USPTO Examiner QIAN CELINE X - Art Unit 1637

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
19042264PHOSPHATE SENSING MICROBIAL GENE SWITCHJanuary 2025February 2026Allow1221YesNo
18646267METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCESApril 2024November 2025Allow1910NoNo
18617782PHAGE-DERIVED PARTICLES FOR IN SITU DELIVERY OF DNA PAYLOAD INTO C. ACNES POPULATIONMarch 2024July 2025Allow1510NoNo
18491484ENGINEERED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN THE HUMAN BETA-2 MICROGLOBULIN GENEOctober 2023September 2025Abandon2311NoNo
18490484DYSTROPHIN GENE EXON DELETION USING ENGINEERED NUCLEASESOctober 2023September 2025Abandon2311NoNo
18487610SYSTEMS, METHODS, AND COMPOSITIONS FOR SITE-SPECIFIC GENETIC ENGINEERING USING PROGRAMMABLE ADDITION VIA SITE-SPECIFIC TARGETING ELEMENTS (PASTE)October 2023August 2024Allow1010NoNo
18471187METHODS OF TREATING EYE DISEASESSeptember 2023January 2026Allow2830YesNo
18461798CHO INTEGRATION SITES AND USES THEREOFSeptember 2023October 2025Allow2610NoNo
18326689METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCESMay 2023December 2025Allow3120NoNo
18326708METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCESMay 2023July 2025Allow2610NoNo
18326634METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCESMay 2023July 2025Allow2620YesNo
18326588METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCESMay 2023November 2024Allow1720YesNo
18324926RNA TARGETING METHODS AND COMPOSITIONSMay 2023September 2025Abandon2811NoNo
18314411HUMAN INNATE LYMPHOID CELL PRECURSORS: IDENTIFICATION, CHARACTERIZATION, APPLICATIONSMay 2023May 2025Abandon2520NoNo
18152367NOVEL ENZYMATIC METHODS TO GENERATE HIGH YIELDS OF SEQUENCE SPECIFIC RNA OLIGONUCLEOTIDES WITH EXTREME PRECISIONJanuary 2023February 2025Allow2510NoNo
18088683Adult stem cell compositions and methods of identification and isolationDecember 2022August 2025Allow3231NoNo
18007667QUANTIFICATION OF CORONAVIRUS RNAAEMIADecember 2022January 2026Abandon3801NoNo
17992039Method for increasing the specific production rate of eukaryotic cellsNovember 2022February 2025Allow2710NoNo
17913638INACTIVATED SARS-COV-2 VIRUS VACCINESeptember 2022January 2026Abandon4001NoNo
17906784HAPTENIZED CORONAVIRUS SPIKE PROTEINSSeptember 2022December 2025Abandon3901NoNo
17798051COMPOSITION AND METHOD OF mRNA VACCINES AGAINST NOVEL CORONAVIRUS INFECTIONAugust 2022December 2025Abandon4001NoNo
17861207NUCLEASE CASCADE ASSAYJuly 2022November 2024Abandon2822NoNo
17811138TARGETING PD-L1 ON TUMOR CELLSJuly 2022April 2025Allow3330NoNo
17810373PLASMID ADDICTION SYSTEM TO DRIVE DESIRED GENE EXPRESSIONJuly 2022January 2026Allow4231NoNo
17854371MEANS AND METHODS FOR AAV GENE THERAPY IN HUMANSJune 2022October 2024Allow2820NoNo
