.
  • Review individual examiner statistics within this art unit to identify examiners with particularly favorable or challenging prosecution patterns.

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.