USPTO Examiner KOMATSU LI N - Art Unit 1658

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
18650574ANTI-AGING STURGEON ROE TETRAPEPTIDE AND PREPARATION METHOD AND APPLICATION THEREOFApril 2024April 2025Allow1111YesNo
18591918ACTIVIN RECEPTOR TYPE IIB VARIANTS AND USES THEREOFFebruary 2024May 2025Allow1501YesNo
18568888SURFACE LAYER PROTEIN A (SLPA) AS A THERAPEUTIC AGENT FOR THE TREATMENT OF INFLAMMATORY DISEASESDecember 2023May 2024Allow500YesNo
18385946CNP COMPOUNDSNovember 2023May 2024Allow601YesNo
18491957INSECT NEUROPEPTIDES 1October 2023February 2025Allow1621YesNo
18492076INSECT NEUROPEPTIDES 9October 2023October 2024Allow1221YesNo
18473627BROWN FAT-SELECTIVE ADIPOKINESSeptember 2023April 2025Allow1821YesNo
18457482GLUCAGON-LIKE PEPTIDE 1 RECEPTOR AGONISTS AND USES THEREOFAugust 2023May 2024Allow800YesNo
18450524RAGE PROTEINS FOR THE TREATMENT OF FIBROSIS AND DNA DAMAGE MEDIATED DISEASESAugust 2023June 2025Abandon2211YesNo
18227782COMPOUND WITH ANALGESIC EFFECT FOR USE IN PREVENTION AND TREATMENT OF PAINJuly 2023July 2024Allow1201YesNo
18360773COMPOSITION FOR IMPROVING MILD COGNITIVE IMPAIRMENT AND METHOD FOR IMPROVING MILD COGNITIVE IMPAIRMENTJuly 2023November 2024Abandon1610NoNo
18348878PREPARING METHOD OF HIGHLY FUNCTIONAL PEPTIDE DERIVED FROM KERATINOCYTE PROTEINJuly 2023September 2024Abandon1410YesNo
18330109GROWTH PROMOTING PEPTIDES, AND USES THEREOFJune 2023August 2024Abandon1401NoNo
18203184ERYTHROPOIETIN AND ANALOGS FOR VETERINARY USEMay 2023August 2024Abandon1401NoNo
18318343COMPOSITIONS COMPRISING PCSK9-BINDING MOLECULES AND METHODS OF USEMay 2023May 2025Allow2411YesNo
18301761THERAPEUTICS DIRECTED AGAINST CORONAVIRUSApril 2023January 2024Allow901YesNo
18180002METHODS FOR PRODUCING STABLE THERAPEUTIC FORMULATIONS IN APROTIC POLAR SOLVENTSMarch 2023September 2024Abandon1911NoNo
18118113Skin Compositions and UsesMarch 2023June 2025Abandon2721NoNo
18160787ACTIVIN RECEPTOR TYPE IIB VARIANTS AND USES THEREOFJanuary 2023November 2023Allow1001YesNo
18157293CYSTEINE PROTEASE INHIBITORS AND METHODS OF USE THEREOFJanuary 2023May 2024Allow1611YesNo
18157307METHODS FOR PREVENTING AND TREATING INTRA-ABDOMINAL CANDIDIASISJanuary 2023January 2025Abandon2411NoNo
18061699HISTATIN FOR CORNEAL WOUND HEALING AND OCULAR SURFACE DISEASEDecember 2022December 2024Abandon2411YesNo
18054587BIOFILM PREVENTION, DISRUPTION AND TREATMENT WITH BACTERIOPHAGE LYSINNovember 2022September 2024Abandon2201YesNo
18053965PEPTIDE FOR TREATING SEPSIS DERIVED FROM RV3364C PROTEIN OF MYCOBACTERIUM TUBERCULOSISNovember 2022April 2024Allow1731YesNo
17981595SELF-ASSEMBLING ANTIVIRAL PRODRUGSNovember 2022January 2024Allow1511YesNo
18050604DUAL AMYLIN AND CALCITONIN RECEPTOR AGONISTS AND USES THEREOFOctober 2022March 2025Allow2801YesNo
18050659DUAL AMYLIN AND CALCITONIN RECEPTOR AGONISTS AND USES THEREOFOctober 2022March 2025Allow2901YesNo
