USPTO Examiner XIE XIAOZHEN - Art Unit 1646

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
17122890METHODS FOR TREATING WOUNDSDecember 2020October 2023Allow3411YesNo
17078949OPHTHALMIC COMPOSITIONS AND METHODS OF USE THEREFOROctober 2020November 2023Allow3611NoNo
17079285Bone-Targeting AntibodiesOctober 2020May 2024Allow4231YesNo
17039402BONE REPAIR PRODUCT AND METHODS OF USE THEREOFSeptember 2020April 2023Abandon3001NoNo
17020108TREATMENT FOR BONE DISEASESSeptember 2020October 2023Allow3711YesNo
17020493TREATMENT OF FIBRODYSPLASIA OSSIFICANS PROGRESSIVASeptember 2020March 2023Abandon3001NoNo
16995617ANTIBODIES NEUTRALIZING GM-CSF FOR USE IN THE TREATMENT OF RHEUMATOID ARTHRITIS OR AS ANALGESICSAugust 2020June 2023Allow3411YesNo
16970391GREMLIN-1 INHIBITOR FOR THE TREATMENT OF A BONE FRACTURE OR BONE DEFECTAugust 2020July 2022Allow2321YesNo
16969909Multivalent Binding Molecules Activating WNT Signaling and Uses ThereofAugust 2020October 2024Abandon5031YesNo
16942339FORMULATION OF ANTIBODY BASED DRUGS FOR TREATING LUNG CANCER BY INHALATIONJuly 2020July 2023Abandon3511NoNo
16924473ACTIVIN RECEPTOR TYPE IIB VARIANTS AND METHODS OF USE THEREOFJuly 2020September 2023Allow3801YesNo
16960656COMPOSITIONS AND METHODS FOR TARGETING CD99-EXPRESSING CANCERSJuly 2020March 2024Allow4501YesNo
16919377METHODS FOR INCREASING RED BLOOD CELL LEVELS AND TREATING INEFFECTIVE ERYTHROPOIESISJuly 2020February 2023Abandon3201NoNo
16906118Methods of Using IL-1beta CompoundsJune 2020March 2023Abandon3310NoNo
16906046SOLUBLE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) POLYPEPTIDE FOR USE IN THE PREVENTION OR TREATMENT OF SKELETAL GROWTH RETARDATION DISORDERSJune 2020June 2023Allow3611YesNo
16764116MULTI SPECIFIC MOLECULESMay 2020November 2023Allow4210YesNo
16871765STABLE PROTEIN SOLUTION FORMULATION CONTAINING HIGH CONCENTRATION OF AN ANTI-VEGF ANTIBODYMay 2020September 2023Allow4011YesNo
16762844ACTIVIN RECEPTOR TYPE IIA VARIANTS AND METHODS OF USE THEREOFMay 2020June 2022Allow2511NoNo
16864872CLEC11A IS A BONE GROWTH AGENTMay 2020September 2023Allow4121YesNo
16862776ANTI-IL-17A ANTIBODIES AND THEIR USE IN TREATING AUTOIMMUNE AND INFLAMMATORY DISORDERSApril 2020April 2024Allow4821YesYes
16753923COMPOSITIONS AND METHODS OF USE OF INTERLEUKIN-10 IN COMBINATION WITH IMMUNE CHECK-POINT PATHWAY INHIBITORSApril 2020December 2023Abandon4421NoNo
16837905Use of C-Type Natriuretic Peptide Variants to Treat Skeletal DysplasiaApril 2020October 2023Allow4341YesNo
16818954SOLUBLE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGR3) POLYPEPTIDE FOR USE IN THE PREVENTION OR TREATMENT OF SKELETAL GROWTH RETARDATION DISORDERSMarch 2020February 2023Allow3511YesNo
16813376METHODS AND COMPOSITIONS FOR REGENERATING TISSUESMarch 2020February 2021Allow1111YesNo
16803582ANTI-IL-25 ANTIBODIES AND USES THEREOFFebruary 2020August 2022Allow3011YesNo
16796666SOLUBLE FGFR3 DECOYS FOR TREATING SKELETAL GROWTH DISORDERSFebruary 2020November 2023Allow4521YesNo
