USPTO Examiner HOWARD ZACHARY C - Art Unit 1674

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
18927301PHARMACEUTICAL COMPOSITIONS COMPRISING COLLAGENASE I and COLLAGENASE IIOctober 2024December 2024Allow200NoNo
18909225METHODS OF TREATING OR PREVENTING A CARDIOVASCULAR SYSTEM COMPLICATION OF SICKLE CELL DISEASE WITH AN ANTI-G-CSFR ANTIBODYOctober 2024April 2025Allow711NoNo
18830877ANTI IL-6 DOMAIN ANTIBODIES WITH FATTY ACID SUBSTITUENTSSeptember 2024April 2025Allow711YesNo
18817109ANTI-IL-18BP ANTIBODIESAugust 2024April 2025Allow711YesNo
18773461ANTI-TRANSFERRIN RECEPTOR ANTIBODY-PMO CONJUGATES FOR INDUCING DMD EXON 44 SKIPPINGJuly 2024March 2025Allow811NoNo
18615520NUCLEIC ACID MOLECULES ENCODING CLOSTRIDIUM HISTOLYTICUM COLLAGENASE I AND METHODS OF PRODUCING THE SAMEMarch 2024June 2025Abandon1410NoNo
18441998METHODS OF TREATMENT OR PREVENTION OF IMMUNE RESPONSES AND INFLAMMATORY DISEASES WITH ANTAGONISTIC CD40 MONOCLONAL ANTIBODIESFebruary 2024May 2025Allow1511NoNo
18413753AMELIORATION AND TREATMENT OF INFARCTION DAMAGE WITH A POLYPEPTIDE SEGEMENT OF BNIP3January 2024February 2025Allow1321YesNo
18390569METHODS FOR INDUCING AN IMMUNE RESPONSE BY ADMINISTERING ACTIVATED MESENCHYMAL STEM CELLSDecember 2023April 2025Abandon1601NoNo
18505590METHOD OF ASSESSING REGULATION OF AN IMMUNE RESPONSE TO AN ADMINISTERED AGENT BY MEASURING ACTIVATION OF NODOSE GANGLION NEURONSNovember 2023May 2025Allow1931NoNo
18459465PROPERDIN BINDING PROTEIN AND USE THEREOFSeptember 2023August 2024Allow1121YesNo
18453691Antagonistic CD40 Monoclonal Antibodies and Uses ThereofAugust 2023May 2025Allow2011YesNo
18357639METHOD OF TREATING DIABETES WITH FGF21 AND GLP1 DOUBLE GENE-MODIFIED CELLJuly 2023June 2025Allow2221NoNo
18346205HETERODIMERIC RELAXIN FUSIONS AND USES THEREOFJuly 2023August 2024Allow1400NoNo
18329308NUCLEIC ACIDS ENCODING CLOSTRIDIUM HISTOLYTICUM DELTA TOXIN AND METHODS OF PRODUCING THE SAMEJune 2023May 2025Abandon2320NoNo
18140121METHODS OF TREATING IRON OVERLOAD WITH A BMP INHIBITORApril 2023June 2025Allow2611NoNo
18301924Anti-CD30 and Anti-CD3 Bispecific Antibodies and Methods of Immunotherapy for CD30+ MalignanciesApril 2023April 2025Allow2411NoNo
18193581NATRIURETIC PEPTIDE RECEPTOR 1 ANTIBODIES AND METHODS OF USEMarch 2023April 2025Allow2501YesNo
18193393TREATMENT OF SKIN DISEASES OR DISORDERS BY DELIVERY OF ANTI-OSMRBeta ANTIBODYMarch 2023November 2024Abandon2001NoNo
18125353APLNR Modulators and Uses ThereofMarch 2023December 2024Abandon2101NoNo
18163667ANTI-CD30 ANTIBODIESFebruary 2023February 2025Allow2511YesNo
18156617ANTIBODY ENDOHEDRAL METALLOFULLERENE CONJUGATE AND USES THEREOFJanuary 2023June 2025Abandon2941YesNo
17946916NUCLEIC ACIDS ENCODING SWITCH RECEPTORS USING IL-9 RECEPTOR SIGNALING DOMAINSSeptember 2022September 2024Allow2421NoNo
17933055METHODS OF TREATMENT OF ARTHRITIS AND/OR PSORIASIS WITH PHARMACEUTICAL FORMULATIONS OF ETANERCEPTSeptember 2022September 2024Allow2411NoNo
17881413KIT FOR PREPARING DISEASE-TREATING AGENT, DISEASE-TREATING AGENT AND METHOD FOR PREPARING DISEASE-TREATING AGENTAugust 2022December 2024Abandon2811NoNo
