USPTO Examiner WHITEMAN BRIAN A - Art Unit 1636

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
18430378METHOD FOR PRECISELY PREPARING CIRCULAR RNA WITH ANABAENA INTRON SELF-CLEAVING RIBOZYMEFebruary 2024August 2024Allow610NoNo
18483663COMPOUNDS AND METHODS FOR MODULATING SCN2AOctober 2023October 2024Allow1220NoNo
18320948COMPOSITIONS AND METHODS FOR MODULATING COMPLEMENT FACTOR B EXPRESSIONMay 2023March 2025Allow2200NoNo
18185929CHEMICALLY MODIFIED SINGLE-STRANDED RNA-EDITING OLIGONUCLEOTIDESMarch 2023November 2024Allow2020YesNo
18176868BUILDING DESIGNER RNA NANO-STRUCTURES FOR SYNTHETIC BIOLOGY APPLICATIONSMarch 2023June 2025Allow2721YesNo
18145218RNAi Agents And Compositions for Inhibiting Expression of Apolipoprotein C-III (APOC3)December 2022March 2025Allow2710NoNo
18067686TETRACYCLINE-INDUCIBLE EXPRESSION SYSTEMDecember 2022March 2025Allow2710YesNo
17924966OPA1 ANTISENSE OLIGOMERS FOR TREATMENT OF CONDITIONS AND DISEASESNovember 2022March 2025Allow2811NoNo
17985683MATERIALS AND METHODS FOR THE DELIVERY OF THERAPEUTIC NUCLEIC ACIDS TO TISSUESNovember 2022April 2025Abandon2911NoNo
18054264SYSTEMIC DELIVERY OF MYOSTATIN SHORT INTERFERING NUCLEIC ACIDS (SINA) CONJUGATED TO A LIPOPHILIC MOIETYNovember 2022April 2025Abandon2910NoNo
17978295SIRNA THERAPY FOR TRANSTHYRETIN (TTR) RELATED OCULAR AMYLOIDOSISNovember 2022March 2025Abandon2910NoNo
17978490MICRORNA-BASED LOGIC GATES AND USES THEREOFNovember 2022February 2025Allow2710NoNo
17972299IN VITRO NEPHROTOXICITY SCREENING ASSAYOctober 2022March 2025Abandon2810NoNo
18047723COMPOSITIONS AND METHODS OF TREATING HUNTINGTON'S DISEASEOctober 2022March 2025Abandon2910YesNo
18046108RNAi Agents for Inhibiting Expression of Xanthine Dehydrogenase (XDH), Pharmaceutical Compositions Thereof, and Methods of UseOctober 2022March 2025Abandon2910NoNo
17895615METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF KRAS BY ASYMMETRIC DOUBLE-STRANDED RNAAugust 2022January 2025Abandon2901NoNo
17888084miRNA AS BIOMARKER FOR PARKINSON'S DISEASE AND DIAGNOSTIC KIT USING SAMEAugust 2022June 2025Abandon3421YesNo
17813576NUCLEIC ACID MOLECULE FOR REDUCTION OF PAPD5 AND PAPD7 mRNA FOR TREATING HEPATITIS B INFECTIONJuly 2022January 2025Allow3000NoNo
17863984METHODS RELATING TO CIRCULATING TUMOR CELL CLUSTERS AND THE TREATMENT OF CANCERJuly 2022December 2024Abandon2901NoNo
17864199RIG-I AGONISTS AND METHODS USING SAMEJuly 2022June 2025Abandon3511NoNo
17811593PHOSPHORYLATION-BASED MIRNA SENSORJuly 2022February 2025Allow3110NoNo
17848850MODIFIED RNAi AGENTSJune 2022December 2024Allow3010NoNo
17847770NUCLEIC ACID, COMPOSITION AND CONJUGATE COMPRISING THE SAME, PREPARATION METHOD AND USE THEREOFJune 2022April 2025Allow3420NoNo
17806879DEAMINASE-BASED RNA SENSORSJune 2022September 2024Allow2731NoNo
17804280EXON SKIPPING OLIGOMER CONJUGATES FOR MUSCULAR DYSTROPHYMay 2022January 2025Allow3210NoNo