16792171METHOD FOR CARTILAGE REPAIR AND PRE-OSTEOARTHRITIS TREATMENTFebruary 2020September 2023Abandon4321YesYes
16633618PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RHEUMATOID ARTHRITIS COMPRISING NASAL INFERIOR TURBINATE-DERIVED MESENCHYMAL STEM CELLS AS AN ACTIVE INGREDIENTJanuary 2020December 2022Allow3521YesNo
16631687INTERLEUKIN 12 (IL12) OR DERIVATIVE THEREOF FOR USE IN THE TREATMENT OF SECONDARY DISEASEJanuary 2020May 2024Abandon5280YesNo
16630064COMPOSITION FOR PREDICTING OR DIAGNOSING LIVER DISEASE, AND LIVER DISEASE PREDICTION OR DIAGNOSIS METHOD USING SAMEJanuary 2020September 2022Abandon3321NoNo
16726989METHODS FOR TREATING BONE GAP DEFECTSDecember 2019February 2024Abandon5031NoNo
16625254HLA-G TRANSCRIPTS AND ISOFORMS AND THEIR USESDecember 2019February 2023Allow3721YesNo
16703177PEPTIDES HAVING OSTEOBLAST GROWTH-PROMOTING ACTIVITY AND USE THEREOFDecember 2019February 2022Abandon2601NoNo
16698245COMPOSITIONS FOR TREATING WOUNDSNovember 2019June 2024Allow5531YesNo
16695713GDF-15 and/or Troponin T for Predicting Kidney Failure in Heart Surgery PatientsNovember 2019March 2023Allow4021YesNo
16609918IL-23R ANTAGONISTS TO REPROGRAM INTRATUMORAL T REGULATORY CELLS INTO EFFECTOR CELLSOctober 2019October 2022Allow3621YesNo
16669211SCFV-FC DIMERS THAT BIND TRANSFORMING GROWTH FACTOR-BETA1 WITH HIGH AFFINITY, AVIDITY AND SPECIFICITYOctober 2019December 2021Allow2501YesNo
16663764COMPOSITIONS AND METHODS USING IL-8 TO IMPROVE MILK PRODUCTION AND REPRODUCTIVE HEALTH IN MAMMALSOctober 2019March 2022Allow2911YesNo
16663337COMPOSITIONS AND METHODS FOR TREATING WOUNDSOctober 2019February 2024Allow5121YesNo
16607673N-ACETYLATED AND NON-ACETYLATED DIPEPTIDES CONTAINING ARGININE TO REDUCE THE VISCOSITY OF VISCOUS COMPOSITIONS OF THERAPEUTIC POLYPEPTIDESOctober 2019May 2024Allow5500YesNo
16586516METHOD OF TREATING OSTEOARTHRITISSeptember 2019April 2022Abandon3121NoNo
16583799COMPOSITIONS AND METHODS FOR MODULATING CELL SIGNALINGSeptember 2019June 2022Abandon3311NoNo
16579126Treatment of Fibrodysplasia Ossificans ProgressivaSeptember 2019March 2022Allow3011YesNo
16567991COMPOSITIONS AND METHODS USING IL-8 FOR IMPROVING HEALTH OF MAMMALSSeptember 2019June 2022Allow3321YesNo
16491502AQUEOUS ANTI-PD-L1 ANTIBODY FORMULATIONSeptember 2019March 2024Abandon5431YesNo
16485290COLLAGEN-BINDING AGENT COMPOSITIONS AND METHODS OF USING THE SAMEAugust 2019November 2022Allow3921YesNo
16484657THERAPEUTIC COMPOSITIONSAugust 2019June 2023Allow4631YesNo
16535663STEM CELLS AND METHODS OF USING THEMAugust 2019April 2022Abandon3201NoNo
16532184SOLUBLE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGR3) POLYPEPTIDE FOR USE IN THE PREVENTION OR TREATMENT OF SKELETAL GROWTH RETARDATION DISORDERSAugust 2019July 2021Abandon2401NoNo
16482362COMPOUNDS, COMPOSITIONS AND USES THEREOF FOR IMPROVEMENT OF BONE DISORDERSJuly 2019June 2023Abandon4631NoNo
16525428Compositions and methods for degenerative disc regenerationJuly 2019March 2021Allow2021YesNo
16480765ANTI-SCLEROSTIN ANTIBODIES AND METHODS OF USEJuly 2019November 2022Allow4021YesYes