17814221Method of Making Anti-Pro/Latent Myostatin AntibodiesJuly 2022December 2024Allow2921NoNo
17859130METHOD OF USING NAP-2 AND TGF-alpha TO IMPROVE CARDIAC FUNCTIONJuly 2022March 2025Allow3210YesNo
17810423C-KIT ANTIBODIES AND METHOD FOR TREATING CANCER WITH SUCHJuly 2022August 2024Allow2511NoNo
17838863T-CELL REACTIVITY PLATFORMJune 2022November 2024Abandon2911NoNo
17837943GRP78-BINDING ANTIBODIES AND USES THEREOF IN DETECTING OR NEUTRALIZING GRP78June 2022August 2024Allow2611NoNo
17836473NUCLEIC ACIDS ENCODING CX3CR1-BINDING POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINSJune 2022September 2024Allow2811NoNo
17827100Inhibition of Vascular Matrix Metalloproteinase-9 to Treat Ischemic InjuryMay 2022February 2025Abandon3211NoNo
17725142ANTI-CD39 ANTIBODIES, COMPOSITIONS COMPRISING ANTI-CD39 ANTIBODIES AND METHODS OF USING ANTI-CD39 ANTIBODIESApril 2022October 2024Abandon3011NoNo
17718087IL-12 HETERODIMERIC FC-FUSION PROTEINSApril 2022August 2024Allow2821NoNo
17703747ANTI-BAG3 ANTIBODIES AS THERAPEUTIC REAGENT IN CARDIOVASCULAR DISEASEMarch 2022November 2024Allow3221YesNo
17694295USE OF SOLUBLE UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR LEVELS TO INDICATE PREVENTION OF CARDIOVASCULAR DISEASE WITH A STATINMarch 2022May 2025Allow3820NoNo
17579355METHODS OF DIAGNOSING, DETERMINING THE PROGRESSION OF, AND TREATING A PROSTATE CANCERJanuary 2022September 2024Allow3221NoNo
17626755ANTI-8-HYDROXY-2'-DEOXYGUANOSINE ANTIBODY OR ANTIBODY FRAGMENT THEREOF, PRODUCTION METHOD, KIT, MEASURING METHOD, AND DEVICE FOR MEASUREMENTJanuary 2022March 2025Allow3810YesNo
17486820HUMAN APOB100 EPITOPES, METHODS AND USES FOR MODULATING INFLAMMATORY RESPONSES, AND TREATING ADVERSE CARDIOVASCULAR EVENTS, DISEASE AND ATHEROSCLEROSISSeptember 2021June 2025Allow4531YesNo
17448389METHODS FOR TREATING METABOLIC DISEASES BY INHIBITING MYOSTATIN ACTIVATIONSeptember 2021May 2025Abandon4311NoNo
17405124METHODS OF USING FLT3L-Fc FUSION PROTEINS FOR THE TREATMENT OF DISEASESAugust 2021December 2024Abandon4022NoNo
17359211TREATMENT OF CANCER USING HUMANIZED ANTI-BCMA CHIMERIC ANTIGEN RECEPTORJune 2021September 2024Allow3921NoNo
17239983METHOD FOR TREATING FIBROSIS WITH AN ANTI-GDF-15 ANTIBODYApril 2021March 2025Allow4741NoNo
17202790Methods of Treatment with Anti-PACAP AntibodiesMarch 2021August 2024Allow4121NoYes
17271767METHOD TO ASSESS CAR FUNCTIONALITYFebruary 2021December 2024Abandon4601NoNo
17150457METHODS OF ADMINISTERING MESENCHYMAL STEM CELLS ACTIVATED BY CYTOKINES FOR ENHANCING IMMUNOSUPPRESSIONJanuary 2021August 2024Allow4321NoNo
17256553ANTI-CD6 ANTIBODY-GROWTH FACTOR COMPLEX FOR TREATING AUTOIMMUNE DISEASESDecember 2020March 2025Allow5021NoNo
17250259POZIOTINIB COMBINATIONS WITH AN ANTI-HER1, HER2 OR HER4 ANTIBODY AND METHODS OF USE THEREOFDecember 2020January 2025Abandon4911NoNo
17077433METHOD FOR TREATING PULMONARY HYPERTENSION WITH ANTIBODIES TO HUMAN RESISTINOctober 2020October 2024Allow4831YesNo