17854870RECOMBINANT PROTEIN COMPRISING MULTIPLE MULTI-PEPTIDE SETS, PHARMACEUTICAL COMPOSITION COMPRISING THE RECOMBINANT PROTEIN, AND METHOD FOR PREPARING THE RECOMBINANT PROTEINJune 2022July 2025Abandon3601NoNo
17846620Compositions and Methods Relating to Synthetic RNA Polynucleotides Created From Synthetic DNA OligonucleotidesJune 2022October 2025Allow3940NoNo
17757201MATERIALS AND METHODS FOR INFLAMMATORY MOLECULAR MARKERSJune 2022November 2025Abandon4101NoNo
17664006CANCER BIOMARKERS AND METHODS OF USE THEREOFMay 2022September 2023Allow1630NoNo
17746008METHODS FOR HARVESTING MAMMALIAN CELL CULTURESMay 2022September 2024Allow2821NoNo
17662422ANTIGEN AND ANTIBODIES PREPARED BASED ON PADI4 SERVING AS TUMOR MARKER, AND APPLICATION THEREOFMay 2022January 2026Allow4411NoNo
17713025OLIGONUCLEOTIDES WITH NUCLEOSIDE ANALOGSApril 2022March 2026Allow4711NoNo
17765170Oligonucleotide based ex vivo cell therapyMarch 2022October 2025Abandon4301NoNo
17703782NUTRIENT COMPOSITIONS AND METHODS, KITS, AND CELL COMPOSITIONS FOR PRODUCING THE SAMEMarch 2022February 2025Abandon3551YesNo
17688190METHODS FOR THE DIAGNOSIS AND TREATMENT OF GASTROINTESTINAL STROMAL TUMORSMarch 2022April 2025Allow3841NoNo
17565796ADENOVIRUS POLYNUCLEOTIDES AND POLYPEPTIDESDecember 2021September 2025Abandon4531NoNo
17558406ENHANCED PROTEIN PURIFICATION THROUGH A MODIFIED PROTEIN A ELUTIONDecember 2021November 2025Abandon4710NoNo
17616061COMPOUNDS AND METHODS FOR INHIBITING CANCERS VIA REST INHIBITIONDecember 2021September 2025Abandon4601NoNo
17493469COMPOSITIONS AND METHODS FOR T-CELL RECEPTOR GENE ASSEMBLYOctober 2021March 2025Allow4120NoNo
17412664ANTISENSE OLIGOMERS FOR TREATMENT OF CONDITIONS AND DISEASESAugust 2021November 2025Allow5121NoNo
17395552PRODUCTION METHODS FOR MEGAKARYOCYTES AND PLATELETSAugust 2021February 2026Abandon5540NoNo
17310107CELL SPECIFIC TRANSCRIPTIONAL REGULATORY SEQUENCES AND USES THEREOFJuly 2021February 2025Allow4311NoNo
17418465ENCAPSULATED RNA POLYNUCLEOTIDES AND METHODS OF USEJune 2021October 2025Abandon5221NoNo
17309808APP MODIFICATION VIA BASE EDITING USING THE CRISPR/CAS9 SYSTEMJune 2021March 2025Abandon4501NoNo
17415626GENETIC MODIFICATION OF THE HYDROXYACID OXIDASE 1 GENE FOR TREATMENT OF PRIMARY HYPEROXALURIAJune 2021September 2025Abandon5111NoNo
17312174CRISPR-CAS-BASED COMPOSITION FOR GENE CORRECTIONJune 2021August 2025Allow5021NoNo
17312324ANTI-CRISPR-MEDIATED CONTROL OF GENOME EDITING AND SYNTHETIC CIRCUITS IN EUKARYOTIC CELLSJune 2021February 2025Abandon4401NoNo
17299034CELL-BASED BIOIDENTITY TEST FOR INSULINJune 2021December 2024Abandon4221NoNo
17334862METHODS OF ACTIVATING DYSFUNCTIONAL IMMUNE CELLS AND TREATMENT OF CANCERMay 2021November 2024Abandon4101NoNo
17216303MATERIALS AND METHODS FOR TREATMENT OF AUTOSOMAL DOMINANT CONE-ROD DYSTROPHYMarch 2021July 2025Abandon5121NoNo
