USPTO Examiner ANGELL JON E - Art Unit 1637

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
18899181Compositions and Methods of Generating Novel amiRNASeptember 2024April 2025Allow701NoNo
18782965METHOD FOR TREATING C. ACNES BACTERIA-ASSOCIATED DISEASESJuly 2024May 2025Allow1011YesNo
18361363Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses ThereofJuly 2023May 2024Allow911NoNo
18334632MODULATORS OF HSD17B13 EXPRESSIONJune 2023September 2023Allow310NoNo
18069543GENETIC MODIFICATION OF MAMMALIAN CELLS TO CONFER RESISTANCE TO CSF1R ANTAGONISTSDecember 2022May 2025Allow2930YesNo
18050760COMPOSITIONS AND METHODS FOR THE TREATMENT OF A BETA-CATENIN-ASSOCIATED DISEASE OR DISORDEROctober 2022March 2025Abandon2901NoNo
17916060Double Stranded RNA Specifically Inhibiting Expression of IL-23 and Pharmaceutical Composition Comprising SameSeptember 2022June 2025Allow3300NoNo
17818548TRANSIENT EXPRESSION SYSTEM FOR RNA, FOR VACCINATIONAugust 2022April 2025Abandon3211NoNo
17849513MONOCYTE AND MACROPHAGE BINDING APTAMERS AND THEIR APPLICATIONJune 2022September 2024Allow2720YesNo
17834988COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION OF ALPHA-1 ANTITRYPSINJune 2022August 2024Allow2720NoNo
17663377THERAPEUTIC INHIBITION OF LACTATE DEHYDROGENASE AND AGENTS THEREFORMay 2022April 2025Abandon3510NoNo
17697319LONG NON-CODING RNA IN CANCERMarch 2022April 2025Abandon3731NoNo
17671048REGULATION OF GENE EXPRESSION BY APTAMER-MEDIATED MODULATION OF ALTERNATIVE SPLICINGFebruary 2022May 2025Allow3911NoNo
17537005EXOSOMES AND MICRO-RIBONUCLEIC ACIDS FOR TISSUE REGENERATIONNovember 2021April 2024Allow2831NoNo
17515938MOLECULAR PATHOGENESIS OF MICROCARCINOMA OF THE THYROIDNovember 2021March 2025Allow4121YesNo
17441895OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCERSeptember 2021January 2024Allow2731NoNo
17293153ENCAPSULATED POLYNUCLEOTIDES AND METHODS OF USEMay 2021April 2025Abandon4701NoNo
17289767COMPOSITIONS AND METHODS FOR THE SYNTHESIS AND IDENTIFICATION OF COVALENT APTAMERSApril 2021May 2025Allow4812NoNo
17244835METHODS AND COMPOSITIONS FOR TREATMENT OF INTERFERON-RESISTANT TUMORSApril 2021May 2025Abandon4921NoYes
17276105REDUCING CD33 EXPRESSION TO SELECTIVELY PROTECT THERAPEUTIC CELLSMarch 2021May 2025Allow5011NoNo
17264727METHOD OF IDENTIFYING OR PRODUCING AN APTAMER FOR A DENATURED PEPTIDE OR PROTEINJanuary 2021October 2024Abandon4520YesNo
17156348Treatment Of Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis, And Liver FibrosisJanuary 2021December 2024Abandon4721NoNo
17258879Compositions and Methods for Treating EndometriosisJanuary 2021December 2024Allow4741NoNo
17121835COMPOSITIONS AND METHODS FOR NUCLEIC ACID TRANSFERDecember 2020April 2025Allow5221NoNo
17251200THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASEDecember 2020December 2024Abandon4801NoNo
