USPTO Examiner MARVICH MARIA - Art Unit 1634

Recent Applications

Detailed information about the 100 most recent patent applications.

Application NumberTitleFiling DateDisposal DateDispositionTime (months)Office ActionsRestrictionsInterviewAppeal
19180809REGULATION OF ARTIFICIAL MIRNAS BY ENDOGENOUS TISSUE-SPECIFIC MIRNAS AND METHODS OF USING THE SAMEApril 2025February 2026Abandon1010NoNo
18948625BACULOVIRUS VECTOR AND USE THEREOF IN PREPARATION OF RECOMBINANT ADENO-ASSOCIATED VIRUS (rAAV) IN INSECT CELLNovember 2024December 2025Allow1321YesNo
18936497METHODS USING SURFACE-EXPRESSIBLE ACTIVATABLE EPITOPES TO LOCALIZE AND/OR TREAT DISEASED CELLSNovember 2024October 2025Abandon1110NoNo
18919103COMPOSITIONS FOR TREATING CANCEROctober 2024July 2025Allow921YesNo
18913027COMPOSITION FOR REGULATING PRODUCTION OF PROTEINSOctober 2024May 2025Allow710NoNo
18885902COMPOSITION FOR REGULATING PRODUCTION OF FUSION PROTEINSSeptember 2024May 2025Allow810NoNo
18738959COMPOSITION FOR REGULATING PRODUCTION OF FUSION PROTEINSJune 2024January 2025Allow710YesNo
18646835ADENO-ASSOCIATED VIRUS CAPSIDApril 2024November 2025Allow1830YesNo
18435722PRESERVATION OF PANCREATIC ISLET GRAFTS IN THE EXTRAHEPATIC SPACEFebruary 2024August 2025Allow1930YesNo
18427711NON-TRANSGENE TRANSFECTION FOR THERAPEUTIC PURPOSESJanuary 2024June 2025Allow1730YesNo
18474506Cross-Species Compatible Adeno-Associated Virus Compositions and Methods of Use ThereofSeptember 2023July 2024Allow910YesNo
18275591TARGETED EXTRACELLULAR VESICLES FOR DELIVERY OF THERAPEUTICSAugust 2023October 2024Allow1510NoNo
18351800ENGINEERED HUMAN-ENDOGENOUS VIRUS-LIKE PARTICLES AND METHODS OF USE THEREOF FOR DELIVERY TO CELLSJuly 2023November 2024Allow1720YesNo
18351674ENGINEERED HUMAN-ENDOGENOUS VIRUS-LIKE PARTICLES AND METHODS OF USE THEREOF FOR DELIVERY TO CELLSJuly 2023November 2024Allow1640YesNo
18351689ENGINEERED HUMAN-ENDOGENOUS VIRUS-LIKE PARTICLES AND METHODS OF USE THEREOF FOR DELIVERY TO CELLSJuly 2023November 2024Allow1620YesNo
18322531METHODS AND COMPOSITIONS FOR TRANSDUCING LYMPHOCYTES AND REGULATING THE ACTIVITY THEREOFMay 2023January 2024Allow820NoNo
18316899VIRAL VECTORS FOR CANCER THERAPYMay 2023May 2025Allow2430YesNo
18098456HYPOTHERMIC PRESERVING DILUENT, HYPOTHERMIC PRESERVING METHOD OF PLECTROPOMUS LEOPARDUS SEMEN AND APPLICATION THEREOFJanuary 2023March 2026Abandon3810NoNo
18093119POLYNUCLEOTIDE SECONDARY STRUCTUREJanuary 2023March 2026Abandon3810NoNo
18008674ARTIFICIAL NON-CODING RNA MODULE FOR ENHANCING NITROGEN FIXATION ABILITY OF MICROORGANISMSDecember 2022January 2025Allow2520YesNo
18000174BISPECIFIC ANTIBODY AGAINST CLDN18.2 AND CD3November 2022January 2026Abandon3701NoNo
17936023D-DOMAIN CONTAINING POLYPEPTIDES AND USES THEREOFSeptember 2022June 2025Allow3300NoNo
17843916METHODS OF OBTAINING TUMOR-SPECIFIC T CELL RECEPTORSJune 2022May 2024Abandon2340NoNo
17611726PHARMACEUTICAL COMPOSITION FOR TREATMENT OF TUMOR OR CANCER, AND APPLICATION THEREOFMay 2022March 2026Abandon5201NoNo
