USPTO Examiner ANGELL JON E - Art Unit 1635

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
17132793NUCLEIC ACID-DRUG COMPLEX AND USE THEREOFDecember 2020January 2023Allow2411NoNo
17127581ANTISENSE OLIGOMERS FOR TREATMENT OF CONDITIONS AND DISEASESDecember 2020August 2023Allow3211YesNo
17110525Preparation and Use of Sugar-targeting Nanoparticles for Modifying SiRNADecember 2020February 2024Allow3911NoNo
17110121THERAPEUTIC INHIBITION OF LACTATE DEHYDROGENASE AND AGENTS THEREFORDecember 2020January 2021Allow200NoNo
17090596APTAMER FIBERSNovember 2020August 2022Abandon2120NoNo
17086616MAMMALIAN CELLS FOR PRODUCING A SECRETED PROTEINNovember 2020September 2022Allow2210NoNo
17076696TAILORED MODULATION OF GENE REGULATION PROGRAMS VIA FUNCTIONAL ENHANCER RNAOctober 2020August 2023Allow3420NoNo
17073163NOVEL SHORT HAIRPIN RNA COMPOSITIONS, METHODS OF MAKING AND APPLICATIONS THEREOFOctober 2020May 2023Allow3121NoNo
17071685COMBINATIONS OF MRNAS ENCODING IMMUNE MODULATING POLYPEPTIDES AND USES THEREOFOctober 2020March 2021Allow510NoNo
17046124MICRORNA-BASED COMPOSITIONS AND METHODS USED IN DISEASE TREATMENTOctober 2020March 2023Allow3011NoNo
17045426MODULATORS OF EZH2 EXPRESSIONOctober 2020February 2022Allow1600YesNo
17039075USES FOR PREVENTION OR TREATMENT OF BRAIN DISEASES USING MICRORNASeptember 2020October 2022Allow2511NoNo
17036369COMPOSITIONS AND METHODS FOR THE TREATMENT OF A BETA-CATENIN-ASSOCIATED DISEASE OR DISORDERSeptember 2020July 2022Allow2211NoNo
16982787METHODS FOR MODULATING FMR1 EXPRESSIONSeptember 2020September 2022Allow2410NoNo
17025345EXOSOMAL MICRORNA IN SERUM AS AN INDICATOR FOR THE ACTIVATION OF BROWN AND BEIGE FAT TISSUE (BAT)September 2020January 2023Allow2811NoNo
16981329METHOD OF PRODUCING HAIRPIN SINGLE-STRANDED RNA MOLECULESeptember 2020October 2023Allow3711NoNo
17016021RNAI THERAPY FOR HEPATITIS B VIRUS INFECTIONSeptember 2020October 2022Allow2511NoNo
16978815METHODS FOR TREATING OVARIAN CANCERSeptember 2020October 2022Abandon2521NoNo
16975946METHODS AND COMPOSITIONS FOR TREATING BILE DUCT PAUCITY-ASSOCIATED CONDITIONSAugust 2020December 2022Allow2711NoNo
16990916RNAI AGENTS FOR HEPATITIS B VIRUS INFECTIONAugust 2020February 2022Allow1810YesNo
16986557Nucleic Acid AmplificationAugust 2020January 2023Allow2911NoNo
16963998DOUBLE-HELIX OLIGONUCLEOTIDE CONSTRUCT COMPRISING DOUBLE-STRANDED MIRNA AND USE THEREOFJuly 2020June 2023Allow3521NoNo
16930035RNAi Induced Huntingtin Gene SuppressionJuly 2020January 2022Allow1810NoNo
16926040ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF USHER SYNDROME TYPE 2July 2020April 2022Allow2110NoNo
16961205PATTERN RECOGNITION RECEPTOR AGONIST PRODRUGS AND METHODS OF USE THEREOFJuly 2020April 2024Allow4511NoNo
16922948METHODS AND COMPOSITIONS FOR INCREASED DOUBLE STRANDED RNA PRODUCTIONJuly 2020March 2023Allow3220NoNo
16921390RNAi CONJUGATES, PARTICLES AND FORMULATIONS THEREOFJuly 2020October 2021Abandon1601NoNo
