USPTO Examiner MACFARLANE STACEY NEE - Art Unit 1675

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
18984062METHODS OF PERMEABILIZING THE BLOOD BRAIN BARRIERDecember 2024September 2025Allow910NoNo
18743624GENE THERAPY FOR NEURODEGENERATIVE DISORDERSJune 2024January 2026Abandon1901NoNo
18649453MARKER FOR ACID SPHINGOMYELINASE DISORDERS AND USES THEREOFApril 2024November 2025Allow1910NoNo
18645977PROTEIN BIOMARKER INDICATORS OF NEUROLOGICAL INJURY AND/OR DISEASE AND METHODS OF USE THEREOFApril 2024January 2026Allow2111YesNo
18637770BIOMARKER DETECTION PROCESS AND ASSAY OF NEUROLOGICAL CONDITIONApril 2024December 2025Allow2010NoNo
18604668ANTIBODIES TO AMYLOID BETAMarch 2024February 2025Allow1100NoNo
18603889METHOD OF DETERMINING TOXICITY OF AN IMMUNOMODULATORY DRUG FOR USE IN HUMANSMarch 2024August 2025Allow1711YesNo
18443416USE OF ONE OR MORE BIOMARKERS TO DETERMINE TRAUMATIC BRAIN INJURY (TBI) IN A HUMAN SUBJECT HAVING RECEIVED A HEAD COMPUTERIZED TOMOGRAPHY SCAN THAT IS NEGATIVE FOR A TBIFebruary 2024December 2025Abandon2210NoNo
18526952COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DISEASESDecember 2023June 2025Abandon1901NoNo
18507265TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS BY INTRANASAL ADMINISTRATION OF IMMUNOGLOBULIN GNovember 2023August 2025Allow2110NoNo
18506582CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS FOR BRAIN AND SPINAL CORD REPAIRNovember 2023July 2025Abandon2101NoNo
18490689METHODS FOR TREATING SYSTEMIC SCLEROSISOctober 2023July 2025Abandon2110NoNo
18370557COMPOSITIONS, DEVICES AND METHODS FOR TREATING AUTISMSeptember 2023December 2025Abandon2611NoNo
18243915SENSE INDICATOR COMPOSITIONSeptember 2023March 2025Abandon1921NoNo
18453286BIOMARKERS AND METHODS OF USE FOR RADIATION-INDUCED LUNG INJURYAugust 2023November 2024Abandon1510NoNo
18449971METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLSAugust 2023November 2024Allow1510NoNo
18363113ANTIBODY WHICH BINDS TO MYELIN OLIGODENDROCYTE GLYCOPROTEINAugust 2023January 2025Allow1700NoNo
18221053BIOMARKERS FOR COGNITIVE DYSFUNCTION DISEASES AND METHOD FOR DETECTING COGNITIVE DYSFUNCTION DISEASE USING BIOMARKERSJuly 2023April 2025Allow2130YesNo
18329892BIOMARKER LEVELS AND NEUROIMAGING FOR DETECTING, MONITORING AND TREATING BRAIN INJURY OR TRAUMAJune 2023July 2025Allow2521YesNo
18135543METHODS OF TREATING NEUROPSYCHIATRIC DISORDERSApril 2023July 2025Abandon2731NoNo
18190416METHODS OF PERMEABILIZING THE BLOOD BRAIN BARRIERMarch 2023September 2024Allow1820NoNo
18121626COMPOSITION AND METHOD FOR TREATMENT OF NEUROPSYCHIATRIC DISORDERSMarch 2023January 2025Allow2210NoNo
18160624COMPOSITIONS AND METHODS FOR A UNIVERSAL CLINICAL TEST FOR OLFACTORY DYSFUNCTIONJanuary 2023March 2025Allow2611NoNo
18146791Novel Therapeutic Uses of Mu-Opiate Receptor PeptidesDecember 2022November 2024Abandon2201NoNo
18077711DETECTION OF PHOSPHOINOSITIDES IN BLOOD CELLS AS A BIOMARKER FOR ALPHA SYNUCLEIN ASSOCIATED PATHOLOGIES AND A METHOD OF TREATMENT OF PARKINSON'S DISEASE AND THE RELATED NEURODEGENERATIONSDecember 2022February 2026Abandon3801NoNo