17921508FUSION POLYPEPTIDES FOR TARGET PEPTIDE PRODUCTIONOctober 2022July 2025Allow3201YesNo
17908853ANTIBACTERIAL PROTEIN HAVING LYTIC ACTIVITY TO BACILLUS GENUS AND METHOD FOR PREPARING THE SAMESeptember 2022June 2025Allow3300YesNo
17898470NANO SMALL PEPTIDE AND ITS USE IN PREPARATION OF DRUGS FOR TREATING AND PREVENTING FUNDUS VASCULAR DISEASESAugust 2022July 2023Allow1101YesNo
17864486USES OF BREMELANOTIDE IN THERAPY FOR FEMALE SEXUAL DYSFUNCTIONJuly 2022August 2024Abandon2521NoNo
17756721ECHINOCANDIN ANALOGUES AND PREPARATION METHOD THEREFORJune 2022April 2025Allow3521YesNo
17747788COMPOSITIONS AND METHODS OF USING ISLET NEOGENESIS PEPTIDES AND ANALOGS THEREOFMay 2022June 2024Abandon2521NoNo
17741692POLYPEPTIDE, PHOTORESIST COMPOSITION INCLUDING THE SAME, AND METHOD OF FORMING PATTERN USING THE SAMEMay 2022October 2024Allow2931YesNo
17740202PHARMACEUTICAL COMBINATION FOR USE IN GLYCEMIC CONTROL IN DIABETES TYPE 2 PATIENTSMay 2022November 2023Abandon1801NoNo
17727579PTD-SMAD7 THERAPEUTICSApril 2022October 2023Abandon1801NoNo
17709731ANTI-RNA VIRAL PHARMACEUTICAL COMBINATION THERAPY WITH APROTININ + anti-RNA DRUGMarch 2022October 2023Abandon1921YesNo
17765342Muscle Tissue-Regenerating AgentMarch 2022April 2025Abandon3601NoNo
17682277Novel Hybrid ActRIIB Ligand Trap Proteins for Treating Muscle Wasting DiseasesFebruary 2022November 2023Allow2011YesNo
17665179HIGHLY POTENT ACID ALPHA-GLUCOSIDASE WITH ENHANCED CARBOHYDRATESFebruary 2022October 2022Allow911YesNo
17586774PEPTIDE FOR COMPLEXING ZINC ION, COMPLEX THEREOF AND USE THEREFORJanuary 2022February 2025Allow3611YesNo
17629999COMPOSITIONS AND METHODS FOR PREPARING FACTOR XA AND DERIVATIVESJanuary 2022April 2025Allow3901YesNo
17579455THERAPEUTICS DIRECTED AGAINST CORONAVIRUSJanuary 2022August 2023Abandon1921YesNo
17627359ACETYLCHOLINE MODULATION OF IMMUNE FUNCTIONJanuary 2022December 2023Abandon2301NoNo
17574865ANTI-INFLAMMATORY PEPTIDES, AND USES THEREOFJanuary 2022May 2023Allow1601YesNo
17566368METHOD FOR DECREASING IMMUNOGENICITY OF PROTEIN AND PEPTIDEDecember 2021December 2023Abandon2411YesNo
17621807PEPTIDE ACETALS FOR STABILISING ENZYMESDecember 2021March 2025Allow3911YesNo
17618117DE NOVO DESIGN OF PHOSPHORYLATION INDUCIBLE PROTEIN SWITCHES (PHOSPHO-SWITCHES)December 2021June 2025Abandon4201NoNo
17546739PREPARING METHOD OF HIGHLY FUNCTIONAL PEPTIDE DERIVED FROM KERATINOCYTE PROTEINDecember 2021December 2023Abandon2421NoNo
17541145Compositions and Formulations and Methods of Production and Use ThereofDecember 2021June 2024Abandon3021YesNo
17538924OCULAR DELIVERY OF CELL PERMEANT THERAPEUTICS FOR THE TREATMENT OF RETINAL EDEMANovember 2021November 2023Allow2311YesNo
17536296AGENTS AND METHODS FOR TREATING CBP-DEPENDENT CANCERSNovember 2021December 2023Allow2421YesNo
17535451TUMOR-SPECIFIC CLEAVABLE LINKERSNovember 2021January 2025Allow3812YesNo