16918239THERAPEUTIC INHIBITION OF LACTATE DEHYDROGENASE AND AGENTS THEREFORJuly 2020February 2022Allow1911NoNo
16956700APTAMER TEMPLATE AND METHOD FOR PREPARING APTAMER BY USING SAMEJune 2020August 2023Abandon3821YesYes
16908346Influenza-Activated Constructs and Methods of Use ThereofJune 2020September 2021Allow1501YesNo
16956271CHIRALLY-ENRICHED DOUBLE-STRANDED RNA AGENTSJune 2020August 2022Allow2511NoNo
16955521METHODS OF GENETIC MEDIATED ENGINEERING OF RNAi MODELSJune 2020February 2024Allow4421NoNo
16902029P38 MAP KINASE INHIBITORSJune 2020September 2021Allow1511NoNo
16772574HOMOLOGOUS RECOMBINATION VIA TRANSCRIPTIONAL ACTIVATIONJune 2020November 2023Allow4111NoNo
16770161OLIGONUCLEOTIDES, MANUFACTURING METHOD FOR SAME, AND TARGET RNA SITE-SPECIFIC EDITING METHODJune 2020December 2022Allow3021NoNo
16891571MOUSE COMPRISING A HUMANIZED TTR LOCUS WITH A BETA-SLIP MUTATION AND METHODS OF USEJune 2020September 2023Allow3911NoNo
16767683ANTI-CHYMASE APTAMER AND USE FOR SAMEMay 2020December 2022Allow3121YesNo
16867603DYNAMIN 2 INHIBITOR FOR THE TREATMENT OF CENTRONUCLEAR MYOPATHIESMay 2020July 2022Allow2621YesNo
16857652METHODS AND COMPOSITIONS FOR ENHANCING FUNCTIONAL MYELIN PRODUCTIONApril 2020February 2021Allow1021YesNo
16758624DIAGNOSIS AND/OR PROGNOSIS OF HER2-DEPENDENT CANCER USING ONE OR MORE MIRNA AS A BIOMARKERApril 2020May 2023Allow3621NoNo
16758185APTAMER AGAINST M.TB MPT51 AND USES THEREOFApril 2020December 2022Abandon3201NoNo
16842300POLYNUCLEOTIDES ENCODING INTERLEUKIN-12 (IL12) AND USES THEREOFApril 2020March 2021Allow1110NoNo
16650614MODULATION OF IMMUNE RESPONSE THROUGH STIMULATOR OF INTERFERON GENESMarch 2020October 2022Abandon3011NoNo
16824592DUAL ACTIVITY SUPER TOXIC RNAi ACTIVE dsRNAsMarch 2020December 2023Allow4521NoNo
16644151SINGLE STRANDED OLIGONUCLEOTIDES INHIBITING ENDOCYTOSISMarch 2020February 2022Allow2411YesNo
16804173METHODS FOR DETECTING AND TREATING LOW-VIRULENCE INFECTIONSFebruary 2020January 2022Abandon2201NoNo
16640521TARGET SEQUENCE SPECIFIC ALTERATION TECHNOLOGY USING NUCLEOTIDE TARGET RECOGNITIONFebruary 2020January 2024Allow4712NoNo
16639389NUCLEIC ACID APTAMER FOR INHIBITING ACTIVITY OF GENOME-EDITING ENZYMEFebruary 2020September 2023Abandon4321NoNo
16639027INHIBITION OF NGLY1 FOR THE TREATMENT OF CANCERFebruary 2020July 2023Allow4122NoNo
16752742XANTHINE DEHYDROGENASE (XDH) IRNA COMPOSITIONS AND METHODS OF USE THEREOFJanuary 2020December 2021Allow2311NoNo
16773738Methods and Compositions for RNAi Mediated Inhibition of Gene Expression in MammalsJanuary 2020October 2021Abandon2101NoNo
16634019ANTISENSE DRUGS AGAINST CANINE ICAM-1 FOR USE IN THE TREATMENT OF INFLAMMATION OF THE BUCCAL CAVITYJanuary 2020January 2021Allow1211NoNo
16752325RNAi Inhibition of Alpha-ENaC ExpressionJanuary 2020August 2021Allow1911NoNo
16630795Gene Editing System and Gene Editing MethodJanuary 2020February 2023Abandon3701NoNo
