USPTO Examiner LYONS MARY M - Art Unit 1645

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
18664120Cellular Adjuvants for Viral InfectionMay 2024February 2025Allow910NoNo
18664198Cellular Adjuvants for Viral InfectionMay 2024March 2025Allow1010NoNo
18596916ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOFMarch 2024March 2025Allow1210NoNo
18291870METHODS FOR THE REDUCTION OF METHANE PRODUCTION IN RUMINANTSJanuary 2024February 2025Allow1321NoNo
18394580COMPOSITIONS AND METHODS FOR GENERATING AN IMMUNE RESPONSE TO TREAT OR PREVENT MALARIADecember 2023February 2025Allow1410NoNo
18476731Liquid Neurotoxin Formulation Stabilized with Tryptophan or TyrosineSeptember 2023March 2025Allow1820NoNo
18235530METHOD TO MANUFACTURE A STABLE PROTEINAugust 2023February 2025Abandon1801NoNo
18223835METHODS AND COMPOSITIONS FOR ASSESSING AND TREATING INTRAOCULAR DISEASES AND DISORDERSJuly 2023April 2025Allow2110NoNo
18221644METHOD FOR DETERMINING FACIAL MUSCLE RESPONSESJuly 2023March 2025Allow2010NoNo
18221835MICROORGANISM IDENTIFICATION METHODJuly 2023June 2025Allow2320YesYes
18326511TREATMENT OF CLOSTRIDIUM DIFFICILE INFECTIONMay 2023April 2025Allow2321YesNo
18318689EFFICACIOUS MRNA VACCINESMay 2023January 2025Abandon2010NoNo
18136696COMPOSITION COMPRISING OIL DROPSApril 2023December 2024Abandon2001NoNo
18301121APPARATUS, SYSTEMS, AND METHODS FOR DETERMINING THE CONCENTRATION OF MICROORGANISMS AND THE SUSCEPTIBILITY OF MICROORGANISMS TO ANTI-INFECTIVES BASED ON REDOX REACTIONSApril 2023December 2024Allow2120NoNo
18301015PROMOTER POLYNUCLEOTIDE, SIGNAL POLYPEPTIDE AND USE THEREOFApril 2023October 2024Allow1811YesNo
18300126MICROORGANISMS FOR PLANT PATHOGEN INHIBITIONApril 2023November 2024Allow1910YesNo
18187241ENHANCED CHEMILUMINESCENT ENZYME-LINKED IMMUNOSORBENT ASSAY FOR DETECTION OF ANTIBODIES AGAINST BABESIA MICROTIMarch 2023September 2024Allow1810NoNo
18186588PATHOGEN VACCINES AND METHODS OF PRODUCING AND USING THE SAMEMarch 2023December 2024Abandon2101NoNo
18173991LIQUID NEUROTOXIN FORMULATION STABILIZED WITH TRYPTOPHAN OR TYROSINEFebruary 2023March 2024Abandon1320NoNo
18103166GUT MICROBIOTA AND TREATMENT OF CANCERJanuary 2023February 2025Allow2510YesNo
18103082PSEUDOMONAS STRAINS AND THEIR METABOLITES TO CONTROL PLANT DISEASESJanuary 2023July 2024Allow1820NoNo
18065689METHOD FOR RAPID IN VITRO SYNTHESIS OF GLYCOPROTEINS VIA RECOMBINANT PRODUCTION OF N-GLYCOSYLATED PROTEINS IN PROKARYOTIC CELL LYSATESDecember 2022April 2025Allow2820NoNo
17922173Method to Reduce Tick Population with a Universal Tick AntigenOctober 2022June 2023Allow811NoNo
18045914HEME-BINDING SMALL PEPTIDEOctober 2022April 2024Allow2711NoNo
17816318LYSIN-ANTIMICROBIAL PEPTIDE (AMP) POLYPEPTIDE CONSTRUCTS, LYSINS, ISOLATED POLYNUCLEOTIDES ENCODING SAME AND USES THEREOFJuly 2022June 2025Abandon3520NoNo
