USPTO Art Unit 1686 Prosecution Statistics

Art Unit Information

Art Unit: 1686
Group: 1680
Tech Center: 1600
Total Cases: 449
Last Active: July 2025

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
19268839SCHEDULING METHOD FOR DAILY ECOLOGICAL FLOW VARIATION OF RIVER REACH BASED ON FISH HABITAT SUITABILITY OVERLAP RATEJuly 2025February 2026Abandon710NoNo
19258562Context-Specific Tumor-Only Mutation ClassificationJuly 2025February 2026Allow810YesNo
19207265REASONING FROM SUPERVISED FINE TUNING OF LANGUAGE FUSION MODELS FOR AI-BASED PROTEIN AND DRUG DESIGNMay 2025September 2025Allow410YesNo
19175905RECURSIVE TRANSFORMERS FOR AI-BASED PROTEIN-PROTEIN INTERACTION AND DRUG DESIGNApril 2025August 2025Allow510YesNo
19093126Methods and Systems for Machine-Learning Based Molecule Generation and ScoringMarch 2025January 2026Allow1020YesNo
19072478TREATMENT OF DEPRESSION USING MACHINE LEARNINGMarch 2025October 2025Allow810YesNo
19072452TREATMENT OF DEPRESSION USING MACHINE LEARNINGMarch 2025October 2025Allow810YesNo
19072469TREATMENT OF DEPRESSION USING MACHINE LEARNINGMarch 2025August 2025Allow510NoNo
19064276Methods and Systems for Determining Proportions of Distinct Cell SubsetsFebruary 2025January 2026Allow1011NoNo
19057774Methods and Systems for Determining Proportions of Distinct Cell SubsetsFebruary 2025January 2026Allow1111YesNo
19057757Methods and Systems for Determining Proportions of Distinct Cell SubsetsFebruary 2025March 2026Allow1321YesNo
19057786Systems and Methods for Analyzing Mixed Cell PopulationsFebruary 2025December 2025Allow1010YesNo
19031343DRUG DESIGN METHOD BASED ON AUTOREGRESSIVE MODELJanuary 2025August 2025Allow710NoNo
19025994METHOD FOR TESTING LEUKOCYTES FOR A DISEASE STATEJanuary 2025October 2025Allow911YesNo
19025868METHOD FOR DETERMINING PROPERTIES OF FLOWING LEUKOCYTESJanuary 2025October 2025Allow911YesNo
19000940SYNTHON EMBEDDINGS FOR MODELING DNA-ENCODED LIBRARIESDecember 2024March 2026Allow1530YesNo
18980953SYSTEM AND METHOD FOR MAPPING MOLECULES INTO INTERFACESDecember 2024February 2026Allow1420NoNo
18948372GENOMIC MATING METHOD FOR HUAXI CATTLE BASED ON WHOLE GENOME SINGLE NUCLEOTIDE POLYMORPHISM INFORMATION AND APPLICATION THEREOFNovember 2024July 2025Allow810NoNo
18851870MOLECULAR DOCKING METHOD AND APPARATUS BASED ON COHERENT ISING MACHINENovember 2024February 2026Allow1620YesNo
18929229MACHINE-LEARNING VIRTUALIZATION-ENABLED HARVESTINGOctober 2024December 2025Allow1421NoNo
18914164GENE MINING METHOD AND SYSTEM BASED ON TRANSCRIPTOME AND DNA METHYLOMEOctober 2024April 2025Abandon610NoNo
18894542INTELLIGENT DESIGN METHOD OF TYPE I DIABETES VACCINESeptember 2024October 2025Abandon1320NoNo
18824839System and Method for Planning and Simulating a Surgical Operation to Create a Patient-Specific Spinal ImplantSeptember 2024March 2025Allow611YesNo
18812691Parallel Bitwise Determination of OriginAugust 2024June 2025Abandon1010NoNo
18768731SYSTEMS AND METHODS FOR IDENTIFYING DISEASE CAUSING AGENTS AND INTERVENTIONS BASED ON SAMPLE METADATA AND MOLECULAR SIGNATURESJuly 2024June 2025Allow1120NoNo
18745375DETECTION OF EARLY-STAGE LUNG CANCER IN SPUTUM USING AUTOMATED FLOW CYTOMETRY AND MACHINE LEARNINGJune 2024September 2025Allow1520NoNo