17727263OLIGONUCLEOTIDE PROBES AND USES THEREOFApril 2022December 2024Abandon3110NoNo
17725102DYNAMIC PHARMACOKINETIC-MODIFYING ANCHORSApril 2022August 2024Allow2821YesNo
17705609CELL-SPECIFIC EXPRESSION OF modRNAMarch 2022October 2024Allow3020NoNo
17706522COMPOSITIONS AND PROCESSES FOR TARGETED DELIVERY, EXPRESSION AND MODULATION OF CODING RIBONUCLEIC ACIDS IN TISSUEMarch 2022November 2024Allow3231YesNo
17688985HIGH PERFORMANCE MULTI-INPUT MICRORNA SENSORS AND USES THEREOFMarch 2022January 2025Allow3420NoNo
17678433ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF LEBER CONGENITAL AMAUROSISFebruary 2022July 2024Allow2810YesNo
17580269O-METHYL RICH FULLY STABILIZED OLIGONUCLEOTIDESJanuary 2022January 2025Allow3520NoYes
17549817IMMUNOTHERAPEUTIC CONSTRUCTS AND METHODS OF THEIR USEDecember 2021April 2025Abandon4021YesYes
17497571Bruton's Tyrosine Kinase as Anti-Cancer Drug TargetOctober 2021December 2024Abandon3811NoNo
17319744SARNA COMPOSITIONS AND METHODS OF USEMay 2021March 2025Allow4621NoYes
17293065CXCL8 Binding Nucleic AcidsMay 2021March 2025Allow4610YesNo
17308572CRISPR-CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE THEREOFMay 2021June 2025Abandon4920NoNo
17213852SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES WITH INCREASED STABILITYMarch 2021October 2023Allow3131YesYes
17280454RECOMBINANT TYPE I CRISPR-CAS SYSTEM AND USES THEREOF FOR SCREENING FOR VARIANT CELLSMarch 2021September 2024Allow4220NoNo
17181142METHOD FOR DETERMINING DECREASE IN FUNCTIONS OF HIPPOCAMPUS BY USING CORRELATION BETWEEN MICRO RNA AND NMDA RECEPTOR, METHOD FOR INHIBITING DECREASE IN FUNCTIONS, AND METHOD FOR SCREENING FOR INHIBITORS OF DECREASE IN FUNCTIONSFebruary 2021March 2025Allow4920NoNo
17177747COMPOSITIONS AND METHODS FOR INDUCED TISSUE REGENERATION IN MAMMALIAN SPECIESFebruary 2021April 2024Allow3831YesNo
17252050APPLICATION OF NIEMANN-PICK C1 PROTEIN IN DIAGNOSIS AND TREATMENT OF CANCERDecember 2020April 2025Allow5231YesNo
17115791SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIESDecember 2020November 2024Abandon4711NoNo
17084460Sequence Multiplicity Within Spherical Nucleic AcidsOctober 2020April 2025Allow5331NoNo
17072056COMPOSITIONS AND METHODS FOR TREATING SPINAL MUSCULAR ATROPHYOctober 2020January 2025Abandon5111NoNo
16967102APPLICATION OF APTAMER IN RECOGNITION AND BINDING OF ALKALINE PHOSPHATASE HETERODIMER OR TUMOR DETECTIONAugust 2020March 2025Allow5521NoNo
16966840METHODS FOR THERAPEUTIC USE OF EXOSOMES AND Y-RNASJuly 2020July 2024Allow4720YesNo
16961578ANTISENSE OLIGONUCLEOTIDES TARGETING ALPHA-SYNUCLEIN AND USES THEREOFJuly 2020October 2024Allow5220NoNo
16878409TARGETED AUGMENTATION OF NUCLEAR GENE OUTPUTMay 2020September 2022Allow2831NoYes
16870960MODIFIED PLURIPOTENT CELLSMay 2020October 2024Allow5341YesNo
