USPTO Examiner LEONARD ARTHUR S - Art Unit 1631

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
18406232ENGINEERED CAS PROTEIN AND USE THEREOFJanuary 2024January 2025Allow1221YesNo
18518831GENE-MODIFYING ENDONUCLEASESNovember 2023May 2025Allow1711YesNo
18231697METHOD OF MAKING LIPID FORMULATIONS WITH RNA ENCODING IMMUNOGENSAugust 2023November 2023Allow300NoNo
18231693LIPID FORMULATIONS WITH RNA ENCODING IMMUNOGENSAugust 2023October 2023Allow200NoNo
18231692IMMUNISATION WITH LIPID FORMULATIONS WITH RNA ENCODING IMMUNOGENSAugust 2023October 2023Allow300YesNo
18333467EFFECTOR PROTEINS AND METHODS OF USEJune 2023November 2023Allow511YesNo
18188312TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOFMarch 2023September 2024Abandon1821NoNo
17848299VACCINE FOR ELICITING IMMUNE RESPONSE COMPRISING LIPID FORMULATIONS AND RNA ENCODING MULTIPLE IMMUNOGENSJune 2022February 2023Allow801YesNo
17808519VACCINE FOR ELICITING IMMUNE RESPONSE COMPRISING RNA ENCODING AN IMMUNOGEN AND LIPID FORMULATIONS COMPRISING MOLE PERCENTAGE OF LIPIDSJune 2022February 2023Allow801YesNo
17848294VACCINE FOR ELICITING IMMUNE RESPONSE COMPRISING LIPID NANOPARTICLES AND RNA COMPRISING SEGMENT ENCODING AN IMMUNOGENJune 2022November 2022Abandon501NoNo
17848337METHODS OF ELICITING AN IMMUNE RESPONSEJune 2022November 2022Abandon500NoNo
17836793GENE-REGULATING COMPOSITIONS AND METHODS FOR IMPROVED IMMUNOTHERAPYJune 2022December 2022Allow610NoNo
17705037HUMANIZED MOUSE MODELS FOR ASSESSING IMMUNE CELL THERAPYMarch 2022September 2024Allow2930YesNo
17693173MRNA TARGETING MOLECULE COMPRISING N-ACETYLGALACTOSAMINE BINDING POLYPEPTIDE AND PREPARATION METHOD THEREFORMarch 2022May 2023Allow1421YesNo
17560092METHODS OF MAKING LIPID FORMULATIONS WITH VIRAL IMMUNOGENSDecember 2021December 2022Abandon1111NoNo
17560019LIPID FORMULATIONS WITH IMMUNOGENSDecember 2021January 2023Allow1321YesNo
17560052LIPID FORMULATIONS WITH VIRAL IMMUNOGENSDecember 2021January 2023Allow1321YesNo
17560059METHODS OF ADMINISTERING LIPID FORMULATIONS WITH IMMUNOGENSDecember 2021January 2023Allow1321YesNo
17560138METHODS OF ADMINISTERING LIPID FORMULATIONS WITH VIRAL IMMUNOGENSDecember 2021February 2023Allow1411NoNo
17560116METHODS OF MAKING LIPID FORMULATIONS WITH IMMUNOGENSDecember 2021September 2023Abandon2121YesNo
17462925TREATMENT OF A CANINE CD20 POSITIVE DISEASE OR CONDITION USING A CANINE CD20-SPECIFIC CHIMERIC ANTIGEN RECEPTORAugust 2021May 2025Allow4410NoNo
17383059Sulfated-Oxysterol and Oxysterol Sulfation by Hydroxysterol Sulfotransferase Promote Lipid Homeostasis and Liver Tissue RegenerationJuly 2021June 2025Abandon4701NoNo
17239510Therapeutic Nanoparticles and Related Compositions, Methods and SystemsApril 2021May 2025Abandon4901NoNo
