USPTO Examiner MIKNIS ZACHARY J - Art Unit 1658

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
19235902VASCULAR EMBOLIC SYSTEMJune 2025February 2026Allow810NoNo
19082426SENESCENCE INHIBITORMarch 2025January 2026Allow1020NoNo
18955985HANGTAIMYCIN DERIVATIVES AND THEIR PREPARATION METHODS AND APPLICATIONNovember 2024September 2025Allow1021YesNo
18954145ACTRII PROTEINS FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH)November 2024December 2025Allow1221YesNo
18917707ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAMEOctober 2024February 2025Allow410NoNo
18883592Long-Acting GLP-1 CompoundSeptember 2024October 2025Abandon1311NoNo
18834736USE OF COLLAGEN HYDROLYSATE IN PREVENTION AND/OR TREATMENT OF FOOD CRAVINGJuly 2024December 2025Allow1720YesNo
18774846COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC AND LIVER DISORDERSJuly 2024January 2025Allow711NoNo
17855222ANTIBACTERIAL PRODUCTSJune 2024March 2026Abandon4421YesNo
18722415ISOCYCLOSPORIN A FOR TOPICAL TREATMENT OF OCULAR DISEASESJune 2024October 2025Allow1620YesNo
18742845MATRIX METALLOPROTEASE-CLEAVABLE AND SERINE OR CYSTEINE PROTEASE-CLEAVABLE SUBSTRATES AND METHODS OF USE THEREOFJune 2024October 2025Allow1610NoNo
18719490DUAL TARGETING FOR CELL-SPECIFIC DELIVERY TO THE CENTRAL NERVOUS SYSTEMJune 2024August 2025Allow1520NoNo
18637124ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAMEApril 2024March 2025Allow1110NoNo
18626600SYSTEMS AND METHODS FOR TREATMENT OF HEARING USING DIHEXAApril 2024March 2025Allow1110NoNo
18582180HETERODIMERIC FC CYTOKINES AND USES THEREOFFebruary 2024August 2024Allow611NoNo
18436212TREATMENT OF AGE-RELATED MACULAR DEGENERATIONFebruary 2024September 2025Abandon1910NoNo
18415415MATRIX METALLOPROTEASE-CLEAVABLE AND SERINE OR CYSTEINE PROTEASE-CLEAVABLE SUBSTRATES AND METHODS OF USE THEREOFJanuary 2024January 2026Allow2411NoNo
18414112MODIFIED ANTI-INFLAMMATORY PROTEINS AND METHOD OF USEJanuary 2024June 2025Allow1710YesNo
18541682NOVEL INSULIN ANALOGUES AND USES THEREOFDecember 2023August 2024Allow820NoNo
18527402CYCLOTHEONELLAZOLEA, AND SYNTHETIC METHOD THEREFOR, AND APPLICATION METHOD THEREOFDecember 2023January 2026Abandon2610NoNo
18518000METHODS AND COMPOSITIONS FOR DELIVERY OF VIRAL VECTORS ACROSS THE BLOOD-BRAIN BARRIERNovember 2023December 2024Allow1300NoNo
18518227PREPARATION METHOD AND APPLICATION OF HIGH-PURITY PLANT-DERIVED RECOMBINANT HUMAN SERUM ALBUMINNovember 2023September 2024Allow1021NoNo
18516047HETERODIMERIC FC CYTOKINES AND USES THEREOFNovember 2023August 2025Allow2120YesNo
18511430SITE-SPECIFIC BIO-CONJUGATION METHODS AND COMPOSITIONS USEFUL FOR NANOPORE SYSTEMSNovember 2023July 2025Allow2010YesNo
18504561LIQUID FORMULATIONS COMPRISING MUTANT FGF-21 PEPTIDE PEGYLATED CONJUGATESNovember 2023March 2025Allow1610YesNo
18486310ULTRA-LONG ACTING INSULIN-FC FUSION PROTEIN AND METHODS OF USEOctober 2023October 2024Allow1200YesNo
18240295PEPTIDE COMPOUNDS AND PEPTIDE CONJUGATES FOR THE TREATMENT OF CANCER THROUGH RECEPTOR-MEDIATED CHEMOTHERAPYAugust 2023November 2024Allow1510NoNo
18447990COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC AND LIVER DISORDERSAugust 2023October 2025Allow2620YesNo
18355539CTLA-4 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOFJuly 2023March 2025Allow2001YesNo
18350543IL-7R-ALPHA-GAMMA BINDING COMPOUNDSJuly 2023February 2024Allow711NoNo
18219159HIGHLY POTENT ISVD COMPOUNDS CAPABLE OF SUBSTITUTING FOR FVIII(A)July 2023February 2024Allow801YesNo
18213779ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAMEJune 2023December 2023Allow510NoNo
18339152SYSTEMS AND METHODS FOR TREATMENT OF HEARING USING DIHEXAJune 2023January 2024Allow701NoNo
18331667BIOACTIVE PEPTIDES HAVING DETRIMENTAL EFFECTS ON PEST SLUGSJune 2023November 2025Allow2921NoNo
