USPTO Examiner D' AMBROSIO THEA - Art Unit 1654

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
19219183DESMOPRESSIN ORAL COMPOSITIONSMay 2025November 2025Allow610NoNo
18955504DESMOPRESSIN ORAL COMPOSITIONSNovember 2024May 2025Allow610YesNo
18926573Methods and Compositions for Delivery of Biotin to MitochondriaOctober 2024October 2025Allow1220YesNo
18896310STABLE LIQUID COMPOSITIONS OF GLUCAGONSeptember 2024November 2025Abandon1320NoNo
18824445Formulations of MANP and Uses ThereofSeptember 2024August 2025Allow1121YesNo
18674657POLYPEPTIDES HAVING ANTI-SENESCENT EFFECTS AND USES THEREOFMay 2024January 2025Allow811YesNo
18647078PHARMACEUTICAL COMPOSITION COMPRISING A GLP-1 AGONIST, AN INSULIN AND METHIONINEApril 2024March 2026Abandon2210NoNo
18626956CNP CYCLIC PEPTIDE, AND MEDICINE, EXTERNAL PREPARATION AND COSMETIC EACH CONTAINING SAID CYCLIC PEPTIDEApril 2024October 2025Abandon1801NoNo
18625923DESMOPRESSIN ORAL COMPOSITIONSApril 2024October 2024Allow3811YesNo
18604400CLEAVABLE RADIOLIGANDS FOR TARGETING CELL SURFACE RECEPTORS AND USES THEREOFMarch 2024November 2024Allow811NoNo
18598878GLYCOPROTEINS HAVING LIPID MOBILIZING PROPERTIES AND THERAPEUTIC USES THEREOFMarch 2024September 2025Abandon1902NoNo
18402297PLANT MESSENGER PACKS ENCAPSULATING POLYPEPTIDES AND USES THEREOFJanuary 2024February 2026Abandon2501NoNo
18386839SOLID COMPOSITIONS COMPRISING A GLP-1 AGONIST AND A SALT OF N-(8-(2-HYDROXYBENZOYL)AMINO)CAPRYLIC ACIDNovember 2023June 2025Allow1911YesNo
18484819LIQUID DALBAVANCIN COMPOSITIONSOctober 2023May 2024Allow711YesNo
18466693USE OF THYMOSIN ALPHA FOR THE TREATMENT OF SEPSISSeptember 2023November 2025Abandon2601NoNo
18365367LIPOPROTEIN COMPLEXES AND MANUFACTURING AND USES THEREOFAugust 2023March 2024Allow710NoNo
18214651COMPOSITIONS AND METHODS OF CELL ATTACHMENTJune 2023April 2025Abandon2211YesNo
18316893PEPTIDE MIMOTOPES OF CLAUDIN 18.2 AND USES THEREOFMay 2023December 2025Abandon3111NoNo
18307124SOMATOSTATIN RECEPTOR AGONIST FORMULATIONSApril 2023March 2025Abandon2311NoNo
18139030COMPOUNDSApril 2023June 2025Abandon2621NoNo
18130299TREATMENT OF HMGB1-MEDIATED INFLAMMATIONApril 2023September 2024Abandon1711NoNo
18112262STABLE INTRANASAL FORMULATIONS OF CARBETOCINFebruary 2023March 2026Abandon3701NoNo
18170994COMPOSITIONS AND METHOD FOR OPTIMIZED PEPTIDE VACCINES USING RESIDUE OPTIMIZATIONFebruary 2023April 2024Allow1421YesNo
18145676Combination Therapy with Controlled-Release CNP AgonistsDecember 2022February 2026Allow3841NoNo
18078518PROPYLENE GLYCOL-CONTAINING PEPTIDE FORMULATIONS WHICH ARE OPTIMAL FOR PRODUCTION AND FOR USE IN INJECTION DEVICESDecember 2022June 2025Abandon3111YesNo