17233373COMPOSITIONS AND METHODS FOR TRANSGENE EXPRESSION FROM AN ALBUMIN LOCUSApril 2021April 2023Allow2450YesNo
17153212METHODS AND COMPOSITIONS FOR TREATING INFLAMMATIONJanuary 2021June 2025Allow5311YesNo
17123918ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS WITH NEW ARCHITECTURES FOR SEQUENCE MANIPULATIONDecember 2020June 2025Allow5311YesNo
17118378CCCTC-Binding Factor VariantsDecember 2020January 2025Abandon4901NoNo
16972920MODIFIED Cas9 PROTEIN AND USE THEREOFDecember 2020December 2024Abandon4801NoNo
17112611POLYCISTRONIC EXPRESSION SYSTEM FOR BACTERIADecember 2020May 2025Abandon5411NoNo
17084535CELLOctober 2020February 2025Abandon5211NoNo
17077942ANTI-TAU CONSTRUCTSOctober 2020September 2024Abandon4701NoNo
17064496EXPRESSION VECTOR DELIVERY SYSTEM AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSEOctober 2020April 2025Allow5411YesNo
17032034PLASMID CONSTRUCTS FOR HETEROLOGOUS PROTEIN EXPRESSION AND METHODS OF USESeptember 2020August 2024Abandon4701NoNo
16757981CAS12C COMPOSITIONS AND METHODS OF USEAugust 2020August 2024Abandon5201NoNo
16986413NOVEL ADENOVIRUSAugust 2020July 2024Abandon4701NoNo
16944014POLYNUCLEOTIDES ENCODING RELAXINJuly 2020April 2024Allow4510NoNo
16923387LYM-1 AND LYM-2 TARGETED CAR CELL IMMUNOTHERAPYJuly 2020November 2024Abandon5311NoNo
16912291METHODS OF TREATMENTS USING ANTIGEN-BINDING PROTEINS TARGETING CD56June 2020February 2024Allow4410YesNo
16901335TUBULAR NANOSTRUCTURE TARGETED TO CELL MEMBRANEJune 2020December 2023Abandon4201NoNo
16900363INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPYJune 2020October 2023Abandon4051YesNo
16900368INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPYJune 2020June 2023Allow3651NoNo
16876979NATURAL KILLER CELLS AND USES THEREOFMay 2020June 2024Abandon4911NoNo
16758602PROGRAMMABLE ASSEMBLY OF VIRUS COMPOSITES FOR RECEPTOR-TARGETED GENE DELIVERYApril 2020August 2023Allow4021YesNo
16839947METHODS AND COMPOSITIONS FOR INCREASING RNA ACTIVITY IN A CELLApril 2020May 2024Abandon4911NoNo
16838545MATERIALS AND METHODS FOR TREATMENT OF AUTOSOMAL DOMINANT RETINITIS PIGMENTOSAApril 2020November 2024Allow5511NoNo
16809674NANO-PLASMONIC MOLECULAR PROBES AND METHODS OF USEMarch 2020August 2024Allow5321YesNo
16715521METHOD OF PREPARING AND CRYOPRESERVING CANCER ANTIGEN-SPECIFIC CD8+ T CELLSDecember 2019September 2024Abandon5761YesNo
16709727COMPOSITIONS AND METHODS FOR TREATING B-LYMPHOID MALIGNANCIESDecember 2019July 2024Abandon5611NoNo
16690395IDENTIFICATION OF A NOVEL B CELL CYTOKINENovember 2019September 2023Abandon4601NoNo
16613592CELL THERAPY WITH LENTIVIRAL TRANSDUCED CSF2RA TRANSGENE IN THE TREATMENT OF HEREDITARY PULMONARY ALVEOLAR PROTEINOSISNovember 2019April 2024Allow5321YesNo
16596228METHODS OF FULL GENE REPLACEMENT AND TRANSGENIC NON-HUMAN CELLS COMPRISING FULL HUMAN GENESOctober 2019August 2024Abandon5821NoYes
