USPTO Examiner WEHBE ANNE MARIE SABRINA - Art Unit 1634

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
18983137METHODS FOR ISOLATING, CULTURING, AND GENETICALLY ENGINEERING IMMUNE CELL POPULATIONS FOR ADOPTIVE THERAPYDecember 2024March 2025Allow310NoNo
18490030PAPN MUTANT AND COMPOSITION FOR SITE-DIRECTED MODIFICATION OF PAPN GENE AND APPLICATION THEREOFOctober 2023January 2025Allow1521NoNo
18320789NON-HUMAN ANIMALS COMPRISING A HUMANIZED ASGR1 LOCUSMay 2023March 2026Allow3410NoNo
18137110HUMANIZED NON-HUMAN ANIMALS WITH RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN LOCIApril 2023March 2026Allow3510NoNo
18166447METHODS FOR ISOLATING, CULTURING, AND GENETICALLY ENGINEERING IMMUNE CELL POPULATIONS FOR ADOPTIVE THERAPYFebruary 2023November 2024Allow2230YesNo
18107000IN VIVO Method for Generating Diversity in a Protein ScaffoldFebruary 2023January 2026Allow3610YesNo
18047233TARGETING PEPTIDES FOR DIRECTING ADENO-ASSOCIATED VIRUSES (AAVs)October 2022February 2026Allow4010NoNo
17906781In vivo targeting of T cells for mRNA therapeuticsSeptember 2022October 2025Abandon3750YesNo
17818730RODENT MODEL OF MOOD DISORDERSAugust 2022December 2025Abandon4010NoNo
17862668TREATMENT AND PREVENTION OF OCULAR NEURODEGENERATIVE DISORDERJuly 2022February 2025Allow3110NoNo
17744970ENGINEERING AND DELIVERY OF THERAPEUTIC COMPOSITIONS OF FRESHLEY ISOLATED CELLSMay 2022October 2025Abandon4110NoNo
17739955Gene Editing to Improve Joint FunctionMay 2022May 2025Allow3610NoNo
17734392HUMANIZED UNIVERSAL LIGHT CHAIN MICEMay 2022January 2026Allow4410NoNo
17728874TRANSGENIC ANIMAL FOR PRODUCING DIVERSIFIED ANTIBODIES THAT HAVE THE SAME LIGHT CHAIN IApril 2022May 2025Allow3720NoNo
17697623VACCINE COMPOSITIONS COMPRISING C-C MOTIF CHEMOKINE 22 (CCL22) OR FRAGMENTS THEREOFMarch 2022August 2025Allow4110NoNo
17669839BACILLUS THURINGIENSIS TOXIN RECEPTORS AND USES THEREOFFebruary 2022December 2025Allow4621YesNo
17574626AFFINITY MATURATED T CELL RECEPTORS AND USE THEREOFJanuary 2022September 2025Abandon4420NoNo
17565302ARTIFICIAL RECOMBINANT CHROMOSOME AND USE THEREOFDecember 2021January 2026Abandon4910NoNo
17558052RECOMBINANT AAV-CRUMBS HOMOLOGUE COMPOSITION AND METHODS FOR TREATING LCA-8 AND PROGRESSIVE RPDecember 2021February 2025Abandon3801NoNo
17490765METHODS FOR PROTECTING PORCINE FETUSES FROM INFECTION WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV)September 2021June 2025Allow4420NoNo
17442759CAR FOR USE IN THE TREATMENT OF HVG DISEASESeptember 2021September 2025Allow4820YesNo
17481484PROTEIN HAVING NUCLEASE ACTIVITY, FUSION PROTEINS AND USES THEREOFSeptember 2021January 2025Abandon4010NoNo
17402233HTT REPRESSORS AND USES THEREOFAugust 2021October 2025Allow5030YesNo
17368266MANIPULATION OF IMMUNOGLOBULIN GENE DIVERSITY AND MULTI-ANTIBODY THERAPEUTICSJuly 2021August 2025Abandon5001NoNo