17752436METHOD FOR REVERSING MULTIPLE RESISTANCE IN ANIMAL CELLSMay 2022September 2025Abandon4010NoNo
17660114DEFINED COMPOSITION GENE MODIFIED T-CELL PRODUCTSApril 2022August 2025Allow4010NoNo
17769495CAL-T CONSTRUCTS AND USES THEREOFApril 2022January 2026Abandon4520YesNo
17719473PHOTORECEPTORS AND PHOTORECEPTOR PROGENITORS PRODUCED FROM PLURIPOTENT STEM CELLSApril 2022October 2025Allow4240NoYes
17707944ENGINEERED MUSCLE TARGETING COMPOSITIONSMarch 2022December 2025Allow4581YesNo
17696978IL-36 CYTOKINE EXPRESSING ONCOLYTIC VIRUSES FOR TREATING CANCERMarch 2022December 2025Allow4521YesNo
17634050IMMUNE EFFECTOR CELL FOR CO-EXPRESSING CHEMOKINE RECEPTORFebruary 2022December 2025Abandon4610NoNo
17581203NUCLEIC ACID MOLECULES CONTAINING SPACERS AND METHODS OF USE THEREOFJanuary 2022November 2025Allow4610NoNo
17574118INTRANASAL ADMINISTRATION OF ADENO-ASSOCIATED VIRUS TO TREAT CENTRAL NERVOUS SYSTEM DISORDERSJanuary 2022July 2025Abandon4210YesNo
17559538REGULATABLE ADENO-ASSOCIATED VIRUS (AAV) VECTORDecember 2021February 2026Allow4911YesNo
17546951ANGIOGENIC CONDITIONING TO ENHANCE CARDIAC CELLULAR REPROGRAMMING OF FIBROBLASTS OF THE INFARCTED MYOCARDIUMDecember 2021March 2026Abandon5120NoNo
17543543MRNA THERAPY FOR ARGININOSUCCINATE SYNTHETASE DEFICIENCYDecember 2021September 2025Allow4520NoYes
17540377Compositions and Methods for Treating Cancer with DuoCARsDecember 2021March 2025Allow3910YesNo
17614327ENGINEERED MUSCLE TARGETING COMPOSITIONSNovember 2021February 2026Allow5121YesNo
17605976ALLOGENEIC CAR-T CELL, PREPARATION THEREFOR, AND APPLICATION THEREOFOctober 2021September 2025Abandon4701NoNo
17498520ADMINISTRATION OF KYNURENINE DEPLETING ENZYMES FOR TUMOR THERAPYOctober 2021January 2025Abandon3910NoNo
17493032Antigen Binding Regions Against Fibronectin Type III Domains and Methods of Using the SameOctober 2021November 2024Allow3800YesNo
17599750ADENO-ASSOCIATED VIRUS WITH ENGINEERED CAPSIDSeptember 2021January 2026Allow5211NoNo
17483484Universal Killer T-CellSeptember 2021September 2025Abandon4720YesNo
17472037AAV-EPO FOR TREATING COMPANION ANIMALSSeptember 2021January 2026Allow5220YesYes
17458044NON-DISRUPTIVE GENE TARGETINGAugust 2021January 2026Abandon5320NoYes
17386063FABRY DISEASE GENE THERAPYJuly 2021April 2025Allow4420NoNo
17371546ONCOLYTIC ADENOVIRUS COMPOSITIONSJuly 2021December 2025Allow5311YesNo
17369168GENE THERAPIES FOR LYSOSOMAL DISORDERSJuly 2021November 2025Allow5221YesNo
17358904HELPER-DEPENDENT ADENOVIRAL GENE THERAPY DELIVERY AND EXPRESSION SYSTEMJune 2021February 2026Allow5530NoNo
17350971PRIMING OF AN IMMUNE RESPONSEJune 2021March 2026Abandon5730NoNo
17337018COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ANTI-BCMA IMMUNOTHERAPYJune 2021April 2025Allow4711YesNo
17331733Compositions and Methods for Treating Cancer with Anti-CD38 ImmunotherapyMay 2021March 2025Allow4511YesNo
17332470COMPOSITIONS AND METHODS FOR REPROGRAMMING DISEASED MUSCULOSKELETAL CELLSMay 2021August 2025Allow5121YesNo
