USPTO Art Unit 1652 Prosecution Statistics

Art Unit Information

Art Unit: 1652
Group: 1650
Tech Center: 1600
Total Cases: 16,994
Last Active: October 2025

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
19347136ENGINEERED MEGANUCLEASES HAVING SPECIFICITY FOR A RECOGNITION SEQUENCE IN THE HEPATITIS B VIRUS GENOMEOctober 2025March 2026Allow511YesNo
19273915ENGINEERED MEGANUCLEASES HAVING SPECIFICITY FOR A RECOGNITION SEQUENCE IN THE HEPATITIS B VIRUS GENOMEJuly 2025March 2026Abandon810NoNo
19273324METHOD OF FACILITATING MITIGATION OF COSMETIC IMPERFECTIONS ASSOCIATED WITH FINGERPRINT IMPRESSIONS ON ANODIZED MATERIALS AND ANODIZED MATERIALS TREATED FOR PROVIDING SAMEJuly 2025September 2025Allow220NoNo
19242226Hyaluronidase Enzyme Formulations for High Volume AdministrationJune 2025January 2026Allow711NoNo
19212294STABILIZATION OF TRYPTAMINES BY DENATURING ENZYMES, OPTIMIZING IONIZATION STATES, AND CONTROLLING CONFOUNDING VARIABLESMay 2025October 2025Allow511NoNo
19186618GERMACRENE SYNTHASE SgTPS7 PROTEIN, CODING GENE AND USE IN SYNTHESIS OF GERMACRENEApril 2025November 2025Allow710YesNo
19186223METHODS FOR MAKING L-GLUFOSINATEApril 2025August 2025Allow410NoNo
19184659LIPID-ENCAPSULATED DUAL-CLEAVING ENDONUCLEASE FOR DNA AND GENE EDITINGApril 2025September 2025Allow510NoNo
19081211FUSION PROTEINS COMPRISING ACID ALPHA-GLUCOSIDASE ENZYMES AND METHODS THEREOFMarch 2025June 2025Allow300YesNo
18998009METHODS OF USING SYNTROPHUS ACIDITROPHICUS TO PRODUCE CYCLOHEXANE-1-CARBOXYLATE (CHC)January 2025March 2026Allow1401YesNo
19028581COMPOSITE BACTERIAL AGENT AND APPLICATION THEREOFJanuary 2025February 2026Abandon1320NoNo
19019039MODIFIED PH129 POLYMERASE AND USES THEREOFJanuary 2025November 2025Allow1010NoNo
19014260PFU DNA POLYMERASE MUTANTS WITH REVERSE TRANSCRIPTASE ACTIVITY AND THEIR APPLICATIONSJanuary 2025October 2025Allow911YesNo
18880346RECOMBINANT ORGANISM AND METHODDecember 2024February 2026Allow1320NoNo
18879111MODIFIED MICROORGANISM OF GENUS CORYNEBACTERIUM PRODUCING L-GLUTAMIC ACID AND METHOD FOR PRODUCING L-GLUTAMIC ACID USING SAMEDecember 2024January 2026Allow1320NoNo
18963644BACILLUS PROTEOLYTICUS CWJ-2-GJ AND APPLICATION THEREOFNovember 2024April 2025Allow410YesNo
18957929NOVEL CAS EFFECTOR PROTEINS, GENE EDITING SYSTEMS, AND USES THEREOFNovember 2024October 2025Allow1011YesNo
18946900METHOD FOR PRODUCING HYDROGEN GAS FROM SWEET SORGHUMNovember 2024July 2025Allow810YesNo
18940001Hyaluronidase Enzyme Formulations for High Volume AdministrationNovember 2024June 2025Allow811YesNo
18940031Hyaluronidase Enzyme Formulations for High Volume AdministrationNovember 2024July 2025Allow811YesNo
18937712HYDROGENOPHILUS BACTERIUM TRANSFORMANTNovember 2024July 2025Allow820YesNo
18935987FOOD COMPOSITION CONTAINING NOVEL ALDEHYDE DEHYDROGENASE FOR IMPROVING MEMORY AND COGNITIVE FUNCTIONNovember 2024April 2025Allow510NoNo
18933327CARBONYL REDUCTASE MUTANT AND ITS APPLICATIONOctober 2024March 2025Allow510NoNo
18859487ALDITOL OXIDASE AND APPLICATION THEREOFOctober 2024February 2025Allow400NoNo
18918210SELENIUM-CONTAINING NANO HOF, ANTIOXIDANT NANOZYME, PREPARATION METHOD AND APPLICATION THEREOFOctober 2024June 2025Allow811NoNo
18886923ELECTRO-RESPONSIVE SILK FIBROIN MATERIAL, ELECTRO-RESPONSIVE SILK FIBROIN MICRONEEDLE, INSULIN MICRONEEDLE PATCH HAVING ELECTRO-RESPONSIVE SILK FIBROIN AND PREPARATION METHOD THEREFOR, AND TRANSDERMAL DRUG DELIVERY DEVICESeptember 2024April 2025Allow710NoNo
18846061ENZYMATIC METHOD FOR THE PRODUCTION OF L-GLUFOSINATE P-ESTERSSeptember 2024June 2025Allow910YesNo
18882341CELL WALL HYDROLASES TARGETING C. ACNESSeptember 2024April 2025Allow711YesNo
18825195GENETIC ENGINEERING BACTERIUM FOR DE NOVO SYNTHESIS OF CIS,CIS-MUCONIC ACID BY TAKING GLUCOSE AS SUBSTRATE AND APPLICATIONS THEREOFSeptember 2024April 2025Allow820YesNo
18814865DEAMINASES AND VARIANTS THEREOF FOR USE IN BASE EDITINGAugust 2024March 2025Allow611NoNo
