USPTO Examiner XIE XIAOZHEN - Art Unit 1674

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
19058528COAGULATION MOLD, A KIT AND A METHOD FOR PREPARING A COAGULATED BLOOD MASSFebruary 2025April 2025Allow200YesNo
18861616COLLAGEN HYDROLYSATE COMPOSITION FOR REDUCING JOINT PAIN AFTER EXERCISEOctober 2024June 2025Allow700YesNo
18783156COAGULATION MOLD, A KIT AND A METHOD FOR PREPARING A COAGULATED BLOOD MASSJuly 2024June 2025Allow1101YesNo
18750971PLK1 INHIBITOR IN COMBINATION WITH ANTI-ANGIOGENICS FOR TREATING METASTATIC CANCERJune 2024September 2024Allow301YesNo
18407929ACTIVIN RECEPTOR TYPE IIB VARIANTS AND METHODS OF USE THEREOFJanuary 2024December 2024Allow1100YesNo
18391146METHODS AND COMPOSITIONS FOR REGENERATING TISSUESDecember 2023December 2024Allow1200YesNo
18492150MODIFIED-IgG ANTIBODIES THAT BIND TRANSFORMING GROWTH FACTOR-BETA1 WITH HIGH AFFINITY, AVIDITY AND SPECIFICITYOctober 2023July 2024Allow900YesNo
18279476LA PROTEIN AS A NOVEL REGULATOR OF OSTEOCLASTOGENESISAugust 2023November 2024Abandon1511NoNo
18457861ANTI-ROR2 ANTIBODIES, ANTIBODY FRAGMENTS, THEIR IMMUNOCONJUGATES AND USES THEREOFAugust 2023March 2025Allow1911YesNo
18352366TUNABLE SILK-BASED BIOMATERIALS WITH SACCHARIDE SUBSTITUTIONS, AND METHODS OF PRODUCING THE SAMEJuly 2023February 2025Allow1911YesNo
18317277COMPOSITIONS FOR TREATING AUTOIMMUNE ARTHRITISMay 2023August 2024Allow1511YesNo
18301839MAMMALIAN CELL POPULATION AND MEDICAMENTS FOR CELL THERAPIES IN HUMANS AND IMPROVED CELL CULTIVATION METHODSApril 2023October 2024Allow1831YesNo
18177642CARTILAGE-HOMING PEPTIDESMarch 2023December 2024Abandon2101NoNo
18175849Methods of Using IL-1beta CompoundsFebruary 2023February 2025Allow2410YesNo
18175163TWISTED GASTRULATION POLYPEPTIDES AND USES THEREOFFebruary 2023July 2024Allow1611YesNo
18114832IL-23R ANTAGONISTS TO REPROGRAM INTRATUMORAL T REGULATORY CELLS INTO EFFECTOR CELLSFebruary 2023September 2024Allow1801YesNo
18166211ANTI-SCLEROSTIN ANTIBODIES AND METHODS OF USEFebruary 2023September 2024Allow1901YesNo
18157689SAPOSIN C PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CANCERJanuary 2023September 2024Allow1921YesNo
18088272DOSAGE REGIMEN FOR PEGYLATED INTERFERONDecember 2022May 2025Allow2921YesNo
18062608GREMLIN-1 INHIBITOR FOR THE TREATMENT OF A BONE FRACTURE OR BONE DEFECTDecember 2022October 2024Allow2311YesNo
18046810COMPOSITIONS AND METHODS FOR TARGETED THERAPEUTIC DELIVERY TO BONEOctober 2022January 2025Allow2821YesNo
17903910COMPOSITIONS AND METHODS FOR DEGENERATIVE DISC REGENERATIONSeptember 2022March 2025Allow3021YesNo
17663384INTERLEUKIN-2/INTERLEUKIN-2 RECEPTOR ALPHA FUSION PROTEINS AND METHODS OF USEMay 2022September 2024Allow2811YesNo
17698602BONE REPAIR PRODUCT AND METHODS OF USE THEREOFMarch 2022February 2025Allow3521YesNo
17616391ANTIBODY TARGETING THE VP-1 PROTEIN, FRAGMENTS THEREOF, AND USES OF SAME FOR DETECTING INFECTION WITH THE BK POLYOMAVIRUSDecember 2021April 2025Allow4000YesNo
