USPTO Examiner RAGHU GANAPATHIRAM - Art Unit 1652

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
19186223METHODS FOR MAKING L-GLUFOSINATEApril 2025August 2025Allow410NoNo
19184659LIPID-ENCAPSULATED DUAL-CLEAVING ENDONUCLEASE FOR DNA AND GENE EDITINGApril 2025September 2025Allow510NoNo
18770533MICROORGANISMS AND METHODS FOR THE CONTINUOUS PRODUCTION OF FATTY ACIDS, FATTY ALCOHOLS, AND CULTURED PROTEIN FROM C1 SUBSTRATESJuly 2024June 2025Abandon1111NoNo
18741103USE AND PRODUCTION OF STORAGE-STABLE NEUTRAL METALLOPROTEASEJune 2024March 2026Abandon2101NoNo
18676494BETA-GLYCOSIDASE SS-BGL MUTANT FOR MODIFYING GINSENOSIDE AND APPLICATION THEREOFMay 2024October 2025Allow1620NoNo
18661739METHOD FOR PRODUCING SCLAREOL BY FERMENTATION OF CIGAR TOBACCO FLOWER BUDSMay 2024October 2024Allow510NoNo
18660840RECOMBINANT OLIVETOLIC ACID CYCLASE POLYPEPTIDES ENGINEERED FOR ENHANCED BIOSYNTHESIS OF CANNABINOIDSMay 2024January 2026Allow2110NoNo
18658735COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIAMay 2024February 2026Allow2210NoNo
18657713ALPHA-AMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAMEMay 2024February 2026Allow2120YesNo
18641275COMPOSITIONS AND METHODS OF DUST CONTROLApril 2024February 2026Abandon2210NoNo
18635214SERINE PROTEASESApril 2024May 2025Allow1300NoNo
18627748METHOD FOR EXTRACTING PULLULAN POLYSACCHARIDE FROM HIGH-VISCOSITY FERMENTATION BROTHApril 2024August 2024Allow510NoNo
18623612METHODS AND COMPOSITIONS FOR MODULATING A GENOMEApril 2024April 2025Allow1301YesNo
18614099KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANEMarch 2024April 2025Allow1210YesNo
18611182DNA SEQUENCE MODIFICATION-BASED GENE DRIVEMarch 2024November 2025Allow2010NoNo
18437445GLUCOAMYLASE ENGINEERED YEAST AND FERMENTATION METHODSFebruary 2024April 2025Abandon1410NoNo
18435340METHODS FOR MAKING L-GLUFOSINATEFebruary 2024March 2025Allow1410NoNo
18435544METHODS FOR MAKING L-GLUFOSINATEFebruary 2024April 2025Allow1410NoNo
18416852THERAPEUTIC PROTEINS WITH INCREASED HALF-LIFE AND METHODS OF PREPARING SAMEJanuary 2024September 2025Abandon2011NoNo
18412090INSECT INHIBITORY TOXIN FAMILY ACTIVE AGAINST HEMIPTERAN AND/OR LEPIDOPTERAN INSECTSJanuary 2024March 2025Abandon1411NoNo
18402680ENGINEERED NUCLEIC ACID-GUIDED NUCLEASESJanuary 2024July 2024Allow610YesNo
18525234UDP-DEPENDENT GLYCOSYLTRANSFERASE FOR HIGH EFFICIENCY PRODUCTION OF REBAUDIOSIDESNovember 2023April 2025Allow1610NoNo
18512848Enzyme Variants and Polynucleotides Encoding the SameNovember 2023August 2025Allow2121NoNo
18511394METHODS OF PRODUCING MORPHINAN ALKALOIDS AND DERIVATIVESNovember 2023June 2025Allow1910NoNo
18506648Liquid Cleaning Compositions Comprising Protease VariantsNovember 2023December 2024Allow1410NoNo