18781694RNA-GUIDED NUCLEASES AND ACTIVE FRAGMENTS AND VARIANTS THEREOF AND METHODS OF USEJuly 2024April 2025Allow911NoNo
18778981MODULATING EXPRESSION OF ALAS1 (5'-AMINOLEVULINATE SYNTHASE 1) GENEJuly 2024January 2026Allow1811NoNo
18770533MICROORGANISMS AND METHODS FOR THE CONTINUOUS PRODUCTION OF FATTY ACIDS, FATTY ALCOHOLS, AND CULTURED PROTEIN FROM C1 SUBSTRATESJuly 2024June 2025Abandon1111NoNo
18767621UDP-GLYCOSYLTRANSFERASE VARIANTS AND USES THEREOFJuly 2024April 2025Allow900NoNo
18767461SYSTEM AND METHOD FOR CO2 HYDROGENATION USING MULTI-ENZYME IMMOBILIZATION ON MODIFIED METAL-ORGANIC FRAMEWORK (MOF)July 2024February 2025Allow811YesNo
18767086SUBTERRANEAN WATER BARRIERJuly 2024February 2025Allow711NoNo
18762259COMPOSITIONS AND METHODS FOR EPIGENETIC REGULATION OF HBV GENE EXPRESSIONJuly 2024April 2025Allow1011NoNo
18752282PRODUCTION AND SEPARATION OF 3-HYDROXYPROPIONIC ACIDJune 2024October 2025Allow1600NoNo
18749788USE OF MUTANT OF IMMUNOGLOBULIN DEGRADING ENZYME IDEEJune 2024March 2025Allow911NoNo
18745084GENE DUPLICATIONS FOR CRABTREE-WARBURG-LIKE AEROBIC XYLOSE FERMENTATIONJune 2024October 2025Allow1611NoNo
18744124PHOTOSYSTEM I-HYDROGENASE CHIMERAS FOR HYDROGEN PRODUCTIONJune 2024March 2026Allow2111NoNo
18742500High Throughput Reaction AssemblyJune 2024January 2026Allow1910NoNo
18741273METHODS FOR ORGANIC ACID PRODUCTIONJune 2024August 2025Allow1411NoNo
18741103USE AND PRODUCTION OF STORAGE-STABLE NEUTRAL METALLOPROTEASEJune 2024March 2026Abandon2101NoNo
18717423LACTIPLANTIBACILLUS PLANTARUM STRAIN FOR ALLEVIATING HYPERURICEMIA AND COMBINATION AND USE THEREOFJune 2024May 2025Allow1110NoNo
18736354GENETICALLY ENGINEERED STRAINS WITH REDUCED BYPRODUCT FORMATIONJune 2024October 2025Allow1630YesNo
18731620Lipase Variants and Microcapsule Compositions Comprising Such Lipase VariantsJune 2024August 2025Allow1410YesNo
18680175Production of Lipids and Terpenoids in Auxenochlorella ProtothecoidesMay 2024December 2025Allow1910NoNo
18678629EXOGENOUS KETONE BLEND COMPOSITIONS FOR DELIVERY OF KETONE BODIESMay 2024October 2025Allow1621NoNo
18676494BETA-GLYCOSIDASE SS-BGL MUTANT FOR MODIFYING GINSENOSIDE AND APPLICATION THEREOFMay 2024October 2025Allow1620NoNo
18674430INTEGRATED GAS FERMENTATION AND CARBON BLACK PROCESSESMay 2024June 2025Allow1221NoNo
18674362INTEGRATED GAS FERMENTATIONMay 2024March 2025Allow911YesNo
18672113VERSATILE PEROXIDASES AND USES THEREOFMay 2024January 2025Allow811NoNo
18671324KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINEMay 2024August 2025Allow1410NoNo
18661739METHOD FOR PRODUCING SCLAREOL BY FERMENTATION OF CIGAR TOBACCO FLOWER BUDSMay 2024October 2024Allow510NoNo
18662443REGENERATIVE POLYPEPTIDES AND USES THEREOFMay 2024February 2025Allow920YesNo
18660667DNA POLYMERASE MUTANT SUITED TO NUCLEIC ACID AMPLIFICATION FROM RNAMay 2024April 2025Allow1110YesNo
18660840RECOMBINANT OLIVETOLIC ACID CYCLASE POLYPEPTIDES ENGINEERED FOR ENHANCED BIOSYNTHESIS OF CANNABINOIDSMay 2024January 2026Allow2110NoNo
18659585MODIFIED PHI29 DNA POLYMERASES AND USES THEREOFMay 2024November 2024Allow611NoNo
18659299METHOD OF FACILITATING MITIGATION OF COSMETIC IMPERFECTIONS ASSOCIATED WITH FINGERPRINT IMPRESSIONS ON ANODIZED MATERIALS AND ANODIZED MATERIALS TREATED FOR PROVIDING SAMEMay 2024July 2025Allow1410NoNo
18658938CPF1 PROTEIN AND ITS USE IN GENE EDITINGMay 2024February 2025Allow910NoNo
18658735COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIAMay 2024February 2026Allow2210NoNo
18657159Heat Resistant Biopesticide And A Method Of Preparing The SameMay 2024June 2025Allow1321YesNo
18657101ENGINEERED GALACTOSE OXIDASE VARIANT ENZYMESMay 2024July 2025Allow1511NoNo
18657713ALPHA-AMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAMEMay 2024February 2026Allow2120YesNo
18655701PEROXIDASE ACTIVITY TOWARDS 10-ACETYL-3,7-DIHYDROXYPHENOXAZINEMay 2024October 2025Allow1721YesNo