17182142METHODS AND COMPOSITIONS FOR AIDING IN THE DETECTION OF LUNG CANCERFebruary 2021May 2025Abandon5121NoYes
17270170METHODS OF TREATING CANCERFebruary 2021April 2025Abandon4911NoNo
17269741RECOMBINANT VIRUS PRODUCTS AND METHODS FOR INHIBITING EXPRESSION OF DYSTROPHIA MYOTONICA PROTEIN KINASE AND/OR INTERFERING WITH A TRINUCLEOTIDE REPEAT EXPANSION IN THE 3' UNTRANSLATED REGION OF THE DMPK GENEFebruary 2021August 2025Allow5321NoNo
17269490AGENT USING HSP47 INHIBITOR TO SUPPRESS METASTASISFebruary 2021July 2025Abandon5321NoNo
17175324METHOD FOR SCALABLE SKELETAL MUSCLE LINEAGE SPECIFICATION AND CULTIVATIONFebruary 2021June 2025Abandon5210NoNo
17166004Delta133P53Beta and Delta133P53Gamma Isoforms Are Biomarkers of Cancer Stem CellsFebruary 2021August 2024Allow4230NoNo
17152025TREATMENT OF RETINAL DEGENERATION USING GENE THERAPYJanuary 2021December 2025Abandon5940NoNo
17260804METHODS FOR SAFELY REDUCING THROMBOPOIETINJanuary 2021August 2025Allow5530YesNo
17260071METHOD FOR EDITING DNA IN CELL-FREE SYSTEMJanuary 2021November 2025Abandon5830YesNo
17254191METHODS OF AAV THERAPYDecember 2020January 2025Allow4911NoNo
17251104COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISEASESDecember 2020September 2025Abandon5831YesNo
17057628BIOMARKERS FOR DIAGNOSING TUBERCULOUS MENINGITISNovember 2020August 2024Allow4511NoNo
17053148COMPOSITIONS AND METHODS FOR CULTURING AND EXPANDING CELLSNovember 2020April 2025Abandon5321NoNo
17090807FURTHER IMPROVED AAV VECTORS PRODUCED IN INSECT CELLSNovember 2020June 2025Allow5651NoNo
17051578IMPROVED BCL11A MICRORNAS FOR TREATING HEMOGLOBINOPATHIESOctober 2020March 2025Allow5221NoNo
17050686HIGHLY ACCURATE SEQUENCING METHODOctober 2020February 2026Allow6020YesNo
16934573MYELIN OLIGODENDROCYTE GLYCOPROTEIN, MYELIN BASIC PROTEIN, AND PROTEOLIPID PROTEIN COMPOSITIONS AND METHODS OF USEJuly 2020June 2025Allow5931NoNo
16885162SYSTEMS AND METHODS TO DETECT STEM CELL STRESS AND USES THEREOFMay 2020September 2025Abandon6041YesNo
16759251METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLSApril 2020September 2025Abandon6041NoNo
16480273SYSTEMS AND METHODS FOR IMMUNOMODULATION OF MUCOSAL-ASSOCIATED INVARIANT T CELLSJuly 2019July 2024Allow6031YesNo
16435710METHOD OF EVALUATING NEUTROPHIL ACTIVITYJune 2019June 2025Abandon6061YesNo
16432107POLYPEPTIDES FOR ENGINEERING INTEGRASE CHIMERIC PROTEINS AND THEIR USE IN GENE THERAPYJune 2019April 2025Abandon6061YesNo
16463886AGENTS FOR THE TREATMENT OF PATIENTS WITH NSCLC AND METHODS TO PREDICT RESPONSEMay 2019December 2024Abandon6011NoNo
16415187PROTEIN EXPRESSION STRAINSMay 2019March 2025Allow6041YesNo
16355932ENGINEERING OF BACTERIOPHAGES BY GENOME EDITING USING THE CRISPR-CAS9 SYSTEMMarch 2019March 2026Abandon6061YesYes
16334269METHOD FOR EVALUATING THE EYE IRRITATION POTENTIAL OF CHEMICALSMarch 2019July 2025Allow6051YesNo