15780800MONOCLONAL ANTIBODIES AGAINST BAMBI AND USE FOR THE TREATMENT OF INFLAMMATORY DISEASESJuly 2019August 2022Allow5121YesNo
16460498BONE INDUCTION SYSTEM AND METHODSJuly 2019June 2022Allow3521YesNo
16443306MUTANT INTERLEUKIN-2 POLYPEPTIDESJune 2019July 2022Abandon3621NoNo
16435420INTERLEUKIN-2/INTERLEUKIN-2 RECEPTOR ALPHA FUSION PROTEINS AND METHODS OF USEJune 2019May 2020Allow1101YesNo
16424094Methods for Treating Skin Infection by Administering an IL-4R AntagonistMay 2019November 2022Allow4131YesNo
16417174SOLUBLE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (SFGFR3) POLYPEPTIDES AND USES THEREOFMay 2019February 2021Allow2101YesNo
16461555Methods for Treating Bone-Related DisordersMay 2019June 2022Abandon3721NoNo
16349435METHODS AND COMPOSITIONS FOR TREATMENT OF CARTILAGE DAMAGE AND ARTHRITISMay 2019February 2022Allow3321YesNo
16403677PEPTIDES AND COMPOSITIONS FOR TREATMENT OF JOINT DAMAGEMay 2019August 2021Allow2711YesNo
16396511COMPOSITION AND METHOD FOR THE TREATMENT OR PREVENTION OF SPINAL DISORDERSApril 2019July 2021Abandon2711NoNo
16344311METHODS AND COMPOSITIONS FOR MODULATON OF TRANSFORMING GROWTH FACTOR BETA-REGULATED FUNCTIONSApril 2019June 2021Allow2611YesNo
16372064IMPLANTABLE MATRIX HAVING OPTIMUM LIGAND CONCENTRATIONSApril 2019February 2022Allow3521YesNo
16369246INDUCER FOR REGENERATION OF BONE AND SOFT TISSUE, AND METHOD FOR MAKING SAME AND USES THEREOFMarch 2019September 2022Allow4241YesNo
16366838INTERLEUKIN-2/INTERLEUKIN-2 RECEPTOR ALPHA FUSION PROTEINS AND METHODS OF USEMarch 2019February 2022Allow3421YesNo
16362119COMPOSITIONS AND METHODS FOR TREATING BONEMarch 2019September 2022Allow4221YesNo
16358343Composition and Method for Delivery of BMP-2 Amplifier/Co-Activator for Enhancement of OsteogenesisMarch 2019March 2021Allow2411NoNo
16332939PLATELET COMPOSITIONS AND METHODS FOR THE DELIVERY OF THERAPEUTIC AGENTSMarch 2019March 2023Allow4821YesNo
16332724TWISTED GASTRULATION POLYPEPTIDES AND USES THEREOFMarch 2019August 2023Abandon5341NoNo
16330069STABLE PEPTIDES AND METHODS OF USE THEREOFMarch 2019December 2023Allow5752YesNo
16287963ANTI-RANKL ANTIBODIES AND METHODS OF USEFebruary 2019November 2021Abandon3221NoNo
16328476POLYPEPTIDE FOR PROMOTING BONE REGENERATION OR BONE FORMATION AND ITS USEFebruary 2019February 2024Abandon6011NoNo
16277888MODIFIED CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) POLYPEPTIDES WITH INCREASED STABILITY AND USES THEREOFFebruary 2019September 2022Allow4321YesNo
16277466ANTIBODIES THAT BIND NOTUM PECTINACETYLESTERASEFebruary 2019April 2021Allow2620YesNo
16324501TGF-BETA ANTAGONIST CONJUGATESFebruary 2019July 2021Abandon2911NoNo
16264664OLEANOLIC ACID ENHANCES MESENCHYMAL STROMAL CELL OSTEOGENIC POTENTIAL BY INHIBITION OF NOTCH SIGNALINGJanuary 2019April 2022Abandon3821YesNo
16318512COMPANION DIAGNOSTIC FOR COMBINATION LENALIDOMIDE AND ERYTHROPOIETIN TREATMENTJanuary 2019March 2021Abandon2611NoNo
16316254FUSION PROTEIN, POLYNUCLEOTIDE, GENETIC CONSTRUCT, PRODUCER, PREPARATION FOR REGENERATION OF CARTILAGEJanuary 2019December 2021Allow3521YesNo