17541992USE OF C-TYPE NATRIURETIC PEPTIDE VARIANTS TO TREAT OSTEOARTHRITISDecember 2021September 2024Allow3421YesNo
17517533Method of Treating OsteoarthritisNovember 2021December 2024Allow3731YesNo
17598049COMPOSITION FOR PROMOTING CARTILAGE TISSUE REGENERATIONSeptember 2021February 2025Abandon4101NoNo
17438634A METHOD FOR IMMUNOSUPPRESSIONSeptember 2021April 2025Abandon4301NoNo
17470455BIOMARKERS AND METHODS FOR ASSESSING PSORIATIC ARTHRITIS DISEASE ACTIVITYSeptember 2021January 2024Abandon2921NoNo
17465092METHOD FOR PURIFYING ACTIVE POLYPEPTIDES OR IMMUNOCONJUGATESSeptember 2021February 2025Abandon4110NoNo
17276916Human Monoclonal Antibody Binding Specifically to Human Hmgb1, and Pharmaceutical Composition for Treating or Preventing Alzheimer's Disease Containing Said Human Monoclonal AntibodyAugust 2021February 2025Allow4701YesNo
17433295COMBINED THERAPIES OF ACTIVATABLE IMMUNE CHECKPOINT INHIBITORS AND CONJUGATED ACTIVATABLE ANTIBODIESAugust 2021February 2025Abandon4201NoNo
17432185ANTI-CSP ANTIBODY VARIANTSAugust 2021June 2025Abandon4601NoNo
17402325MULTIFUNCTIONAL MOLECULES THAT BIND TO T CELL RELATED CANCER CELLS AND USES THEREOFAugust 2021April 2025Allow4411YesNo
17286355MARKER FOR DETERMING CRITICAL STAGE KIDNEY DISEASEAugust 2021February 2025Abandon4601NoNo
17427559IMMUNOASSAY METHOD FOR FREE AIM IN BIOLOGICAL SAMPLE, AND ASSAY KITJuly 2021December 2024Allow4010YesNo
17443012COMPOSITION AND METHOD FOR DELIVERY OF BMP-2 AMPLIFIER/CO-ACTIVATOR FOR ENHANCEMENT OF OSTEOGENESISJuly 2021August 2024Allow3721YesNo
17422075ANTI-CD40 ANTIBODIES FOR USE IN TREATMENT OF HIDRADENITIS SUPPURATIVAJuly 2021May 2025Allow4611YesNo
17298865PHARMACEUTICAL COMPOSITIONS COMPRISING ANTI-191P4D12 ANTIBODY DRUG CONJUGATES AND METHODS OF USE THEREOFJune 2021November 2024Allow4201YesNo
17290016BIOMARKER PROTEINS FOR DIAGNOSING ALZHEIMER'S DEMENTIA AND USE THEREOFApril 2021November 2024Abandon4301NoNo
17288234MONOCLONAL ANTIBODY THAT SPECIFICALLY BINDS TO CD20April 2021August 2024Allow4001YesNo
17287367ANTI-IL-25 ANTIBODIES AND USE THEREOFApril 2021December 2024Allow4411YesNo
17232145CYCLIC PEPTIDE FROM NOVEL BONE MORPHOGENETIC PROTEIN 2, PREPARATION METHOD THEREFOR AND APPLICATION THEREOFApril 2021August 2024Allow4011YesNo
17282577MENISCUS REGENERATION MATERIALApril 2021June 2025Allow5021YesNo
17211261SYSTEMS, COMPOSITIONS, AND METHODS FOR TRANSPLANTATIONMarch 2021November 2024Abandon4431YesNo
17279359AXL-SPECIFIC ANTIBODIES FOR TREATMENT OF NON-SMALL CELL LUNG CANCERMarch 2021December 2024Abandon4501NoNo
17256509ANABOLIC TARGETING STEM CELL GENE THERAPY FOR OSTEOPOROSISDecember 2020November 2024Abandon4711NoNo
17030416Personalized Immunotherapies for Reduction of Brain Inflammation and Suicide PreventionSeptember 2020November 2024Abandon5021YesNo
16967922METHODS FOR TREATING HETEROTOPIC OSSIFICATIONAugust 2020March 2025Allow5621YesNo