17532978RECOMBINANT COLLAGEN AND ELASTIN MOLECULES AND USES THEREOFNovember 2021August 2024Abandon3321NoNo
17532597METHODS AND COMPOSITIONS COMPRISING A C-TERMINAL BAX PEPTIDENovember 2021March 2025Abandon3931YesNo
17454931ANTIBODY-DRUG-CONJUGATE AND ITS USE FOR THE TREATMENT OF CANCERNovember 2021November 2023Allow2421YesNo
17609818PROTEIN INHIBITORS OF CLOSTRIDIUM DIFFICILE TOXIN BNovember 2021August 2024Allow3311YesNo
17512550Antithrombin-III Treatment of Traumatic Brain InjuryOctober 2021September 2023Abandon2201NoNo
17450613THERAPEUTIC METHOD OF TREATMENT FOR INHIBITING TUMOR DEVELOPMENT USING TAMM-HORSFALL GLYCOPROTEIN (THP) AS IMMUNOSTIMULATING DRUG AND COMPOSITIONSOctober 2021March 2023Allow1801NoNo
17493598RECOMBINANT ELASTIN AND PRODUCTION THEREOFOctober 2021November 2024Allow3831YesNo
17600468SELECTIVE TARGETING OF UBIQUITIN- AND UBIQUITIN-LIKE E1-ACTIVATING ENZYMES BY STRUCTURALLY-STABILIZED PEPTIDESSeptember 2021April 2025Allow4211YesNo
17599625Reagents and Assays using Modified Integrin DomainsSeptember 2021December 2024Allow3911YesNo
17487099METHODS AND COMPOSITIONS FOR TREATMENT OF CORONAVIRUS INFECTION AND ASSOCIATED COAGULOPATHYSeptember 2021February 2025Abandon4151YesNo
17598641SELF-ASSEMBLING 2D ARRAYS WITH DE NOVO PROTEIN BUILDING BLOCKSSeptember 2021April 2025Abandon4301NoNo
17442258SALT FORMS OF S-(N, N-DIETHYLCARBAMOYL)GLUTATHIONESeptember 2021January 2025Abandon3901NoNo
17440527Peptide Inhibitors Targeting The CXCL12/HMGB1 Interaction And Uses ThereofSeptember 2021July 2024Allow3401YesNo
17475451DRUG FOR PREVENTING AND/OR TREATING POLYCYSTIC KIDNEY DISEASESeptember 2021December 2023Allow2711YesNo
17475248ANTIBODY-DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOFSeptember 2021October 2024Allow3711YesNo
17437025A PEPTIDE FOR THE DELIVERY OF ANIONIC MATERIALSSeptember 2021March 2024Allow3000YesNo
17435215INHIBITION OF MYOSTATIN SIGNAL BY MYOSTATIN SPLICE VARIANT-DERIVED PROTEIN AND UTILIZATION THEREOFAugust 2021October 2024Allow3711YesNo
17433860PEPTIDES AND COMPOSITIONS FOR USE IN COSMETICSAugust 2021October 2024Allow3801YesNo
17310517NOVEL OCT-3/4 VARIANTAugust 2021July 2024Allow3510NoNo
17427109ANTI-ATOPIC DERMATITIS PROTEINJuly 2021December 2024Abandon4131YesNo
17389064ANTIBACTERIAL COMPOSITION COMPRISING MICROCIN S AND ANTIBIOTICJuly 2021October 2023Abandon2711YesNo
17425688NOVEL NON-OPIOID ANTI-PAIN MEDICATIONJuly 2021December 2024Allow4111YesNo
17383597MASPIN, MASPIN DERIVATIVES, AND MASPIN MIMETICS FOR REDUCING ROS, INFLAMMATION, AND SKIN AGINGJuly 2021March 2023Allow2001YesNo
17379987Mutant Peptides And Methods Of Treating Subjects Using The SameJuly 2021January 2025Abandon4211NoNo
17423680POLYETHYLENE GLYCOL-MODIFIED FORM OF HEPATOCYTE GROWTH FACTOR OR ACTIVE FRAGMENT THEREOFJuly 2021October 2024Abandon3901NoNo