17348356ADENO-ASSOCIATED VIRUS ANTIBODIES AND FRAGMENTS THEREOFJune 2021May 2025Allow4721YesNo
17343563Muscle-Specific Nucleic Acid Regulatory Elements and Methods and Use ThereofJune 2021May 2025Allow4720NoNo
17318316Compositions and Methods for Generating a Persisting Population of T Cells Useful for the Treatment of CancerMay 2021March 2025Allow4620YesNo
17316266Genetically Modified Non-Human Animals And Methods Of Use ThereofMay 2021June 2024Allow3810NoNo
17290843COMPOSITIONS AND METHODS FOR DIAGNOSIS OF CARDIOVASCULAR DISEASEMay 2021June 2025Allow5021YesNo
17241839Gene Editing to Improve Joint FunctionApril 2021September 2024Allow4010NoNo
17241171NON-HUMAN ANIMALS HAVING A HUMANIZED SIGNAL-REGULATORY PROTEIN GENEApril 2021July 2024Allow3920YesNo
17238710MICE EXPRESSING A LIMITED IMMUNOGLOBULIN LIGHT CHAIN REPERTOIREApril 2021April 2025Allow4820NoNo
17237475TOLEROGENIC DENDRITIC CELLS FOR TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROMEApril 2021July 2025Abandon5111NoNo
17209964COMMON LIGHT CHAIN MOUSEMarch 2021April 2025Abandon4811NoNo
17277008TARGETED IMMUNOTOLERANCEMarch 2021March 2025Abandon4801NoNo
17166398RNA VIRUSES FOR IMMUNOVIROTHERAPYFebruary 2021February 2024Abandon3620YesNo
17163040IMMUNE EFFECTOR CELL ENGINEERING AND USE THEREOFJanuary 2021August 2025Abandon5461YesYes
15734533PRODUCTION OF ANTIBODIES BY MODIFICATION OF AN AUTONOMOUS HEAVY CHAIN VARIABLE DOMAIN BY GENE CONVERSIONDecember 2020December 2025Allow6031NoNo
15734189TRANSGENIC ANIMAL FOR PRODUCING DIVERSIFIED ANTIBODIES THAT HAVE THE SAME LIGHT CHAIN IIDecember 2020October 2025Allow5830NoNo
17052835A pharmaceutical combination for use in the treatment of cancerNovember 2020March 2025Abandon5211NoNo
17045266HINGES 1 AND/OR 4 MODIFIED DYSTROPHINS FOR DYSTROPHINOPATHY THERAPYOctober 2020September 2025Abandon5940YesNo
17042865AAV6 VARIANTSSeptember 2020January 2026Allow6050YesNo
17042543LIVER TROPIC RECOMBINANT AAV6 VECTORS THAT EVADE NEUTRALIZATIONSeptember 2020March 2025Abandon5411NoNo
17041359TALE-NUCLEASES FOR ALLELE-SPECIFIC CODON MODIFICATION AND MULTIPLEXINGSeptember 2020January 2025Abandon5220NoNo
17030995IMMUNODEFICIENT NON-HUMAN ANIMALSeptember 2020February 2025Allow5340NoNo
17040017MODIFIED ONCOLYTIC ADENOVIRUSESSeptember 2020March 2026Allow6041NoNo
16869416TRANSGENIC NON-HUMAN VERTEBRATE FOR THE IN VIVO PRODUCTION OF DUAL SPECIFICITY IMMUNOGLOBULINS OR HYPERMUTATED HEAVY CHAIN ONLY IMMUNOGLOBULINSMay 2020September 2025Abandon6040NoNo
16849954ENGINEERING AND DELIVERY OF THERAPEUTIC COMPOSITIONS OF FRESHLY ISOLATED CELLSApril 2020July 2025Abandon6040NoNo
16626816ARTIFICIAL RECOMBINANT CHROMOSOME AND USE THEREOFDecember 2019May 2025Abandon6040NoNo
16657961COMPOSITIONS AND METHODS FOR EXPRESSING FACTOR IXOctober 2019September 2024Allow5911YesNo