17925160MEANS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL AGGREGATIONNovember 2022January 2026Abandon3801NoNo
17924214FORMULATION COMPRISING ANTI-IL-23P19 ANTIBODY, METHOD FOR PREPARING SAME AND USE THEREOFNovember 2022January 2026Allow3810NoNo
17968606Detection of Structural Forms of ProteinsOctober 2022August 2025Abandon3421NoNo
17918860FELINE ANTIBODY VARIANTSOctober 2022February 2026Allow4010NoNo
17937529USE OF FcgammaRIII INHIBITOR IN PREPARATION OF MEDICAMENT FOR TREATING PULMONARY FIBROSISOctober 2022February 2026Allow4110NoNo
17937109TAU IMMUNOTHERAPYSeptember 2022September 2024Allow2320YesNo
17915334AGENTS FOR USE IN THE THERAPEUTIC OR PROPHYLACTIC TREATMENT OF RETINAL PIGMENT EPITHELIUM ASSOCIATED DISEASESSeptember 2022December 2025Abandon3901NoNo
17915153METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEASeptember 2022March 2026Abandon4211NoNo
17914101Type XIX Collagen AssaySeptember 2022January 2026Abandon4010NoNo
17893019USE OF PAK4 AND CRTC1 FOR TREATMENT OR DIAGNOSIS OF BRAIN DEGENERATIVE DISEASEAugust 2022December 2025Allow4010NoNo
17812678Determining WT-1-Specific T Cells and WT-1 Specific T Cell Receptors (TCRS)July 2022January 2026Allow4301NoNo
17784417IMMUNOASSAY METHOD AND IMMUNOASSAY APPARATUSJune 2022November 2025Allow4210NoNo
17782468Neo-Epitope Specific Assay Measuring Protease Mediated Degradation of Type IV CollagenJune 2022October 2025Allow4110YesNo
17824980COMPOSITIONS AND METHODS FOR IDENTIFYING MHC-II BINDING PEPTIDESMay 2022November 2025Abandon4101NoNo
17778738COMPOSITIONS AND METHODS FOR DEREPRESSING RE1 SILENCING TRANSCRIPTION FACTOR TARGET GENESMay 2022September 2024Allow2811YesNo
17748943LITHIUM AS A MONOTHERAPY AND/OR STEM CELL ADJUVANT THERAPY FOR PULMONARY FIBROSISMay 2022December 2024Abandon3120NoNo
17743288CHIMERIC ANTIGEN RECEPTOR T CELL THERAPYMay 2022March 2025Allow3421NoNo
17739912Methods For The Treatment Of NeurodegenerationMay 2022August 2024Allow2810NoNo
17719243DETECTION OF DEBRIS IN RECIRCULATING PHAGOCYTESApril 2022December 2025Abandon4411NoNo
17765466NOVEL FLUORESCENT PROTEIN AND UTILIZATION THEREOFMarch 2022September 2025Allow4110NoNo
17671430ASSEMBLY OF FUNCTIONALLY INTEGRATED HUMAN FOREBRAIN SPHEROIDS AND METHODS OF USE THEREOFFebruary 2022August 2024Allow3020YesNo
17630880CULTURE MEDIUM FOR HAEMATOPOIETIC INDUCTIONJanuary 2022October 2025Abandon4511NoNo
17580689INHIBITION OF LET7I AS A MEANS TO ENHANCE THE PROTECTIVE EFFECT OF PROGESTERONE AGAINST STROKEJanuary 2022December 2024Abandon3520NoNo
17625434METHOD AND COMPOSITION FOR TREATING PAINJanuary 2022March 2026Allow5021YesNo
17617048METHODS AND COMPOSITIONS FOR DIFFERENTIATING STEM CELLSDecember 2021February 2026Abandon5011NoNo
17616031ANTI-OPIOID COMPOUNDS AND METHODS OF MAKING AND USING SAMEDecember 2021December 2025Allow4811YesNo
17605327CANCER DETECTION METHOD AND DETECTION REAGENTOctober 2021May 2025Abandon4321YesNo