16739245Mesothelioma Gene TherapyJanuary 2020November 2023Abandon4621NoYes
16732725DOUBLE-STRANDED NUCLEIC ACID MOLECULE, DNA, VECTOR, CANCER CELL GROWTH INHIBITOR, CANCER CELL MIGRATION INHIBITOR, AND DRUGJanuary 2020September 2020Allow801NoNo
16725723NOVEL THERAPEUTIC AGENT FOR A LUNG DISEASE AND/OR METHOD FOR SCREENING FOR THE SAMEDecember 2019December 2021Allow2421YesNo
16723744Methods and Compositions for RNAi Mediated Inhibition of Gene Expression in MammalsDecember 2019October 2021Abandon2201NoNo
16718911IN VIVO DELIVERY OF OLIGONUCLEOTIDESDecember 2019October 2021Allow2211NoNo
16716085THERAPEUTIC AGENT FOR IMMUNE CELL MIGRATION-CAUSED DISEASE AND METHOD FOR SCREENING SAMEDecember 2019February 2022Allow2611YesNo
16622249COMPOSITIONS AND METHODS FOR TREATING CONDITIONS ASSOCIATED WITH GAIN-OF-FUNCTION MUTATIONS IN KCNT1December 2019February 2023Allow3821NoNo
16620700LONG NON-CODING RNA IN CANCERDecember 2019December 2021Allow2421YesNo
16699944MICRO-RNA-155 ENHANCES THE EFFICACY OF DENDRITIC CELL VACCINE FOR CANCERDecember 2019March 2021Allow1520NoNo
16692928REGULATION OF GENE EXPRESSION BY APTAMER-MEDIATED MODULATION OF ALTERNATIVE SPLICINGNovember 2019September 2021Allow2211NoNo
16616224BCL11A GUIDE DELIVERYNovember 2019April 2023Allow4111YesNo
16687525SAFE LENTIVIRAL VECTORS FOR TARGETED DELIVERY OF MULTIPLE THERAPEUTIC MOLECULESNovember 2019January 2021Allow1400YesNo
16613732POLYNUCLEOTIDES ENCODING TETHERED INTERLEUKIN-12 (IL12) POLYPEPTIDES AND USES THEREOFNovember 2019April 2022Allow2911YesNo
16613322COMPOSITIONS AND METHODS FOR NON-ANTIBIOTIC TREATING OF BACTERIAL INFECTIONS BY BLOCKING OR DISRUPTING BACTERIAL GENES INVOLVED IN VIRULENCE OR VIABILITYNovember 2019August 2021Allow2111NoNo
16612734COMPOSITIONS AND METHODS FOR LOADING EXTRACELLULAR VESICLES WITH CHEMICAL AND BIOLOGICAL AGENTS/MOLECULESNovember 2019July 2023Allow4411YesNo
16610899IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKSNovember 2019April 2023Abandon4121NoNo
16660387Methods and means for treating DNA repeat instability associated genetic disordersOctober 2019November 2021Allow2521NoNo
16606377P-ETHOXY NUCLEIC ACIDS FOR IGF-1R INHIBITIONOctober 2019November 2021Abandon2511NoNo
16604444Biomarkers And Targets For Proliferative DiseasesOctober 2019October 2021Abandon2411NoNo
16603771TARGETED COMPOSITIONSOctober 2019April 2022Allow3011NoNo
16500005RNA FOR TREATMENT OF AUTOIMMUNE DISEASESOctober 2019October 2022Allow3611YesNo
16499991COMPOSITIONS AND METHODS FOR DIFFERENTIAL INDUCTION OF CELL DEATH AND INTERFERON EXPRESSIONOctober 2019November 2022Allow3821NoNo
16498102ANTISENSE NUCLEIC ACID FOR INHIBITING BIOSYNTHESIS OF CHONDROITIN SULFATESeptember 2019June 2022Allow3321NoNo
16497294MODULATING dsRNA EDITING, SENSING, AND METABOLISM TO INCREASE TUMOR IMMUNITY AND IMPROVE THE EFFICACY OF CANCER IMMUNOTHERAPY AND/OR MODULATORS OF INTRATUMORAL INTERFERONSeptember 2019August 2023Allow4722NoNo