16562560NOVEL CAS9 PROTEINS AND GUIDING FEATURES FOR DNA TARGETING AND GENOME EDITINGSeptember 2019May 2023Allow4401NoNo
16562494METHODS AND PRODUCTS FOR NUCLEIC ACID PRODUCTION AND DELIVERYSeptember 2019September 2024Allow6040NoNo
16561847GENETICALLY MODIFIED GENES AND CELLS, AND METHODS OF USING SAME FOR SILENCING VIRUS GENE EXPRESSIONSeptember 2019July 2023Allow4622YesNo
16557820Method and Apparatus for High Throughput High Efficiency Transfection of CellsAugust 2019August 2023Allow4821YesNo
16543839METHODS OF GENERATING OLIGODENDROCYTES AND CELL POPULATIONS COMPRISING SAMEAugust 2019September 2023Abandon4901NoNo
16486632Targeted Ligand-Payload Based Drug Delivery for Cell TherapyAugust 2019February 2025Allow6031YesNo
16486804NUCLEIC ACID CONSTRUCTS COMPRISING GENE EDITING MULTI-SITES AND USES THEREOFAugust 2019June 2025Allow6041YesNo
16538334ANIMAL MODELS OF CORNEAL ECTATIC DISEASES, METHODS OF PRODUCING, AND METHODS OF USE THEREOFAugust 2019October 2023Allow5011YesNo
16483209TUNABLE ENDOGENOUS PROTEIN DEGRADATION WITH HETEROBIFUNCTIONAL COMPOUNDSAugust 2019February 2024Allow5421YesNo
16525145MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONSJuly 2019August 2023Abandon4821NoYes
16510646COMPOSITIONS AND METHODS TO MODIFY CELLS FOR THERAPEUTIC OBJECTIVESJuly 2019March 2025Abandon6031YesNo
16460848METHODS FOR INDUCING SELECTIVE APOPTOSISJuly 2019October 2022Abandon3911NoNo
16454537BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOFJune 2019December 2023Abandon5311YesNo
16448671SYNTHETIC ADENOVIRUSES TARGETING BONE TISSUE AND USES THEREOFJune 2019July 2023Abandon4921NoNo
16466634RNAS FOR WOUND HEALINGJune 2019August 2022Allow3811YesNo
16463646COMPLEXES FOR GENE DELETION AND EDITINGMay 2019July 2022Allow3811YesNo
16408923SWITCH COSTIMULATORY RECEPTORSMay 2019May 2025Allow6041YesNo
16348829METHODS AND COMPOSITIONS FOR ADAPTIVE IMMUNE MODULATIONMay 2019June 2023Allow5021YesYes
16406895INTRATHECAL DELIVERY OF RECOMBINANT ADENO-ASSOCIATED VIRUS 9May 2019April 2023Allow4751YesNo
16302120GENE THERAPYMay 2019April 2024Allow6031YesNo
16388376METHOD FOR PRODUCING AN IMMUNOCONJUGATEApril 2019December 2023Abandon5611NoNo
16336488RECOMBINANT DGKK GENE FOR FRAGILE X SYNDROME GENE THERAPYMarch 2019October 2022Allow4221YesNo
16364763CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOFMarch 2019December 2022Abandon4521NoNo
16365065CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOFMarch 2019December 2022Abandon4521NoNo
16335743METHODS OF MODIFYING THE DYSTROPHIN GENE AND RESTORING DYSTROPHIN EXPRESSION AND USES THEREOFMarch 2019October 2023Abandon5511NoNo
16359626Acoustically-Driven Buffer Switching for MicroparticlesMarch 2019February 2025Allow6041YesNo
16358395TRANSCRIPTION MODULATION IN ANIMALS USING CRISPR/CAS SYSTEMSMarch 2019July 2022Allow4021YesNo