18504743Liquid Cleaning Compositions Comprising Protease VariantsNovember 2023December 2024Allow1320YesNo
18496269AUTOMATIC DISHWASHING DETERGENT COMPOSITIONSOctober 2023February 2025Abandon1601NoNo
18384044PRODUCTION OF CAROTENOIDS AND APOCAROTENOIDSOctober 2023April 2025Allow1721YesNo
18485895TUNABLE NANOSCALE CAGES FROM SELF-ASSEMBLING DNA AND PROTEIN BUILDING BLOCKSOctober 2023March 2025Allow1710YesNo
18485501Construction Method and Application of Microorganism Capable of Realizing High Production of Lacto-N-tetroseOctober 2023April 2024Allow610NoNo
18484214METHODS OF REDUCING ODOROctober 2023August 2025Allow2230YesNo
18453987METHODS AND ORGANISMS WITH INCREASED CARBON FLUX EFFICIENCIESAugust 2023June 2025Allow2221NoNo
18264639PROTEIN HAVING 1,3-FUCOSYLTRANSFERASE ACTIVITY, AND METHOD FOR PRODUCING FUCOSE-CONTAINING SUGARAugust 2023January 2026Allow3010YesNo
18275163PREPHENATE DEHYDRATASE VARIANT AND METHOD OF PRODUCING BRANCHED-CHAIN AMINO ACIDS USING THE SAMEJuly 2023February 2026Allow3110NoNo
18227147HETEROLOGOUS PRODUCTION OF 10-METHYLSTEARIC ACIDJuly 2023December 2024Abandon1610NoNo
18352899KETOREDUCTASE POLYPEPTIDES AND POLYNUCLEOTIDESJuly 2023November 2024Allow1611NoNo
18260333BACILLUS SUBTILIS GENETICALLY ENGINEERED BACTERIUM FOR PRODUCING TAGATOSE AND METHOD FOR PREPARING TAGATOSEJuly 2023January 2026Allow3010YesNo
18270750METHOD FOR PRODUCING CELLOOLIGOSACCHARIDEJuly 2023January 2026Allow3110NoNo
18269907Xylanase VariantsJune 2023January 2026Allow3010NoNo
18339027MICROORGANISMS AND METHODS FOR THE CONTINUOUS CO-PRODUCTION OF HIGH-VALUE, SPECIALIZED PROTEINS AND CHEMICAL PRODUCTS FROM C1-SUBSTRATESJune 2023October 2024Allow1621YesNo
18258770A DFL-PRODUCING STRAINJune 2023March 2026Abandon3201NoNo
18338242RECOMBINANT OLIVETOLIC ACID CYCLASE POLYPEPTIDES ENGINEERED FOR ENHANCED BIOSYNTHESIS OF CANNABINOIDSJune 2023April 2024Allow1010YesNo
18267625METHOD FOR PRODUCING ALCOHOLS USING A SUPPORT ON WHICH MICROORGANISMS ARE IMMOBILISEDJune 2023January 2026Allow3110NoNo
18267531MODIFIED POLYPEPTIDE HAVING XYLANASE ACTIVITYJune 2023February 2026Allow3220YesNo
18267524MODIFIED POLYPEPTIDE HAVING XYLANASE ACTIVITYJune 2023February 2026Allow3220YesNo
18267326CYTOCHROME P450 ENZYME MUTANT AND APPLICATION THEREOFJune 2023November 2025Allow2901YesNo
18333776COMPOSITIONS FOR SACCHARIFICATION OF CELLULOSIC MATERIALJune 2023September 2024Allow1510NoNo
18208030PRODUCTION OF ISOPRENOIDSJune 2023July 2024Allow1310NoNo
18266238OLIVETOLIC ACID CYCLASE VARIANTS AND METHODS FOR THEIR USEJune 2023March 2026Abandon3301NoNo
18327373A UNIVERSAL PLATFORM TO ENHANCE CRISPR-BASED GENE EDITING FOR IN VIVO THERAPIESJune 2023April 2024Allow1101NoNo
18199278METHODS FOR GENOMIC INTEGRATION FOR KLUYVEROMYCES HOST CELLSMay 2023August 2024Allow1510NoNo
18197870COMPOSITIONS AND METHODS INVOLVING ENGINEERED P27May 2023January 2025Allow2021YesNo