17600728METHOD FOR DETECTING OR MONITORING THE DEVELOPMENT OF A CHRONIC PROLIFERATIVE DISEASE BY IMMUNOASSAYOctober 2021June 2025Abandon4401NoNo
17441010Patient Populations Amenable to IL23-Antagonist TherapySeptember 2021June 2025Abandon4510NoNo
17411787DECELLULARIZED NERVE ALLOGRAFTSAugust 2021June 2025Abandon4621NoNo
17433970LIVE CELL IMAGING DYNAMIC BH3 PROFILINGAugust 2021September 2025Allow4920NoNo
17406051RECOMBINANT CLUSTERIN AND USE THEREOF IN THE TREATMENT AND PREVENTION OF DISEASEAugust 2021January 2025Abandon4120NoNo
17402986ANTI-TREM2 ANTIBODIES AND METHODS OF USE THEREOFAugust 2021June 2024Allow3400YesNo
17429046Type XXIII Collagen AssayAugust 2021April 2025Allow4410NoNo
17428567TREATMENT OF CANCER METASTASIS BY TARGETING EXOSOME PROTEINSAugust 2021October 2025Allow5011NoNo
17427698METHOD FOR TREATING CHECKPOINT INHIBITORS INDUCED ADVERSE EVENTSAugust 2021December 2025Allow5330NoNo
17380704Compositions and Methods for Modulating Kinase ActivityJuly 2021December 2024Allow4020NoNo
17421874MULTI-TARGETING FUSION PROTEIN FOR BLOCKING THE GROWTH OF VASCULAR ENDOTHELIAL CELLS AND ACTIVATING T CELLS AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAMEJuly 2021November 2024Abandon4001NoNo
17362126ANTI-RABBIT CD19 ANTIBODIES AND METHODS OF USEJune 2021March 2025Allow4511NoNo
17345451Microfluidic Device For Cell Separation And Uses ThereofJune 2021January 2025Abandon4310NoNo
17298234CANCER DETECTION UTILIZING NORMAL TISSUE ADJACENT TO BREAST TUMORS WITH GENETIC ANCESTRY-MAPPINGMay 2021July 2025Abandon5020NoNo
17313587THERAPEUTIC AND DIAGNOSTIC METHODS AND COMPOSITIONS FOR NEURODEGENERATIVE DISEASESMay 2021August 2024Allow4030NoNo
17274399METHOD FOR DIAGNOSING DEMENTIA OR DETERMINING THE RISK OF DEVELOPING DEMENTIAMarch 2021March 2026Abandon6041NoNo
17192679Compositions and Methods for Detecting and Treating Brain Injury Associated Fatigue and Altered Cognition (BIAFAC)March 2021March 2025Abandon4831NoNo
17264601COMBINED INVASION AND CYTOTOXICITY ASSAY USING CHEMOKINE SECRETING TARGET CELLSJanuary 2021August 2025Allow5531YesNo
17146336METHOD AND COMPOSITION FOR GENERATING BASAL FOREBRAIN CHOLINERGIC NEURONS (BFCNs)January 2021December 2024Abandon4721NoNo
17255811SYNTHETIC ODORANT RECEPTORSDecember 2020August 2024Allow4331YesNo
17250209Sponge patch complex of stem cell preparation for treating brain diseases, preparation method thereof, and application thereofDecember 2020January 2025Abandon4911YesNo
17112570MHC CLASS II MOLECULE-BASED PEPTIDE EXCHANGE SYSTEM AND METHODDecember 2020May 2025Abandon5421YesNo
16972015ANTI-CANCER TREATMENT OF PRESELECTED SUBJECTS AND SCREENING METHODS TO IDENTIFY SUSCEPTIBLE SUBJECTSDecember 2020December 2025Allow6011YesNo
17108441CELL-BASED ZNT8 ASSAYDecember 2020March 2025Allow5120NoNo
17099209COMPOSITIONS AND METHODS FOR MODULATING NEURONAL EXCITABILITY AND MOTOR BEHAVIORNovember 2020August 2024Allow4521NoNo
16766529METHOD FOR PRODUCING CELL MASS INCLUDING PITUITARY TISSUE, AND CELL MASS THEREOFMay 2020July 2025Allow6041YesNo