16979471NUCLEIC ACIDS ENCODING IL-13 RECEPTOR ALPHA 2 (IL13RA2) CHIMERIC ANTIGEN RECEPTOR FOR TUMOR SPECIFIC T CELL IMMUNOTHERAPYSeptember 2020July 2024Allow4611YesNo
16987237ANTI-ASGR-1 MONOCLONAL INHIBITORY ANTIBODIESAugust 2020March 2024Allow4341NoNo
16964785METHODS FOR PREVENTING ISCHEMIA REPERFUSION INJURY IN AN ORGAN WITH ANTIBODY ANTAGONISTS OF IL-33July 2020July 2024Allow4861NoNo
16772260Cell Comprising a Chimeric Antigen Receptor or a Transgenic T-Cell Receptor and Comprising a Chimeric TNF ReceptorJune 2020February 2025Allow5631YesNo
16753216TRANSTHYRETIN IMMUNOGLOBULIN FUSIONSApril 2020December 2024Allow5651YesNo
16711067TIE2 RECEPTOR ACTIVATION FOR GLAUCOMADecember 2019January 2024Abandon5041NoYes
16677267T-CELLS EXPRESSING ANTI-LIV1 CHIMERIC ANTIGEN RECEPTORNovember 2019January 2025Allow6051NoNo
16461258METHOD FOR INCREASING THE SECRETION LEVELS OF INTERLEUKIN 2 AND MUTEINS THEREOF BY INTRODUCING A POINT MUTATIONMay 2019March 2025Allow6041YesNo
16248507ANTI-APOC3 ANTIBODIES AND COMPOSITIONS THEREOFJanuary 2019November 2019Allow1021YesNo
16315684TREATMENT OF ISCHEMIA REPERFUSION INJURY USING ALPHA-2 MACROGLOBULINJanuary 2019March 2020Allow1421YesNo
16056068ANGIOPOIETIN-LIKE PROTEIN 8 POLYPEPTIDE FRAGMENTS AND COMPOSITIONS THEREOFAugust 2018March 2020Allow1921NoNo
15992567KIT FOR IMMUNOLOGICAL DETECTION OF TNF-ALPHA, STNFR1 AND IL-8 IN PROSTATE CANCERMay 2018April 2019Allow1010YesNo
15951929FOLLISTATIN IN TREATING DUCHENNE MUSCULAR DYSTROPHYApril 2018May 2020Allow2521NoNo
15820943Methods Of Protecting a Solid Organ Transplant Tissue With Angiopoietin-2 AntibodiesNovember 2017April 2019Allow1711YesNo
15800512METHODS OF TREATING A SUBJECT HAVING HEART FAILURE THAT INCLUDE DETECTING LEVELS OF GALECTIN-3 AND SOLUBLE ST2November 2017April 2019Allow1711NoNo
15716005Etanercept Formulations Stabilized with XylitolSeptember 2017October 2018Allow1711YesNo
15644450METHODS FOR TREATING CENTRAL OR PERIPHERAL NERVOUS SYSTEM DAMAGEJuly 2017August 2019Allow2611NoNo
15506665NEPRILYSIN AS HEART FAILURE PROGNOSTIC MARKERFebruary 2017September 2018Allow1911NoNo
15376358TREATMENT OF MYOCARDIAL INFARCTION USING TGF BETA ANTAGONISTSDecember 2016December 2019Allow3631YesNo
15070788METHODS OF TREATING HEDGEHOG-RELATED DISEASES WITH AN ANTI-LGR5 ANTIBODYMarch 2016November 2018Allow3221NoNo
14893122Inflammatory Disease Treatment Composition Including Anti-Myosin Regulatory Light-Chain Polypeptide AntibodyNovember 2015June 2017Allow1921YesNo
14879702ANTI-LRP5 ANTIBODIES AND METHODS OF USEOctober 2015August 2016Allow1001NoNo
14762373FOLLISTATIN IN TREATING DUCHENNE MUSCULAR DYSTROPHYJuly 2015January 2018Allow3021NoNo
14598664Methods of Treating Cancer With Antibodies That Target the Insulin-Like Growth Factor Type I Receptor (IGF-1R)January 2015April 2016Allow1531YesNo
14388649ANTI-LAMP5 ANTIBODY AND UTILIZATION THEREOFJanuary 2015May 2017Allow3231YesNo
14389219THROMBIN/PLASMIN-REGULATED ANTIBODIES THAT BIND TFPISeptember 2014February 2017Allow2831YesNo
14386250METHOD FOR USE IN THE TREATMENT OF ANEURYSMSeptember 2014October 2016Allow2531NoNo