18304187Inducible, Tunable, and Multiplex Human Gene Regulation Using CRISPR-Cpf1April 2023September 2024Allow1720NoNo
18249751MICROORGANISMS FOR DITERPENE PRODUCTIONApril 2023February 2026Allow3411YesNo
18301460PROTEASE VARIANTS AND USES THEREOFApril 2023July 2024Allow1510YesNo
18030970POLY-3-HYDROXYALKANOATES HAVING VINYL MOIETIES AND METHOD OF PRODUCING SUCHApril 2023January 2026Abandon3301NoNo
18182136CONSTRUCTION OF A LACTOBACILLUS CASEI ETHANOLOGENMarch 2023January 2026Abandon3410NoNo
18179136METHODS FOR MAKING L-GLUFOSINATEMarch 2023October 2023Allow710NoNo
18024614METHOD TO PRODUCE A SYNTHESIS PRODUCT, E.G. METHANE UTILIZING METHANOGENIC MICROORGANISMS IN A MICROBIAL ELECTROLYSIS CELL (MEC) BY APPLYING A SEPARATED NUTRIENT FEEDING STRATEGYMarch 2023November 2025Allow3310NoNo
180216272709 ALKALI PROTEASE MUTANT MODIFIED BASED ON MOLECULAR DYNAMICS CALCULATION AND USE THEREOFFebruary 2023December 2025Allow3410YesNo
18170454OVER-EXPRESSION OF GDS1 IN YEAST FOR INCREASED ETHANOL AND DECREASED ACETATE PRODUCTIONFebruary 2023December 2025Allow3411NoNo
18040629PRODUCTION OF A MIXTURE OF NEUTRAL NON-FUCOSYLATED OLIGOSACCHARIDES BY A CELLFebruary 2023February 2024Allow1311YesNo
18161236BIOSYNTHESIS OF RETINOIDSJanuary 2023November 2024Allow2211NoNo
18018304PROCESSES FOR IMPROVING PERFORMANCE AND ENERGY EFFICIENCY IN BIOMASS CONVERSION TO SUGARS, BIOCHEMICALS, BIOFUELS, AND/OR BIOMATERIALSJanuary 2023October 2025Allow3310YesNo
17790417D-xylulose 4-epimerase, mutants and uses thereofJanuary 2023November 2025Allow4111YesNo
18015329METHOD FOR INCREASING THE EXTRACTION RATE OF CHONDROITIN SULFATE PREPARED FROM TILAPIA SKULLJanuary 2023January 2026Allow3721NoNo
18013427OPTIMIZED IBE FERMENTATION METHOD FOR UPGRADING ACETONEDecember 2022January 2026Allow3620NoNo
18001741SEMISYNTHETIC PROCESS FOR THE PREPARATION OF COLCHICINEDecember 2022July 2025Allow3111YesNo
18062628BIOSYNTHETIC PRODUCTION OF GAMMA-LACTONESDecember 2022April 2025Allow2811YesNo
18062198Integration Sites in CHO CellsDecember 2022February 2024Allow1400NoNo
17999017COMPOSITIONS AND METHODS FOR PRODUCING HUMAN MILK OLIGOSACCHARIDESNovember 2022October 2025Allow3511YesNo
18055713LIPID-ENCAPSULATED DUAL-CLEAVING ENDONUCLEASE FOR DNA AND GENE EDITINGNovember 2022August 2023Allow910YesNo
17998759CONVERTING LIGNOCELLULOSIC FEEDSTOCK TO FUELNovember 2022December 2025Allow3721NoNo
17986618LACTASE ENZYMES WITH IMPROVED PROPERTIESNovember 2022October 2024Allow2311NoNo
17924944ENGINEERED MICROORGANISM FOR IMPROVED PENTOSE FERMENTATIONNovember 2022January 2026Abandon3811NoNo
17983665PROBIOTIC BACTERIA FOR YEAST BIOETHANOL PRODUCTIONNovember 2022June 2024Allow1910YesNo
18052066Biocementation Method and SystemNovember 2022August 2024Allow2110YesNo