16596829GENOME EDITED CANCER CELL VACCINESOctober 2019January 2025Allow6041YesNo
16472794VIRUS AAV/IGF2, GENETIC TREATMENT METHOD AND USE THEREOF IN PROTEIN MISFOLDING-RELATED DISEASES, SUCH AS HUNTINGTON'S DISEASEJune 2019January 2026Allow6060YesNo
16346614DNA Plasmids for the Fast Generation of Homologous Recombination Vectors for Cell Line DevelopmentMay 2019March 2025Allow6061YesNo
16335653AUTOLOGOUS IRRADIATED WHOLE CELL TUMOR VACCINES LENTIVIRALLY ENGINEERED TO EXPRESS CD80, IL-15 AND IL-15 RECEPTOR ALPHAMarch 2019August 2024Allow6040NoNo
16327299TRANSGENIC NON-HUMAN ANIMALS PRODUCING MODIFIED HEAVY CHAIN-ONLY ANTIBODIESFebruary 2019August 2025Allow6080NoNo
16265546METHOD FOR CHEMOSELECTIONFebruary 2019March 2020Allow1320NoNo
15960642HUMANIZED IL-7 RODENTSApril 2018January 2019Allow910NoNo
15947469FUSION MOLECULE BASED ON TAA VARIANTApril 2018March 2019Allow1220NoNo
15763419TCR AND USES THEREOFMarch 2018March 2025Allow6051YesNo
15870172Nucleic Acid Construct with a p16 Promoter that Causes a Prodrug Converting Enzyme to be Expressed Specifically in Senescent CellsJanuary 2018January 2020Allow2420NoNo
15866374ANTIBODY PRODUCING NON-HUMAN ANIMALSJanuary 2018September 2025Abandon6061NoYes
15824230IMMUNIZATION OF AVIANS BY ADMINISTRATION OF NON-REPLICATING VECTORED VACCINESNovember 2017March 2020Allow2820YesYes
15568683TREATMENT OF CANCER USING CHIMERIC ANTIGEN RECEPTOR AND PROTEIN KINASE A BLOCKEROctober 2017April 2024Allow6070NoYes
15649797HUMANIZED IL-7 RODENTSJuly 2017January 2018Allow610NoNo
15357021HUMANIZED IL-7 RODENTSNovember 2016April 2017Allow410YesNo
15293710FUSION MOLECULE BASED ON NOVEL TAA VARIANTOctober 2016January 2018Allow1520NoNo
15103457TRANSGENIC NON-HUMAN MAMMAL THAT EXPRESSES HUMAN MMP2September 2016September 2017Allow1510YesNo
15111483FUSION PROTEIN FOR INDUCING PLURIPOTENT STEM CELLS AND APPLICATION METHOD THEREOFJuly 2016February 2018Allow1921NoNo
15031169METHODS FOR GENETIC MODIFICATION OF STEM CELLSApril 2016November 2019Allow4320YesNo
15132125ANIMAL MODEL AND METHOD FOR STUDYING GENE-GENE INTERACTIONSApril 2016December 2017Allow2021YesNo
15048964COMPOSITION AND METHOD OF USING MIR-302 PRECURSORS AS DRUGS FOR TREATING ALZHEIMER'S DISEASESFebruary 2016August 2019Allow4221YesNo
14418781CELL LINE DERIVED FROM THREAD-SAIL FILEFISH (STEPHANOLEPIS CIRRHIFER)January 2015June 2017Allow2820NoNo
14551538HUMANIZED IL-7 RODENTSNovember 2014September 2015Allow1030YesNo
14495614ENDOTHELIAL CELL-SPECIFIC POLYNUCLEOTIDES AND USE THEREOFSeptember 2014February 2015Allow520YesNo
14476626Novel Inflammation in Vivo ModelSeptember 2014October 2015Allow1320YesNo
14299480SURGICAL DEVICE FOR SKIN THERAPY OR TESTINGJune 2014March 2015Allow920YesNo
14277969Muscle-Derived Cells (MDCs) for Treating Muscle- or Bone-Related Injury or DysfunctionMay 2014February 2016Allow2120NoNo
