USPTO Examiner D' AMBROSIO THEA - Art Unit 1654

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
18955504DESMOPRESSIN ORAL COMPOSITIONSNovember 2024May 2025Allow610YesNo
18674657POLYPEPTIDES HAVING ANTI-SENESCENT EFFECTS AND USES THEREOFMay 2024January 2025Allow811YesNo
18625923DESMOPRESSIN ORAL COMPOSITIONSApril 2024October 2024Allow3811YesNo
18604400CLEAVABLE RADIOLIGANDS FOR TARGETING CELL SURFACE RECEPTORS AND USES THEREOFMarch 2024November 2024Allow811NoNo
18386839SOLID COMPOSITIONS COMPRISING A GLP-1 AGONIST AND A SALT OF N-(8-(2-HYDROXYBENZOYL)AMINO)CAPRYLIC ACIDNovember 2023June 2025Allow1911YesNo
18484819LIQUID DALBAVANCIN COMPOSITIONSOctober 2023May 2024Allow711YesNo
18365367LIPOPROTEIN COMPLEXES AND MANUFACTURING AND USES THEREOFAugust 2023March 2024Allow710NoNo
18214651COMPOSITIONS AND METHODS OF CELL ATTACHMENTJune 2023April 2025Abandon2211YesNo
18307124SOMATOSTATIN RECEPTOR AGONIST FORMULATIONSApril 2023March 2025Abandon2311NoNo
18139030COMPOUNDSApril 2023June 2025Abandon2621NoNo
18130299TREATMENT OF HMGB1-MEDIATED INFLAMMATIONApril 2023September 2024Abandon1711NoNo
18170994COMPOSITIONS AND METHOD FOR OPTIMIZED PEPTIDE VACCINES USING RESIDUE OPTIMIZATIONFebruary 2023April 2024Allow1421YesNo
18078518PROPYLENE GLYCOL-CONTAINING PEPTIDE FORMULATIONS WHICH ARE OPTIMAL FOR PRODUCTION AND FOR USE IN INJECTION DEVICESDecember 2022June 2025Abandon3111YesNo
17823018BCL-W Polypeptides and Mimetics for Treating or Preventing Chemotherapy-Induced Peripheral Neuropathy and Hearing LossAugust 2022June 2025Allow3421YesNo
17810565GLYCOTARGETING THERAPEUTICSJuly 2022May 2025Abandon3521NoNo
17810573GLYCOTARGETING THERAPEUTICSJuly 2022June 2025Abandon3521NoNo
17810574GLYCOTARGETING THERAPEUTICSJuly 2022June 2025Abandon3521NoNo
17810561GLYCOTARGETING THERAPEUTICSJuly 2022May 2025Abandon3521NoNo
17845144COMPOSITIONS AND METHODS FOR TARGETING NUCLEAR IMPORT SHUTTLES AND TREATING INFLAMMATORY DISORDERSJune 2022April 2024Allow2211YesNo
17826659LIPOPROTEIN COMPLEXES AND MANUFACTURING AND USES THEREOFMay 2022March 2025Allow3321YesNo
17729290COMPOSITIONS AND METHOD FOR OPTIMIZED PEPTIDE VACCINES USING RESIDUE OPTIMIZATIONApril 2022January 2023Allow821YesNo
17718906RECOMBINANT GLYCOSYLATED ECULIZUMAB AND ECULIZUMAB VARIANTSApril 2022November 2024Abandon3211NoNo
17650975RECOMBINANT VECTOR FOR EXPRESSING TARGET PROTEIN IN PLANT CELLFebruary 2022October 2023Allow2001YesNo
17589588ANTIBIOTIC CANNABINOID-TERPENE FORMULATIONSJanuary 2022June 2023Allow1721YesNo
17566249PEPTIDE AND METHOD FOR MANUFACTURING SAMEDecember 2021January 2025Abandon3701NoNo
17550098Cystatin C and Cystatin 9 to Treat Inflammation Caused by BacteriaDecember 2021May 2025Abandon4121YesNo
17527408WHEY PROTEIN MICELLES AGAINST MUSCLE ATROPHY AND SARCOPENIANovember 2021March 2025Abandon4030YesNo
