USPTO Examiner MACFARLANE STACEY NEE - Art Unit 1649

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
17121553TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS BY INTRANASAL ADMINISTRATION OF IMMUNOGLOBULIN GDecember 2020July 2023Allow3110NoNo
17119035METHODS OF TREATING ACID SPHINGOMYELINASE DEFICIENCYDecember 2020January 2024Allow3720NoNo
17119075APOAEQUORIN AND VITAMIN D-CONTAINING COMPOSITIONS AND METHODS OF USING SAMEDecember 2020April 2024Allow4040YesNo
17116104PREPARATION OF FLAGELLIN VACCINE ADJUVANT-BASED VACCINE TO INDUCE PRODUCTION OF ANTIBODY RECOGNIZING CONFORMATION OF ANTIGENS, AND APPLICATION THEREOFDecember 2020June 2023Allow3010NoNo
17113711Antibodies Against BACE1 and Use Thereof for Neural Disease ImmunotherapyDecember 2020April 2023Allow2901YesNo
17110512DIAGNOSTIC METHOD FOR MULTIPLE SCLEROSISDecember 2020May 2023Abandon2910NoNo
17065246ANTI-SEMAPHORIN 3A ANTIBODY AND TREATMENT OF ALZHEIMER'S DISEASE AND INFLAMMATORY IMMUNE DISEASES USING SAMEOctober 2020April 2023Abandon3010NoNo
17060541DOSING REGIMENS OF PKC ACTIVATORSOctober 2020July 2023Allow3320NoNo
17034883CARDIAC NEURAL CREST CELLS AND METHODS OF USE THEREOFSeptember 2020April 2023Abandon3001NoNo
15733660ANTIBODY-BASED METHODS OF DETECTING AND TREATING ALZHEIMER'S DISEASESeptember 2020November 2023Abandon3701NoNo
17018954COMPOSITIONS AND METHODS USEFUL FOR THE TREATMENT OF NEUROMYELITIS OPTICA SPECTRUM DISORDERSSeptember 2020November 2023Allow3811YesNo
16993914Ameliorating Nervous Systems DisordersAugust 2020September 2022Allow2611YesNo
16986802Materials and Methods for Treatment of InflammationAugust 2020January 2022Allow1710NoNo
16963897COMPOSITIONS AND METHODS FOR TREATMENT OF SPINAL CORD INJURYJuly 2020August 2024Abandon4810NoNo
16933792TAU IMMUNOTHERAPYJuly 2020June 2022Allow2310NoNo
16921223NOVEL THERAPEUTIC USES OF MU-OPIATE RECEPTOR PEPTIDESJuly 2020December 2022Abandon3020NoNo
16909896COMPOSITIONS AND METHODS FOR TREATING OR AMELIORATING NEUROINFLAMMATION, NEURODEGENERATION, NEUROPATHIC PAIN, AND MIGRAINEJune 2020June 2022Allow2310YesNo
16956339COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DISEASESJune 2020September 2023Allow3931NoNo
16902829DIAGNOSTIC BIOMARKER PROFILES FOR THE DETECTION AND DIAGNOSIS OF ALZHEIMER'S DISEASEJune 2020February 2022Abandon2011NoNo
16891841NOVEL IMMUNOTHERAPY AGAINST NEURONAL AND BRAIN TUMORSJune 2020November 2022Allow2921NoNo
16890739BIOMARKERS FOR COGNITIVE DYSFUNCTION DISEASES AND METHOD FOR DETECTING COGNITIVE DYSFUNCTION DISEASE USING BIOMARKERSJune 2020August 2023Abandon3840YesNo
16890943BIOMARKER DETECTION PROCESS AND ASSAY OF NEUROLOGICAL CONDITIONJune 2020February 2024Allow4441NoNo
16884980ASSEMBLY OF FUNCTIONALLY INTEGRATED HUMAN FOREBRAIN SPHEROIDS AND METHODS OF USE THEREOFMay 2020November 2021Allow1811NoNo
16881863METHODS FOR TREATING SYSTEMIC SCLEROSISMay 2020July 2023Allow3810YesNo