14224274TISSUE SPECIFIC EXPRESSION OF ANTIBODIES IN CHICKENSMarch 2014May 2015Allow1410NoNo
14152673METHOD OF IN VITRO TOXICITY TESTING USING ISOLATED LIVER STEM CELLSJanuary 2014March 2014Allow200NoNo
14094109SYSTEM FOR PRODUCTION OF ANTIBODIES AND THEIR DERIVATIVESDecember 2013November 2016Allow3631YesNo
14086817PCP2 Mini-PromotersNovember 2013December 2014Allow1210NoNo
13795765Humanized IL-7 RodentsMarch 2013December 2014Allow2130YesNo
13769182USE OF HERPES VECTORS FOR TUMOR THERAPYFebruary 2013July 2017Allow5341YesNo
13600711HERPES VIRUS STRAINSAugust 2012October 2013Allow1420NoNo
13558078NEURAL PROGENITOR CELL POPULATIONSJuly 2012June 2017Allow5931NoYes
13550488Tissue Specific Expression Of Antibodies In ChickensJuly 2012November 2014Allow2830YesNo
13532035MODIFIED CEA NUCLEIC ACID AND EXPRESSION VECTORSJune 2012May 2013Allow1010YesNo
13448112Stem Cell Fusion Model of CarcinogenesisApril 2012March 2014Allow2320NoNo
13212078RESCUE OF PHOTORECEPTORS BY INTRAVITREAL ADMINISTRATION OF AN EXPRESSION VECTOR ENCODING A THERAPEUTIC PROTEINAugust 2011December 2012Allow1610NoNo
13161817MOUSE MODEL FOR DEPRESSION, SCHIZOPHRENIA AND ALZHEIMER'S DISEASE AND THE USE THEREOFJune 2011November 2013Allow2920YesNo
13078119METHODS AND COMPOSITIONS TO GENERATE AND CONTROL THE EFFECTOR PROFILE OF T CELLS BY SIMULTANEOUS LOADING AND ACTIVATION OF SELECTED SUBSETS OF ANTIGEN PRESENTING CELLSApril 2011May 2014Allow3730NoNo
13025449MUSCLE-DERIVED CELLS (MDCS) FOR AUGMENTING OR BULKING URETHRAL SPHINCTER-MUSCLE TISSUEFebruary 2011February 2014Allow3621NoNo
12879931RECOMBINANT GENE WHICH ENHANCES THE ABILITY OF FISH TO TOLERATE LOW DISSOLVED OXYGEN STRESS AND THE USE THEREOFSeptember 2010June 2013Allow3311YesNo
12517194CODON MODIFIED IMMUNOGENIC COMPOSITIONS AND METHODS OF USEJune 2010December 2013Allow5521YesYes
12767086HUMAN MONOCLONAL ANTIBODIES TO EPIDERMAL GROWTH FACTOR RECEPTORApril 2010October 2011Allow1810YesNo
12758177HUMAN CHRONIC LYMPHOCYTIC LEUKEMIA MODELED IN MOUSE BY TARGETED TCL1 EXPRESSIONApril 2010September 2011Allow1710YesNo
12755266MICROPARTICLE-BASED TRANSFECTION AND ACTIVATION OF DENDRITIC CELLSApril 2010September 2011Allow1710YesNo
12716239MODIFIED CEA NUCLEIC ACID AND EXPRESSION VECTORSMarch 2010March 2012Allow2500YesNo
12439431Method for Improving the Specific Effector Function of Single-Chain Antigen-Recognizing Genetic Constructs (SCARC) Through Murinization ThereofNovember 2009February 2016Allow6051YesYes
12610815MONOCYTES AS A GENE DELIVERY VECTOR FOR SECRETED PROTEINS TO TREAT ALZHEIMER'S DISEASENovember 2009February 2013Allow4030YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner WEHBE, ANNE MARIE SABRINA.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
2
Examiner Affirmed
1
(50.0%)
Examiner Reversed
1
(50.0%)
Reversal Percentile
69.9%
Higher than average