17993916MULTIPARTICULATE GRANULATE COMPRISING INSULINNovember 2022July 2025Allow3210NoNo
18054407USE OF BOTULINUM NEUROTOXIN IN THE TREATMENT OF SIALORRHEANovember 2022July 2025Allow3340YesNo
17983349ACTIVATION OF (NA++K+)-ATPASE INHIBITS PLATELET AGGREGATION AND PREVENTS THROMBOSISNovember 2022December 2025Allow3821YesNo
17919171STABLE READY TO DILUTE FORMULATIONS OF CARFILZOMIBOctober 2022January 2026Abandon3901NoNo
17823018BCL-W Polypeptides and Mimetics for Treating or Preventing Chemotherapy-Induced Peripheral Neuropathy and Hearing LossAugust 2022June 2025Allow3421YesNo
17800453SUBCUTANEOUS ADMINISTRATION OF FACTOR VIIIAugust 2022January 2026Abandon4101NoNo
17810574GLYCOTARGETING THERAPEUTICSJuly 2022June 2025Abandon3521NoNo
17810565GLYCOTARGETING THERAPEUTICSJuly 2022May 2025Abandon3521NoNo
17810561GLYCOTARGETING THERAPEUTICSJuly 2022May 2025Abandon3521NoNo
17810573GLYCOTARGETING THERAPEUTICSJuly 2022June 2025Abandon3521NoNo
17845144COMPOSITIONS AND METHODS FOR TARGETING NUCLEAR IMPORT SHUTTLES AND TREATING INFLAMMATORY DISORDERSJune 2022April 2024Allow2211YesNo
17826659LIPOPROTEIN COMPLEXES AND MANUFACTURING AND USES THEREOFMay 2022March 2025Allow3321YesNo
17729290COMPOSITIONS AND METHOD FOR OPTIMIZED PEPTIDE VACCINES USING RESIDUE OPTIMIZATIONApril 2022January 2023Allow821YesNo
17727677METALLOENZYMES FOR BIOMOLECULAR RECOGNITION OF N-TERMINAL MODIFIED PEPTIDESApril 2022November 2025Abandon4342YesNo
17768514MRNAS ENCODING GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR FOR TREATING PARKINSON'S DISEASEApril 2022September 2025Abandon4201NoNo
17718906RECOMBINANT GLYCOSYLATED ECULIZUMAB AND ECULIZUMAB VARIANTSApril 2022November 2024Abandon3211NoNo
17696769CONTROLLED-RELEASE CNP AGONISTS WITH LOW NPR-C BINDINGMarch 2022January 2026Allow4631YesNo
17650975RECOMBINANT VECTOR FOR EXPRESSING TARGET PROTEIN IN PLANT CELLFebruary 2022October 2023Allow2001YesNo
17589588ANTIBIOTIC CANNABINOID-TERPENE FORMULATIONSJanuary 2022June 2023Allow1721YesNo
17626463EXCIPIENT FOR BIOTHERAPEUTICSJanuary 2022October 2025Abandon4501NoNo
17566249PEPTIDE AND METHOD FOR MANUFACTURING SAMEDecember 2021January 2025Abandon3701NoNo
17555374USE OF PROTEIN-BASED LONG-ACTING PREPARATION IN IMPROVING SEXUAL DYSFUNCTIONDecember 2021December 2025Abandon4821YesNo
17550098Cystatin C and Cystatin 9 to Treat Inflammation Caused by BacteriaDecember 2021May 2025Abandon4121YesNo
17619168PEPTIDES AND METHODS OF USE THEREOF IN TREATING UVEITISDecember 2021July 2025Allow4311YesNo
17643533CYCLIC PEPTIDE, CELL SCAFFOLD MATERIAL, CELL SEPARATING MATERIAL, AND MEDIUMDecember 2021March 2026Allow5121YesNo
17616877PEPTIDE INHIBITORS FOR THE INHIBITION OF HIV CAPSIDDecember 2021December 2025Allow4811YesNo