16763794PROTEIN BIOMARKER INDICATORS OF NEUROLOGICAL INJURY AND/OR DISEASE AND METHODS OF USE THEREOFMay 2020January 2024Allow4431YesNo
15931081METHODS AND COMPOSITIONS FOR REDUCING GROWTH, MIGRATION AND INVASIVENESS OF BRAIN CANCER STEM CELLS AND IMPROVING SURVIVAL OF PATIENTS WITH BRAIN TUMORSMay 2020February 2022Allow2111NoNo
16872064DETECTION OF DEBRIS IN RECIRCULATING PHAGOCYTESMay 2020May 2022Abandon2411NoNo
16761935NOVEL HUMAN INDUCED PLURIPOTENT STEM CELL LINES FOR MODELING ALZHEIMER'S DISEASE AND USAGE THEREOFMay 2020April 2023Allow3511YesNo
16761827IMMUNE RESPONSE PROFILING OF TUMOR-DERIVED EXOSOMES FOR CANCER DIAGNOSISMay 2020October 2023Abandon4121NoNo
16864439ANTIBODIES TO AMYLOID BETAMay 2020November 2021Allow1910NoNo
16860319COMPOSITIONS AND METHODS FOR TREATMENT OF GCASE RELATED DISEASE STATESApril 2020October 2021Allow1811YesNo
16759431PODOPLANIN POSITIVE MACROPHAGESApril 2020August 2022Abandon2701NoNo
16838993GENE THERAPY FOR NEURODEGENERATIVE DISORDERSApril 2020March 2024Allow4721YesNo
16652804ASSAY FOR THE DETECTION OF ALPHA-SYNUCLEIN SEEDING ACTIVITY ASSOCIATED WITH SYNUCLEINOPATHIESApril 2020December 2021Allow2011NoNo
16649247METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF NEURODEGENERATIVE AND NEUROINFLAMMATORY PATHOLOGIESMarch 2020February 2022Allow2320YesNo
16808458COMPOSITION AND METHOD FOR TREATMENT OF NEUROPSYCHIATRIC DISORDERSMarch 2020April 2023Abandon3730YesNo
16807902Pharmaceutical Use of FAM19A5 Involved in Regulating GliogenesisMarch 2020March 2023Allow3741YesNo
16799548Oligodendrocytes Derived from Human Embryonic Stem Cells for Remyelination and Treatment of Spinal Cord InjuryFebruary 2020October 2022Abandon3221NoNo
16795675METHOD FOR INCREASING NEPRILYSIN EXPRESSION AND ACTIVITYFebruary 2020November 2022Abandon3321NoNo
16639678Detection of Fumarate Ester-Derived Modification in a Test SampleFebruary 2020September 2022Abandon3121NoNo
16639125TUMOR BLOOD MARKER, USE THEREOF, AND KIT COMPRISING THE SAMEFebruary 2020November 2023Allow4531YesNo
16639139INHIBITION OF LET7I AS A MEANS TO ENHANCE THE PROTECTIVE EFFECT OF PROGESTERONE AGAINST STROKEFebruary 2020September 2021Allow1911NoNo
16789319ANTI-TRANSTHYRETIN ANTIBODIESFebruary 2020October 2021Allow2010YesNo
16632483METHODS OF TREATING NEURODEGENERATIVE DISEASESJanuary 2020September 2022Abandon3221NoNo
16631991METHODS FOR TREATMENT OR PREVENTION OF A NEUROLOGICAL IMMUNITY DISORDERJanuary 2020December 2021Allow2320NoNo
16744404HUMANIZED ANTIBODIESJanuary 2020February 2021Allow1300YesNo
16740077TENEURIN C-TERMINAL ASSOCIATED PEPTIDES (TCAP) AND METHODS AND USES THEREOFJanuary 2020October 2022Abandon3321NoNo
16628075COMPOSITIONS AND METHODS FOR A UNIVERSAL CLINICAL TEST FOR OLFACTORY DYSFUNCTIONJanuary 2020August 2023Abandon4401NoNo
16624777COMPOSITIONS, DEVICES AND METHODS FOR TREATING AUTISMDecember 2019January 2022Abandon2511NoNo
16616051BIOMARKER LEVELS AND NEUROIMAGING FOR DETECTING, MONITORING AND TREATING BRAIN INJURY OR TRAUMANovember 2019February 2023Allow3911YesNo