18719810SYSTEM AND METHODS FOR PERFORMING SALIVA-BASED DIAGNOSTIC SCREENINGSJune 2024October 2025Abandon1620YesNo
18719517PROGRAM, INFORMATION PROCESSING DEVICE AND METHODJune 2024December 2025Abandon1840YesNo
18733681DETECTING MUTATIONS AND PLOIDY IN CHROMOSOMAL SEGMENTSJune 2024September 2025Allow1520NoNo
18675760Methods and Systems for Determining Proportions of Distinct Cell SubsetsMay 2024March 2026Allow2111NoNo
18664821OLIGONUCLEOTIDE-BASED MACHINE LEARNINGMay 2024May 2025Allow1211NoNo
18665197DNA Access Control SystemsMay 2024April 2025Allow1120NoNo
18653855COMPUTER SYSTEM AND METHOD FOR PREDICTING NUTRIENT LEVELS AND GENERATING TREATMENT RECOMMENDATIONS FOR COCOA TREESMay 2024May 2025Allow1211YesNo
18705594METHOD AND SYSTEM OF MOLECULAR TYPING AND SUBTYING CLASSIFIER FOR IMMUNE-RELATED DISEASESApril 2024March 2026Allow2230YesNo
18645889COMBINATION THERAPY WITH DIGITAL THERAPEUTICS FOR IMPROVED IMMUNE FUNCTIONApril 2024August 2025Allow1611NoNo
18638701SCREENING METHOD FOR DROUGHT-RESISTANT GERMPLASM OF OPHIOPOGON JAPONICUSApril 2024May 2025Allow1320NoNo
18628848ENVIRONMENTAL SENSING METHOD BASED ON MODEL EVOLUTIONApril 2024March 2025Allow1110NoNo
18613558SELECTION OF A CHEMICAL COMPOUND APPLICABLE ON A CLASS OF HUMAN HAIRSMarch 2024August 2025Allow1720YesNo
18608874PREDICTION SYSTEM FOR IDENTIFYING KEY HETEROGENEOUS MOLECULES DRIVING TUMOR METASTASISMarch 2024August 2025Allow1730NoNo
18692344ANALYTIC PLATFORM USING NPM1-ASSOCIATED GENES INTERACTION NETWORK FOR IDENTIFYING GENETIC TRAITSMarch 2024April 2025Abandon1310NoNo
18596526METHODS FOR PROCESSING NEXT-GENERATION SEQUENCING GENOMIC DATAMarch 2024August 2025Abandon1810NoNo
18583948CALCULATION METHOD FOR ANNUAL AVERAGE PROBABILISTIC SEISMIC LOSS OF EXTERNAL SUBSTRUCTURE REINFORCEMENT SYSTEM BASED ON INTERFACIAL SHEAR STRESSESFebruary 2024April 2025Allow1410NoNo
18436053GENOME-WIDE PREDICTION METHOD BASED ON DEEP LEARNING BY USING GENOME-WIDE DATA AND BIOINFORMATICS FEATURESFebruary 2024March 2025Allow1420YesNo
18422789Systems and Methods for Correcting for Noise and Systemic Variations in Sequencing DataJanuary 2024March 2026Allow2630YesNo
18513357FLOW CYTOMETRY IMMUNOPROFILING OF PERIPHERAL BLOODNovember 2023November 2025Allow2440YesNo
18510106METHODS OF ENRICHING TARGETED NUCLEIC ACID, IDENTIFYING OFF-TARGET AND EVALUATING GENE EDITING EFFICIENCYNovember 2023October 2025Allow2322YesNo
18505728UTILIZING COMPOUND-PROTEIN MACHINE LEARNING REPRESENTATIONS TO GENERATE BIOACTIVITY PREDICTIONSNovember 2023August 2025Allow2131YesNo
18505004DIFFUSION MODEL FOR GENERATIVE PROTEIN DESIGNNovember 2023June 2025Abandon1920NoNo
18482779METHODS FOR MULTI-RESOLUTION ANALYSIS OF CELL-FREE NUCLEIC ACIDSOctober 2023May 2025Allow1910NoNo
18464705COMPUTER IMPLEMENTED METHOD AND SYSTEM FOR SMALL MOLECULE DRUG DISCOVERYSeptember 2023December 2024Allow1530NoNo
18463962METHOD AND SYSTEM FOR PREDICTING RESPONSE TO IMMUNE CHECKPOINT INHIBITOR BASED ON A DENSITY OF IMMUNE CELLSSeptember 2023March 2025Allow1840YesNo
18461736IMMUNOPHENOTYPING METHOD FOR SMALL-CELL LUNG CANCER ESTABLISHED BASED ON MULTIDIMENSIONAL ANALYSESSeptember 2023March 2025Abandon1820NoNo