17052945EXTRAHEPATIC DELIVERYNovember 2020October 2024Allow4831YesNo
16968904GENE EDITING USING HOMOLOGY-INDEPENDENT UNIVERSAL GENOME ENGINEERING TECHNOLOGYAugust 2020February 2025Allow5422NoNo
16647241RNA moleculesMarch 2020May 2025Allow6031YesYes
16371026PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING MICRORNA AS ACTIVE INGREDIENTMarch 2019February 2020Allow1110YesNo
16316378COLLAGEN-MIMETIC PEPTIDE MEDIATED DELIVERY OF NUCLEIC ACID CARRIERS FOR EFFICIENT DELIVERY FROM COLLAGENJanuary 2019August 2024Allow6031NoNo
15878176MIR-92 INHIBITORS AND USES THEREOFJanuary 2018December 2018Allow1101YesNo
15553097PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING MICRORNA AS ACTIVE INGREDIENTAugust 2017April 2019Allow2021YesNo
15675877MIRNAS AS NOVEL THERAPEUTIC ADJUVANTS AND BIOMARKERS FOR THE PROGNOSIS AND TREATMENT OF DRUG RESISTANT BREAST CANCERSAugust 2017August 2019Allow2421YesNo
15514043CDC25A INHIBITOR FOR THE TREATMENT OF DRUG RESISTANT CANCER OR FOR THE PREVENTION OF TUMOR RELAPSEMarch 2017September 2018Allow1711NoNo
14613657LENTIVIRAL TRIPLEX DNA, AND VECTORS AND RECOMBINANT CELLS CONTAINING LENTIVIRAL TRIPLEX DNAFebruary 2015April 2019Allow5121YesYes
14414393COMBINATION THERAPY IIIJanuary 2015August 2018Allow4321NoYes
13941262Methods and Compositions for RNAi Mediated Inhibition of Gene Expression in MammalsJuly 2013September 2019Allow6071YesYes
13876103AXL RECEPTOR TYROSINE KINASE APTAMER INHIBITOR FOR USE IN THERAPYMarch 2013January 2014Allow1011NoNo
13656195TREATMENT OF TUMORS WITH GENETICALLY ENGINEERED HERPES VIRUSOctober 2012March 2014Allow1711YesNo
13651123RTP801L SIRNA COMPOUNDS AND METHODS OF USE THEREOFOctober 2012August 2013Allow1000NoNo
13266219COMPOSITIONS AND METHODS FOR THERAPY OF MACULAR DEGENERATIONMarch 2012January 2013Allow1500NoNo
13359271OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNASJanuary 2012July 2013Allow1811NoNo
13301147LENTIVIRAL TRIPLEX DNA, AND VECTORS AND RECOMBINANT CELLS CONTAINING LENTIVIRAL TRIPLEX DNANovember 2011April 2013Allow1721YesNo
13301204LENTIVIRAL TRIPLEX DNA, AND VECTORS AND RECOMBINANT CELLS CONTAINING LENTIVIRAL TRIPLEX DNANovember 2011April 2013Allow1721YesNo
13296448METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING MIR-29ANovember 2011September 2012Allow1010YesNo
13296291METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING MIR-103-2November 2011September 2012Allow1010YesNo
13296500METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING MIR-10ANovember 2011September 2012Allow1010YesNo
13296371METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING MIR-203November 2011September 2012Allow1110YesNo
13295280METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING LET-7GNovember 2011September 2012Allow1010YesNo