17858642BIOFUSION PROTEINS AS ANTI-MALARIA VACCINESJuly 2022November 2024Abandon2801NoNo
17857110Immunogenic Compositions of Polysaccharide-Protein Pegylated CompoundsJuly 2022January 2025Allow3020NoNo
17852669CELL-TARGETING MOLECULES COMPRISING DE-IMMUNIZED, SHIGA TOXIN A SUBUNIT EFFECTORS AND CD8+ T-CELL EPITOPESJune 2022March 2025Abandon3220NoNo
17838890VACCINE DELIVERY METHODJune 2022August 2024Allow2611NoNo
17806206APPARATUS, SYSTEMS, AND METHODS FOR DETERMINING SUSCEPTIBILITY OF MICROORGANISMS TO ANTI-INFECTIVESJune 2022January 2025Allow3220NoNo
17832745MUCOADHESIVE MICROORGANISMJune 2022November 2024Allow2911YesNo
17777075NEW FORMULATION OF LACTOBACILLUS STRAINS FOR THE TREATMENT AND PREVENTION OF HELICOBACTER PYLORI COLONISATION IN THE UPPER AIRWAYS AND THE DIGESTIVE SYSTEMMay 2022March 2025Abandon3410NoNo
17730030Pro-Inflammatory and Adjuvant Functions of Toll-Like Receptor 4 AntagonistsApril 2022April 2024Allow2410NoNo
17729056METABOLIC ENGINEERING FOR MICROBIAL PRODUCTION OF TERPENOID PRODUCTSApril 2022October 2024Allow2910YesNo
17726254COMPOSITIONS AND METHODS FOR GENERATING AN IMMUNE RESPONSE TO TREAT OR PREVENT MALARIAApril 2022August 2023Allow1610NoNo
17713456NMR METHODS AND SYSTEMS FOR THE RAPID DETECTION OF TICK-BORNE PATHOGENSApril 2022December 2024Abandon3210NoNo
17763542LACTOBACILLUS REUTERIMarch 2022October 2024Allow3110YesNo
17689927PROBIOTIC FOR INHIBITING GROWTH OF PROTEUS MIRABILIS, AND FERMENTATION BROTH AND APPLICATION THEREOFMarch 2022June 2025Allow3921YesNo
17684121Cellular Adjuvants for Viral InfectionMarch 2022October 2024Allow3221NoNo
17681946TREATMENT OF BACTERIAL VAGINOSISFebruary 2022March 2025Abandon3711NoNo
17638137COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY AND IMMUNE DISEASESFebruary 2022March 2025Allow3711NoNo
17673488Lactobacillus Gasseri KBL697 Strain and Use ThereofFebruary 2022August 2023Allow1810NoNo
17590290CHIMERIC VACCINE ANTIGENS FOR ANAPLASMOSISFebruary 2022October 2024Allow3310NoNo
17630107FILAMENTOUS FUNGAL EXPRESSION SYSTEMJanuary 2022January 2025Abandon3601NoNo
17553098ANTI-MALARIA COMPOSITIONS AND METHODSDecember 2021October 2024Abandon3401NoNo
17552256VACCINE COMPOSITION AGAINST CHLAMYDIACEAE INFECTIONSDecember 2021August 2023Allow2010YesNo
17614876METHODS OF TREATING PATIENTS WITH AN IMMUNOGENIC COMPOSITION THAT PROTECTS AGAINST S. PNEUMONIAE SEROTYPE 29November 2021March 2025Abandon4020NoNo
17612893COMPOSITION AND METHOD FOR SPRAY DRYING AN ADJUVANT VACCINE EMULSIONNovember 2021January 2025Allow3811YesNo
17525804TARGETING OF MELANOCYTES FOR DELIVERING THERAPEUTIC OR DIAGNOSTIC AGENTS USING PROTEIN NANOCAGESNovember 2021January 2025Allow3911NoNo
17517477MUTANT FRAGMENTS OF OSPA AND METHODS AND USES RELATING THERETONovember 2021September 2024Allow3410NoNo
17515882COMPOSITIONS AND METHODS FOR TREATING THE EYENovember 2021August 2023Allow2110NoNo