18276808NEW DRUG CANDIDATE DISCOVERY SYSTEM AND COMPUTER PROGRAM IMPLEMENTING NEW DRUG CANDIDATE DISCOVERY PLATFORMAugust 2023November 2025Abandon2820YesNo
18198558Ancestry FinderAugust 2023December 2024Abandon1910NoNo
18263503SYSTEMS AND METHODS FOR DIAGNOSING NEURODEGENERATIVE DISEASES VIA MACHINE LEARNING AND BLOOD RNAJuly 2023September 2025Allow2531YesNo
18222939FORCE AND/OR MOTION MEASUREMENT SYSTEM THAT INCLUDES AT LEAST ONE KINEMATIC SENSOR DEVICE AND AT LEAST ONE DATA PROCESSING DEVICE CONFIGURED TO EXECUTE COMPUTER EXECUTABLE INSTRUCTIONS FOR DETERMINING A POSITION AND/OR MOVEMENT OF A PERSON BASED UPON OUTPUT DATA FROM THE AT LEAST ONE KINEMATIC SENSOR DEVICEJuly 2023April 2025Allow2111YesNo
18352112SIGNAL ENCODING AND DECODING IN MULTIPLEXED BIOCHEMICAL ASSAYSJuly 2023July 2024Allow1220YesNo
18336782Systems and Methods for Risk Based Insulin Delivery ConversionJune 2023March 2026Abandon3340YesNo
18327008METHOD AND SYSTEM FOR EVALUATING MELT FRAGMENTATION IN SODIUM-COOLED FAST REACTOR (SFR)May 2023November 2025Allow2920NoNo
18135094PERSONALIZED HEALTH OR BEAUTY SYSTEMApril 2023May 2025Allow2520YesNo
18171802PREDICTIVE TEST FOR PROGNOSIS OF MYELODYSPLASTIC SYNDROME PATIENTS USING MASS SPECTROMETRY OF BLOOD-BASED SAMPLEFebruary 2023August 2025Abandon2910NoNo
18105214USES OF SYSTEMS WITH DEGREES OF FREEDOM POISED BETWEEN FULLY QUANTUM AND FULLY CLASSICAL STATESFebruary 2023August 2025Abandon3010NoNo
18163169MARKERS FOR THE EARLY DETECTION OF COLON CELL PROLIFERATIVE DISORDERSFebruary 2023October 2024Allow2041YesNo
18163149MARKERS FOR THE EARLY DETECTION OF COLON CELL PROLIFERATIVE DISORDERSFebruary 2023March 2025Allow2540YesNo
18003455ARTIFICIAL-INTELLIGENCE-BASED CANCER DIAGNOSIS AND CANCER TYPE PREDICTION METHODDecember 2022September 2024Allow2121YesNo
18082487MACHINE LEARNING ENABLED PULSE AND BASE CALLING FOR SEQUENCING DEVICESDecember 2022July 2025Allow3110NoNo
18081526Methods and Systems For Calculating Free Energy Differences Using A Modified Bond Stretch PotentialDecember 2022June 2025Allow3010YesNo
18072716DISCOVERING POPULATION STRUCTURE FROM PATTERNS OF IDENTITY-BY-DESCENTDecember 2022October 2025Abandon3420YesNo
18070377METHODS AND SYSTEMS FOR ENHANCING NUCLEIC ACID SEQUENCING QUALITY IN HIGH-THROUGHPUT SEQUENCING PROCESSES WITH MACHINE LEARNINGNovember 2022March 2026Allow5031YesNo
18052681IN SILICO PROCESS FOR SELECTING PROTEIN FORMULATION EXCIPIENTSNovember 2022May 2025Abandon3010NoNo
17971400SYSTEMS AND METHODS FOR ANALYSES OF BIOLOGICAL SAMPLESOctober 2022May 2025Abandon3010NoNo
17951779METAGENOMIC LIBRARY AND NATURAL PRODUCT DISCOVERY PLATFORMSeptember 2022March 2025Abandon3001NoNo
17940776BIOMARKERS FOR SMOKE EXPOSURESeptember 2022February 2026Abandon4112NoNo
17907900CONCENTRATION-LEVEL ESTIMATION DEVICE, CONCENTRATION-LEVEL ESTIMATION METHOD, AND RECORDING MEDIUMAugust 2022February 2026Abandon4100NoNo
17880809METHOD FOR TREATING AND PREDICTING PROGNOSIS OF GASTRIC CANCER PATIENT BY CALCULATING RNA EXPRESSION WITH LOGISTIC REGRESSIONAugust 2022February 2026Allow4211NoNo
17856497METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR DETERMINING A PATIENT RADIATION AND DIAGNOSTIC STUDY SCOREJuly 2022April 2025Allow3410NoNo