16642244METHODS AND COMPOSITIONS FOR APTAMER-DRIVEN SURFACE FORMULATION OF SELF-FORMING POLYNUCLEOTIDE NANOPARTICLESFebruary 2020November 2024Abandon5611NoNo
16494279CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS FOR VIRUS DETECTIONSeptember 2019September 2024Allow6051YesNo
16316298INTRACELLULAR KINASE ASSOCIATED WITH RESISTANCE AGAINST ANTI-TUMOUR IMMUNE RESPONSES, AND USES THEREOFJanuary 2019February 2025Allow6041YesYes
16100906METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATIONAugust 2018May 2019Allow1000NoNo
15886386NOTCH 1 SPECIFIC siRNA MOLECULEFebruary 2018January 2020Allow2411NoNo
15743988METHOD OF PRODUCING RNA FROM CIRCULAR DNA AND CORRESPONDING TEMPLATE DNAJanuary 2018July 2019Allow1811NoNo
15814353IN VIVO PRODUCTION OF SMALL INTERFERING RNAS THAT MEDIATE GENE SILENCINGNovember 2017March 2020Allow2830YesYes
15533965Compositions and methods for Editing Nucleic Acids in Cells Utilizing OligonucleotidesSeptember 2017March 2025Allow6061NoNo
15685983INHIBITORS OF MYH7B AND USES THEREOFAugust 2017July 2018Allow1101NoNo
15543728NUCLEIC ACID NANOSTRUCTURES WITH CORE MOTIFSJuly 2017February 2020Allow3121NoNo
15543513METHOD FOR SELECTING SKELETAL MUSCLE PROGENITOR CELLJuly 2017January 2020Allow3030YesNo
15601170BIOTIN COMPLEXES FOR TREATMENT AND DIAGNOSIS OF ALZHEIMER'S DISEASEMay 2017August 2019Allow2721YesNo
15383600MODULATION OF HUMAN CYTOMEGALOVIRUS REPLICATION BY MICRO-RNA 132 (miR132), MICRO-RNA 145 (miR145) AND MICRO-RNA 212 (miR212)December 2016October 2018Allow2221NoNo
15305058METHODS FOR ENHANCING OR DECREASING THE LEVELS OF MIR124 AND MIR29 IN SUBJECTS WITH MUSCULAR DYSTROPHYOctober 2016August 2018Allow2221YesNo
15034529USE OF IKK EPSILON INHIBITORS TO ACTIVATE NFAT AND T CELL RESPONSEMay 2016March 2019Allow3421NoNo
14783078Mutations in DSTYK Cause Dominant Urinary Tract MalformationsOctober 2015September 2018Allow3511NoNo
14761083METHOD FOR INHIBITING TUMOR GROWTH THROUGH RNA-INTERFERENCE USING LIPOSOMALLY ASSOCIATED CDC20 siRNAJuly 2015October 2018Allow3941YesNo
14012302METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULESAugust 2013March 2014Allow610NoNo
13470154TREATMENT OF INFLUENZAMay 2012December 2013Allow1921YesNo
13457394MODIFIED SIRNA MOLECULES AND USES THEREOFApril 2012April 2013Allow1210NoNo
13323461PROINFLAMMATORY NUCLEIC ACIDSDecember 2011July 2013Allow1910NoNo
13290609SYNTHETIC GENES AND GENETIC CONSTRUCTSNovember 2011December 2012Allow1410NoNo
13274730METHOD FOR DIAGNOSING ACUTE LYMPHOMIC LEUKEMIA (ALL) USING MIR-146aOctober 2011November 2012Allow1310NoNo
13274719METHOD FOR DIAGNOSING ACUTE LYMPHOMIC LEUKEMIA (ALL) USING MIR-221October 2011November 2012Allow1310YesNo
13274737METHOD FOR DIAGNOSING ACUTE LYMPHOMIC LEUKEMIA (ALL) USING MIR-125BOctober 2011October 2012Allow1210YesNo
13274724METHOD FOR DIAGNOSING ACUTE LYMPHOMIC LEUKEMIA (ALL) USING MIR-222October 2011October 2012Allow1210YesNo