16945494METHODS OF REDUCING AGGREGATION OF IL-1RAJuly 2020June 2025Abandon5951YesNo
16960704CALRETICULIN BINDING CONSTRUCTS AND ENGINEERED T CELLS FOR THE TREATMENT OF DISEASESJuly 2020December 2024Allow5321YesNo
16760731HETEROTOPIC OSSIFICATION AND METHOD OF TREATMENTApril 2020October 2024Allow5441YesNo
16863630INJECTABLE BONE MORPHOGENETIC PROTEINApril 2020August 2024Allow5241YesNo
16858301METHOD OF DIAGNOSIS AND TREATMENT OF RHEUMATOID ARTHRITISApril 2020June 2025Allow6061YesYes
16805481IL-4/IL-13 PATHWAY INHIBITORS FOR ENHANCED EFFICACY IN TREATING CANCERFebruary 2020August 2024Allow5431YesNo
16659604NON-RESORBABLE BONE ALLOGRAFTS AND METHOD FOR MAKING SAMEOctober 2019October 2023Abandon4820YesNo
15855398COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING DISEASES, CONDITIONS OR PROCESSES CHARACTERIZED BY ABERRANT FIBROBLAST PROLIFERATION AND EXTRACELLULAR MATRIX DEPOSITIONDecember 2017September 2019Allow2101YesNo
15553930ANTI-TGF-BETA ANTIBODY FOR THE TREATMENT OF FANCONI ANEMIAAugust 2017August 2019Allow2411YesNo
15165150ANTIBODIES TARGETING BONE MORPHOGENETIC PROTEIN 9 (BMP9) AND METHODS THEREFORMay 2016April 2018Allow2201YesNo
14757770Method of treating skeletal dysplasias using vessel dilatorDecember 2015February 2018Allow2621YesNo
14875812BINDING PROTEINS SPECIFIC FOR INSULIN-LIKE GROWTH FACTORS AND USES THEREOFOctober 2015June 2017Allow2101YesNo
14767117HIGHLY GALACTOSYLATED ANTI-TNF-ALPHA ANTIBODIES AND USES THEREOFAugust 2015October 2018Allow3811YesNo
14812908Immunoconjugates for the Treatment of TumoursJuly 2015June 2017Allow2211YesNo
14759535A Soluble Fibroblast Growth Factor Receptor 3 (FGR3) Polypeptide For Use In The Prevention Or Treatment Of Skeletal Growth Retardation DisordersJuly 2015March 2020Allow5651YesNo
14626274COMPOSITIONS AND METHODS FOR INCREASING BONE MINERALIZATIONFebruary 2015June 2017Allow2811YesNo
14419063METHODS FOR DIAGNOSING, PROGNOSING AND TREATING MUSCULAR DYSTROPHYFebruary 2015September 2017Allow3121YesNo
14473339COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING DISEASES, CONDITIONS, OR PROCESSES CHARACTERIZED BY ABERRANT FIBROBLAST PROLIFERATION AND EXTRACELLULAR MATRIX DEPOSITIONAugust 2014September 2017Allow3721YesNo
14368080PEPTIDES TARGETING RECEPTOR ACTIVATOR OF NUCLEAR FACTOR - KAPPA B (RANK) AND THEIR APPLICATIONSJune 2014March 2016Allow2111YesNo
14004944INJECTABLE DELIVERY SYSTEM FOR HEPARAN-BINDING GROWTH FACTORSSeptember 2013November 2016Allow3921YesNo
13989303HLA-G Isoform for use in the Treatment of a Disease Associated with Bone ResorptionAugust 2013February 2016Allow3321YesNo
13947918Interleukin-B30 ProteinsJuly 2013February 2014Allow701YesNo
13803711BINDING PROTEINS SPECIFIC FOR INSULIN-LIKE GROWTH FACTORS AND USES THEREOFMarch 2013July 2015Allow2811YesNo
13644728Compositions and Methods for Increasing Bone MineralizationOctober 2012November 2014Allow2521YesYes
