USPTO Examiner MELCHIOR JAMES RYLAND - Art Unit 1644

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
18910549Humanized Anti-DNAM-1 AntibodyOctober 2024March 2025Abandon1010NoNo
18747102MULTIVALENT AND BISPECIFIC ANTIBODY CONSTRUCTS AND METHODS OF USE THEREOFJune 2024March 2025Allow911YesNo
18023701ANTI-VEGF-ANTI-PD-L1 BISPECIFIC ANTIBODY, PHARMACEUTICAL COMPOSITION OF SAME, AND USES THEREOFFebruary 2023April 2025Allow2510NoNo
18006189GP130 Binding Molecules and Methods of UseJanuary 2023July 2025Allow2921YesNo
17993502METHODS FOR TREATING AND DIAGNOSING SYSTEMIC LUPUS ERYTHEMATOSUSNovember 2022June 2025Allow3121YesNo
17937666COMPOSITION OF HUMAN RECOMBINANT ANTIBODY FRAGMENTS THAT COMPLETELY NEUTRALIZE THE VENOM OF THE SCORPION CENTRUROIDES SCULPTURATUSOctober 2022December 2024Abandon2620NoNo
17845742Antibodies Binding to ILT4June 2022June 2025Allow3600YesNo
17642171ANTI-PD-L1 SINGLE-DOMAIN ANTIBODY AND DERIVATIVES AND USE THEREOFMarch 2022June 2025Allow3900YesNo
17682082ANTI-ALPHA-SYNUCLEIN ANTIBODIESFebruary 2022May 2025Allow3800YesNo
17667349STIMULATION OF NATURAL KILL CELL MEMORY BY ADMINISTRATION OF DENDRITIC CELLSFebruary 2022February 2025Abandon3720NoNo
17532688METHOD OF INDUCING ANTIGEN-SPECIFIC TOLERANCE IN A SUBJECT BY ADMINISTERING A COMPOSITION COMPRISING AN APOPTOTIC BODY SURROGATE AND COUPLED IMMUNODOMINANT ANTIGENIC EPITOPES ASSOCIATED WITH AUTOIMMUNE DISEASENovember 2021February 2025Abandon3921NoNo
17525673MONOCYTE COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFECTIOUS DISEASENovember 2021August 2024Allow3411YesNo
17440836ANTIBODIES HAVING SPECIFICITY FOR BTN2 AND USES THEREOFSeptember 2021November 2024Allow3800YesNo
17421334CROSS SPECIES SINGLE DOMAIN ANTIBODIES TARGETING MESOTHELIN FOR TREATING SOLID TUMORSJuly 2021August 2024Allow3800YesNo
17268915T CELL RECEPTOR CONSTRUCTS AND USES THEREOFJune 2021February 2025Allow4810NoNo
17418681USE OF ANTI-FAM19A5 ANTIBODIES FOR TREATING ATHEROSCLEROSISJune 2021October 2024Allow4010YesNo
17418768Anti-PD-L1 Binding Proteins and Methods of Use ThereofJune 2021December 2024Abandon4201NoNo
17418764Anti-PD-1 Binding Proteins and Methods of Use ThereofJune 2021December 2024Abandon4201NoNo
17417686MONOCLONAL ANTIBODIES AGAINST THE BETA CHAIN REGION OF HUMAN TRBV9June 2021October 2024Allow4010YesNo
17413360METHODS OF TREATING NEURODEGENERATIVE DISORDERS AND IDENTIFYING TARGETS THEREFOREJune 2021April 2025Abandon4611NoNo
17312747TREM2 ANTIBODIES AND USES THEREOFJune 2021February 2025Allow4510YesNo
17311114COMBINATIONAL TCR-T CELL THERAPY TARGETING TUMOR ANTIGENS, TGF-BETA, AND IMMUNE CHECKPOINTSJune 2021January 2025Abandon4310NoNo
17335677MODIFIED MEMBRANE SPANNING PROTEINS AND METHODS FOR THE PREPARATION AND USE THEREOFJune 2021May 2025Allow4720YesNo
17288600METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING T CELL-DRIVEN DISEASESApril 2021October 2024Abandon4201NoNo
17288273Novel Rationally Designed Protein CompositionsApril 2021April 2025Allow4811YesNo
17288139FORMULATIONS COMPRISING A TRIS BUFFER AND A PROTEINApril 2021October 2024Abandon4210NoNo
17288485HEAVY CHAIN ANTIBODIES BINDING TO CD38April 2021October 2024Abandon4201NoNo
17283292CONFORMATION-SPECIFIC EPITOPES IN ALPHA-SYNUCLEIN, ANTIBODIES THERETO AND METHODS RELATED THEREOFApril 2021February 2025Allow4621YesNo
17283128ANTIBODIES TARGETING CD137 AND METHODS OF USE THEREOFApril 2021September 2024Allow4110YesNo
17280246NEOANTIGEN COMPOSITIONS; AND METHODS OF PREPARATION AND USE THEREOFMarch 2021March 2025Abandon4811NoNo
17278345Antibody against human cardiac troponin I and use thereofMarch 2021September 2024Allow4211NoNo
17276796CONDITIONALLY ACTIVATED TARGET-BINDING MOLECULESMarch 2021September 2024Abandon4201NoNo
17274746Anti-IL4 Receptor Antibodies for Veterinary UseMarch 2021March 2025Allow4811YesNo
17274458SINGLE-DOMAIN ANTIBODIES AGAINST CD33 AND CONSTRUCTS THEREOFMarch 2021January 2025Allow4621NoNo
17273965TREATMENT AND PREVENTION OF HEMOPHILIC ARTHROPATHY WITH AN ANTIBODY AGAINST ENDOTHELIAL CELL PROTEIN C RECEPTOR (EPCR)March 2021February 2025Allow4730YesNo
17273753HUMANIZED ANTI-C5 ANTIBODIES AND USES THEREOFMarch 2021May 2024Allow3801YesNo
17270323IMMUNOTHERAPY WITH METABOLIC ENZYME EXPRESSIONFebruary 2021February 2025Allow4810NoNo
17268933CATABODIES AND METHODS OF USE THEREOFFebruary 2021January 2025Allow4711NoNo
17266356COMBINATION THERAPIES COMPRISING PD-1-BASED CHIMERIC PROTEINSFebruary 2021July 2024Abandon4101NoNo
17266419HIGH AFFINITY MONOCLONAL ANTIBODIES TARGETING GLYPICAN-2 AND USES THEREOFFebruary 2021February 2024Allow3600YesNo
17266015COMBINATION THERAPIES COMPRISING SIRP ALPHA-BASED CHIMERIC PROTEINSFebruary 2021June 2025Abandon5221NoNo
17250443ANTIBODIES TARGETING A COMPLEX COMPRISING NON-CLASSICAL HLA-I AND NEOANTIGEN AND THEIR METHODS OF USEJanuary 2021June 2024Abandon4110NoNo
17260398THERAPEUTIC COMBINATION OF QUINOLINE DERIVATIVE AND ANTIBODYJanuary 2021April 2025Allow5141YesNo
17259584MART-1(27-35) EPITOPE-SPECIFIC T CELL RECEPTORJanuary 2021June 2024Allow4211NoNo
16955197ANTIBODIES TO ICOSJune 2020December 2024Allow5411YesNo
16759937ANTIBODIES TO alpha-SYNUCLEIN AND USES THEREOFApril 2020March 2025Allow5821YesNo
16753488ANTI-IL-5RAlpha MONOCLONAL ANTIBODYApril 2020August 2024Allow5220YesNo