17507994SIGNATURES AND DETERMINANTS FOR DIAGNOSING INFECTIONS AND METHODS OF USE THEREOFOctober 2021August 2024Allow3420YesNo
17494068PSEUDOMONAS STRAINS AND THEIR METABOLITES TO CONTROL FISH DISEASESOctober 2021January 2023Allow1510YesNo
17493594PSEUDOMONAS STRAINS AND THEIR METABOLITES TO CONTROL PLANT DISEASESOctober 2021July 2024Allow3310NoNo
17492190OPTIMIZED CELL-FREE SYNTHESIS OF INVASION PLASMID ANTIGEN B AND RELATED COMPOSITIONS AND METHODS OF USEOctober 2021December 2024Allow3811NoNo
17468989NEISSERIA MENINGITIDIS VACCINESeptember 2021March 2023Allow1800NoNo
17420982TRYPANOSOMAL VACCINEJuly 2021June 2024Allow3511NoNo
17304888LIQUID NEUROTOXIN FORMULATION STABILIZED WITH TRYPTOPHAN OR TYROSINEJune 2021March 2024Abandon3320NoNo
17350683MUCOADHESIVE DEVICES FOR THE RELEASE OF PROBIOTICS AND FOR THE MAINTENANCE OF THEIR ENZYME ACTIVITIESJune 2021June 2024Allow3620NoNo
17346030SYSTEMS AND METHODS FOR ALGAE CULTIVATION USING DIRECT AIR CAPTUREJune 2021June 2025Allow4820NoNo
17333255ANTIGEN-DRIVEN DETECTION AND TREATMENT OF COCCIDIOIDOMYCOSISMay 2021August 2023Allow2710NoNo
17319004BOTULINUM TOXIN CELL BINDING DOMAIN POLYPEPTIDES AND METHODS OF USE FOR TREATMENTS OF FIBROSIS ASSOCIATED DISORDERSMay 2021September 2023Abandon2801NoNo
17290566METHOD FOR DETERMINING ESCHERICHIA COLIApril 2021April 2024Allow3510YesNo
17228579CELL-TARGETING MOLECULES COMPRISING DE-IMMUNIZED, SHIGA TOXIN A SUBUNIT EFFECTORS AND CD8+ T-CELL EPITOPESApril 2021March 2022Allow1120YesNo
17228699DESIGN AND EXPRESSION OF SARS-COV-2 SPIKE PROTEIN RECEPTOR BINDING DOMAIN IN ATTENUATED SALMONELLA AS A VACCINEApril 2021March 2022Allow1121YesNo
17224888METHODS OF TREATING FUNGAL INFECTIONSApril 2021August 2024Allow4010NoNo
17213619INDUCTION OF PROTECTIVE IMMUNITY AGAINST ANTIGENSMarch 2021June 2023Allow2610NoNo
17210965PROCESS TO REDUCE ENDOTOXIN IN GELATINMarch 2021November 2023Abandon3211NoNo
17207948FOOD SAFETY VACCINE TO CONTROL SALMONELLA ENTERICA AND REDUCE CAMPYLOBACTER IN POULTRYMarch 2021May 2023Allow2610NoNo
17184580MICROORGANISMS ENGINEERED FOR MUCONATE PRODUCTIONFebruary 2021July 2023Allow2811YesNo
17180959ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOFFebruary 2021March 2024Abandon3731NoNo
17170912METHOD OF IDENTIFICATION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUSFebruary 2021April 2022Allow1411YesNo
17300020Method and apparatus for avoiding false positive coliform testingFebruary 2021November 2024Abandon4521NoYes
17154536Anti-Microbial ImmunomodulationJanuary 2021July 2023Allow3010YesNo
17152146RAPID TEST FOR LYME BACTERIAJanuary 2021August 2023Allow3110NoNo
17127530Listeria-Based Compositions Comprising a Peptide Minigene Expression System and Methods of Use ThereofDecember 2020February 2023Allow2610NoNo
17118391COMPOSITION COMPRISING OIL DROPSDecember 2020April 2023Abandon2810NoNo