17527408WHEY PROTEIN MICELLES AGAINST MUSCLE ATROPHY AND SARCOPENIANovember 2021March 2025Abandon4030YesNo
17607247ANTIBIOTIC CANNABINOID-TERPENE FORMULATIONSOctober 2021October 2024Abandon3601NoNo
17605859COMPOSITIONS AND METHODS FOR SELECTIVE PROTEIN DEGRADATIONOctober 2021January 2026Allow5112NoNo
17604925SHORT SYNTHETIC PEPTIDES AND THEIR USES FOR TREATING RETINAL DEGENERATIVE DISEASES AND/OR TISSUE INJURIESOctober 2021September 2024Allow3511YesNo
17501486ALPHA-V BETA-6 INTEGRIN LIGANDS AND USES THEREOFOctober 2021May 2024Abandon3111YesNo
17401929PHARMACEUTICAL COMPOSITIONSAugust 2021March 2025Allow4321NoNo
17396947ARTIFICIAL SYNAPSESAugust 2021November 2024Abandon4051YesNo
17427751Peptide Ligands of the Gdnf Family Receptor A-Like (Gfral) ReceptorAugust 2021September 2025Allow4921YesNo
17383617PLANT MESSENGER PACKS ENCAPSULATING POLYPEPTIDES AND USES THEREOFJuly 2021February 2024Abandon3140YesNo
17421672PROCESS FOR SOLID-PHASE PEPTIDE SYNTHESIS AND DEVICEJuly 2021December 2025Allow5411YesNo
17366332PHARMACEUTICAL COMPOSITION COMPRISING A GLP-1 AGONIST, AN INSULIN AND METHIONINEJuly 2021July 2024Abandon3620NoNo
17352506INJECTABLE COMPOSITION FOR PREVENTING HAIR LOSS OR STIMULATING HAIR GROWTHJune 2021July 2024Allow3721YesNo
17350363CONTROLLED RELEASE PEPTIDE FORMULATIONSJune 2021October 2024Abandon4021NoNo
17348023METHOD AND FORMULATION FOR INHALATIONJune 2021August 2024Allow3821YesNo
17298512Modified GIP Peptide AnaloguesMay 2021March 2025Allow4611YesNo
17306435ENGINEERED PD-1 VARIANTSMay 2021October 2023Allow2911YesNo
17243096COMPOSITIONS AND METHOD FOR OPTIMIZED PEPTIDE VACCINES USING RESIDUE OPTIMIZATIONApril 2021December 2021Allow831YesNo
17202064IDENTIFICATION OF CHANNELRHODOPSIN-2 (CHR2) MUTATIONS AND METHODS OF USEMarch 2021May 2024Abandon3821NoNo
17197980MULTIFUNCTIONAL OPIOID RECEPTOR LIGANDS AND METHODS OF TREATING PAINMarch 2021April 2025Abandon4921NoNo
17165070METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING POLYCYSTIC OVARY SYNDROMEFebruary 2021January 2023Abandon2311NoNo
17264793ENGINEERED HEMICHANNELS, ENGINEERED VESICLES, AND USES THEREOFJanuary 2021February 2025Abandon4911NoNo
17141778PEPTIDES FOR USE IN PROMOTING TRANSPORT OF GLUCOSEJanuary 2021April 2025Allow5221YesYes
17142026TREATING INFLAMMATION USING LLP2A-BISPHOSPHONATE CONJUGATES AND MESENCHYMAL STEM CELLSJanuary 2021November 2025Allow5941NoNo
17138448PEPTIDIC TGF-BETA ANTAGONISTSDecember 2020June 2023Allow2911YesNo
17253333COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASEDecember 2020May 2024Abandon4101NoNo
17113957METHODS FOR DIAGNOSING AND ASSESSING RISK OF DEVELOPING GLOMERULOSCLEROSISDecember 2020June 2024Allow4221YesNo