16572101EXOSOMES AND MICRO-RIBONUCLEIC ACIDS FOR TISSUE REGENERATIONSeptember 2019September 2021Allow2421NoNo
16568387Alpha-1 AntiTrypsin (AAT) RNAi Agents, Compositions Including AAT RNAi Agents, And Methods of UseSeptember 2019August 2021Allow2311NoNo
16561952ANTISENSE OLIGOMERS FOR TREATMENT OF CONDITIONS AND DISEASESSeptember 2019October 2020Allow1411YesNo
16490494RNA TARGETING OF MUTATIONS VIA SUPPRESSOR tRNAs AND DEAMINASESAugust 2019November 2023Allow5031YesNo
16557043TEST KIT FOR DETECTING CONCENTRATION OF CARDIOVASCULAR DISEASE-RELATED BIOMARKER AND CONCENTRATION DETECTION METHOD FOR DETECTING CONCENTRATION OF CARDIOVASCULAR DISEASE-RELATED BIOMARKERAugust 2019July 2020Allow1001NoNo
16487762ANTISENSE OLIGONUCLEIC ACIDAugust 2019October 2021Allow2511YesNo
16487689MATERIALS AND METHODS FOR TREATMENT OF SPINOCEREBELLAR ATAXIA TYPE 1 (SCA1) AND OTHER SPINOCEREBELLAR ATAXIA TYPE 1 PROTEIN (ATXN1) GENE RELATED CONDITIONS OR DISORDERSAugust 2019September 2022Allow3701YesNo
16543102COMBINATIONS OF MRNAS ENCODING IMMUNE MODULATING POLYPEPTIDES AND USES THEREOFAugust 2019July 2021Allow2311NoNo
16542381METHODS OF USING OX40 LIGAND ENCODING POLYNUCLEOTIDESAugust 2019December 2020Allow1610YesNo
16538602STABLE TRANSFORMATION OF A POPULATION AND A METHOD OF BIOCONTAINMENT USING HAPLOINSUFFICIENCY AND UNDERDOMINANCE PRINCIPLESAugust 2019February 2024Allow5521NoNo
16484046COMPOSITIONS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIESAugust 2019March 2022Allow3101NoNo
16477406PUM 1 PROTEIN AS TARGET FOR VIRUS INHIBITIONJuly 2019February 2021Allow1911YesNo
16509365MICRO-RNA FAMILY THAT MODULATES FIBROSIS AND USES THEREOFJuly 2019November 2020Abandon1601NoNo
16457300MRNA COMBINATION THERAPY FOR THE TREATMENT OF CANCERJune 2019December 2020Allow1702YesNo
16451101Antisense oligonucleotides rescue aberrant splicing of ABCA4June 2019April 2023Allow4520NoNo
16448498TREATMENT OF COLLAGEN GENE RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO A COLLAGEN GENEJune 2019September 2021Allow2721YesNo
16443705METHOD FOR DIAGNOSIS OF ALZHEIMER'S DISEASE USING MICRORNAJune 2019August 2021Allow2611NoNo
16443700USES FOR PREVENTION OR TREATMENT OF BRAIN DISEASES USING MICRORNAJune 2019August 2020Allow1411NoNo
16441811LONG NON-CODING RNA USED FOR ANTICANCER THERAPYJune 2019May 2021Abandon2321YesNo
16436696ANTIVIRAL AGENTSJune 2019July 2021Allow2521NoNo
16434787COMPOSITIONS AND METHODS FOR THE MODULATION OF ADAPTIVE IMMUNITYJune 2019November 2023Abandon5331NoNo
16429501Compositions and Methods for Inhibiting Gene Expression of Factor XIIJune 2019August 2020Allow1401NoNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner ANGELL, JON E.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
6
Examiner Affirmed
4
(66.7%)
Examiner Reversed
2
(33.3%)
Reversal Percentile
50.1%
Higher than average