Appeals Overview

No appeal data available for this record. This may indicate that no appeals have been filed or decided for applications in this dataset.

Examiner MELCHIOR, JAMES RYLAND - Prosecution Strategy Guide

Executive Summary

Examiner MELCHIOR, JAMES RYLAND works in Art Unit 1644 and has examined 45 patent applications in our dataset. With an allowance rate of 66.7%, this examiner allows applications at a lower rate than most examiners at the USPTO. Applications typically reach final disposition in approximately 42 months.

Allowance Patterns

Examiner MELCHIOR, JAMES RYLAND's allowance rate of 66.7% places them in the 20% percentile among all USPTO examiners. This examiner is less likely to allow applications than most examiners at the USPTO.

Office Action Patterns

On average, applications examined by MELCHIOR, JAMES RYLAND receive 1.07 office actions before reaching final disposition. This places the examiner in the 15% percentile for office actions issued. This examiner issues significantly fewer office actions than most examiners.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by MELCHIOR, JAMES RYLAND is 42 months. This places the examiner in the 4% percentile for prosecution speed. Applications take longer to reach final disposition with this examiner compared to most others.

Interview Effectiveness

Conducting an examiner interview provides a +68.2% benefit to allowance rate for applications examined by MELCHIOR, JAMES RYLAND. This interview benefit is in the 99% percentile among all examiners. Recommendation: Interviews are highly effective with this examiner and should be strongly considered as a prosecution strategy. Per MPEP § 713.10, interviews are available at any time before the Notice of Allowance is mailed or jurisdiction transfers to the PTAB.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 25.0% of applications are subsequently allowed. This success rate is in the 28% percentile among all examiners. Strategic Insight: RCEs show below-average effectiveness with this examiner. Carefully evaluate whether an RCE or continuation is the better strategy.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 50.0% of cases where such amendments are filed. This entry rate is in the 69% percentile among all examiners. Strategic Recommendation: This examiner shows above-average receptiveness to after-final amendments. If your amendments clearly overcome the rejections and do not raise new issues, consider filing after-final amendments before resorting to an RCE.

Petition Practice

When applicants file petitions regarding this examiner's actions, 60.0% are granted (fully or in part). This grant rate is in the 76% percentile among all examiners. Strategic Note: Petitions are frequently granted regarding this examiner's actions compared to other examiners. Per MPEP § 1002.02(c), various examiner actions are petitionable to the Technology Center Director, including prematureness of final rejection, refusal to enter amendments, and requirement for information. If you believe an examiner action is improper, consider filing a petition.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 0.0% of allowed cases (in the 2% percentile). This examiner rarely makes examiner's amendments compared to other examiners. You should expect to make all necessary claim amendments yourself through formal amendment practice.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 0.0% of allowed cases (in the 2% percentile). This examiner rarely issues Quayle actions compared to other examiners. Allowances typically come directly without a separate action for formal matters.

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Prepare for rigorous examination: With a below-average allowance rate, ensure your application has strong written description and enablement support. Consider filing a continuation if you need to add new matter.
  • Prioritize examiner interviews: Interviews are highly effective with this examiner. Request an interview after the first office action to clarify issues and potentially expedite allowance.
  • Plan for extended prosecution: Applications take longer than average with this examiner. Factor this into your continuation strategy and client communications.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.