17845682AGILE NUCLEIC ACID SENSOR AND MEASURING A BIOMARKERJune 2022March 2026Allow4411NoNo
17806930ADAPTIVE COMPRESSION AND MODIFICATION OF NANOPORE MEASUREMENT DATAJune 2022August 2025Allow3840YesYes
17805147METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR IMPROVING BASE CALLING ACCURACYJune 2022May 2025Abandon3530NoNo
17824098QUANTITATION AND MODELING OF QUALITY ATTRIBUTES OF THERAPEUTIC MONOCLONAL ANTIBODIESMay 2022June 2025Allow3620NoNo
17744387Detecting False Positive Variant Calls In Next-Generation SequencingMay 2022December 2024Allow3120YesNo
17711390SYSTEM AND METHOD FOR MEASURING LOW-NOISE VIBRATIONAL SPECTRAApril 2022September 2025Allow4240YesNo
17709185MULTI-OMIC ASSESSMENT USING PROTEINS AND NUCLEIC ACIDSMarch 2022February 2025Allow3461YesNo
17761046Methods for Predicting Patient Response to DMARDsMarch 2022March 2026Allow4811NoNo
17694796ORGANIC MOLECULE VIBRATION SPECTRUM ANALYSIS USING COMBINATORIAL OPTIMIZATION AND AN ISING MODELMarch 2022January 2026Allow4610YesNo
17684458STABLE STRUCTURE SEARCH SYSTEM, STABLE STRUCTURE SEARCH METHOD, AND STORAGE MEDIUMMarch 2022March 2026Abandon4810NoNo
17639726METHOD FOR ACQUIRING INTRACELLULAR DETERMINISTIC EVENTS AND ELECTRONIC APPARATUSMarch 2022January 2026Allow4610NoNo
17592223Systems and Methods for Risk Based Insulin Delivery ConversionFebruary 2022March 2026Abandon4940NoNo
17592137Systems and Methods for Risk Based Insulin Delivery ConversionFebruary 2022January 2026Abandon4730NoNo
17588221METHOD FOR EVALUATING OF BIOAVAILABILITY OF ORGANIC NITROGEN IN SEWAGEJanuary 2022March 2026Abandon4910NoNo
17584074APPARATUS AND METHOD FOR DIAGNOSING CANCER USING LIQUID BIOPSY DATAJanuary 2022February 2026Abandon4810NoNo
17577604SYSTEMS AND METHODS FOR ASSESSING SPECIMEN FIXATION DURATION AND QUALITY USING VIBRATIONAL SPECTROSCOPYJanuary 2022March 2026Allow5020NoNo
17568835OPTIMIZED GAMMA-PRIME STRENGTHENED AUSTENITIC TRIP STEEL AND DESIGNING METHODS OF SAMEJanuary 2022July 2024Allow3011NoNo
17620768COMPUTER IMPLEMENTED METHOD TO OPTIMIZE PHYSICAL-CHEMICAL PROPERTIES OF BIOLOGICAL SEQUENCESDecember 2021March 2026Abandon5010NoNo
17554721COPY NUMBER VARIANT CALLERDecember 2021November 2025Allow4720YesNo
17551238NON-TRANSITORY COMPUTER-READABLE STORAGE MEDIUM, INFORMATION PROCESSING APPARATUS, AND INFORMATION PROCESSING METHODDecember 2021February 2026Abandon5010NoNo
17542398HIERARCHICAL MACHINE LEARNING TECHNIQUES FOR IDENTIFYING MOLECULAR CATEGORIES FROM EXPRESSION DATADecember 2021November 2024Allow3651YesNo
17541457METHOD FOR PREDICTING MITOCHONDRIAL DNA MUTATION THRESHOLD, FERTILITY RISK AND OOCYTE RETRIEVAL NUMBERDecember 2021November 2025Abandon4810NoNo
17539946PROTEIN STRUCTURE INFORMATION PREDICTION METHOD AND APPARATUS, DEVICE, AND STORAGE MEDIUMDecember 2021January 2025Allow3820YesNo
17615657METHOD AND SYSTEM FOR IDENTIFICATION OF CANDIDATE TARGET SITES FOR COMBATING PATHOGENSDecember 2021December 2025Allow4920NoNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for art-unit 1686.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
12
Examiner Affirmed
4
(33.3%)
Examiner Reversed
8
(66.7%)
Reversal Percentile
97.5%
Higher than average