16689523MUTANT HUNTINGTIN-MEDIATED PROTEIN DYSFUNCTIONNovember 2019February 2022Allow2721NoNo
16688425METHODS OF MAINTAINING, EXPANDING, AND DIFFERENTIATING NEURONAL SUBTYPE SPECIFIC PROGENITORSNovember 2019December 2021Allow2521YesNo
16613264COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASENovember 2019October 2023Allow4731YesNo
16612529METHODS OF TREATING NEUROPSYCHIATRIC DISORDERSNovember 2019February 2023Allow3911YesNo
16671595Methods For The Treatment Of NeurodegenerationNovember 2019January 2022Allow2720NoNo
16609885Monoclonal Antibodies Against Alpha-Synuclein FibrilsOctober 2019September 2021Allow2211NoNo
16670880BIOMARKERS AND METHODS OF USE FOR RADIATION-INDUCED LUNG INJURYOctober 2019March 2023Allow4121NoNo
16605753METHOD OF DETERMINING TOXICITY OF AN IMMUNOMODULATORY DRUG FOR USE IN HUMANSOctober 2019February 2024Allow5241YesNo
16597400RECOMBINANT CLUSTERIN AND USE THEREOF IN THE TREATMENT AND PREVENTION OF DISEASEOctober 2019April 2021Allow1920NoNo
16596258EARLY STAGE PARKINSON'S DISEASE DIAGNOSTIC KITS AND METHODSOctober 2019September 2021Allow2420YesNo
16603466POLYPEPTIDE-ANTIBODY COMPLEXES AND USES THEREOFOctober 2019August 2022Allow3410NoNo
16500289Synthetic Particle Antibody Compositions And Uses ThereofOctober 2019May 2023Abandon4321NoNo
16588054CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS FOR BRAIN AND SPINAL CORD REPAIRSeptember 2019May 2021Allow1921NoNo
16582742Diagnosis of a neuroautoimmune diseaseSeptember 2019February 2021Allow1721YesNo
16493657IDENTIFICATION OF SIGNATURES FOR NEURODEGENERATION DISEASES DIAGNOSESSeptember 2019December 2020Abandon1501NoNo
16489778PREVENTIVE OR THERAPEUTIC AGENT FOR HTLV-1 ASSOCIATED MYELOPATHY USING LOW-DOSE OF ANTI-CCR4 ANTIBODYAugust 2019March 2021Allow1920NoNo
16547695DETECTION AND QUANTIFICATION OF RAS-RAF-MAPK PATHWAY PROTEINSAugust 2019June 2024Abandon5841YesNo
16487720COMPOUND AND METHOD OF MEASURING INTESTINAL PERMEABILITY AND LEAKY GUTAugust 2019January 2023Abandon4111NoNo
16543854Antibodies and Vaccines for Use in Therapeutic and Diagnostic Methods for Alpha-Synuclein-Related DisordersAugust 2019December 2020Abandon1610NoNo
16486238ANTIBODIES TO ALPHA-SYNUCLEIN AND USES THEREOFAugust 2019June 2020Allow1000YesNo
16486286NON-INVASIVE BRAIN INJURY DIAGNOSTIC DEVICEAugust 2019July 2023Abandon4721NoNo
16482160METHOD FOR CONTROLLING DIFFERENTIATION OF PLURIPOTENT STEM CELLSJuly 2019November 2022Allow3921NoNo
16481013METHOD FOR DETECTING CONSTITUENT COMPONENT OF ANTIBODY-DRUG CONJUGATEJuly 2019November 2022Allow4021NoNo
16514701METHODS TO ENHANCE NERVE REGENERATION UTILIZING NEURAL STEM CELLS AND IL12P40July 2019January 2021Abandon1811NoNo
16513058DOSING REGIMENS OF PKC ACTIVATORSJuly 2019July 2021Allow2430YesNo
16477391GAMMA-SECRETASE STABILIZING COMPOUND SCREENING ASSAYJuly 2019January 2022Allow3041NoNo
16507586METHOD OF CREATING HUMAN PLURIPOTENT STEM CELL DERIVED BRAIN PERICYTE-LIKE CELLSJuly 2019December 2022Allow4111NoNo