16876030Genome-Based Methods For Reducing Cardiovascular RiskMay 2020November 2024Allow5431NoNo
16640907METHODS OF TREATING UREA CYCLE DISORDERS BY INTERFERING WITH GLUCAGON RECEPTOR SIGNALINGFebruary 2020June 2024Allow5221YesNo
16622891BIOMARKERS FOR WOUND HEALINGDecember 2019March 2026Allow6031YesNo
16495131METHOD OF SCREENING FOR ANTI-DRUG ANTIBODIES AGAINST IMMUNOGLOBULIN SINGLE VARIABLE DOMAIN-BASED DRUGSSeptember 2019July 2025Allow6070YesNo
16470537USE OF APOE4 MOTIF-MEDIATED GENES FOR DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASEJune 2019April 2025Allow6071YesNo
16441902COMPOSITIONS, DEVICES, AND METHODS OF ATTENTION DEFICIT DISORDER/ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADD/ADHD) SENSITIVITY TESTINGJune 2019June 2025Abandon6051NoYes
16410763METHODS FOR DRUG DISCOVERY USING STEM CELL-DERIVED SCHWANN CELLSMay 2019April 2025Abandon6062NoNo
16230216MAMMALIAN CELL CULTURE-PRODUCED NEUBLASTIN ANTIBODIESDecember 2018January 2020Allow1310NoNo
16304060METHOD FOR PRODUCING NEURAL STEM CELLS, MEDIUM, SUPPLEMENT, SUPPLEMENT SET, MEDIUM KIT, AND CELL CULTURE DEVICENovember 2018July 2024Allow6071YesNo
15772515METHODS FOR APOLIPOPROTEIN DETECTIONSeptember 2018February 2026Allow6061YesNo
16015748CELL-BASED TREATMENT AND DRUG DISCOVERY IN HIRSCHSPRUNG'S DISEASE ENABLED BY PLURIPOTENT STEM CELL-DERIVED HUMAN ENTERIC NEURAL CREST LINEAGESJune 2018March 2025Allow6081NoNo
15458185Neuromuscular Junction: NMJ-ON-CHIPMarch 2017July 2025Abandon6081NoNo
15504301METHODS TO ENHANCE NERVE REGENERATION UTILIZING NEURAL STEM CELLS AND IL12P40February 2017April 2019Allow2621YesNo
15104149BIOMARKERS AND METHODS RELATING TO ALZHEIMER'S DISEASEJune 2016March 2025Allow6082YesYes
14916602NAV1.7 ANTIBODIES AND METHODS OF USING THE SAMEMarch 2016September 2018Allow3121NoNo
14894980SINGLE DOMAIN ANTIBODIES AGAINST SOD1 AND THEIR USE IN MEDICINENovember 2015September 2017Allow2121YesNo
14782078METHOD FOR DETECTING ASYN-SPECIFIC ANTIBODIES IN A BIOLOGICAL SAMPLEOctober 2015January 2018Allow2721YesNo
14402145Method of Inhibiting C5aNovember 2014February 2019Allow5181YesNo
14334643METHODS FOR INHIBITING THE DEVELOPMENT OF HUNTINGTON'S DISEASEJuly 2014March 2016Allow2010NoNo
14288374ANTIBODIES AND THEIR USE IN THE TREATMENT, PREVENTION AND DIAGNOSIS OF A DISEASE ASSOCIATED WITH SOD1 ABNORMALITIESMay 2014October 2015Allow1711YesNo
14068648METHOD OF TREATING STROKE COMPRISING ADMINISTERING METAL CHELATORS TO THE UPPER ONE-THIRD OF THE NASAL CAVITYOctober 2013January 2016Allow2710NoNo
14063125METHODS OF TREATING HUNTINGTON'S DISEASE COMPRISING ADMINISTERING METAL CHELATORS TO THE UPPER ONE-THIRD OF THE NASAL CAVITYOctober 2013August 2015Allow2110YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner MACFARLANE, STACEY NEE.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
2
Examiner Affirmed
1
(50.0%)
Examiner Reversed
1
(50.0%)
Reversal Percentile
70.1%
Higher than average