16314136COMPOSITIONS AND METHODS FOR PREVENTING BONE LOSS AND/OR STIMULATING BONE HEALINGDecember 2018May 2023Abandon5341NoNo
16209889TGF-� RECEPTOR FUSION PROTEINS AND OTHER TGF-� ANTAGONISTS FOR REDUCING TGF-� SIGNALINGDecember 2018September 2021Abandon3421NoNo
16209510System and Method for Multiphasic Release of Growth FactorsDecember 2018April 2021Abandon2811NoNo
16208322THERAPEUTIC INTERVENTION FOR OSTEOPOROSISDecember 2018July 2022Allow4331YesNo
16306419PREVENTIVE AND/OR THERAPEUTIC AGENT FOR OSTEOGENESIS IMPERFECTA AND OTHER DISEASESNovember 2018October 2021Allow3411YesNo
16305947COMPOSITION COMPRISING AN AB6 FAMILY DESIGNER LIGAND OF TGF-BETA SUPERFAMILY FOR TREATING BONE AND CARTILAGE DISEASE AND USE THEREOFNovember 2018November 2020Allow2411YesNo
16306058COMPOSITION COMPRISING AN AB6 FAMILY DESIGNER LIGAND OF TGF-BETA SUPERFAMILY FOR TREATING LIVER DISEASE AND USE THEREOFNovember 2018June 2021Abandon3121NoNo
16198531MUTANT INTERLEUKIN-2 POLYPEPTIDESNovember 2018April 2021Allow2911YesNo
16195679TREATMENT OF FIBRODYSPLASIA OSSIFICANS PROGRESSIVANovember 2018October 2020Abandon2211NoNo
16302582Methods for Treating Disorders Associated with Fibrosis and Systemic SclerosisNovember 2018December 2021Abandon3721NoNo
16192214HIGHLY GALACTOSYLATED ANTI-TNF-ALPHA ANTIBODIES AND USES THEREOFNovember 2018December 2020Abandon2511NoNo
16192273HIGHLY GALACTOSYLATED ANTI-TNF-ALPHA ANTIBODIES AND USES THEREOFNovember 2018January 2021Abandon2711NoNo
16190537METHOD FOR TREATING OR/AND PREVENTING CALCIUM DEFICIENCY-RELATED DISEASESNovember 2018August 2020Allow2111YesNo
16184705USE OF LIPOSOMAL WNT COMPOSITIONS TO ENHANCE OSSEOINTEGRATIONNovember 2018October 2022Abandon4740NoNo
16096429METHODS AND COMPOSITIONS FOR EXPANSION OF HEMATOPOIETIC STEM AND/OR PROGENITOR CELLS EMPLOYING A CYTOCHROME P450 1B1 (CYP1B1) INHIBITOR OR A MUSASHI-2 (MSI2) ACTIVATOROctober 2018December 2022Abandon5011NoNo
16165759SUSTAINED DELIVERY OF A GROWTH DIFFERENTIATION FACTOROctober 2018January 2022Allow3941YesNo
16164297BIOMARKERS AND METHODS FOR ASSESSING RESPONSE TO INFLAMMATORY DISEASE THERAPYOctober 2018March 2022Allow4121YesNo
16088769ANTI-ROR2 ANTIBODIES, ANTIBODY FRAGMENTS, THEIR IMMUNOCONJUCATES AND USES THEREOFSeptember 2018September 2021Allow3521YesNo
16087774SELF-ASSEMBLED NANOSTRUCTURES OF ELASTIN-AND RESILIN-BASED BLOCK COPOLYPEPTIDES WITH STIMULI RESPONSIVENESS AND RESILIENCE FOR DRUG DELIVERY SYSTEM, TISSUE ENGINEERING AND REGENERATIVE MEDICINE AND METHODS OF PREPARING THE SAMESeptember 2018September 2023Allow6021YesNo
16085871NEUTRALIZING MONOCLONAL ANTIBODIES TO IL-25 AND USES THEREOFSeptember 2018June 2022Allow4521YesNo
16084525BONE-TARGETING THERAPEUTIC CONJUGATE AND METHODS OF MAKING AND USING THE SAMESeptember 2018March 2021Abandon3021NoNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner XIE, XIAOZHEN.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
4
Examiner Affirmed
4
(100.0%)
Examiner Reversed
0
(0.0%)
Reversal Percentile
0.9%
Lower than average