18327916COMPOSITIONS AND METHODS INVOLVING PROBIOTIC MOLECULESJune 2023April 2025Abandon2211NoNo
18320697GENERAL AMYLOID INTERACTION MOTIF (GAIM)May 2023November 2024Allow1810YesNo
18306965Silk-Hyaluronic Acid Based Tissue Fillers and Methods of Using the SameApril 2023December 2025Allow3211YesNo
18303642Compositions and Methods for Diagnosis and Treatment of CancerApril 2023September 2025Allow2920NoNo
18133767Fluorocarbon-Linked Peptide FormulationApril 2023December 2024Abandon2001NoNo
18298056PHARMACEUTICAL COMBINATION THERAPY AND PREVENTION WITH APROTININ + NIRMATRELVIR OF SARS-CoV-2 AND/OR DISEASE ASSOCIATED WITH THIS INFECTION, INCLUDING COVID-19April 2023December 2025Abandon3221YesNo
18181942Activatable Therapeutic Peptides and Uses ThereofMarch 2023June 2025Allow2811NoNo
18116166ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAMEMarch 2023August 2023Allow610YesNo
18021645PEPTIDE-BASED DOPA CONTAINING ADHESIVE GELSFebruary 2023July 2024Allow1711NoNo
18165081LIQUID FORMULATIONS COMPRISING MUTANT FGF-21 PEPTIDE PEGYLATED CONJUGATESFebruary 2023August 2023Allow600YesNo
18164802GLP-1 AND GLUCAGON DUAL AGONIST PEPTIDES WITH IMPROVED BIOLOGICAL STABILITYFebruary 2023January 2026Allow3630YesNo
18162833PEPTIDES HAVING SPECIFICITY FOR THE LUNGSFebruary 2023January 2025Abandon2310NoNo
18161799CTLA-4 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOFJanuary 2023December 2025Allow3521NoNo
18158746BONE-PROMOTING THERMORESPONSIVE MACROMOLECULESJanuary 2023March 2025Abandon2511NoNo
18157081ACE INHIBITORY PEPTIDE COMPOSITION DERIVED FROM GINKGO PROTEIN AND PREPARATION METHOD AND APPLICATION THEREOFJanuary 2023June 2024Allow1610NoNo
18156633PHARMACEUTICAL PREPARATION FOR IMPROVING ABSORPTION AND POSTPRANDIAL HYPOGLYCEMIC ACTION OF INSULINJanuary 2023November 2024Allow2211NoNo
18147796THERMALLY STABLE FGF7 POLYPEPTIDE AND USE OF THE SAMEDecember 2022August 2025Allow3220NoNo
18090259PHOSPHATIDYLSERINE-BINDING CONJUGATESDecember 2022December 2024Allow2411NoNo
18064719STAPLED PEPTIDE AND USE THEREOF IN PREPARATION OF DRUG FOR TREATING PANCREATIC CANCERDecember 2022September 2024Allow2101NoNo
18058131MEANS AND METHODS FOR TREATING AND DIAGNOSING FIBROSIS OR FIBROSIS-ASSOCIATED DISEASESNovember 2022November 2025Allow3621YesNo
17990629COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC AND LIVER DISORDERSNovember 2022July 2023Allow1811NoNo
18054596RELAXIN-2 FUSION PROTEIN ANALOGS AND METHODS OF USING SAMENovember 2022October 2025Allow3511YesNo
17982883UBIQUITIN HIGH AFFINITY CYCLIC PEPTIDES AND METHODS OF USE THEREOFNovember 2022May 2024Allow1810NoNo
18052529COMPLEXATION OF NUCLEIC ACIDS WITH DISULFIDE-CROSSLINKED CATIONIC COMPONENTS FOR TRANSFECTION AND IMMUNOSTIMULATIONNovember 2022August 2024Abandon2201NoNo
17997801REGENTIDE-041 AND COMPOSITION COMPRISING REGENTIDE-041 FOR IMPROVING SKIN CONDITIONNovember 2022February 2026Allow4011YesNo
17997808COMPOSITION COMPRISING REGENTIDE-012 OR REGENTIDE-013 FOR IMPROVING SKIN CONDITIONNovember 2022November 2025Allow3610NoNo
17977247FIBRONECTIN TYPE III DOMAIN-BASED PROTEIN AND APPLICATION THEREOFOctober 2022March 2025Allow2811YesNo
17996460COMPOSITIONS COMPRISING CYS-PEPTIDESOctober 2022February 2026Abandon4061NoNo
17961438NOVEL INSULIN ANALOGUES AND USES THEREOFOctober 2022December 2023Allow1400YesNo
17936424High-activity memory-improving derivative peptide and use thereofSeptember 2022August 2023Allow1110YesNo
17956031PEPTIDES AND OTHER AGENTS FOR TREATING PAIN AND INCREASING PAIN SENSITIVITYSeptember 2022April 2024Allow1910YesNo
17914277COMPOSITIONS AND METHODS FOR MODULATING MYOSIN SUBFRAGMENT-2 COILED COIL STABILITY AND METHODS FOR USING THEMSeptember 2022January 2026Allow4001YesNo