17607247ANTIBIOTIC CANNABINOID-TERPENE FORMULATIONSOctober 2021October 2024Abandon3601NoNo
17604925SHORT SYNTHETIC PEPTIDES AND THEIR USES FOR TREATING RETINAL DEGENERATIVE DISEASES AND/OR TISSUE INJURIESOctober 2021September 2024Allow3511YesNo
17501486ALPHA-V BETA-6 INTEGRIN LIGANDS AND USES THEREOFOctober 2021May 2024Abandon3111YesNo
17401929PHARMACEUTICAL COMPOSITIONSAugust 2021March 2025Allow4321NoNo
17396947ARTIFICIAL SYNAPSESAugust 2021November 2024Abandon4051YesNo
17383617PLANT MESSENGER PACKS ENCAPSULATING POLYPEPTIDES AND USES THEREOFJuly 2021February 2024Abandon3140YesNo
17366332PHARMACEUTICAL COMPOSITION COMPRISING A GLP-1 AGONIST, AN INSULIN AND METHIONINEJuly 2021July 2024Abandon3620NoNo
17352506INJECTABLE COMPOSITION FOR PREVENTING HAIR LOSS OR STIMULATING HAIR GROWTHJune 2021July 2024Allow3721YesNo
17350363CONTROLLED RELEASE PEPTIDE FORMULATIONSJune 2021October 2024Abandon4021NoNo
17348023METHOD AND FORMULATION FOR INHALATIONJune 2021August 2024Allow3821YesNo
17298512Modified GIP Peptide AnaloguesMay 2021March 2025Allow4611YesNo
17306435ENGINEERED PD-1 VARIANTSMay 2021October 2023Allow2911YesNo
17243096COMPOSITIONS AND METHOD FOR OPTIMIZED PEPTIDE VACCINES USING RESIDUE OPTIMIZATIONApril 2021December 2021Allow831YesNo
17202064IDENTIFICATION OF CHANNELRHODOPSIN-2 (CHR2) MUTATIONS AND METHODS OF USEMarch 2021May 2024Abandon3821NoNo
17197980MULTIFUNCTIONAL OPIOID RECEPTOR LIGANDS AND METHODS OF TREATING PAINMarch 2021April 2025Abandon4921NoNo
17165070METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING POLYCYSTIC OVARY SYNDROMEFebruary 2021January 2023Abandon2311NoNo
17264793ENGINEERED HEMICHANNELS, ENGINEERED VESICLES, AND USES THEREOFJanuary 2021February 2025Abandon4911NoNo
17141778PEPTIDES FOR USE IN PROMOTING TRANSPORT OF GLUCOSEJanuary 2021April 2025Allow5221YesYes
17138448PEPTIDIC TGF-BETA ANTAGONISTSDecember 2020June 2023Allow2911YesNo
17253333COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASEDecember 2020May 2024Abandon4101NoNo
17113957METHODS FOR DIAGNOSING AND ASSESSING RISK OF DEVELOPING GLOMERULOSCLEROSISDecember 2020June 2024Allow4221YesNo
15734957METHODS OF USE OF CD24 FOR THE PREVENTION AND TREATMENT OF LEUKEMIA RELAPSEDecember 2020October 2023Allow3411YesNo
17086786Q-PEPTIDE HYDROGEL PROMOTES IMMUNE MODULATION AND MACROPHAGE DIFFERENTIATIONNovember 2020May 2023Allow3111YesNo
17075295LONG-ACTING FATTY ACID-CONJUGATED GnRH DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAMEOctober 2020March 2022Abandon1721YesNo
17032540PREPARATION AND APPLICATION OF SURFACE DOUBLE MODIFIED HUMAN SERUM ALBUMIN AS TARGETING NANO DRUG CARRIERSeptember 2020June 2024Abandon4521NoNo
17041459Targeted Thrombolysis for Treatment of Microvascular ThrombosisSeptember 2020September 2024Abandon4811YesNo