17422935BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR INTEGRIN ALPHA-V-BETA-3July 2021September 2024Abandon3801NoNo
17422932BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR CAIXJuly 2021September 2024Abandon3801NoNo
17422718SERINE PROTEINASE INHIBITORS: SERP-1 AND SERP-1 RCL-DERIVED PEPTIDES EFFECT ON MICROBIOME COMPOSITION AND USES THEREOFJuly 2021February 2024Allow3111YesNo
17421477COMPOSITIONS CONTAINING A PEPTIDE ABLE TO STIMULATE THE GPRC6A-DEPENDENT SIGNALING PATHWAYJuly 2021July 2024Abandon3721YesNo
17420865HUMAN HEPATOCYTE GROWTH FACTOR MUTANT AND USES THEREOFJuly 2021January 2025Allow4221YesNo
17368065TMEM100 PEPTIDES AND VARIANTS THEREOF AND THEIR USE IN TREATING OR PREVENTING DISEASES OR CONDITIONSJuly 2021October 2024Abandon4001NoNo
17364557Methods for Reducing Perinatal Morbidity and / or MortalityJune 2021March 2024Abandon3221NoNo
17420130COMPOSITION COMPRISING SERICIN FOR TREATING, PREVENTING, OR ALLEVIATING FATTY LIVER, AND METHOD OF PREPARING SAMEJune 2021December 2023Abandon3001NoNo
17312806ANTIMICROBIAL PEPTIDESJune 2021December 2024Allow4221YesNo
17332215GLUCAGON-LIKE PEPTIDE 1 RECEPTOR AGONISTS AND USES THEREOFMay 2021May 2023Allow2411YesNo
17303250CYTOPLASMIC TRANSDUCTION PEPTIDE AND INTRACELLULAR MESSENGER COMPRISING SAMEMay 2021June 2025Abandon4931NoNo
17318198PRG-4 FOR TREATING GOUT AND ITS SYMPTOMSMay 2021September 2023Abandon2811YesNo
17239934Glycemic Control Using Intrinsic Factor Bound to A Vitamin B12 Conjugate of a Glucagon-Like Peptide-1 Receptor AgonistApril 2021May 2023Allow2511YesNo
17235485TOPICAL COMPOSITIONS FOR SKIN COMPRISING A CELL PENETRATING PEPTIDE AND METHODS OF USING THE SAMEApril 2021May 2025Abandon4951YesNo
17232891METHODS AND COMPOSITIONS FOR TREATING A RESPIRATORY DISEASEApril 2021October 2023Abandon3011YesNo
17282872Disease Treatment Drug Based on Mesenchymal-Stem-Cell MobilizationApril 2021April 2024Allow3611YesNo
17280058AMPHIPHILIC POLY (AMINO ACID), BLOCK COPOLYER USING THE AMPHIPHILIC POLY (AMINO ACID), AND COMPLEX INCLUDING THE AMPHIPHILIC POLY (AMINO ACID) OR THE BLOCK COPOLYMER AND NUCLEIC ACIDMarch 2021September 2024Allow4101YesNo
17249175HIGHLY POTENT ACID ALPHA-GLUCOSIDASE WITH ENHANCED CARBOHYDRATESFebruary 2021April 2023Allow2611YesNo
17266939CELL-PENETRATING PEPTIDESFebruary 2021November 2024Allow4611YesNo
17266811PEPTIDE HAVING ANTIOXIDANT ACTIVITY AND COMPOSITION CONTAINING SAMEFebruary 2021November 2023Allow3311YesNo
17165154CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLSFebruary 2021March 2025Abandon5061YesYes
17165149CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLSFebruary 2021October 2023Abandon3211YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner KOMATSU, LI N.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
5
Examiner Affirmed
4
(80.0%)
Examiner Reversed
1
(20.0%)
Reversal Percentile
30.0%
Lower than average