What This Means

With a 33.3% reversal rate, the PTAB reverses the examiner's rejections in a meaningful percentage of cases. This reversal rate is above the USPTO average, indicating that appeals have better success here than typical.

Strategic Value of Filing an Appeal

Total Appeal Filings
51
Allowed After Appeal Filing
7
(13.7%)
Not Allowed After Appeal Filing
44
(86.3%)
Filing Benefit Percentile
17.2%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 13.7% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

Appeals to PTAB show good success rates. If you have a strong case on the merits, consider fully prosecuting the appeal to a Board decision.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner ANGELL, JON E - Prosecution Strategy Guide

Executive Summary

Examiner ANGELL, JON E works in Art Unit 1635 and has examined 630 patent applications in our dataset. With an allowance rate of 44.9%, this examiner allows applications at a lower rate than most examiners at the USPTO. Applications typically reach final disposition in approximately 33 months.

Allowance Patterns

Examiner ANGELL, JON E's allowance rate of 44.9% places them in the 10% percentile among all USPTO examiners. This examiner is less likely to allow applications than most examiners at the USPTO.

Office Action Patterns

On average, applications examined by ANGELL, JON E receive 1.66 office actions before reaching final disposition. This places the examiner in the 30% percentile for office actions issued. This examiner issues fewer office actions than average, which may indicate efficient prosecution or a more lenient examination style.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by ANGELL, JON E is 33 months. This places the examiner in the 46% percentile for prosecution speed. Prosecution timelines are slightly slower than average with this examiner.

Interview Effectiveness

Conducting an examiner interview provides a +39.6% benefit to allowance rate for applications examined by ANGELL, JON E. This interview benefit is in the 86% percentile among all examiners. Recommendation: Interviews are highly effective with this examiner and should be strongly considered as a prosecution strategy. Per MPEP § 713.10, interviews are available at any time before the Notice of Allowance is mailed or jurisdiction transfers to the PTAB.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 23.8% of applications are subsequently allowed. This success rate is in the 36% percentile among all examiners. Strategic Insight: RCEs show below-average effectiveness with this examiner. Carefully evaluate whether an RCE or continuation is the better strategy.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 44.5% of cases where such amendments are filed. This entry rate is in the 69% percentile among all examiners. Strategic Recommendation: This examiner shows above-average receptiveness to after-final amendments. If your amendments clearly overcome the rejections and do not raise new issues, consider filing after-final amendments before resorting to an RCE.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 66.7% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 53% percentile among all examiners. Strategic Recommendation: Pre-appeal conferences show above-average effectiveness with this examiner. If you have strong arguments, a PAC request may result in favorable reconsideration.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 66.7% of appeals filed. This is in the 47% percentile among all examiners. Of these withdrawals, 66.7% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner shows below-average willingness to reconsider rejections during appeals. Be prepared to fully prosecute appeals if filed.

Petition Practice

When applicants file petitions regarding this examiner's actions, 62.1% are granted (fully or in part). This grant rate is in the 65% percentile among all examiners. Strategic Note: Petitions show above-average success regarding this examiner's actions. Petitionable matters include restriction requirements (MPEP § 1002.02(c)(2)) and various procedural issues.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 3.7% of allowed cases (in the 83% percentile). Per MPEP § 1302.04, examiner's amendments are used to place applications in condition for allowance when only minor changes are needed. This examiner frequently uses this tool compared to other examiners, indicating a cooperative approach to getting applications allowed. Strategic Insight: If you are close to allowance but minor claim amendments are needed, this examiner may be willing to make an examiner's amendment rather than requiring another round of prosecution.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 2.1% of allowed cases (in the 71% percentile). This examiner issues Quayle actions more often than average when claims are allowable but formal matters remain (MPEP § 714.14).

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Prepare for rigorous examination: With a below-average allowance rate, ensure your application has strong written description and enablement support. Consider filing a continuation if you need to add new matter.
  • Prioritize examiner interviews: Interviews are highly effective with this examiner. Request an interview after the first office action to clarify issues and potentially expedite allowance.
  • Examiner cooperation: This examiner frequently makes examiner's amendments to place applications in condition for allowance. If you are close to allowance, the examiner may help finalize the claims.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.