17932302Methods of Preventing or Treating Diseases, Conditions, or Disorders Associated With ChemotherapySeptember 2022November 2024Allow2611NoNo
17940460MIR-145 MICELLES FOR MITIGATING ATHEROSCLEROSISSeptember 2022August 2025Allow3621NoNo
17802388CHEMICALLY-STABILIZED ALLOSTERIC MODULATORS OF LEUCINE-RICH REPEAT KINASE 2 (LRRK2)August 2022October 2025Allow3801YesNo
17818583CHIMERIC INHIBITOR MOLECULES OF COMPLEMENT ACTIVATIONAugust 2022November 2023Allow1500YesNo
17818318ARC-BASED CAPSIDS AND USES THEREOFAugust 2022May 2024Abandon2210NoNo
17862617DRUG COMPOSITION, METHOD FOR TREATING INFECTION, DISINFECTING COMPOSITION, AND DRUG ADJUVANTJuly 2022October 2024Allow2721NoNo
17858724ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAMEJuly 2022March 2023Allow810YesNo
17854986COLLAGEN PEPTIDE-BASED MEDICAMENT COMPOSITIONS AND DEVICES AND METHODS OF PRODUCTION AND USE THEREOFJune 2022May 2025Allow3531YesNo
17758113Long-Acting GLP-1 CompoundJune 2022March 2026Allow4521NoNo
17846686METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF DISEASEJune 2022February 2025Allow3220NoNo
17842286ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAMEJune 2022October 2022Allow400YesNo
17839026NOVEL COMPOUNDS AND THERAPEUTICS USES THEREOFJune 2022June 2024Allow2511YesNo
17837082AMINO ACID-SPECIFIC BINDER AND SELECTIVELY IDENTIFYING AN AMINO ACIDJune 2022January 2025Allow3121YesNo
17835689COLLAGEN DAILY WITH ENZYME INHIBITORS FOR ANTI-AGINGJune 2022September 2023Allow1521YesNo
17782573PEPTIDE CONJUGATES AND METHODS OF USEJune 2022November 2025Allow4101YesNo
17782603PEPTIDE-BASED SYNTHETIC CHLORIDE ION TRANSPORTERSJune 2022November 2025Abandon4201NoNo
17829180PROHEMOSTATIC PROTEINS FOR THE TREATMENT OF BLEEDINGMay 2022May 2024Allow2310YesNo
17825243COMPOSITIONS AND METHODS OF CLOSTRIDIODIDES DIFFICILE TREATMENT, DECOLONIZATION, AND PREVENTIONMay 2022June 2024Allow2521YesNo
17750530EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EARMay 2022March 2024Allow2201YesNo
17778624METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF TYPE 1 DIABETESMay 2022December 2025Allow4321NoNo
17744540MODULATORS OF G-PROTEIN COUPLED RECEPTORSMay 2022April 2024Allow2301YesNo
17776217LIPID NANO DRUG DELIVERY SYSTEM TARGETING BRAIN LESION AND PREPARATION METHOD AND APPLICATION THEREOFMay 2022January 2026Allow4411NoNo
17775871CXCR4 ANTAGONIST PEPTIDESMay 2022September 2025Abandon4001NoNo
17775034SOLID COMPOSITIONS COMPRISING A GLP-1 AGONIST, AN SGLT2 INHIBITOR AND A SALT OF N-(8-(2-HYDROXYBENZOYL)AMINO)CAPRYLIC ACIDMay 2022September 2025Abandon4101NoNo
17761255ANTI-TUMOR PEPTIDE AND USE THEREOFMay 2022September 2025Abandon4201NoNo
17768636USE OF ESCULENTIN AND ITS DERIVATIVES FOR USE IN THE TREATMENT OF CYSTIC FIBROSISApril 2022November 2025Allow4311YesNo
17718758PEPTIDE FOR TREATING INFLAMMATION AND WOUNDSApril 2022October 2025Allow4211NoNo
17768142ANALGESIC AND ANESTHETIC PEPTIDES AND OTHER AGENTSApril 2022January 2026Abandon4511NoNo
17709608PHARMACEUTICAL COMBINATION THERAPY AND PREVENTION WITH APROTININ + MOLNUPIRAVIR OF SARS-CoV-2 AND/OR DISEASE ASSOCIATED WITH THIS INFECTION, INCLUDI COVID-19March 2022October 2023Abandon1930YesNo
17704522ANTI-ANGIOGENIC TREATMENT USING VLO4 WITH A BLOCKING PEPTIDEMarch 2022March 2024Allow2420NoNo
17692024LIQUID FORMULATIONS COMPRISING MUTANT FGF-21 PEPTIDE PEGYLATED CONJUGATESMarch 2022January 2023Allow1020NoNo
17688588PURIFICATION OF FACTOR VIII SUBSPECIESMarch 2022April 2024Allow2501YesNo
17753420POLYPEPTIDE MONOLAYER WITH HIGH POTENTIAL AND HYDROPHOBICITY, AND PREPARATION METHOD AND APPLICATION THEREOFMarch 2022February 2026Abandon4821NoNo
17682782ASPARTIC PROTEASE-TRIGGERED ANTIFUNGAL HYDROGELSFebruary 2022December 2025Abandon4530YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner MIKNIS, ZACHARY J.