14446073METHODS OF USING AN ANTIBODY TO INHIBIT WNT-MEDIATED SIGNALING IN CANCERJuly 2014June 2015Allow1111YesNo
14306992COMBINATION OF AN ANTI-EDB FIBRONECTIN ANTIBODY-IL-2 FUSION PROTEIN, AND A MOLECULE BINDING TO B CELLS, B CELL PROGENITORS AND/OR THEIR CANCEROUS COUNTERPARTJune 2014November 2015Allow1721YesNo
14360678METHODS OF REGULATING ANGIOGENESIS BY ADMINISTERING AGENTS WHICH INCREASE APOB-100 POLYPEPTIDEMay 2014January 2017Allow3131NoNo
14280940ALTERATION OF CELL MEMBRANE FOR NEW FUNCTIONS USING IL-2 and STREPTAVIDINMay 2014September 2015Allow1611YesNo
14357971USE OF FIBROMODULIN AND LUMICAN FOR INCREASING MUSCLE MASSMay 2014July 2015Allow1411NoNo
14357393USE OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND PACAP ANALOGS FOR TREATING CONTRAST-INDUCED NEPHROPATHYMay 2014January 2016Allow2111NoNo
14357204METHODS FOR TREATING KIDNEY DISEASE WITH FRAGMENTS OF APOB-100May 2014October 2015Allow1821YesNo
14129446LRP1 AS KEY RECEPTOR FOR THE TRANSFER OF STERIFIED CHOLESTEROL FROM VERY-LOW-DENSITY LIPOPROTEINS (VLDL) TO ISCHAEMIC CARDIAC MUSCLEMarch 2014May 2015Allow1611NoNo
14205170METHOD OF SCREENING FOR AN AGENT THAT ENHANCES BEIGE FAT ADIPOGENESISMarch 2014April 2016Allow2511NoNo
14152837MUTANT PROTEIN CAPABLE OF BINDING SPECIFICALLY AND QUICKLY TO TROPONIN I DERIVED FROM HUMAN MYOCARDIUMJanuary 2014July 2014Allow610NoNo
14140849USE OF EPIDERMAL GROWTH FACTOR FOR THE MORPHOFUNCTIONAL RESTORATION OF PERIPHERAL NERVES IN DIABETIC NEUROPATHYDecember 2013January 2015Allow1310YesNo
14088097METHODS FOR TREATING TOURNIQUET-INDUCED INJURIESNovember 2013December 2014Allow1311NoNo
14116075CETP FRAGMENTSNovember 2013March 2015Allow1611YesNo
14000850METHODS FOR TREATING LIVER INFLAMMATION IN A SUBJECT SUFFERING FROM NON-ALCOHOLIC STEATOHEPATITISOctober 2013March 2016Allow3121NoNo
13953622CHIMERIC IMMUNORECEPTOR USEFUL IN TREATING HUMAN CANCERSJuly 2013August 2015Allow2421NoNo
13636578METHODS FOR CARDIOPROTECTION AND CARDIOREGENERATION WITH DIMERS OF EGF FAMILY LIGANDSApril 2013January 2015Allow2711NoNo
13827023INHIBITION OF MYPB-C BINDING TO MYOSIN AS A TREATMENT FOR HEART FAILUREMarch 2013January 2015Allow2321NoYes
13793931THERAPEUTIC APPLICATION OF ADIPONECTIN IN PATIENTS WITH VENTRICULAR FIBRILLATIONMarch 2013June 2014Allow1501NoNo
13713594USE OF A PEPTIDE FRAGMENT OF CD44V6 IN THE TREATMENT OF OPHTHALMIC DISEASESDecember 2012August 2014Allow2011NoNo
13680866METHODS FOR IDENTIFYING A GLP-1 SECRETAGOGUENovember 2012July 2015Allow3211YesNo
13654919Etanercept Formulations Stabilized with XylitolOctober 2012June 2015Abandon3141NoNo
13552533METHODS OF TREATING CARDIOVASCULAR DISEASES AND PREDICTING THE EFFICACY OF EXERCISE THERAPYJuly 2012January 2014Allow1811YesNo
13534833METHODS FOR INHIBITING HEMATOPOIESIS WITH A HEDGEHOG ANTAGONISTJune 2012November 2013Allow1711NoNo
13530580METHODS FOR TREATING REPERFUSION INJURIES USING FLAGELLINJune 2012August 2013Allow1411YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner HOWARD, ZACHARY C.