What This Means

With a 66.7% reversal rate, the PTAB has reversed the examiner's rejections more often than affirming them. This reversal rate is in the top 25% across the USPTO, indicating that appeals are more successful here than in most other areas.

Strategic Value of Filing an Appeal

Total Appeal Filings
51
Allowed After Appeal Filing
16
(31.4%)
Not Allowed After Appeal Filing
35
(68.6%)
Filing Benefit Percentile
45.5%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 31.4% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is below the USPTO average, suggesting that filing an appeal has limited effectiveness in prompting favorable reconsideration.

Strategic Recommendations

✓ Appeals to PTAB show good success rates. If you have a strong case on the merits, consider fully prosecuting the appeal to a Board decision.

⚠ Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Art Unit 1686 - Prosecution Statistics Summary

Executive Summary

Art Unit 1686 is part of Group 1680 in Technology Center 1600. This art unit has examined 449 patent applications in our dataset, with an overall allowance rate of 64.1%. Applications typically reach final disposition in approximately 54 months.

Comparative Analysis

Art Unit 1686's allowance rate of 64.1% places it in the 21% percentile among all USPTO art units. This art unit has a significantly lower allowance rate than most art units at the USPTO.

Prosecution Patterns

Applications in Art Unit 1686 receive an average of 2.78 office actions before reaching final disposition (in the 93% percentile). The median prosecution time is 54 months (in the 1% percentile).

Strategic Considerations

When prosecuting applications in this art unit, consider the following:

  • The art unit's allowance rate suggests a more challenging examination environment compared to the USPTO average.
  • With more office actions than average, plan for multiple rounds of prosecution.
  • The median prosecution time is longer than average and should be factored into your continuation and client communication strategies.
  • Review individual examiner statistics within this art unit to identify examiners with particularly favorable or challenging prosecution patterns.

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.