13595436USE OF CYTOKINE RECEPTORS AS BIOMARKERS AND THERAPEUTIC TARGETS IN HUMAN CANCERAugust 2012June 2013Allow901YesNo
13497562TREATMENT OF CANCERJuly 2012February 2016Allow4731YesNo
13463018OSTEOGENIC DEVICE FOR INDUCING BONE FORMATION IN CLINICAL CONTEXTSMay 2012April 2015Allow3621YesNo
13445759Compositions And Methods For Preventing Or Treating Diseases, Conditions, Or Processes Characterized By Aberrant Fibroblast Proliferation And Extracellular Matrix DepositionApril 2012January 2017Allow5741NoNo
13434629IL-B30 ANTIBODIESMarch 2012March 2013Allow1211YesNo
13380185AVIAN COLONY STIMULATING FACTOR 1 RECEPTOR BINDING PROTEINSMarch 2012March 2016Allow5141YesYes
13413242METHODS FOR TREATING CANCER USING PROSTATE SPECIFIC ANTIGEN AND TUMOR ENDOTHELIAL MARKER PEPTIDESMarch 2012August 2013Allow1711YesNo
13375562COMPOUNDS AND METHODS FOR TREATING BONE DISORDERS AND CONTROLLING WEIGHTFebruary 2012August 2015Allow4432YesNo
13344509MODIFIED DEFENSINS AND THEIR USEJanuary 2012August 2013Allow1911NoNo
13343127Methods for Promoting Wound Healing and/or Reducing Scar FormationJanuary 2012February 2014Allow2521YesNo
13122637MODULATION OF THE ACTIVITY AND DIFFERENTIATION OF CELLS EXPRESSING THE OSTEOCLAST-ASSOCIATED RECEPTOROctober 2011November 2013Allow3211YesNo
13246197METHODS FOR TREATING INFLAMMATORY BOWEL DISEASESeptember 2011January 2014Allow2721YesNo
13169641USE OF CYTOKINE RECEPTORS AS BIOMARKERS AND THERAPEUTIC TARGETS IN HUMAN CANCERJune 2011June 2012Allow1101YesNo
13167431CO-TARGETING OF AURORA A KINASE AND LIM KINASE 1 FOR CANCER THERAPYJune 2011September 2013Allow2621YesNo
13140931ANTI PERIODONTITIS-CAUSING MICROORGANISM AGENT AND MEDICAL OR DENTAL MATERIALS USING THE SAMEJune 2011June 2016Allow6041YesNo
13044607AFFINITY PEPTIDES TOWARD BMP-2March 2011May 2013Allow2621YesNo
12996260POLYPEPTIDEFebruary 2011November 2015Allow6021YesNo
11992234MODULATION OF OSTEOCLAST DIFFERENTIATIONFebruary 2011May 2014Allow6021YesNo
12930858INHIBITOR PROTEIN OF THE WNT SIGNAL PATHWAYJanuary 2011February 2013Allow2531YesNo
12909405CHIMERIC ANTIGEN-SPECIFIC T CELL-ACTIVATING POLYPEPTIDESOctober 2010April 2014Allow4210YesNo
12902994COMPONENT OF BROMELAINOctober 2010January 2017Allow6061YesNo
12819583USE OF CALCITONIN IN OSTEOARTHRITISJune 2010September 2013Allow3921YesNo
12771696IMMUNOCONJUGATES FOR THE TREATMENT OF TUMOURSApril 2010April 2015Allow6041YesYes
12756995METHOD FOR BONE MARROW PRESERVATION OR RECOVERYApril 2010March 2016Allow6062NoNo
12730469Methods and Devices for Correcting Spinal Deformity With Pharmaceutical-Eluting Pedicle ScrewsMarch 2010December 2015Allow6041YesNo
12704187TREATMENT OF OSTEOPOROSIS IN PERI- AND POST- MENOPAUSAL WOMEN WITH HEPCIDINFebruary 2010December 2014Allow5822YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner XIE, XIAOZHEN.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
3
Examiner Affirmed
2
(66.7%)
Examiner Reversed
1
(33.3%)
Reversal Percentile
48.5%
Lower than average