17041638ANTIMICROBIAL, BACTERIOPHAGE-DERIVED POLYPEPTIDES AND THEIR USE AGAINST GRAM-NEGATIVE BACTERIASeptember 2020July 2024Abandon4611NoNo
17016473TREATMENT OF HMGB1-MEDIATED INFLAMMATIONSeptember 2020December 2022Allow2711YesNo
16997760LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENTAugust 2020September 2022Abandon2501NoNo
16987764MODULATION OF STRUCTURED POLYPEPTIDE SPECIFICITYAugust 2020April 2023Allow3221YesNo
16943822MULTIPARTICULATE GRANULATE COMPRISING INSULINJuly 2020December 2022Abandon2810NoNo
16943114ANTHELMINTIC DEPSIPEPTIDE COMPOUNDSJuly 2020February 2025Allow5541YesNo
16965814AFFINITY LIGANDS FOR ANTIBODY FC REGIONJuly 2020October 2024Allow5041NoNo
16937316COMPOUNDS USEFUL TO TREAT METABOLIC DISORDERSJuly 2020April 2025Abandon5741NoNo
16936177POLYPEPTIDES HAVING ANTI-SENESCENT EFFECTS AND USES THEREOFJuly 2020January 2025Allow5461YesNo
16911712GALACTOENGINEERED IMMUNOGLOBULIN 1 ANTIBODIESJune 2020August 2022Abandon2601NoNo
16910945PROPYLENE GLYCOL-CONTAINING PEPTIDE FORMULATIONS WHICH ARE OPTIMAL FOR PRODUCTION AND FOR USE IN INJECTION DEVICESJune 2020December 2022Abandon3031YesYes
16955896POLYMYXIN-BASED PHARMACEUTICAL COMPOSITION FOR TREATING INFECTIOUS DISEASESJune 2020August 2021Allow1421NoNo
16903107CYSTATIN C AND CYSTATIN 9 TO TREAT GUT INFLAMMATION CAUSED BY THERMAL INJURYJune 2020April 2024Allow4631YesNo
16899192MODULATION OF STRUCTURED POLYPEPTIDE SPECIFICITYJune 2020October 2023Allow4031YesNo
16768584PEPTIDE HORMONE WITH ONE OR MORE O-GLYCANSMay 2020May 2023Abandon3511YesNo
16881314USE OF THYMOSIN ALPHA FOR THE TREATMENT OF SEPSISMay 2020November 2022Abandon3011YesNo
16876683NOVEL MODULATORS OF MELANOCORTIN RECEPTORS FOR THE TREATMENT OF DEPRESSION AND ANXIETYMay 2020September 2022Allow2821YesNo
16763963USE OF CELL MEMBRANE-BOUND SIGNALING FACTORSMay 2020November 2024Abandon5431NoNo
15733085METHODS AND COMPOSITIONS FOR THE TREATMENT OF WOUNDSMay 2020March 2023Allow3412YesNo
16872156METHODS, COMPOSITIONS, AND KITS FOR DETECTION OF ASPERGILLOSISMay 2020March 2023Allow3421YesNo
16870648SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASEMay 2020April 2024Abandon4721NoNo
16868850Factor VII Composition Having a Substantially Homogeneous Isoelectric PointMay 2020December 2022Abandon3221NoNo
16868803Factor VII Composition Having a Substantially Homogenous Isoelectric PointMay 2020January 2022Allow2011YesNo
16760658METHODS TO PREVENT TERATOGENICITY OF IMID LIKE MOLECULES AND IMID BASED DEGRADERS/PROTACSApril 2020April 2024Abandon4821NoNo
16861496THE COMPBODY - A MULTIVALENT TARGET BINDERApril 2020November 2023Allow4321YesNo
16858557METHODS AND COMPOSITIONS FOR MANAGEMENT OF GASTROINTESTINAL DISORDERSApril 2020January 2023Allow3311YesNo
16755636CANCER VACCINE COMPOSITIONS AND METHODS FOR USING SAME TO TREAT CANCERApril 2020April 2023Abandon3601NoNo