17103392PROTECTIVE BARRIER COMPOSITIONS AND USES THEREOFNovember 2020July 2022Allow2011YesNo
17102301Lactobacillus Gasseri KBL697 Strain and Use ThereofNovember 2020November 2021Allow1220YesNo
16953162Methods of Treating Cancer Using Bacteria Expressing c-di-AMPNovember 2020November 2022Allow2421YesNo
17097534CHEMOENZYMATIC GLYCOENGINEERING OF ANTIBODIES AND FC FRAGMENTS THEREOFNovember 2020December 2022Allow2521NoNo
17097371BISPECIFIC ANTIGEN-BINDING MOLECULES THAT BIND A STAPHYLOCOCCUS TARGET ANTIGEN AND A COMPLEMENT COMPONENT AND USES THEREOFNovember 2020February 2023Allow2711NoNo
16956071MAKE-UP COMPOSITION COMPRISING A HYDROLYSATE OF THEOBROMA CACAO L BEANS AND AT LEAST ONE PREBIOTIC AND A PROBIOTICNovember 2020April 2025Abandon5821NoNo
17093396METHODS FOR INHIBITING BIOFILM FORMATIONNovember 2020March 2023Abandon2910NoNo
17052731BIOMARKERS FOR DETECTING MICROBIAL INFECTIONNovember 2020April 2023Allow2921YesNo
17077354METHOD FOR RAPID IN VITRO SYNTHESIS OF GLYCOPROTEINS VIA RECOMBINANT PRODUCTION OF N-GLYCOSYLATED PROTEINS IN PROKARYOTIC CELL LYSATESOctober 2020August 2022Allow2211NoNo
17047900INHIBITION OF FUNGAL GROWTH BY MANGANESE DEPLETIONOctober 2020March 2023Allow2820NoNo
17070477METHOD OF REDUCING EGG CONTAMINATIONOctober 2020March 2023Abandon2910NoNo
17070021COMPOSITIONS AND METHODS FOR TREATING DISEASE USING SALMONELLA T3SS EFFECTOR PROTEIN (SipA)October 2020December 2022Abandon2610NoNo
17063540PSEUDOMONAS STRAINS AND THEIR METABOLITES TO CONTROL PLANT DISEASESOctober 2020January 2023Allow2711YesNo
17061696VACCINE DELIVERY METHODOctober 2020August 2022Allow2221NoNo
17061137HAEMORRHAGIC DISORDER DUE TO VENTRICULAR ASSIST DEVICEOctober 2020April 2022Allow1901YesNo
17060067NEISSERIA MENINGITIDIS COMPOSITION AND METHODS THEREOFSeptember 2020April 2022Allow1800NoNo
17026379MUCOADHESIVE MICROORGANISMSeptember 2020March 2022Allow1800YesNo
17023133A QUANTITATIVE ENZYME-LINKED IMMUNOASSAY (ELISA) TO APPROXIMATE COMPLEMENT FIXING ANTIBODY TITERS IN SERUM FROM PATIENTS WITH COCCIDIOIDOMYCOSISSeptember 2020June 2022Allow2110NoNo
17018045PRO-INFLAMMATORY AND ANTI-CANCER FUNCTIONS OF TOLL-LIKE RECEPTOR 4 ANTAGONISTSSeptember 2020January 2022Allow6030YesNo
17018038Pro-Inflammatory and Adjuvant Functions of Toll-Like Receptor 4 AntagonistsSeptember 2020January 2022Allow1630YesNo
17015177PATHOGEN VACCINES AND METHODS OF PRODUCING AND USING THE SAMESeptember 2020December 2022Allow2721NoNo
17000590IMMUNOGENIC COMPOSITIONS FOR USE IN PNEUMOCOCCAL VACCINESAugust 2020March 2024Abandon4350NoNo
16996457MULTILAYER NANO-CELLAugust 2020November 2020Allow310YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner LYONS, MARY M.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
13
Examiner Affirmed
12
(92.3%)
Examiner Reversed
1
(7.7%)
Reversal Percentile
20.9%
Lower than average