16307708Herpesvirus with Modified Glycoprotein H for Propagation in a CellDecember 2018December 2025Allow6061NoNo
16305003PEPTIDES AND NANOPARTICLES FOR INTRACELLULAR DELIVERY OF GENOME-EDITING MOLECULESNovember 2018January 2025Abandon6032NoNo
16092761MASSIVELY MULTIPLEXED HOMOLOGOUS TEMPLATE REPAIR FOR WHOLE-GENOME REPLACEMENTOctober 2018April 2024Abandon6050NoNo
16144822METHODS FOR PROMOTING OLIGODENDROCYTE REGENERATION AND REMYELINATIONSeptember 2018December 2024Abandon6050NoNo
16011263PLASMA CELL CYTOKINE VEHICLE CONTAINING FUSION PROTEINS FOR TARGETED INTRODUCTION OF SIRNA INTO CELLS AND TISSUESJune 2018July 2019Allow1311NoNo
15909666METHOD FOR SCREENING INDUCED PLURIPOTENT STEM CELLSMarch 2018May 2019Allow1410NoNo
15575325SCREENING METHODS FOR TARGETS FOR CANCER THERAPYNovember 2017July 2020Abandon3281YesYes
15709144HOMOLOGOUS RECOMBINATION IN MULTIPOTENT ADULT PROGENITOR CELLSSeptember 2017October 2019Allow2520NoNo
14909713METHODS FOR THE DETECTION AND TREATMENT OF LEUKEMIAS THAT ARE RESPONSIVE TO DOT1L INHIBITIONFebruary 2016April 2019Allow3921NoNo
14960136DNA MOLECULES AND METHODSDecember 2015September 2019Allow4641NoNo
14655744PGC-1beta-Protein-Function Regulator, Mitochondria-Function Regulator, Anti-Obesity Agent, And Screening Method ThereforAugust 2015May 2017Allow2311NoNo
14414253METHOD FOR IDENTIFYING MOLECULAR MARKERS OF CHILDREN'S SKINJune 2015January 2026Allow60111YesNo
14669957MIXER FOR REMOVING IMPURITIES FROM GASES AND LIQUIDSMarch 2015June 2015Allow300NoNo
14415064Hypoxia Inducible Factor (HIF) Activity Reporter Cell LineJanuary 2015March 2018Allow3841NoNo
14345745miRNA Biomarkers For Ulcerative ColitisSeptember 2014March 2017Allow3621NoNo
14084030Gene Cluster for Biosynthesis of Cornexistin and HydroxycornexistinNovember 2013June 2017Allow4331NoNo
13944979Enrichment of Stem Cells from Adult TissuesJuly 2013November 2015Allow2710NoNo
13864778METHOD FOR DETERMINING THE NEURODEVELOPMENTAL TOXICITY OF A COMPOUND IN VITROApril 2013June 2017Allow5030NoNo
13800478Promoters Exhibiting Endothelial Cell Specificity and Methods of Using SameMarch 2013June 2014Allow1511NoNo
13572067BIOMARKERS OF CANCER METASTASISAugust 2012January 2014Allow1720YesNo
13476305ANF-RGC IN-GENE KNOCK-OUT ANIMALMay 2012June 2014Allow2541NoNo
13454171PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAMEApril 2012April 2014Allow2430YesNo
13361628CELL CULTURE SYSTEM FOR DETERMINING THE SENSITIZING, ALLERGENIC AND/OR IRRITATING EFFECT OF A SUBSTANCEJanuary 2012July 2015Allow4140NoNo
13328785BIOMARKER DACT1 FOR GASTRIC CANCERDecember 2011June 2015Allow4231YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner QIAN, CELINE X.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
2
Examiner Affirmed
1
(50.0%)
Examiner Reversed
1
(50.0%)
Reversal Percentile
69.9%
Higher than average