18650206Improved transfection method using a Sleeping Beauty transposase variant with increased solubility that transfects a target cell when used in protein formApril 2024March 2025Allow1121YesNo
18649712PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATESApril 2024October 2024Allow610YesNo
18645049METHODS AND COMPOSITIONS FOR TREATMENT OF HUNTER SYNDROME COMPRISING IDURONATE-2-SULFATASEApril 2024February 2025Allow1010NoNo
18642135Hyaluronidase Enzyme Formulations for High Volume AdministrationApril 2024October 2025Allow1811NoNo
18641275COMPOSITIONS AND METHODS OF DUST CONTROLApril 2024February 2026Abandon2210NoNo
18638690BETA-GLYCOSIDASE SS-BGL MUTANT FOR MODIFYING GINSENOSIDE AND APPLICATION THEREOFApril 2024January 2025Allow921NoNo
18635214SERINE PROTEASESApril 2024May 2025Allow1300NoNo
18636074VARIANTS OF TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE AND USES THEREOFApril 2024March 2025Allow1110NoNo
18634373Triglycerides and Structured Lipids from Short- and Medium-Chain Fatty AcidsApril 2024August 2025Allow1711NoNo
18632080Methods for Producing a Composition Containing Lipids From Recombinant Algae Having High Lipid ProductivityApril 2024May 2025Allow1320NoNo
18631568DNA MODIFYING ENZYMES AND ACTIVE FRAGMENTS AND VARIANTS THEREOF AND METHODS OF USEApril 2024November 2024Allow700YesNo
18628140ENGINEERED GLUCOSYLTRANSFERASESApril 2024April 2025Allow1211YesNo
18627748METHOD FOR EXTRACTING PULLULAN POLYSACCHARIDE FROM HIGH-VISCOSITY FERMENTATION BROTHApril 2024August 2024Allow510NoNo
18628400DNA MODIFYING ENZYMES AND ACTIVE FRAGMENTS AND VARIANTS THEREOF AND METHODS OF USEApril 2024October 2025Abandon1820NoNo
18627839DNA MODIFYING ENZYMES AND ACTIVE FRAGMENTS AND VARIANTS THEREOF AND METHODS OF USEApril 2024August 2024Allow500YesNo
18628461ENGINEERED DNA POLYMERASE VARIANTSApril 2024June 2025Abandon1510NoNo
18623612METHODS AND COMPOSITIONS FOR MODULATING A GENOMEApril 2024April 2025Allow1301YesNo
18623704NUCLEIC ACID MOLECULES ENCODING DNA MODIFYING ENZYMES AND ACTIVE FRAGMENTS AND VARIANTS THEREOF AND COMPOSITIONS COMPRISING THE SAMEApril 2024August 2024Allow510YesNo
18620636COMPOSITIONS AND METHODS FOR TREATING MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHYMarch 2024March 2026Allow2311YesNo
18618330Modified Enzyme and Method of Producing Imidazole Dipeptide Using SameMarch 2024March 2026Allow2400NoNo
18616877ALPHA SYNUCLEIN SUBSTRATES AND METHODS FOR MAKING AND USING THE SAMEMarch 2024February 2026Abandon2211NoNo
18614099KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANEMarch 2024April 2025Allow1210YesNo
18612686SYSTEMS FOR PROCESSING PLANT MATERIALS AND PRODUCING DRIED PRODUCTSMarch 2024July 2025Allow1611NoNo
18611058Bacterium And Obtaining Method And Application ThereofMarch 2024January 2026Allow2221NoNo
18611182DNA SEQUENCE MODIFICATION-BASED GENE DRIVEMarch 2024November 2025Allow2010NoNo
18611354ENGINEERED ACID ALPHA-GLUCOSIDASE VARIANTSMarch 2024August 2025Allow1711NoNo
18609276MATERIALS AND METHODS FOR PROTEIN PRODUCTIONMarch 2024September 2025Allow1811NoNo
18609707POLYHYDROXYALKANOATE PRODUCTION METHODS AND MATERIALS AND MICROORGANISMS USED IN SAMEMarch 2024April 2025Allow1310NoNo
18606664Enzymatic Methods for Treating Neurodegenerative DisordersMarch 2024November 2024Allow811YesNo
18605166PROCESS FOR THE MANIPULATION OF NUCLEIC ACIDSMarch 2024June 2025Allow1501NoNo
18600576METHOD FOR PRODUCING MULTI-HYDROXY DERIVATIVES OF POLYUNSATURATED FATTY ACIDSMarch 2024January 2025Allow1000NoNo
18598466Cleaning Compositions Comprising EnzymesMarch 2024January 2026Abandon2221YesNo
18598872PROTEASE COMPOSITIONS AND METHODS OF USE THEREOFMarch 2024October 2025Abandon1911NoNo
18597204RECOMBINANT HUMAN SIALIDASES, SIALIDASE FUSION PROTEINS, AND METHODS OF USING THE SAMEMarch 2024March 2026Allow2411YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for art-unit 1652.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
166
Examiner Affirmed
103
(62.0%)
Examiner Reversed
63
(38.0%)
Reversal Percentile
74.2%
Higher than average