13269407MIR-182-, MIR-191, MIR-199A-BASED METHODS FOR THE DIAGNOSIS AND PROGNOSIS OF ACUTE MYELOID LEUKEMIA (AML)October 2011January 2013Allow1520NoNo
13269410MIR-25-BASED METHODS FOR THE DIAGNOSIS AND PROGNOSIS OF ACUTE MYELOID LEUKEMIA (AML)October 2011November 2012Allow1320NoNo
13269404MIR-29-BASED METHODS FOR THE DIAGNOSIS AND PROGNOSIS OF ACUTE MYELOID LEUKEMIA (AML)October 2011May 2013Allow1930NoNo
13245180HUMAN SERUM ALBUMIN-SIRNA NANO-SIZED CARRIER SYSTEMSeptember 2011April 2013Allow1910NoNo
13084772STRESS-RESPONSIVE INDUCTION OF A THERAPEUTIC AGENT AND METHODS OF USEApril 2011October 2012Abandon1810NoNo
13039100INHIBITION OF VIRAL GENE EXPRESSION USING SMALL INTERFERING RNAMarch 2011January 2013Allow2321NoNo
13031522IN VIVO PRODUCTION OF SMALL INTERFERING RNAS THAT MEDIATE GENE SILENCINGFebruary 2011March 2012Allow1310NoNo
12947865RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF PIK3CA EXPRESSIONNovember 2010August 2012Allow2100NoNo
12858892THERAPEUTIC AGENT FOR NEUROBLASTOMA TARGETING ARID3BAugust 2010October 2011Allow1400NoNo
12835333NUCLEOLAR TARGETING OF THERAPEUTICS AGAINST HIVJuly 2010March 2012Allow2030NoNo
12799758SIRNA TARGETING INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4(IRAK4)April 2010March 2012Allow2321NoNo
12305637RESTORATION OF HEARING LOSSApril 2010March 2012Allow3921NoNo
12666738TREATMENT OF INFLUENZAMarch 2010February 2012Allow2611NoNo
12704226ENIGMA-MDM2 INTERACTION AND USES THEREOFFebruary 2010November 2011Allow2111NoNo
12700009COMPOSITIONS AND METHODS FOR MODULATING GHRELIN-MEDIATED CONDITIONSFebruary 2010August 2012Allow3021NoNo
12651810EXPRESSED PSEUDOGENE REGULATES GENE EXPRESSIONJanuary 2010September 2011Allow2011NoNo
12649141HYPOXIA INDUCIBLE VEGF PLASMID FOR ISCHEMIC DISEASEDecember 2009April 2011Allow1510NoNo
12644674NRIP1 REGULATION OF APOLIPOPROTEIN A1December 2009April 2012Allow2801NoNo
12590252SIRNA TARGETING AMYLOID BETA (A4) PRECURSOR PROTEIN (APP)November 2009June 2010Allow801NoNo
12579323SHORT HAIRPIN RNAS FOR INHIBITION OF GENE EXPRESSIONOctober 2009May 2012Allow3121NoNo
12579259FAS/FASL OR OTHER DEATH RECEPTOR TARGETED METHODS AND COMPOSITIONS FOR KILLING TUMOR CELLSOctober 2009June 2011Allow2011YesNo
12583073METHODS AND COMPOSITIONS FOR DETECTING AND TREATING RETINAL DISEASES BASED ON METARGIDIN (ADAM-15)August 2009December 2011Allow2812NoNo
12299607COMPOUNDS AND METHODS FOR MODULATING EXPRESSION OF PTP1BJuly 2009July 2013Allow5632YesNo
12462029SIRNA TARGETING INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 (IRAK4)July 2009April 2010Allow901NoNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner WHITEMAN, BRIAN A.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
1
Examiner Affirmed
1
(100.0%)
Examiner Reversed
0
(0.0%)
Reversal Percentile
0.5%
Lower than average