What This Means

With a 20.0% reversal rate, the PTAB affirms the examiner's rejections in the vast majority of cases. This reversal rate is below the USPTO average, indicating that appeals face more challenges here than typical.

Strategic Value of Filing an Appeal

Total Appeal Filings
34
Allowed After Appeal Filing
6
(17.6%)
Not Allowed After Appeal Filing
28
(82.4%)
Filing Benefit Percentile
18.7%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 17.6% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

Appeals to PTAB face challenges. Ensure your case has strong merit before committing to full Board review.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner KOMATSU, LI N - Prosecution Strategy Guide

Executive Summary

Examiner KOMATSU, LI N works in Art Unit 1658 and has examined 409 patent applications in our dataset. With an allowance rate of 53.1%, this examiner allows applications at a lower rate than most examiners at the USPTO. Applications typically reach final disposition in approximately 29 months.

Allowance Patterns

Examiner KOMATSU, LI N's allowance rate of 53.1% places them in the 9% percentile among all USPTO examiners. This examiner is less likely to allow applications than most examiners at the USPTO.

Office Action Patterns

On average, applications examined by KOMATSU, LI N receive 1.77 office actions before reaching final disposition. This places the examiner in the 53% percentile for office actions issued. This examiner issues a slightly above-average number of office actions.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by KOMATSU, LI N is 29 months. This places the examiner in the 44% percentile for prosecution speed. Prosecution timelines are slightly slower than average with this examiner.

Interview Effectiveness

Conducting an examiner interview provides a +71.6% benefit to allowance rate for applications examined by KOMATSU, LI N. This interview benefit is in the 99% percentile among all examiners. Recommendation: Interviews are highly effective with this examiner and should be strongly considered as a prosecution strategy. Per MPEP § 713.10, interviews are available at any time before the Notice of Allowance is mailed or jurisdiction transfers to the PTAB.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 16.1% of applications are subsequently allowed. This success rate is in the 7% percentile among all examiners. Strategic Insight: RCEs show lower effectiveness with this examiner compared to others. Consider whether a continuation application might be more strategic, especially if you need to add new matter or significantly broaden claims.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 30.7% of cases where such amendments are filed. This entry rate is in the 36% percentile among all examiners. Strategic Recommendation: This examiner shows below-average receptiveness to after-final amendments. You may need to file an RCE or appeal rather than relying on after-final amendment entry.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 50.0% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 40% percentile among all examiners. Note: Pre-appeal conferences show below-average success with this examiner. Consider whether your arguments are strong enough to warrant a PAC request.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 61.5% of appeals filed. This is in the 34% percentile among all examiners. Of these withdrawals, 25.0% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner shows below-average willingness to reconsider rejections during appeals. Be prepared to fully prosecute appeals if filed.

Petition Practice

When applicants file petitions regarding this examiner's actions, 58.2% are granted (fully or in part). This grant rate is in the 74% percentile among all examiners. Strategic Note: Petitions show above-average success regarding this examiner's actions. Petitionable matters include restriction requirements (MPEP § 1002.02(c)(2)) and various procedural issues.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 0.2% of allowed cases (in the 52% percentile). This examiner makes examiner's amendments more often than average to place applications in condition for allowance (MPEP § 1302.04).

Quayle Actions: This examiner issues Ex Parte Quayle actions in 2.8% of allowed cases (in the 70% percentile). This examiner issues Quayle actions more often than average when claims are allowable but formal matters remain (MPEP § 714.14).

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Prepare for rigorous examination: With a below-average allowance rate, ensure your application has strong written description and enablement support. Consider filing a continuation if you need to add new matter.
  • Prioritize examiner interviews: Interviews are highly effective with this examiner. Request an interview after the first office action to clarify issues and potentially expedite allowance.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.