15734957METHODS OF USE OF CD24 FOR THE PREVENTION AND TREATMENT OF LEUKEMIA RELAPSEDecember 2020October 2023Allow3411YesNo
17086786Q-PEPTIDE HYDROGEL PROMOTES IMMUNE MODULATION AND MACROPHAGE DIFFERENTIATIONNovember 2020May 2023Allow3111YesNo
17075295LONG-ACTING FATTY ACID-CONJUGATED GnRH DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAMEOctober 2020March 2022Abandon1721YesNo
17032540PREPARATION AND APPLICATION OF SURFACE DOUBLE MODIFIED HUMAN SERUM ALBUMIN AS TARGETING NANO DRUG CARRIERSeptember 2020June 2024Abandon4521NoNo
17041638ANTIMICROBIAL, BACTERIOPHAGE-DERIVED POLYPEPTIDES AND THEIR USE AGAINST GRAM-NEGATIVE BACTERIASeptember 2020July 2024Abandon4611NoNo
17041459Targeted Thrombolysis for Treatment of Microvascular ThrombosisSeptember 2020September 2024Abandon4811YesNo
17016473TREATMENT OF HMGB1-MEDIATED INFLAMMATIONSeptember 2020December 2022Allow2711YesNo
16997760LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENTAugust 2020September 2022Abandon2501NoNo
16987764MODULATION OF STRUCTURED POLYPEPTIDE SPECIFICITYAugust 2020April 2023Allow3221YesNo
16943822MULTIPARTICULATE GRANULATE COMPRISING INSULINJuly 2020December 2022Abandon2810NoNo
16943114ANTHELMINTIC DEPSIPEPTIDE COMPOUNDSJuly 2020February 2025Allow5541YesNo
16965814AFFINITY LIGANDS FOR ANTIBODY FC REGIONJuly 2020October 2024Allow5041NoNo
16937316COMPOUNDS USEFUL TO TREAT METABOLIC DISORDERSJuly 2020April 2025Abandon5741NoNo
16936177POLYPEPTIDES HAVING ANTI-SENESCENT EFFECTS AND USES THEREOFJuly 2020January 2025Allow5461YesNo
16911712GALACTOENGINEERED IMMUNOGLOBULIN 1 ANTIBODIESJune 2020August 2022Abandon2601NoNo
16910945PROPYLENE GLYCOL-CONTAINING PEPTIDE FORMULATIONS WHICH ARE OPTIMAL FOR PRODUCTION AND FOR USE IN INJECTION DEVICESJune 2020December 2022Abandon3031YesYes
16955896POLYMYXIN-BASED PHARMACEUTICAL COMPOSITION FOR TREATING INFECTIOUS DISEASESJune 2020August 2021Allow1421NoNo
16903107CYSTATIN C AND CYSTATIN 9 TO TREAT GUT INFLAMMATION CAUSED BY THERMAL INJURYJune 2020April 2024Allow4631YesNo
16899192MODULATION OF STRUCTURED POLYPEPTIDE SPECIFICITYJune 2020October 2023Allow4031YesNo
16768584PEPTIDE HORMONE WITH ONE OR MORE O-GLYCANSMay 2020May 2023Abandon3511YesNo
16881314USE OF THYMOSIN ALPHA FOR THE TREATMENT OF SEPSISMay 2020November 2022Abandon3011YesNo
16876683NOVEL MODULATORS OF MELANOCORTIN RECEPTORS FOR THE TREATMENT OF DEPRESSION AND ANXIETYMay 2020September 2022Allow2821YesNo
16763963USE OF CELL MEMBRANE-BOUND SIGNALING FACTORSMay 2020November 2024Abandon5431NoNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner D' AMBROSIO, THEA.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
4
Examiner Affirmed
4
(100.0%)
Examiner Reversed
0
(0.0%)
Reversal Percentile
0.8%
Lower than average