Strategic Value of Filing an Appeal

Total Appeal Filings
22
Allowed After Appeal Filing
7
(31.8%)
Not Allowed After Appeal Filing
15
(68.2%)
Filing Benefit Percentile
46.2%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 31.8% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is below the USPTO average, suggesting that filing an appeal has limited effectiveness in prompting favorable reconsideration.

Strategic Recommendations

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner HOWARD, ZACHARY C - Prosecution Strategy Guide

Executive Summary

Examiner HOWARD, ZACHARY C works in Art Unit 1674 and has examined 174 patent applications in our dataset. With an allowance rate of 89.7%, this examiner has an above-average tendency to allow applications. Applications typically reach final disposition in approximately 31 months.

Allowance Patterns

Examiner HOWARD, ZACHARY C's allowance rate of 89.7% places them in the 69% percentile among all USPTO examiners. This examiner has an above-average tendency to allow applications.

Office Action Patterns

On average, applications examined by HOWARD, ZACHARY C receive 2.09 office actions before reaching final disposition. This places the examiner in the 70% percentile for office actions issued. This examiner issues a slightly above-average number of office actions.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by HOWARD, ZACHARY C is 31 months. This places the examiner in the 34% percentile for prosecution speed. Prosecution timelines are slightly slower than average with this examiner.

Interview Effectiveness

Conducting an examiner interview provides a +13.3% benefit to allowance rate for applications examined by HOWARD, ZACHARY C. This interview benefit is in the 54% percentile among all examiners. Recommendation: Interviews provide an above-average benefit with this examiner and are worth considering.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 30.3% of applications are subsequently allowed. This success rate is in the 51% percentile among all examiners. Strategic Insight: RCEs show above-average effectiveness with this examiner. Consider whether your amendments or new arguments are strong enough to warrant an RCE versus filing a continuation.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 61.7% of cases where such amendments are filed. This entry rate is in the 84% percentile among all examiners. Strategic Recommendation: This examiner is highly receptive to after-final amendments compared to other examiners. Per MPEP § 714.12, after-final amendments may be entered "under justifiable circumstances." Consider filing after-final amendments with a clear showing of allowability rather than immediately filing an RCE, as this examiner frequently enters such amendments.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 0.0% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 1% percentile among all examiners. Note: Pre-appeal conferences show limited success with this examiner compared to others. While still worth considering, be prepared to proceed with a full appeal brief if the PAC does not result in favorable action.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 100.0% of appeals filed. This is in the 85% percentile among all examiners. Of these withdrawals, 94.4% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner frequently reconsiders rejections during the appeal process compared to other examiners. Per MPEP § 1207.01, all appeals must go through a mandatory appeal conference. Filing a Notice of Appeal may prompt favorable reconsideration even before you file an Appeal Brief.

Petition Practice

When applicants file petitions regarding this examiner's actions, 56.4% are granted (fully or in part). This grant rate is in the 71% percentile among all examiners. Strategic Note: Petitions show above-average success regarding this examiner's actions. Petitionable matters include restriction requirements (MPEP § 1002.02(c)(2)) and various procedural issues.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 20.7% of allowed cases (in the 99% percentile). Per MPEP § 1302.04, examiner's amendments are used to place applications in condition for allowance when only minor changes are needed. This examiner frequently uses this tool compared to other examiners, indicating a cooperative approach to getting applications allowed. Strategic Insight: If you are close to allowance but minor claim amendments are needed, this examiner may be willing to make an examiner's amendment rather than requiring another round of prosecution.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 3.8% of allowed cases (in the 75% percentile). Per MPEP § 714.14, a Quayle action indicates that all claims are allowable but formal matters remain. This examiner frequently uses Quayle actions compared to other examiners, which is a positive indicator that once substantive issues are resolved, allowance follows quickly.

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Consider after-final amendments: This examiner frequently enters after-final amendments. If you can clearly overcome rejections with claim amendments, file an after-final amendment before resorting to an RCE.
  • Appeal filing as negotiation tool: This examiner frequently reconsiders rejections during the appeal process. Filing a Notice of Appeal may prompt favorable reconsideration during the mandatory appeal conference.
  • Examiner cooperation: This examiner frequently makes examiner's amendments to place applications in condition for allowance. If you are close to allowance, the examiner may help finalize the claims.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.