16507437NOVEL IMMUNOTHERAPY AGAINST NEURONAL AND BRAIN TUMORSJuly 2019March 2020Allow810YesNo
16505534DETECTION AND TREATMENT OF NEUROLOGICAL DISEASESJuly 2019February 2023Allow4321YesNo
16474662METHOD FOR PRODUCING PLURIPOTENT STEM CELL-DERIVED SPHERICAL NEURAL MASS HAVING SUPPRESSED TERATOMA FORMATIONJune 2019December 2023Allow5431YesNo
16474170DETECTION METHOD FOR CHROMOSOMAL ABNORMALITIES AND METHOD FOR EVALUATING INDUCIBILITYJune 2019October 2021Abandon2801NoNo
16473482ANTIBODY WHICH BINDS TO MYELIN OLIGODENDROCYTE GLYCOPROTEINJune 2019May 2021Allow2221NoNo
16449547MATERIALS AND METHODS FOR TREATMENT OF INFLAMMATIONJune 2019September 2020Abandon1520NoNo
16449096NEURAL PROTEINS AS BIOMARKERS FOR NERVOUS SYSTEM INJURY AND OTHER NEURAL DISORDERSJune 2019August 2021Allow2620YesNo
16468960ANTIBODY VARIANTS TRANSMIGRATING THE BLOOD-BRAIN BARRIER AND USES THEREOFJune 2019May 2020Allow1100NoNo
16467750NEURONAL SURVIVAL AND AXONAL REGENERATION THROUGH INCREASING MITOCHONDRIAL MOTILITYJune 2019April 2022Allow3421YesYes
16426795Basal Ganglia-On-Chip For Screening Therapeutic Agents For Brain And Nervous System DiseasesMay 2019February 2024Allow5731YesNo
16464517NEW BIOMARKERS OF HUMAN SKIN AGINGMay 2019May 2024Abandon6031NoNo
16421152METHODS FOR EVALUATION OF TREATMENT AND PROGRESSION OF NEUROLOGICAL DISORDERSMay 2019May 2021Abandon2421NoNo
16346841INFRARED ASSAY DETECTING SECONDARY STRUCTURE PROFILES OF ALPHA-SYNUCLEINMay 2019September 2021Allow2821YesNo
16345562ANTIBODIES TO UBIQUITIN C-TERMINAL HYDROLASE L1 (UCH-L1) AND GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) AND RELATED METHODSApril 2019March 2021Allow2311YesNo
16342504Neuronal and Oligodendrocyte Survival ModulationApril 2019September 2020Abandon1710NoNo
16340026DETECTION OF CD-155, THE POLIOVIRUS RECEPTORApril 2019July 2022Allow3920NoNo
16338654GENETIC SUSCEPTIBILITY DIAGNOSIS AND TREATMENT OF MENTAL DISORDERSApril 2019July 2020Abandon1601NoNo
16336016APOAEQUORIN AND VITAMIN D-CONTAINING COMPOSITIONS AND METHODS OF USING SAMEMarch 2019December 2020Abandon2111NoNo
16355661DIAGNOSTIC METHOD FOR MULTIPLE SCLEROSISMarch 2019September 2020Abandon1911NoNo
16333979BIOMARKERS FOR USE IN DETERMINING RESPONSE TO TREATMENT OF NEURODEGENERATION DISEASEMarch 2019December 2020Abandon2120NoNo
16331063Bi-Functional Anti-Tau Polypeptides and Use ThereofMarch 2019February 2021Allow2421YesNo
16293134COMPOSITIONS AND METHODS USEFUL FOR THE TREATMENT OF NEUROMYELITIS OPTICA SPECTRUM DISORDERSMarch 2019June 2020Allow1510YesNo
16283530CHIMERIC ANTIGEN RECEPTORS HAVING GITR INTRACELLULAR DOMAIN AS CO-STIMULATORY DOMAINFebruary 2019January 2022Allow3511NoNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner MACFARLANE, STACEY NEE.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
8
Examiner Affirmed
8
(100.0%)
Examiner Reversed
0
(0.0%)
Reversal Percentile
1.0%
Lower than average