What This Means

With a 0.0% reversal rate, the PTAB affirms the examiner's rejections in the vast majority of cases. This reversal rate is in the bottom 25% across the USPTO, indicating that appeals face significant challenges here.

Strategic Value of Filing an Appeal

Total Appeal Filings
25
Allowed After Appeal Filing
0
(0.0%)
Not Allowed After Appeal Filing
25
(100.0%)
Filing Benefit Percentile
0.8%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 0.0% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

Appeals to PTAB face challenges. Ensure your case has strong merit before committing to full Board review.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner D' AMBROSIO, THEA - Prosecution Strategy Guide

Executive Summary

Examiner D' AMBROSIO, THEA works in Art Unit 1654 and has examined 305 patent applications in our dataset. With an allowance rate of 56.7%, this examiner allows applications at a lower rate than most examiners at the USPTO. Applications typically reach final disposition in approximately 38 months.

Allowance Patterns

Examiner D' AMBROSIO, THEA's allowance rate of 56.7% places them in the 17% percentile among all USPTO examiners. This examiner is less likely to allow applications than most examiners at the USPTO.

Office Action Patterns

On average, applications examined by D' AMBROSIO, THEA receive 2.73 office actions before reaching final disposition. This places the examiner in the 80% percentile for office actions issued. This examiner issues more office actions than most examiners, which may indicate thorough examination or difficulty in reaching agreement with applicants.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by D' AMBROSIO, THEA is 38 months. This places the examiner in the 29% percentile for prosecution speed. Prosecution timelines are slightly slower than average with this examiner.

Interview Effectiveness

Conducting an examiner interview provides a +63.0% benefit to allowance rate for applications examined by D' AMBROSIO, THEA. This interview benefit is in the 97% percentile among all examiners. Recommendation: Interviews are highly effective with this examiner and should be strongly considered as a prosecution strategy. Per MPEP § 713.10, interviews are available at any time before the Notice of Allowance is mailed or jurisdiction transfers to the PTAB.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 20.4% of applications are subsequently allowed. This success rate is in the 22% percentile among all examiners. Strategic Insight: RCEs show lower effectiveness with this examiner compared to others. Consider whether a continuation application might be more strategic, especially if you need to add new matter or significantly broaden claims.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 23.0% of cases where such amendments are filed. This entry rate is in the 30% percentile among all examiners. Strategic Recommendation: This examiner shows below-average receptiveness to after-final amendments. You may need to file an RCE or appeal rather than relying on after-final amendment entry.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 80.0% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 62% percentile among all examiners. Strategic Recommendation: Pre-appeal conferences show above-average effectiveness with this examiner. If you have strong arguments, a PAC request may result in favorable reconsideration.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 71.4% of appeals filed. This is in the 58% percentile among all examiners. Of these withdrawals, 90.0% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner shows above-average willingness to reconsider rejections during appeals. The mandatory appeal conference (MPEP § 1207.01) provides an opportunity for reconsideration.

Petition Practice

When applicants file petitions regarding this examiner's actions, 84.3% are granted (fully or in part). This grant rate is in the 86% percentile among all examiners. Strategic Note: Petitions are frequently granted regarding this examiner's actions compared to other examiners. Per MPEP § 1002.02(c), various examiner actions are petitionable to the Technology Center Director, including prematureness of final rejection, refusal to enter amendments, and requirement for information. If you believe an examiner action is improper, consider filing a petition.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 0.0% of allowed cases (in the 2% percentile). This examiner rarely makes examiner's amendments compared to other examiners. You should expect to make all necessary claim amendments yourself through formal amendment practice.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 1.2% of allowed cases (in the 62% percentile). This examiner issues Quayle actions more often than average when claims are allowable but formal matters remain (MPEP § 714.14).

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Prepare for rigorous examination: With a below-average allowance rate, ensure your application has strong written description and enablement support. Consider filing a continuation if you need to add new matter.
  • Expect multiple rounds of prosecution: This examiner issues more office actions than average. Address potential issues proactively in your initial response and consider requesting an interview early in prosecution.
  • Prioritize examiner interviews: Interviews are highly effective with this examiner. Request an interview after the first office action to clarify issues and potentially expedite allowance.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.