16832465HISTONE ANTI-CANCER VACCINESMarch 2020May 2023Allow3721YesNo
16812687GLP-1 FUSION PROTEINS AND USES THEREOFMarch 2020May 2022Abandon2611NoNo
16641959FUSION PROTEINS COMPRISING DETECTABLE TAGS, NUCLEIC ACID MOLECULES, AND METHOD OF TRACKING A CELLFebruary 2020January 2024Abandon4711NoNo
16799350COMPOSITIONS AND METHODS FOR TARGETING NUCLEAR IMPORT SHUTTLES AND TREATING INFLAMMATORY DISORDERSFebruary 2020February 2022Allow2411YesNo
16640754IMMUNOPROTEASOME INHIBITORS AND IMMUNOSUPPRESSIVE AGENT IN THE TREATMENT OF AUTOIMMUNE DISORDERSFebruary 2020December 2023Abandon4631YesNo
16639445APOM-FC FUSION PROTEINS AND USES THEREOFFebruary 2020February 2025Allow6051YesNo
16789196PHARMACEUTICAL COMPOSITIONS AND PREPARATIONS FOR ADMINISTRATION TO THE EYEFebruary 2020January 2023Allow3511YesNo
16752168METHODS FOR MITIGATING LIVER INJURY AND PROMOTING LIVER HYPERTROPHY, REGENERATION AND CELL ENGRAFTMENT IN CONJUNCTION WITH RADIATION AND/OR RADIOMIMETIC TREATMENTSJanuary 2020June 2025Abandon6041NoNo
16631849METHODS FOR PURIFYING PROTEINS HAVING A TUBULIN CARBOXYPEPTIDASE ACTIVITY AND PEPTIDIC BASED INHIBITORS THEREOFJanuary 2020May 2025Allow6051YesNo
16745520CYCLIC PEPTIDE AND A MEDICAMENT, EXTERNAL PREPARATION AND COSMETIC COMPRISING SAID CYCLIC PEPTIDEJanuary 2020April 2024Allow5131YesNo
16630384COMPOSITIONS AND METHODS FOR WOUND CLOSUREJanuary 2020November 2022Abandon3401NoNo
16627383METHOD FOR DIRECT REPROGRAMMING OF URINE CELLS INTO KERATINOCYTE STEM CELLS AND METHOD FOR PREPARING COMPOSITION FOR PROMOTING SKIN REGENERATION USING REPROGRAMMED KERATINOCYTE STEM CELLSDecember 2019January 2023Abandon3701NoNo
16626458A UNIVERSAL VACCINE BASED ON SHARED TUMOR NEOANTIGENS FOR PREVENTION AND TREATMENT OF MICRO SATELLITE INSTABLE (MSI) CANCERSDecember 2019September 2022Allow3311YesNo
16723757GLYCOTARGETING THERAPEUTICSDecember 2019March 2023Allow3941YesNo
16724067GLYCOTARGETING THERAPEUTICSDecember 2019August 2023Allow4441YesNo
16723774GLYCOTARGETING THERAPEUTICSDecember 2019March 2023Allow3941YesNo
16723914GLYCOTARGETING THERAPEUTICSDecember 2019August 2023Allow4441YesNo
16723280METHOD FOR SYNTHESIS OF PROTEIN AMPHIPHILESDecember 2019December 2023Allow4721YesNo
16496725METHOD FOR PREPARING A LIQUID EXTRACT OF PHYCOBILIPROTEINS, IN PARTICULAR PHYCOCYANIN, FROM CYANOBACTERIA OR MICROALGAE AND EXTRACT THUS OBTAINEDDecember 2019March 2023Abandon4211NoNo
16623225FIBRONECTIN BINDING DOMAIN CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE THEREOFDecember 2019January 2025Allow6032YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner D' AMBROSIO, THEA.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
4
Examiner Affirmed
4
(100.0%)
Examiner Reversed
0
(0.0%)
Reversal Percentile
0.8%
Lower than average