What This Means

With a 38.0% reversal rate, the PTAB reverses the examiner's rejections in a meaningful percentage of cases. This reversal rate is above the USPTO average, indicating that appeals have better success here than typical.

Strategic Value of Filing an Appeal

Total Appeal Filings
1431
Allowed After Appeal Filing
382
(26.7%)
Not Allowed After Appeal Filing
1049
(73.3%)
Filing Benefit Percentile
20.9%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 26.7% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

✓ Appeals to PTAB show good success rates. If you have a strong case on the merits, consider fully prosecuting the appeal to a Board decision.

⚠ Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Art Unit 1652 - Prosecution Statistics Summary

Executive Summary

Art Unit 1652 is part of Group 1650 in Technology Center 1600. This art unit has examined 16,994 patent applications in our dataset, with an overall allowance rate of 64.5%. Applications typically reach final disposition in approximately 30 months.

Comparative Analysis

Art Unit 1652's allowance rate of 64.5% places it in the 22% percentile among all USPTO art units. This art unit has a significantly lower allowance rate than most art units at the USPTO.

Prosecution Patterns

Applications in Art Unit 1652 receive an average of 1.70 office actions before reaching final disposition (in the 34% percentile). The median prosecution time is 30 months (in the 53% percentile).

Strategic Considerations

When prosecuting applications in this art unit, consider the following:

  • The art unit's allowance rate suggests a more challenging examination environment compared to the USPTO average.
  • With fewer office actions than average, plan for relatively streamlined prosecution.
  • The median prosecution time is shorter than average and should be factored into your continuation and client communication strategies.
  • Review individual examiner statistics within this art unit to identify examiners with particularly favorable or challenging prosecution patterns.

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.