13295209METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING MIR-181BNovember 2011September 2012Allow1010YesNo
13295440METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING MIR-16BNovember 2011September 2012Allow1010YesNo
13295692METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING MIR-106ANovember 2011September 2012Allow1010YesNo
13059862MICRO RNA (MiRNA) AND NEUROFIBROMATOSIS TYPE 1: A ROLE IN DIAGNOSIS AND THERAPYMay 2011June 2013Allow2811NoNo
13049011PARAMYXOVIRUS VECTOR ENCODING ANGIOGENESIS GENE AND USE THEREOFMarch 2011March 2012Allow1210NoNo
13013758METHOD USEFUL FOR HCV RNA898 INFECTION.January 2011March 2012Allow1301NoNo
12973681METHODS FOR NEUTRALIZING ANTHRAX OR ANTHRAX SPORESDecember 2010October 2012Allow2221YesNo
12811306RNA INTERFERENCE FOR THE TREATMENT OF HEART FAILUREDecember 2010November 2012Allow2911YesNo
12921339Pharmaceutical Compositions for Treatment of MicroRNA Related DiseasesNovember 2010November 2012Allow2622NoNo
12927144SIRNA TARGETING TIE-2November 2010August 2012Allow2111NoNo
12924225APTAMER AND DETECTION METHOD FOR C-REACTIVE PROTEINSeptember 2010August 2013Allow3511NoNo
12807526SIRNA TARGETING PROTO-ONCOGENE METSeptember 2010March 2012Allow1901NoNo
12806570SIRNA TARGETING BETA SECRETASE (BACE)August 2010April 2011Allow701NoNo
12856954COMPOSITIONS AND METHODS FOR TREATING PANCREATIC CANCERAugust 2010October 2012Allow2621NoNo
12802443TREATMENT OF TUMORS WITH GENETICALLY ENGINEERED HERPES VIRUSJune 2010July 2012Allow2521NoNo
12774566POLYCYCLIC SUGAR SURROGATE-CONTAINING OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONMay 2010November 2011Allow1820YesNo
12671580METHODS FOR REVERTING METHYLATION BY TARGETING METHYLTRANSFERASESMarch 2010November 2012Allow3311NoNo
12723466MULTIPLE PROMOTER EXPRESSION CASSETTES FOR SIMULTANEOUS DELIVERY OF RNAI AGENTSMarch 2010June 2012Allow2700NoNo
12714264VECTORFebruary 2010September 2011Allow1810NoNo
12703158PROTEASE SENSITIVITY EXPRESSION SYSTEMFebruary 2010April 2012Allow2611NoNo
12640148SIRNA USEFUL TO SUPPRESS EXPRESSION OF EIF-5A1December 2009April 2012Allow2811NoNo
12641159ANTISENSE COMPOSITIONS AND METHODS FOR MODULATING CONTACT HYPERSENSITIVITY OR CONTACT DERMATITISDecember 2009July 2013Allow4321NoNo
12653402SIRNA TARGETING BETA SECRETASE (BACE)December 2009June 2010Allow601NoNo
12590097SIRNA TARGETING PROTO-ONCOGENE METNovember 2009June 2010Allow710NoNo
12531752RNA INTERFERENCE MEDIATED INACTIVATION OF HEPATITIS B VIRUS IN A SUBJECTSeptember 2009March 2012Allow3011YesNo
12586167SIRNA TARGETING TIE-2September 2009August 2010Allow1111NoNo
12086109MICRORNAS THAT REGULATE MUSCLE CELL PROLIFERATION AND DIFFERENTIATIONSeptember 2009January 2013Allow5521NoNo
12584705SIRNA TARGETING SURVIVINSeptember 2009June 2010Allow911NoNo