16288052PROCESS FOR DNA INTEGRATION USING RNA-GUIDED ENDONUCLEASESFebruary 2019April 2025Abandon6051NoNo
16270444WT1 HLA CLASS II-BINDING PEPTIDES AND COMPOSITIONS AND METHODS COMPRISING SAMEFebruary 2019February 2022Allow3611YesNo
16270501BIO-REDUCIBLE POLYMERSFebruary 2019March 2024Abandon6021NoNo
16322803GENE EDITING OF CAR-T CELLS FOR THE TREATMENT OF T CELL MALIGNANCIES WITH CHIMERIC ANTIGEN RECEPTORSFebruary 2019April 2025Allow6041YesNo
16099880TREATMENT OF COMPLEMENT-MEDIATED DISORDERSJanuary 2019May 2024Abandon6041NoNo
16312630MATERIALS AND METHODS FOR TREATMENT OF FRIEDREICH ATAXIA AND OTHER RELATED DISORDERSDecember 2018September 2022Allow4521YesNo
16311770CIRCULAR RNAS AND THEIR USE IN IMMUNOMODULATIONDecember 2018September 2023Allow5741YesNo
16306273REPRESSORS OF VIRAL INFECTIONNovember 2018November 2022Allow4721YesNo
16186352Targeted CRISPR Delivery PlatformsNovember 2018May 2024Abandon6041NoNo
16182189INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPYNovember 2018February 2023Allow5170YesNo
16182146INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPYNovember 2018February 2023Allow5160YesNo
16180867INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPYNovember 2018October 2023Allow5970YesNo
16095884Thermal Consistency Systems and Methods for the Application of Thermal Support to a Human or Animal Body or to an Organ for TransplantationOctober 2018January 2025Abandon6021NoNo
16161101TREATMENT OF NEUROPATHY WITH DNA CONSTRUCT EXPRESSING HGF ISOFORMS WITH REDUCED INTERFERENCE FROM GABAPENTINOIDSOctober 2018August 2023Abandon5820YesNo
16156757HUMAN EPITHELIAL CELL LINE FOR 3-D MODELIZING OF CANCER AND TREATMENT THEREOFOctober 2018August 2023Abandon5941YesNo
15999476CUSTOMIZED CLASS SWITCH OF IMMUNOGLOBULIN GENES IN LYMPHOMA AND HYBRIDOMA BY CRISPR/CAS9 TECHNOLOGYAugust 2018July 2022Allow4711YesNo
16100832CellAugust 2018June 2023Abandon5841YesNo
16062983Plasmid Constructs For Heterologous Protein Expression And Methods Of UseJune 2018March 2023Allow5731YesNo
16061681GENE CASSETTE FOR HOMOLOGOUS RECOMBINATION KNOCK-OUT IN YEAST CELLSJune 2018November 2022Abandon5331NoNo
16006461METHODS AND PRODUCTS FOR NUCLEIC ACID PRODUCTION AND DELIVERYJune 2018July 2024Abandon6071NoNo
15780877METHOD OF AMPLIFYING A POPULATION OF ANTIGEN-SPECIFIC MEMORY CD4+ T CELLS USING ARTIFICIAL PRESENTING CELLS EXPRESSING HLA CLASS II MOLECULESJune 2018May 2023Abandon5931NoNo
15992833Chimeric Antigen Receptor Cell Preparation and Uses ThereofMay 2018September 2022Allow5141YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner LEONARD, ARTHUR S.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
2
Examiner Affirmed
0
(0.0%)
Examiner Reversed
2
(100.0%)
Reversal Percentile
91.2%
Higher than average