What This Means

With a 7.7% reversal rate, the PTAB affirms the examiner's rejections in the vast majority of cases. This reversal rate is in the bottom 25% across the USPTO, indicating that appeals face significant challenges here.

Strategic Value of Filing an Appeal

Total Appeal Filings
45
Allowed After Appeal Filing
4
(8.9%)
Not Allowed After Appeal Filing
41
(91.1%)
Filing Benefit Percentile
10.5%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 8.9% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

Appeals to PTAB face challenges. Ensure your case has strong merit before committing to full Board review.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner LYONS, MARY M - Prosecution Strategy Guide

Executive Summary

Examiner LYONS, MARY M works in Art Unit 1645 and has examined 565 patent applications in our dataset. With an allowance rate of 63.2%, this examiner allows applications at a lower rate than most examiners at the USPTO. Applications typically reach final disposition in approximately 28 months.

Allowance Patterns

Examiner LYONS, MARY M's allowance rate of 63.2% places them in the 16% percentile among all USPTO examiners. This examiner is less likely to allow applications than most examiners at the USPTO.

Office Action Patterns

On average, applications examined by LYONS, MARY M receive 2.27 office actions before reaching final disposition. This places the examiner in the 77% percentile for office actions issued. This examiner issues more office actions than most examiners, which may indicate thorough examination or difficulty in reaching agreement with applicants.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by LYONS, MARY M is 28 months. This places the examiner in the 49% percentile for prosecution speed. Prosecution timelines are slightly slower than average with this examiner.

Interview Effectiveness

Conducting an examiner interview provides a +42.8% benefit to allowance rate for applications examined by LYONS, MARY M. This interview benefit is in the 91% percentile among all examiners. Recommendation: Interviews are highly effective with this examiner and should be strongly considered as a prosecution strategy. Per MPEP § 713.10, interviews are available at any time before the Notice of Allowance is mailed or jurisdiction transfers to the PTAB.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 19.6% of applications are subsequently allowed. This success rate is in the 13% percentile among all examiners. Strategic Insight: RCEs show lower effectiveness with this examiner compared to others. Consider whether a continuation application might be more strategic, especially if you need to add new matter or significantly broaden claims.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 41.0% of cases where such amendments are filed. This entry rate is in the 55% percentile among all examiners. Strategic Recommendation: This examiner shows above-average receptiveness to after-final amendments. If your amendments clearly overcome the rejections and do not raise new issues, consider filing after-final amendments before resorting to an RCE.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 75.0% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 58% percentile among all examiners. Strategic Recommendation: Pre-appeal conferences show above-average effectiveness with this examiner. If you have strong arguments, a PAC request may result in favorable reconsideration.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 58.1% of appeals filed. This is in the 26% percentile among all examiners. Of these withdrawals, 88.9% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner shows below-average willingness to reconsider rejections during appeals. Be prepared to fully prosecute appeals if filed.

Petition Practice

When applicants file petitions regarding this examiner's actions, 69.4% are granted (fully or in part). This grant rate is in the 87% percentile among all examiners. Strategic Note: Petitions are frequently granted regarding this examiner's actions compared to other examiners. Per MPEP § 1002.02(c), various examiner actions are petitionable to the Technology Center Director, including prematureness of final rejection, refusal to enter amendments, and requirement for information. If you believe an examiner action is improper, consider filing a petition.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 0.0% of allowed cases (in the 2% percentile). This examiner rarely makes examiner's amendments compared to other examiners. You should expect to make all necessary claim amendments yourself through formal amendment practice.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 0.6% of allowed cases (in the 50% percentile). This examiner issues Quayle actions more often than average when claims are allowable but formal matters remain (MPEP § 714.14).

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Prepare for rigorous examination: With a below-average allowance rate, ensure your application has strong written description and enablement support. Consider filing a continuation if you need to add new matter.
  • Expect multiple rounds of prosecution: This examiner issues more office actions than average. Address potential issues proactively in your initial response and consider requesting an interview early in prosecution.
  • Prioritize examiner interviews: Interviews are highly effective with this examiner. Request an interview after the first office action to clarify issues and potentially expedite allowance.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.