What This Means

With a 0.0% reversal rate, the PTAB affirms the examiner's rejections in the vast majority of cases. This reversal rate is in the bottom 25% across the USPTO, indicating that appeals face significant challenges here.

Strategic Value of Filing an Appeal

Total Appeal Filings
25
Allowed After Appeal Filing
0
(0.0%)
Not Allowed After Appeal Filing
25
(100.0%)
Filing Benefit Percentile
0.6%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 0.0% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

Appeals to PTAB face challenges. Ensure your case has strong merit before committing to full Board review.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner D' AMBROSIO, THEA - Prosecution Strategy Guide

Executive Summary

Examiner D' AMBROSIO, THEA works in Art Unit 1654 and has examined 312 patent applications in our dataset. With an allowance rate of 54.8%, this examiner allows applications at a lower rate than most examiners at the USPTO. Applications typically reach final disposition in approximately 35 months.

Allowance Patterns

Examiner D' AMBROSIO, THEA's allowance rate of 54.8% places them in the 10% percentile among all USPTO examiners. This examiner is less likely to allow applications than most examiners at the USPTO.

Office Action Patterns

On average, applications examined by D' AMBROSIO, THEA receive 2.61 office actions before reaching final disposition. This places the examiner in the 88% percentile for office actions issued. This examiner issues more office actions than most examiners, which may indicate thorough examination or difficulty in reaching agreement with applicants.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by D' AMBROSIO, THEA is 35 months. This places the examiner in the 19% percentile for prosecution speed. Applications take longer to reach final disposition with this examiner compared to most others.

Interview Effectiveness

Conducting an examiner interview provides a +66.5% benefit to allowance rate for applications examined by D' AMBROSIO, THEA. This interview benefit is in the 98% percentile among all examiners. Recommendation: Interviews are highly effective with this examiner and should be strongly considered as a prosecution strategy. Per MPEP § 713.10, interviews are available at any time before the Notice of Allowance is mailed or jurisdiction transfers to the PTAB.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 19.8% of applications are subsequently allowed. This success rate is in the 13% percentile among all examiners. Strategic Insight: RCEs show lower effectiveness with this examiner compared to others. Consider whether a continuation application might be more strategic, especially if you need to add new matter or significantly broaden claims.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 25.3% of cases where such amendments are filed. This entry rate is in the 26% percentile among all examiners. Strategic Recommendation: This examiner shows below-average receptiveness to after-final amendments. You may need to file an RCE or appeal rather than relying on after-final amendment entry.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 80.0% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 60% percentile among all examiners. Strategic Recommendation: Pre-appeal conferences show above-average effectiveness with this examiner. If you have strong arguments, a PAC request may result in favorable reconsideration.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 71.4% of appeals filed. This is in the 53% percentile among all examiners. Of these withdrawals, 90.0% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner shows above-average willingness to reconsider rejections during appeals. The mandatory appeal conference (MPEP § 1207.01) provides an opportunity for reconsideration.

Petition Practice

When applicants file petitions regarding this examiner's actions, 81.8% are granted (fully or in part). This grant rate is in the 93% percentile among all examiners. Strategic Note: Petitions are frequently granted regarding this examiner's actions compared to other examiners. Per MPEP § 1002.02(c), various examiner actions are petitionable to the Technology Center Director, including prematureness of final rejection, refusal to enter amendments, and requirement for information. If you believe an examiner action is improper, consider filing a petition.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 0.0% of allowed cases (in the 2% percentile). This examiner rarely makes examiner's amendments compared to other examiners. You should expect to make all necessary claim amendments yourself through formal amendment practice.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 1.2% of allowed cases (in the 58% percentile). This examiner issues Quayle actions more often than average when claims are allowable but formal matters remain (MPEP § 714.14).

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Prepare for rigorous examination: With a below-average allowance rate, ensure your application has strong written description and enablement support. Consider filing a continuation if you need to add new matter.
  • Expect multiple rounds of prosecution: This examiner issues more office actions than average. Address potential issues proactively in your initial response and consider requesting an interview early in prosecution.
  • Prioritize examiner interviews: Interviews are highly effective with this examiner. Request an interview after the first office action to clarify issues and potentially expedite allowance.
  • Plan for extended prosecution: Applications take longer than average with this examiner. Factor this into your continuation strategy and client communications.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.