What This Means

With a 33.3% reversal rate, the PTAB reverses the examiner's rejections in a meaningful percentage of cases. This reversal rate is below the USPTO average, indicating that appeals face more challenges here than typical.

Strategic Value of Filing an Appeal

Total Appeal Filings
24
Allowed After Appeal Filing
5
(20.8%)
Not Allowed After Appeal Filing
19
(79.2%)
Filing Benefit Percentile
24.1%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 20.8% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

Appeals to PTAB face challenges. Ensure your case has strong merit before committing to full Board review.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner XIE, XIAOZHEN - Prosecution Strategy Guide

Executive Summary

Examiner XIE, XIAOZHEN works in Art Unit 1674 and has examined 170 patent applications in our dataset. With an allowance rate of 88.2%, this examiner has an above-average tendency to allow applications. Applications typically reach final disposition in approximately 40 months.

Allowance Patterns

Examiner XIE, XIAOZHEN's allowance rate of 88.2% places them in the 65% percentile among all USPTO examiners. This examiner has an above-average tendency to allow applications.

Office Action Patterns

On average, applications examined by XIE, XIAOZHEN receive 2.22 office actions before reaching final disposition. This places the examiner in the 76% percentile for office actions issued. This examiner issues more office actions than most examiners, which may indicate thorough examination or difficulty in reaching agreement with applicants.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by XIE, XIAOZHEN is 40 months. This places the examiner in the 7% percentile for prosecution speed. Applications take longer to reach final disposition with this examiner compared to most others.

Interview Effectiveness

Conducting an examiner interview provides a +25.2% benefit to allowance rate for applications examined by XIE, XIAOZHEN. This interview benefit is in the 75% percentile among all examiners. Recommendation: Interviews are highly effective with this examiner and should be strongly considered as a prosecution strategy. Per MPEP § 713.10, interviews are available at any time before the Notice of Allowance is mailed or jurisdiction transfers to the PTAB.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 28.4% of applications are subsequently allowed. This success rate is in the 42% percentile among all examiners. Strategic Insight: RCEs show below-average effectiveness with this examiner. Carefully evaluate whether an RCE or continuation is the better strategy.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 40.7% of cases where such amendments are filed. This entry rate is in the 55% percentile among all examiners. Strategic Recommendation: This examiner shows above-average receptiveness to after-final amendments. If your amendments clearly overcome the rejections and do not raise new issues, consider filing after-final amendments before resorting to an RCE.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 133.3% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 84% percentile among all examiners. Strategic Recommendation: Pre-appeal conferences are highly effective with this examiner compared to others. Before filing a full appeal brief, strongly consider requesting a PAC. The PAC provides an opportunity for the examiner and supervisory personnel to reconsider the rejection before the case proceeds to the PTAB.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 88.0% of appeals filed. This is in the 79% percentile among all examiners. Of these withdrawals, 86.4% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner frequently reconsiders rejections during the appeal process compared to other examiners. Per MPEP § 1207.01, all appeals must go through a mandatory appeal conference. Filing a Notice of Appeal may prompt favorable reconsideration even before you file an Appeal Brief.

Petition Practice

When applicants file petitions regarding this examiner's actions, 36.8% are granted (fully or in part). This grant rate is in the 33% percentile among all examiners. Strategic Note: Petitions show below-average success regarding this examiner's actions. Ensure you have a strong procedural basis before filing.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 17.1% of allowed cases (in the 98% percentile). Per MPEP § 1302.04, examiner's amendments are used to place applications in condition for allowance when only minor changes are needed. This examiner frequently uses this tool compared to other examiners, indicating a cooperative approach to getting applications allowed. Strategic Insight: If you are close to allowance but minor claim amendments are needed, this examiner may be willing to make an examiner's amendment rather than requiring another round of prosecution.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 2.7% of allowed cases (in the 69% percentile). This examiner issues Quayle actions more often than average when claims are allowable but formal matters remain (MPEP § 714.14).

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Expect multiple rounds of prosecution: This examiner issues more office actions than average. Address potential issues proactively in your initial response and consider requesting an interview early in prosecution.
  • Prioritize examiner interviews: Interviews are highly effective with this examiner. Request an interview after the first office action to clarify issues and potentially expedite allowance.
  • Request pre-appeal conferences: PACs are highly effective with this examiner. Before filing a full appeal brief, request a PAC to potentially resolve issues without full PTAB review.
  • Appeal filing as negotiation tool: This examiner frequently reconsiders rejections during the appeal process. Filing a Notice of Appeal may prompt favorable reconsideration during the mandatory appeal conference.
  • Plan for extended prosecution: Applications take longer than average with this examiner. Factor this into your continuation strategy and client communications.
  • Examiner cooperation: This examiner frequently makes examiner's amendments to place applications in condition for allowance. If you are close to allowance, the examiner may help finalize the claims.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.