What This Means

With a 0.0% reversal rate, the PTAB affirms the examiner's rejections in the vast majority of cases. This reversal rate is in the bottom 25% across the USPTO, indicating that appeals face significant challenges here.

Strategic Value of Filing an Appeal

Total Appeal Filings
65
Allowed After Appeal Filing
10
(15.4%)
Not Allowed After Appeal Filing
55
(84.6%)
Filing Benefit Percentile
19.2%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 15.4% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

Appeals to PTAB face challenges. Ensure your case has strong merit before committing to full Board review.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner MACFARLANE, STACEY NEE - Prosecution Strategy Guide

Executive Summary

Examiner MACFARLANE, STACEY NEE works in Art Unit 1649 and has examined 690 patent applications in our dataset. With an allowance rate of 40.6%, this examiner allows applications at a lower rate than most examiners at the USPTO. Applications typically reach final disposition in approximately 34 months.

Allowance Patterns

Examiner MACFARLANE, STACEY NEE's allowance rate of 40.6% places them in the 8% percentile among all USPTO examiners. This examiner is less likely to allow applications than most examiners at the USPTO.

Office Action Patterns

On average, applications examined by MACFARLANE, STACEY NEE receive 2.18 office actions before reaching final disposition. This places the examiner in the 56% percentile for office actions issued. This examiner issues a slightly above-average number of office actions.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by MACFARLANE, STACEY NEE is 34 months. This places the examiner in the 42% percentile for prosecution speed. Prosecution timelines are slightly slower than average with this examiner.

Interview Effectiveness

Conducting an examiner interview provides a +47.9% benefit to allowance rate for applications examined by MACFARLANE, STACEY NEE. This interview benefit is in the 91% percentile among all examiners. Recommendation: Interviews are highly effective with this examiner and should be strongly considered as a prosecution strategy. Per MPEP § 713.10, interviews are available at any time before the Notice of Allowance is mailed or jurisdiction transfers to the PTAB.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 18.2% of applications are subsequently allowed. This success rate is in the 20% percentile among all examiners. Strategic Insight: RCEs show lower effectiveness with this examiner compared to others. Consider whether a continuation application might be more strategic, especially if you need to add new matter or significantly broaden claims.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 35.4% of cases where such amendments are filed. This entry rate is in the 55% percentile among all examiners. Strategic Recommendation: This examiner shows above-average receptiveness to after-final amendments. If your amendments clearly overcome the rejections and do not raise new issues, consider filing after-final amendments before resorting to an RCE.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 66.7% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 53% percentile among all examiners. Strategic Recommendation: Pre-appeal conferences show above-average effectiveness with this examiner. If you have strong arguments, a PAC request may result in favorable reconsideration.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 74.2% of appeals filed. This is in the 63% percentile among all examiners. Of these withdrawals, 91.3% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner shows above-average willingness to reconsider rejections during appeals. The mandatory appeal conference (MPEP § 1207.01) provides an opportunity for reconsideration.

Petition Practice

When applicants file petitions regarding this examiner's actions, 101.6% are granted (fully or in part). This grant rate is in the 93% percentile among all examiners. Strategic Note: Petitions are frequently granted regarding this examiner's actions compared to other examiners. Per MPEP § 1002.02(c), various examiner actions are petitionable to the Technology Center Director, including prematureness of final rejection, refusal to enter amendments, and requirement for information. If you believe an examiner action is improper, consider filing a petition.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 1.7% of allowed cases (in the 73% percentile). This examiner makes examiner's amendments more often than average to place applications in condition for allowance (MPEP § 1302.04).

Quayle Actions: This examiner issues Ex Parte Quayle actions in 2.9% of allowed cases (in the 75% percentile). This examiner issues Quayle actions more often than average when claims are allowable but formal matters remain (MPEP § 714.14).

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Prepare for rigorous examination: With a below-average allowance rate, ensure your application has strong written description and enablement support. Consider filing a continuation if you need to add new matter.
  • Prioritize examiner interviews: Interviews are highly effective with this examiner. Request an interview after the first office action to clarify issues and potentially expedite allowance.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.