What This Means

With a 50.0% reversal rate, the PTAB reverses the examiner's rejections in a meaningful percentage of cases. This reversal rate is above the USPTO average, indicating that appeals have better success here than typical.

Strategic Value of Filing an Appeal

Total Appeal Filings
38
Allowed After Appeal Filing
5
(13.2%)
Not Allowed After Appeal Filing
33
(86.8%)
Filing Benefit Percentile
15.9%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 13.2% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is in the bottom 25% across the USPTO, indicating that filing appeals is less effective here than in most other areas.

Strategic Recommendations

Appeals to PTAB show good success rates. If you have a strong case on the merits, consider fully prosecuting the appeal to a Board decision.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner WEHBE, ANNE MARIE SABRINA - Prosecution Strategy Guide

Executive Summary

Examiner WEHBE, ANNE MARIE SABRINA works in Art Unit 1634 and has examined 168 patent applications in our dataset. With an allowance rate of 89.3%, this examiner has an above-average tendency to allow applications. Applications typically reach final disposition in approximately 47 months.

Allowance Patterns

Examiner WEHBE, ANNE MARIE SABRINA's allowance rate of 89.3% places them in the 71% percentile among all USPTO examiners. This examiner has an above-average tendency to allow applications.

Office Action Patterns

On average, applications examined by WEHBE, ANNE MARIE SABRINA receive 2.71 office actions before reaching final disposition. This places the examiner in the 79% percentile for office actions issued. This examiner issues more office actions than most examiners, which may indicate thorough examination or difficulty in reaching agreement with applicants.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by WEHBE, ANNE MARIE SABRINA is 47 months. This places the examiner in the 9% percentile for prosecution speed. Applications take longer to reach final disposition with this examiner compared to most others.

Interview Effectiveness

Conducting an examiner interview provides a +14.0% benefit to allowance rate for applications examined by WEHBE, ANNE MARIE SABRINA. This interview benefit is in the 52% percentile among all examiners. Recommendation: Interviews provide an above-average benefit with this examiner and are worth considering.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 26.7% of applications are subsequently allowed. This success rate is in the 45% percentile among all examiners. Strategic Insight: RCEs show below-average effectiveness with this examiner. Carefully evaluate whether an RCE or continuation is the better strategy.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 60.4% of cases where such amendments are filed. This entry rate is in the 86% percentile among all examiners. Strategic Recommendation: This examiner is highly receptive to after-final amendments compared to other examiners. Per MPEP § 714.12, after-final amendments may be entered "under justifiable circumstances." Consider filing after-final amendments with a clear showing of allowability rather than immediately filing an RCE, as this examiner frequently enters such amendments.

Pre-Appeal Conference Effectiveness

When applicants request a pre-appeal conference (PAC) with this examiner, 50.0% result in withdrawal of the rejection or reopening of prosecution. This success rate is in the 42% percentile among all examiners. Note: Pre-appeal conferences show below-average success with this examiner. Consider whether your arguments are strong enough to warrant a PAC request.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 93.1% of appeals filed. This is in the 84% percentile among all examiners. Of these withdrawals, 88.9% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner frequently reconsiders rejections during the appeal process compared to other examiners. Per MPEP § 1207.01, all appeals must go through a mandatory appeal conference. Filing a Notice of Appeal may prompt favorable reconsideration even before you file an Appeal Brief.

Petition Practice

When applicants file petitions regarding this examiner's actions, 87.9% are granted (fully or in part). This grant rate is in the 87% percentile among all examiners. Strategic Note: Petitions are frequently granted regarding this examiner's actions compared to other examiners. Per MPEP § 1002.02(c), various examiner actions are petitionable to the Technology Center Director, including prematureness of final rejection, refusal to enter amendments, and requirement for information. If you believe an examiner action is improper, consider filing a petition.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 17.3% of allowed cases (in the 97% percentile). Per MPEP § 1302.04, examiner's amendments are used to place applications in condition for allowance when only minor changes are needed. This examiner frequently uses this tool compared to other examiners, indicating a cooperative approach to getting applications allowed. Strategic Insight: If you are close to allowance but minor claim amendments are needed, this examiner may be willing to make an examiner's amendment rather than requiring another round of prosecution.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 1.3% of allowed cases (in the 64% percentile). This examiner issues Quayle actions more often than average when claims are allowable but formal matters remain (MPEP § 714.14).

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Expect multiple rounds of prosecution: This examiner issues more office actions than average. Address potential issues proactively in your initial response and consider requesting an interview early in prosecution.
  • Consider after-final amendments: This examiner frequently enters after-final amendments. If you can clearly overcome rejections with claim amendments, file an after-final amendment before resorting to an RCE.
  • Appeal filing as negotiation tool: This examiner frequently reconsiders rejections during the appeal process. Filing a Notice of Appeal may prompt favorable reconsideration during the mandatory appeal conference.
  • Plan for extended prosecution: Applications take longer than average with this examiner. Factor this into your continuation strategy and client communications.
  • Examiner cooperation: This examiner frequently makes examiner's amendments to place applications in condition for allowance. If you are close to allowance, the examiner may help finalize the claims.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.