18050245VARIANT AIMOctober 2022August 2024Abandon2210YesNo
17969715AFFINITY TAG FOR RECOMBINATION PROTEIN RECRUITMENTOctober 2022August 2024Abandon2201NoNo
17918533GLUCOAMYLASE AND METHODS OF USE THEREOFOctober 2022August 2025Allow3411YesNo
17995957ARRANGEMENT AND METHOD FOR TREATMENT OF LIGNOCELLULOSIC BIOMASSOctober 2022December 2025Abandon3811NoNo
17917932A METHOD FOR PROCESSING RAW PLANT MATERIAL, ESPECIALLY LEGUMES INTO PTOTEIN HAVING A NUTRITIONAL AND FEED VALUE, BIOETHANOL, BIOGAS AND FERTILISER MATERIALSOctober 2022March 2026Abandon4110NoNo
17917859PROCESS FOR THE DIRECT ENZYMATIC CONVERSION OF AMINO SUGARS; ENZYME AND COMPOSITIONS FOR USE IN THE PROCESSOctober 2022November 2025Allow3720NoNo
17912242BIOMANUFACTURING SYSTEMS AND METHODS FOR PRODUCING ORGANIC PRODUCTS FROM RECOMBINANT MICROORGANISMSOctober 2022September 2025Abandon3621NoNo
17957218AprL-CLADE PROTEASE VARIANTS AND USES THEREOFSeptember 2022February 2025Allow2910YesNo
17913858GLUCOSE PRODUCTION METHOD AND ETHANOL PRODUCTION METHODSeptember 2022October 2025Allow3720YesNo
17934560PRENYLTRANSFERASE VARIANTS WITH INCREASED THERMOSTABILITYSeptember 2022May 2024Allow1910NoNo
17900590ENZYMES AND APPLICATIONS THEREOFAugust 2022April 2024Allow1910NoNo
17799414PREPARING AND MODIFYING MEROTERPENE POLYKETIDES, KETONES, AND LACTONES FOR CANNABINOID SEMISYNTHESISAugust 2022June 2025Abandon3401NoNo
17635157NOVEL FRUCTOSE-4-EPIMERASE AND METHOD FOR PREPARING TAGATOSE USING SAMEAugust 2022July 2025Allow4120NoNo
17798197PROCESS FOR PRODUCING ETHANOL FROM RAW STARCH USING ALPHA-AMYLASE VARIANTSAugust 2022October 2025Abandon3821NoNo
17882680IMMOBILIZED ENZYME PRODUCTION LINE, METHOD OF MAKING AN IMMOBILIZED ENZYME PRODUCTION LINE, AND METHOD OF MAKING COMPOUNDS USING THE IMMOBILIZED ENZYME PRODUCTION LINEAugust 2022August 2024Abandon2411NoNo
17797351ALPHA-AMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAMEAugust 2022October 2025Allow3921YesNo
17816892METHODS OF REDUCING ODORAugust 2022July 2023Allow1121YesNo
17816630HETEROLOGOUS BIOSYNTHESIS OF NODULISPORIC ACIDAugust 2022April 2024Allow2001YesNo
17759537Polypeptide VariantsJuly 2022March 2025Allow3201YesNo
17814417VARIANT G6P G7P GLUCOAMYLASE COMPOSITIONS AND METHODSJuly 2022November 2025Abandon3911NoNo
17871400METHOD FOR PRODUCING MERCAPTANS BY DISULFIDE ENZYME HYDROGENOLYSISJuly 2022July 2024Abandon2310NoNo
17759272ENZYME COMPOSITIONS AND USES THEREOFJuly 2022December 2025Abandon4021NoNo
17813950KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANEJuly 2022December 2023Allow1710NoNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner RAGHU, GANAPATHIRAM.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
15
Examiner Affirmed
11
(73.3%)
Examiner Reversed
4
(26.7%)
Reversal Percentile
42.5%
Lower than average