What This Means

With a 50.0% reversal rate, the PTAB reverses the examiner's rejections in a meaningful percentage of cases. This reversal rate is above the USPTO average, indicating that appeals have better success here than typical.

Strategic Value of Filing an Appeal

Total Appeal Filings
16
Allowed After Appeal Filing
6
(37.5%)
Not Allowed After Appeal Filing
10
(62.5%)
Filing Benefit Percentile
61.3%
Higher than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 37.5% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is above the USPTO average, suggesting that filing an appeal can be an effective strategy for prompting reconsideration.

Strategic Recommendations

✓ Appeals to PTAB show good success rates. If you have a strong case on the merits, consider fully prosecuting the appeal to a Board decision.

✓ Filing a Notice of Appeal is strategically valuable. The act of filing often prompts favorable reconsideration during the mandatory appeal conference.

Examiner MACFARLANE, STACEY NEE - Prosecution Strategy Guide

Executive Summary

Examiner MACFARLANE, STACEY NEE works in Art Unit 1675 and has examined 153 patent applications in our dataset. With an allowance rate of 88.9%, this examiner has an above-average tendency to allow applications. Applications typically reach final disposition in approximately 45 months.

Allowance Patterns

Examiner MACFARLANE, STACEY NEE's allowance rate of 88.9% places them in the 70% percentile among all USPTO examiners. This examiner has an above-average tendency to allow applications.

Office Action Patterns

On average, applications examined by MACFARLANE, STACEY NEE receive 2.82 office actions before reaching final disposition. This places the examiner in the 82% percentile for office actions issued. This examiner issues more office actions than most examiners, which may indicate thorough examination or difficulty in reaching agreement with applicants.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by MACFARLANE, STACEY NEE is 45 months. This places the examiner in the 12% percentile for prosecution speed. Applications take longer to reach final disposition with this examiner compared to most others.

Interview Effectiveness

Conducting an examiner interview provides a +21.0% benefit to allowance rate for applications examined by MACFARLANE, STACEY NEE. This interview benefit is in the 65% percentile among all examiners. Recommendation: Interviews provide an above-average benefit with this examiner and are worth considering.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 26.6% of applications are subsequently allowed. This success rate is in the 44% percentile among all examiners. Strategic Insight: RCEs show below-average effectiveness with this examiner. Carefully evaluate whether an RCE or continuation is the better strategy.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 48.9% of cases where such amendments are filed. This entry rate is in the 73% percentile among all examiners. Strategic Recommendation: This examiner shows above-average receptiveness to after-final amendments. If your amendments clearly overcome the rejections and do not raise new issues, consider filing after-final amendments before resorting to an RCE.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 200.0% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 93% percentile among all examiners. Strategic Recommendation: Pre-appeal conferences are highly effective with this examiner compared to others. Before filing a full appeal brief, strongly consider requesting a PAC. The PAC provides an opportunity for the examiner and supervisory personnel to reconsider the rejection before the case proceeds to the PTAB.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 88.2% of appeals filed. This is in the 81% percentile among all examiners. Of these withdrawals, 86.7% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner frequently reconsiders rejections during the appeal process compared to other examiners. Per MPEP § 1207.01, all appeals must go through a mandatory appeal conference. Filing a Notice of Appeal may prompt favorable reconsideration even before you file an Appeal Brief.

Petition Practice

When applicants file petitions regarding this examiner's actions, 56.5% are granted (fully or in part). This grant rate is in the 58% percentile among all examiners. Strategic Note: Petitions show above-average success regarding this examiner's actions. Petitionable matters include restriction requirements (MPEP § 1002.02(c)(2)) and various procedural issues.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 19.0% of allowed cases (in the 98% percentile). Per MPEP § 1302.04, examiner's amendments are used to place applications in condition for allowance when only minor changes are needed. This examiner frequently uses this tool compared to other examiners, indicating a cooperative approach to getting applications allowed. Strategic Insight: If you are close to allowance but minor claim amendments are needed, this examiner may be willing to make an examiner's amendment rather than requiring another round of prosecution.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 2.9% of allowed cases (in the 73% percentile). This examiner issues Quayle actions more often than average when claims are allowable but formal matters remain (MPEP § 714.14).

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Expect multiple rounds of prosecution: This examiner issues more office actions than average. Address potential issues proactively in your initial response and consider requesting an interview early in prosecution.
  • Request pre-appeal conferences: PACs are highly effective with this examiner. Before filing a full appeal brief, request a PAC to potentially resolve issues without full PTAB review.
  • Appeal filing as negotiation tool: This examiner frequently reconsiders rejections during the appeal process. Filing a Notice of Appeal may prompt favorable reconsideration during the mandatory appeal conference.
  • Plan for extended prosecution: Applications take longer than average with this examiner. Factor this into your continuation strategy and client communications.
  • Examiner cooperation: This examiner frequently makes examiner's amendments to place applications in condition for allowance. If you are close to allowance, the examiner may help finalize the claims.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.