12555609METHOD OF USING GOLD NANORODS-SIRNA COMPLEXESSeptember 2009June 2011Allow2111NoNo
12549110TREATMENT OF NEURODEGENERATIVE DISEASE THROUGH INTRACRANIAL DELIVERY OF SIRNAAugust 2009October 2011Allow2621NoNo
12545774HUMAN TELOMERASE CATALYTIC SUBUNITAugust 2009April 2012Allow3110NoNo
12471166NOVEL INHIBITORS OF RETROVIRAL REVERSE TRANSCRIPTACEMay 2009May 2011Allow2411NoNo
12295960PHARMACEUTICAL COMPOSITION COMPRISING ANTI-MIRNA ANTISENSE OLIGONUCLEOTIDEMarch 2009January 2012Allow3911NoNo
12400625PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF MICRORNA RELATED DISEASESMarch 2009September 2012Allow4231YesNo
12391028MICRO-RNAS THAT MODULATE SMOOTH MUSCLE PROLIFERATION AND DIFFERENTIATION AND USES THEREOFFebruary 2009March 2011Allow2511NoNo
12388856CHIMERIC OLIGOMERIC COMPOUNDS COMPRISING ALTERNATING REGIONS OF NORTHERN AND SOUTHERN CONFORMATIONAL GEOMETRYFebruary 2009March 2014Allow6032NoNo
12372899TREATING HEPATOMA BY INHIBITING EXPRESSION OF GANKYRINFebruary 2009December 2010Allow2220YesNo
12376940METHOD FOR TREATMENT OF HUNTINGTON'S DISEASE THROUGH INTRACRANIAL DELIVERY OF SIRNAFebruary 2009March 2011Allow2520YesNo
12346940METHOD FOR INHIBITING THE ACTIVITY OF MIR-155December 2008October 2011Allow3311NoNo
12066903METHOD FOR DETERMINING IMMUNOSTIMULATORY ACTIVITY OF RNA OLIGONUCLEOTIDESNovember 2008August 2011Allow4112NoNo
12092780INHIBITION OF AUTOPHAGY GENES IN CANCER CHEMOTHERAPYOctober 2008August 2011Allow3911YesNo
12192356PRIMER-EXTENSION BASED METHOD FOR THE GENERATION OF siRNA/miRNA EXPRESSION VECTORSAugust 2008May 2014Allow6021NoNo
12183354COMPOSITIONS AND METHODS FOR INHIBITING CAR GENE EXPRESSION BY RNA INTERFERENCEJuly 2008June 2010Allow2311YesNo
10593597MATERIALS AND METHODS FOR TREATMENT OF CANCERJune 2008August 2010Allow4721YesNo
12081790TRANSCRIPTIONAL REPRESSION OF SODIUM-IODIDE SYMPORTER IN THYROID CARCINOMAApril 2008June 2012Allow5021YesNo
12077504NUCLEIC ACIDS ENCODING PRO6308 POLYPEPTIDES AND RELATED VECTORS AND HOST CELLSMarch 2008June 2010Allow2721YesNo
11666001TOPICAL ADMINISTRATIONS OF ANTISENSE COMPOUNDS TO VLA-4 FOR THE TREATMENT OF RESPIRATORY CONDITIONSJanuary 2008February 2014Allow6031NoNo
11980263SIRNA TARGETING PROTO-ONCOGENE METOctober 2007August 2009Allow2101NoNo
11821562METHODS OF PROTEIN DESTABILIZATION AND USES THEREOFJune 2007June 2010Allow3611NoNo
11719517COMPOSITION COMPRISING DOUBLE STRANDED RNA THAT INHIBITS EXPRESSION OF NEU3 AND METHOD FOR TREATING CANCERMay 2007May 2010Allow3611YesNo
11573269INHIBITORS OF L1 AND ADAM10 FOR THE TREATMENT OF CARCINOMASMay 2007March 2011Allow6012YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner ANGELL, JON E.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
3
Examiner Affirmed
1
(33.3%)
Examiner Reversed
2
(66.7%)
Reversal Percentile
85.3%
Higher than average