What This Means

With a 50.0% reversal rate, the PTAB reverses the examiner's rejections in a meaningful percentage of cases. This reversal rate is above the USPTO average, indicating that appeals have better success here than typical.

Strategic Value of Filing an Appeal

Total Appeal Filings
23
Allowed After Appeal Filing
7
(30.4%)
Not Allowed After Appeal Filing
16
(69.6%)
Filing Benefit Percentile
46.1%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 30.4% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is below the USPTO average, suggesting that filing an appeal has limited effectiveness in prompting favorable reconsideration.

Strategic Recommendations

✓ Appeals to PTAB show good success rates. If you have a strong case on the merits, consider fully prosecuting the appeal to a Board decision.

⚠ Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner QIAN, CELINE X - Prosecution Strategy Guide

Executive Summary

Examiner QIAN, CELINE X works in Art Unit 1637 and has examined 179 patent applications in our dataset. With an allowance rate of 82.1%, this examiner has an above-average tendency to allow applications. Applications typically reach final disposition in approximately 44 months.

Allowance Patterns

Examiner QIAN, CELINE X's allowance rate of 82.1% places them in the 54% percentile among all USPTO examiners. This examiner has an above-average tendency to allow applications.

Office Action Patterns

On average, applications examined by QIAN, CELINE X receive 2.67 office actions before reaching final disposition. This places the examiner in the 78% percentile for office actions issued. This examiner issues more office actions than most examiners, which may indicate thorough examination or difficulty in reaching agreement with applicants.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by QIAN, CELINE X is 44 months. This places the examiner in the 14% percentile for prosecution speed. Applications take longer to reach final disposition with this examiner compared to most others.

Interview Effectiveness

Conducting an examiner interview provides a -0.4% benefit to allowance rate for applications examined by QIAN, CELINE X. This interview benefit is in the 12% percentile among all examiners. Note: Interviews show limited statistical benefit with this examiner compared to others, though they may still be valuable for clarifying issues.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 23.6% of applications are subsequently allowed. This success rate is in the 33% percentile among all examiners. Strategic Insight: RCEs show below-average effectiveness with this examiner. Carefully evaluate whether an RCE or continuation is the better strategy.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 48.0% of cases where such amendments are filed. This entry rate is in the 72% percentile among all examiners. Strategic Recommendation: This examiner shows above-average receptiveness to after-final amendments. If your amendments clearly overcome the rejections and do not raise new issues, consider filing after-final amendments before resorting to an RCE.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 50.0% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 42% percentile among all examiners. Note: Pre-appeal conferences show below-average success with this examiner. Consider whether your arguments are strong enough to warrant a PAC request.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 86.7% of appeals filed. This is in the 80% percentile among all examiners. Of these withdrawals, 92.3% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner frequently reconsiders rejections during the appeal process compared to other examiners. Per MPEP § 1207.01, all appeals must go through a mandatory appeal conference. Filing a Notice of Appeal may prompt favorable reconsideration even before you file an Appeal Brief.

Petition Practice

When applicants file petitions regarding this examiner's actions, 76.9% are granted (fully or in part). This grant rate is in the 82% percentile among all examiners. Strategic Note: Petitions are frequently granted regarding this examiner's actions compared to other examiners. Per MPEP § 1002.02(c), various examiner actions are petitionable to the Technology Center Director, including prematureness of final rejection, refusal to enter amendments, and requirement for information. If you believe an examiner action is improper, consider filing a petition.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 14.0% of allowed cases (in the 96% percentile). Per MPEP § 1302.04, examiner's amendments are used to place applications in condition for allowance when only minor changes are needed. This examiner frequently uses this tool compared to other examiners, indicating a cooperative approach to getting applications allowed. Strategic Insight: If you are close to allowance but minor claim amendments are needed, this examiner may be willing to make an examiner's amendment rather than requiring another round of prosecution.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 2.7% of allowed cases (in the 72% percentile). This examiner issues Quayle actions more often than average when claims are allowable but formal matters remain (MPEP § 714.14).

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Expect multiple rounds of prosecution: This examiner issues more office actions than average. Address potential issues proactively in your initial response and consider requesting an interview early in prosecution.
  • Appeal filing as negotiation tool: This examiner frequently reconsiders rejections during the appeal process. Filing a Notice of Appeal may prompt favorable reconsideration during the mandatory appeal conference.
  • Plan for extended prosecution: Applications take longer than average with this examiner. Factor this into your continuation strategy and client communications.
  • Examiner cooperation: This examiner frequently makes examiner's amendments to place applications in condition for allowance. If you are close to allowance, the examiner may help finalize the claims.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.