What This Means

With a 0.0% reversal rate, the PTAB affirms the examiner's rejections in the vast majority of cases. This reversal rate is in the bottom 25% across the USPTO, indicating that appeals face significant challenges here.

Strategic Value of Filing an Appeal

Total Appeal Filings
31
Allowed After Appeal Filing
6
(19.4%)
Not Allowed After Appeal Filing
25
(80.6%)
Filing Benefit Percentile
21.0%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 19.4% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

Appeals to PTAB face challenges. Ensure your case has strong merit before committing to full Board review.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner WHITEMAN, BRIAN A - Prosecution Strategy Guide

Executive Summary

Examiner WHITEMAN, BRIAN A works in Art Unit 1636 and has examined 200 patent applications in our dataset. With an allowance rate of 90.5%, this examiner has an above-average tendency to allow applications. Applications typically reach final disposition in approximately 34 months.

Allowance Patterns

Examiner WHITEMAN, BRIAN A's allowance rate of 90.5% places them in the 72% percentile among all USPTO examiners. This examiner has an above-average tendency to allow applications.

Office Action Patterns

On average, applications examined by WHITEMAN, BRIAN A receive 2.31 office actions before reaching final disposition. This places the examiner in the 79% percentile for office actions issued. This examiner issues more office actions than most examiners, which may indicate thorough examination or difficulty in reaching agreement with applicants.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by WHITEMAN, BRIAN A is 34 months. This places the examiner in the 22% percentile for prosecution speed. Applications take longer to reach final disposition with this examiner compared to most others.

Interview Effectiveness

Conducting an examiner interview provides a +7.2% benefit to allowance rate for applications examined by WHITEMAN, BRIAN A. This interview benefit is in the 37% percentile among all examiners. Recommendation: Interviews provide a below-average benefit with this examiner.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 29.6% of applications are subsequently allowed. This success rate is in the 47% percentile among all examiners. Strategic Insight: RCEs show below-average effectiveness with this examiner. Carefully evaluate whether an RCE or continuation is the better strategy.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 57.8% of cases where such amendments are filed. This entry rate is in the 80% percentile among all examiners. Strategic Recommendation: This examiner is highly receptive to after-final amendments compared to other examiners. Per MPEP § 714.12, after-final amendments may be entered "under justifiable circumstances." Consider filing after-final amendments with a clear showing of allowability rather than immediately filing an RCE, as this examiner frequently enters such amendments.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 0.0% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 0% percentile among all examiners. Note: Pre-appeal conferences show limited success with this examiner compared to others. While still worth considering, be prepared to proceed with a full appeal brief if the PAC does not result in favorable action.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 96.4% of appeals filed. This is in the 84% percentile among all examiners. Of these withdrawals, 92.6% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner frequently reconsiders rejections during the appeal process compared to other examiners. Per MPEP § 1207.01, all appeals must go through a mandatory appeal conference. Filing a Notice of Appeal may prompt favorable reconsideration even before you file an Appeal Brief.

Petition Practice

When applicants file petitions regarding this examiner's actions, 63.5% are granted (fully or in part). This grant rate is in the 80% percentile among all examiners. Strategic Note: Petitions are frequently granted regarding this examiner's actions compared to other examiners. Per MPEP § 1002.02(c), various examiner actions are petitionable to the Technology Center Director, including prematureness of final rejection, refusal to enter amendments, and requirement for information. If you believe an examiner action is improper, consider filing a petition.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 25.5% of allowed cases (in the 100% percentile). Per MPEP § 1302.04, examiner's amendments are used to place applications in condition for allowance when only minor changes are needed. This examiner frequently uses this tool compared to other examiners, indicating a cooperative approach to getting applications allowed. Strategic Insight: If you are close to allowance but minor claim amendments are needed, this examiner may be willing to make an examiner's amendment rather than requiring another round of prosecution.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 14.4% of allowed cases (in the 91% percentile). Per MPEP § 714.14, a Quayle action indicates that all claims are allowable but formal matters remain. This examiner frequently uses Quayle actions compared to other examiners, which is a positive indicator that once substantive issues are resolved, allowance follows quickly.

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Expect multiple rounds of prosecution: This examiner issues more office actions than average. Address potential issues proactively in your initial response and consider requesting an interview early in prosecution.
  • Consider after-final amendments: This examiner frequently enters after-final amendments. If you can clearly overcome rejections with claim amendments, file an after-final amendment before resorting to an RCE.
  • Appeal filing as negotiation tool: This examiner frequently reconsiders rejections during the appeal process. Filing a Notice of Appeal may prompt favorable reconsideration during the mandatory appeal conference.
  • Plan for extended prosecution: Applications take longer than average with this examiner. Factor this into your continuation strategy and client communications.
  • Examiner cooperation: This examiner frequently makes examiner's amendments to place applications in condition for allowance. If you are close to allowance, the examiner may help finalize the claims.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.