What This Means

With a 100.0% reversal rate, the PTAB has reversed the examiner's rejections more often than affirming them. This reversal rate is in the top 25% across the USPTO, indicating that appeals are more successful here than in most other areas.

Strategic Value of Filing an Appeal

Total Appeal Filings
16
Allowed After Appeal Filing
5
(31.2%)
Not Allowed After Appeal Filing
11
(68.8%)
Filing Benefit Percentile
45.2%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 31.2% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is below the USPTO average, suggesting that filing an appeal has limited effectiveness in prompting favorable reconsideration.

Strategic Recommendations

Appeals to PTAB show good success rates. If you have a strong case on the merits, consider fully prosecuting the appeal to a Board decision.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner LEONARD, ARTHUR S - Prosecution Strategy Guide

Executive Summary

Examiner LEONARD, ARTHUR S works in Art Unit 1631 and has examined 127 patent applications in our dataset. With an allowance rate of 59.8%, this examiner allows applications at a lower rate than most examiners at the USPTO. Applications typically reach final disposition in approximately 49 months.

Allowance Patterns

Examiner LEONARD, ARTHUR S's allowance rate of 59.8% places them in the 13% percentile among all USPTO examiners. This examiner is less likely to allow applications than most examiners at the USPTO.

Office Action Patterns

On average, applications examined by LEONARD, ARTHUR S receive 2.51 office actions before reaching final disposition. This places the examiner in the 85% percentile for office actions issued. This examiner issues more office actions than most examiners, which may indicate thorough examination or difficulty in reaching agreement with applicants.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by LEONARD, ARTHUR S is 49 months. This places the examiner in the 1% percentile for prosecution speed. Applications take longer to reach final disposition with this examiner compared to most others.

Interview Effectiveness

Conducting an examiner interview provides a +60.7% benefit to allowance rate for applications examined by LEONARD, ARTHUR S. This interview benefit is in the 97% percentile among all examiners. Recommendation: Interviews are highly effective with this examiner and should be strongly considered as a prosecution strategy. Per MPEP § 713.10, interviews are available at any time before the Notice of Allowance is mailed or jurisdiction transfers to the PTAB.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 15.8% of applications are subsequently allowed. This success rate is in the 7% percentile among all examiners. Strategic Insight: RCEs show lower effectiveness with this examiner compared to others. Consider whether a continuation application might be more strategic, especially if you need to add new matter or significantly broaden claims.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 40.9% of cases where such amendments are filed. This entry rate is in the 55% percentile among all examiners. Strategic Recommendation: This examiner shows above-average receptiveness to after-final amendments. If your amendments clearly overcome the rejections and do not raise new issues, consider filing after-final amendments before resorting to an RCE.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 75.0% of appeals filed. This is in the 59% percentile among all examiners. Of these withdrawals, 33.3% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner shows above-average willingness to reconsider rejections during appeals. The mandatory appeal conference (MPEP § 1207.01) provides an opportunity for reconsideration.

Petition Practice

When applicants file petitions regarding this examiner's actions, 50.0% are granted (fully or in part). This grant rate is in the 59% percentile among all examiners. Strategic Note: Petitions show above-average success regarding this examiner's actions. Petitionable matters include restriction requirements (MPEP § 1002.02(c)(2)) and various procedural issues.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 0.0% of allowed cases (in the 1% percentile). This examiner rarely makes examiner's amendments compared to other examiners. You should expect to make all necessary claim amendments yourself through formal amendment practice.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 0.0% of allowed cases (in the 1% percentile). This examiner rarely issues Quayle actions compared to other examiners. Allowances typically come directly without a separate action for formal matters.

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Prepare for rigorous examination: With a below-average allowance rate, ensure your application has strong written description and enablement support. Consider filing a continuation if you need to add new matter.
  • Expect multiple rounds of prosecution: This examiner issues more office actions than average. Address potential issues proactively in your initial response and consider requesting an interview early in prosecution.
  • Prioritize examiner interviews: Interviews are highly effective with this examiner. Request an interview after the first office action to clarify issues and potentially expedite allowance.
  • Plan for extended prosecution: Applications take longer than average with this examiner. Factor this into your continuation strategy and client communications.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.