What This Means

With a 26.7% reversal rate, the PTAB affirms the examiner's rejections in the vast majority of cases. This reversal rate is below the USPTO average, indicating that appeals face more challenges here than typical.

Strategic Value of Filing an Appeal

Total Appeal Filings
110
Allowed After Appeal Filing
17
(15.5%)
Not Allowed After Appeal Filing
93
(84.5%)
Filing Benefit Percentile
18.3%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 15.5% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

Appeals to PTAB face challenges. Ensure your case has strong merit before committing to full Board review.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner RAGHU, GANAPATHIRAM - Prosecution Strategy Guide

Executive Summary

Examiner RAGHU, GANAPATHIRAM works in Art Unit 1652 and has examined 1,407 patent applications in our dataset. With an allowance rate of 70.5%, this examiner has a below-average tendency to allow applications. Applications typically reach final disposition in approximately 27 months.

Allowance Patterns

Examiner RAGHU, GANAPATHIRAM's allowance rate of 70.5% places them in the 33% percentile among all USPTO examiners. This examiner has a below-average tendency to allow applications.

Office Action Patterns

On average, applications examined by RAGHU, GANAPATHIRAM receive 1.70 office actions before reaching final disposition. This places the examiner in the 35% percentile for office actions issued. This examiner issues fewer office actions than average, which may indicate efficient prosecution or a more lenient examination style.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by RAGHU, GANAPATHIRAM is 27 months. This places the examiner in the 71% percentile for prosecution speed. Prosecution timelines are slightly faster than average with this examiner.

Interview Effectiveness

Conducting an examiner interview provides a +29.1% benefit to allowance rate for applications examined by RAGHU, GANAPATHIRAM. This interview benefit is in the 77% percentile among all examiners. Recommendation: Interviews are highly effective with this examiner and should be strongly considered as a prosecution strategy. Per MPEP § 713.10, interviews are available at any time before the Notice of Allowance is mailed or jurisdiction transfers to the PTAB.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 30.6% of applications are subsequently allowed. This success rate is in the 61% percentile among all examiners. Strategic Insight: RCEs show above-average effectiveness with this examiner. Consider whether your amendments or new arguments are strong enough to warrant an RCE versus filing a continuation.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 58.7% of cases where such amendments are filed. This entry rate is in the 84% percentile among all examiners. Strategic Recommendation: This examiner is highly receptive to after-final amendments compared to other examiners. Per MPEP § 714.12, after-final amendments may be entered "under justifiable circumstances." Consider filing after-final amendments with a clear showing of allowability rather than immediately filing an RCE, as this examiner frequently enters such amendments.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 71.4% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 59% percentile among all examiners. Strategic Recommendation: Pre-appeal conferences show above-average effectiveness with this examiner. If you have strong arguments, a PAC request may result in favorable reconsideration.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 75.0% of appeals filed. This is in the 63% percentile among all examiners. Of these withdrawals, 77.8% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner shows above-average willingness to reconsider rejections during appeals. The mandatory appeal conference (MPEP § 1207.01) provides an opportunity for reconsideration.

Petition Practice

When applicants file petitions regarding this examiner's actions, 71.0% are granted (fully or in part). This grant rate is in the 78% percentile among all examiners. Strategic Note: Petitions are frequently granted regarding this examiner's actions compared to other examiners. Per MPEP § 1002.02(c), various examiner actions are petitionable to the Technology Center Director, including prematureness of final rejection, refusal to enter amendments, and requirement for information. If you believe an examiner action is improper, consider filing a petition.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 10.2% of allowed cases (in the 94% percentile). Per MPEP § 1302.04, examiner's amendments are used to place applications in condition for allowance when only minor changes are needed. This examiner frequently uses this tool compared to other examiners, indicating a cooperative approach to getting applications allowed. Strategic Insight: If you are close to allowance but minor claim amendments are needed, this examiner may be willing to make an examiner's amendment rather than requiring another round of prosecution.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 0.0% of allowed cases (in the 2% percentile). This examiner rarely issues Quayle actions compared to other examiners. Allowances typically come directly without a separate action for formal matters.

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Prioritize examiner interviews: Interviews are highly effective with this examiner. Request an interview after the first office action to clarify issues and potentially expedite allowance.
  • Consider after-final amendments: This examiner frequently enters after-final amendments. If you can clearly overcome rejections with claim amendments, file an after-final amendment before resorting to an RCE.
  • Examiner cooperation: This examiner frequently makes examiner's amendments to place applications in condition for allowance. If you are close to allowance, the examiner may help finalize the claims.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.