What This Means

With a 0.0% reversal rate, the PTAB affirms the examiner's rejections in the vast majority of cases. This reversal rate is in the bottom 25% across the USPTO, indicating that appeals face significant challenges here.

Strategic Value of Filing an Appeal

Total Appeal Filings
66
Allowed After Appeal Filing
9
(13.6%)
Not Allowed After Appeal Filing
57
(86.4%)
Filing Benefit Percentile
17.1%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 13.6% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

Appeals to PTAB face challenges. Ensure your case has strong merit before committing to full Board review.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner XIE, XIAOZHEN - Prosecution Strategy Guide

Executive Summary

Examiner XIE, XIAOZHEN works in Art Unit 1646 and has examined 636 patent applications in our dataset. With an allowance rate of 40.7%, this examiner allows applications at a lower rate than most examiners at the USPTO. Applications typically reach final disposition in approximately 37 months.

Allowance Patterns

Examiner XIE, XIAOZHEN's allowance rate of 40.7% places them in the 8% percentile among all USPTO examiners. This examiner is less likely to allow applications than most examiners at the USPTO.

Office Action Patterns

On average, applications examined by XIE, XIAOZHEN receive 2.08 office actions before reaching final disposition. This places the examiner in the 51% percentile for office actions issued. This examiner issues a slightly above-average number of office actions.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by XIE, XIAOZHEN is 37 months. This places the examiner in the 31% percentile for prosecution speed. Prosecution timelines are slightly slower than average with this examiner.

Interview Effectiveness

Conducting an examiner interview provides a +77.8% benefit to allowance rate for applications examined by XIE, XIAOZHEN. This interview benefit is in the 99% percentile among all examiners. Recommendation: Interviews are highly effective with this examiner and should be strongly considered as a prosecution strategy. Per MPEP § 713.10, interviews are available at any time before the Notice of Allowance is mailed or jurisdiction transfers to the PTAB.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 22.6% of applications are subsequently allowed. This success rate is in the 32% percentile among all examiners. Strategic Insight: RCEs show below-average effectiveness with this examiner. Carefully evaluate whether an RCE or continuation is the better strategy.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 19.9% of cases where such amendments are filed. This entry rate is in the 26% percentile among all examiners. Strategic Recommendation: This examiner shows below-average receptiveness to after-final amendments. You may need to file an RCE or appeal rather than relying on after-final amendment entry.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 40.0% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 37% percentile among all examiners. Note: Pre-appeal conferences show below-average success with this examiner. Consider whether your arguments are strong enough to warrant a PAC request.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 84.0% of appeals filed. This is in the 77% percentile among all examiners. Of these withdrawals, 81.0% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner frequently reconsiders rejections during the appeal process compared to other examiners. Per MPEP § 1207.01, all appeals must go through a mandatory appeal conference. Filing a Notice of Appeal may prompt favorable reconsideration even before you file an Appeal Brief.

Petition Practice

When applicants file petitions regarding this examiner's actions, 96.7% are granted (fully or in part). This grant rate is in the 89% percentile among all examiners. Strategic Note: Petitions are frequently granted regarding this examiner's actions compared to other examiners. Per MPEP § 1002.02(c), various examiner actions are petitionable to the Technology Center Director, including prematureness of final rejection, refusal to enter amendments, and requirement for information. If you believe an examiner action is improper, consider filing a petition.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 2.7% of allowed cases (in the 78% percentile). Per MPEP § 1302.04, examiner's amendments are used to place applications in condition for allowance when only minor changes are needed. This examiner frequently uses this tool compared to other examiners, indicating a cooperative approach to getting applications allowed. Strategic Insight: If you are close to allowance but minor claim amendments are needed, this examiner may be willing to make an examiner's amendment rather than requiring another round of prosecution.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 0.0% of allowed cases (in the 2% percentile). This examiner rarely issues Quayle actions compared to other examiners. Allowances typically come directly without a separate action for formal matters.

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Prepare for rigorous examination: With a below-average allowance rate, ensure your application has strong written description and enablement support. Consider filing a continuation if you need to add new matter.
  • Prioritize examiner interviews: Interviews are highly effective with this examiner. Request an interview after the first office action to clarify issues and potentially expedite allowance.
  • Appeal filing as negotiation tool: This examiner frequently reconsiders rejections during the appeal process. Filing a Notice of Appeal may prompt favorable reconsideration during the mandatory appeal conference.
  • Examiner cooperation: This examiner frequently makes examiner's amendments to place applications in condition for allowance. If you are close to allowance, the examiner may help finalize the claims.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.