What This Means

With a 66.7% reversal rate, the PTAB has reversed the examiner's rejections more often than affirming them. This reversal rate is in the top 25% across the USPTO, indicating that appeals are more successful here than in most other areas.

Strategic Value of Filing an Appeal

Total Appeal Filings
40
Allowed After Appeal Filing
8
(20.0%)
Not Allowed After Appeal Filing
32
(80.0%)
Filing Benefit Percentile
21.3%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 20.0% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

Appeals to PTAB show good success rates. If you have a strong case on the merits, consider fully prosecuting the appeal to a Board decision.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner ANGELL, JON E - Prosecution Strategy Guide

Executive Summary

Examiner ANGELL, JON E works in Art Unit 1637 and has examined 170 patent applications in our dataset. With an allowance rate of 93.5%, this examiner allows applications at a higher rate than most examiners at the USPTO. Applications typically reach final disposition in approximately 39 months.

Allowance Patterns

Examiner ANGELL, JON E's allowance rate of 93.5% places them in the 81% percentile among all USPTO examiners. This examiner is more likely to allow applications than most examiners at the USPTO.

Office Action Patterns

On average, applications examined by ANGELL, JON E receive 2.72 office actions before reaching final disposition. This places the examiner in the 90% percentile for office actions issued. This examiner issues more office actions than most examiners, which may indicate thorough examination or difficulty in reaching agreement with applicants.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by ANGELL, JON E is 39 months. This places the examiner in the 9% percentile for prosecution speed. Applications take longer to reach final disposition with this examiner compared to most others.

Interview Effectiveness

Conducting an examiner interview provides a +8.3% benefit to allowance rate for applications examined by ANGELL, JON E. This interview benefit is in the 41% percentile among all examiners. Recommendation: Interviews provide a below-average benefit with this examiner.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 25.6% of applications are subsequently allowed. This success rate is in the 31% percentile among all examiners. Strategic Insight: RCEs show below-average effectiveness with this examiner. Carefully evaluate whether an RCE or continuation is the better strategy.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 44.2% of cases where such amendments are filed. This entry rate is in the 61% percentile among all examiners. Strategic Recommendation: This examiner shows above-average receptiveness to after-final amendments. If your amendments clearly overcome the rejections and do not raise new issues, consider filing after-final amendments before resorting to an RCE.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 200.0% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 92% percentile among all examiners. Strategic Recommendation: Pre-appeal conferences are highly effective with this examiner compared to others. Before filing a full appeal brief, strongly consider requesting a PAC. The PAC provides an opportunity for the examiner and supervisory personnel to reconsider the rejection before the case proceeds to the PTAB.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 91.7% of appeals filed. This is in the 82% percentile among all examiners. Of these withdrawals, 78.8% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner frequently reconsiders rejections during the appeal process compared to other examiners. Per MPEP § 1207.01, all appeals must go through a mandatory appeal conference. Filing a Notice of Appeal may prompt favorable reconsideration even before you file an Appeal Brief.

Petition Practice

When applicants file petitions regarding this examiner's actions, 62.7% are granted (fully or in part). This grant rate is in the 80% percentile among all examiners. Strategic Note: Petitions are frequently granted regarding this examiner's actions compared to other examiners. Per MPEP § 1002.02(c), various examiner actions are petitionable to the Technology Center Director, including prematureness of final rejection, refusal to enter amendments, and requirement for information. If you believe an examiner action is improper, consider filing a petition.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 21.8% of allowed cases (in the 99% percentile). Per MPEP § 1302.04, examiner's amendments are used to place applications in condition for allowance when only minor changes are needed. This examiner frequently uses this tool compared to other examiners, indicating a cooperative approach to getting applications allowed. Strategic Insight: If you are close to allowance but minor claim amendments are needed, this examiner may be willing to make an examiner's amendment rather than requiring another round of prosecution.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 2.5% of allowed cases (in the 68% percentile). This examiner issues Quayle actions more often than average when claims are allowable but formal matters remain (MPEP § 714.14).

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Expect multiple rounds of prosecution: This examiner issues more office actions than average. Address potential issues proactively in your initial response and consider requesting an interview early in prosecution.
  • Request pre-appeal conferences: PACs are highly effective with this examiner. Before filing a full appeal brief, request a PAC to potentially resolve issues without full PTAB review.
  • Appeal filing as negotiation tool: This examiner frequently reconsiders rejections during the appeal process. Filing a Notice of Appeal may prompt favorable reconsideration during the mandatory appeal conference.
  • Plan for extended prosecution: Applications take longer than average with this examiner. Factor this into your continuation strategy and client communications.
  • Examiner cooperation: This examiner frequently makes examiner's amendments to place applications in condition for allowance. If you are close to allowance, the examiner may help finalize the claims.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.