Strategic Value of Filing an Appeal

Total Appeal Filings
16
Allowed After Appeal Filing
1
(6.2%)
Not Allowed After Appeal Filing
15
(93.8%)
Filing Benefit Percentile
12.0%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 6.2% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner MIKNIS, ZACHARY J - Prosecution Strategy Guide

Executive Summary

Examiner MIKNIS, ZACHARY J works in Art Unit 1658 and has examined 247 patent applications in our dataset. With an allowance rate of 78.5%, this examiner has a below-average tendency to allow applications. Applications typically reach final disposition in approximately 31 months.

Allowance Patterns

Examiner MIKNIS, ZACHARY J's allowance rate of 78.5% places them in the 47% percentile among all USPTO examiners. This examiner has a below-average tendency to allow applications.

Office Action Patterns

On average, applications examined by MIKNIS, ZACHARY J receive 1.96 office actions before reaching final disposition. This places the examiner in the 49% percentile for office actions issued. This examiner issues fewer office actions than average, which may indicate efficient prosecution or a more lenient examination style.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by MIKNIS, ZACHARY J is 31 months. This places the examiner in the 54% percentile for prosecution speed. Prosecution timelines are slightly faster than average with this examiner.

Interview Effectiveness

Conducting an examiner interview provides a +24.9% benefit to allowance rate for applications examined by MIKNIS, ZACHARY J. This interview benefit is in the 71% percentile among all examiners. Recommendation: Interviews provide an above-average benefit with this examiner and are worth considering.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 28.3% of applications are subsequently allowed. This success rate is in the 51% percentile among all examiners. Strategic Insight: RCEs show above-average effectiveness with this examiner. Consider whether your amendments or new arguments are strong enough to warrant an RCE versus filing a continuation.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 53.6% of cases where such amendments are filed. This entry rate is in the 80% percentile among all examiners. Strategic Recommendation: This examiner is highly receptive to after-final amendments compared to other examiners. Per MPEP § 714.12, after-final amendments may be entered "under justifiable circumstances." Consider filing after-final amendments with a clear showing of allowability rather than immediately filing an RCE, as this examiner frequently enters such amendments.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 100.0% of appeals filed. This is in the 87% percentile among all examiners. Of these withdrawals, 100.0% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner frequently reconsiders rejections during the appeal process compared to other examiners. Per MPEP § 1207.01, all appeals must go through a mandatory appeal conference. Filing a Notice of Appeal may prompt favorable reconsideration even before you file an Appeal Brief.

Petition Practice

When applicants file petitions regarding this examiner's actions, 64.8% are granted (fully or in part). This grant rate is in the 70% percentile among all examiners. Strategic Note: Petitions show above-average success regarding this examiner's actions. Petitionable matters include restriction requirements (MPEP § 1002.02(c)(2)) and various procedural issues.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 0.0% of allowed cases (in the 2% percentile). This examiner rarely makes examiner's amendments compared to other examiners. You should expect to make all necessary claim amendments yourself through formal amendment practice.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 0.0% of allowed cases (in the 2% percentile). This examiner rarely issues Quayle actions compared to other examiners. Allowances typically come directly without a separate action for formal matters.

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Consider after-final amendments: This examiner frequently enters after-final amendments. If you can clearly overcome rejections with claim amendments, file an after-final amendment before resorting to an RCE.
  • Appeal filing as negotiation tool: This examiner frequently reconsiders rejections during the appeal process. Filing a Notice of Appeal may prompt favorable reconsideration during the mandatory appeal conference.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.