17297380T Cell ModificationMay 2021December 2025Allow5431NoNo
17317025RETROVIRAL PARTICLE COMPRISING AT LEAST TWO ENCAPSIDATED NONVIRAL RNASMay 2021August 2025Abandon5130NoNo
17291947RNA CANCER VACCINESMay 2021February 2026Allow5830YesNo
17245952DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONSApril 2021December 2024Allow4410NoNo
17284779PLASMID CONTAINING A SEQUENCE ENCODING AN MRNA WITH A SEGMENTED POLY(A) TAILApril 2021January 2026Allow5721YesNo
17206878Intrathecal Delivery of Recombinant Adeno-Associated Virus 9March 2021September 2024Allow4220YesNo
17193030RECOMBINANT AAV VECTORS USEFUL FOR REDUCING IMMUNITY AGAINST TRANSGENE PRODUCTSMarch 2021July 2025Allow5221YesNo
17180159DNA PRESERVATION IN BIOLOGICAL SPECIMENS USING METAL CHELATORSFebruary 2021August 2025Allow5330NoNo
17264911TAG72 TARGETED CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLS FOR TREATMENT OF TAG72-POSITIVE TUMORSFebruary 2021December 2024Allow4610YesNo
17150858METHODS FOR GENERATING ANIMALS WITH DESIRABLE TRAITSJanuary 2021February 2025Allow4920NoNo
17139097COMPOSITIONS AND METHODS FOR TREATING DISEASESDecember 2020October 2024Abandon4620NoNo
17139618IMMUNE CELL TREATMENT OF NERVE DAMAGEDecember 2020February 2026Abandon6040NoNo
17256812ANC80 ENCODING SPHINGOLIPID-METABOLIZING PROTEINSDecember 2020December 2025Allow6021NoNo
17124922Chimeric Growth Factor ReceptorsDecember 2020June 2025Abandon5421YesNo
17253491POLYNUCLEOTIDEDecember 2020January 2025Abandon4930NoNo
15733815USES AND METHODS FOR ONCOLYTIC VIRUS TARGETING OF IL-4/IL-13 AND FUSIONS THEREOFNovember 2020April 2025Allow5330YesNo
17044085PRODUCTION OF BROWN ADIPOCYTESSeptember 2020June 2024Allow4420YesNo
17040009CHIMERIC TRANSMEMBRANE PROTEINS AND USES THEREOFSeptember 2020December 2024Allow5121NoNo
17018088NON-CODING IMMUNOMODULATORY DNA CONSTRUCTSeptember 2020October 2024Abandon4920NoNo
17008086ARTIFICIAL ANTIGEN PRESENTING CELLS HAVING A DEFINED AND DYNAMIC SHAPEAugust 2020June 2025Abandon5830NoNo
16989307ALIGNED FIBER AND METHOD OF USE THEREOFAugust 2020August 2024Allow4820YesNo
16968602METHODS FOR SCREENING VARIANT OF TARGET GENEAugust 2020January 2025Allow5320YesNo
16943335Altering Gene Expression in CART Cells and Uses ThereofJuly 2020February 2025Allow5531YesNo
16965895USE OF LENTIVIRAL VECTORS EXPRESSING FACTOR VIIIJuly 2020March 2025Allow5540NoNo
16923606Electroporation Devices And Methods Of Cell TransfectionJuly 2020July 2024Allow4931YesNo
16921783COMPOSITIONS AND METHODS FOR ENHANCING VISUAL FUNCTIONJuly 2020May 2025Abandon5940NoNo
16917008GENERATION OF INDUCED PLURIPOTENT STEM CELLS FROM NORMAL HUMAN MAMMARY EPITHELIAL CELLSJune 2020February 2026Abandon6050YesNo
16895874CHIMERIC PROTEIN TOXINS FOR EXPRESSION BY THERAPEUTIC BACTERIAJune 2020March 2025Allow5851YesNo
16880402Controlled Transgene Expression in Regulatory T CellsMay 2020May 2024Allow4841YesYes
16758990MATERIALS AND METHODS FOR TREATMENT OF HEMOGLOBINOPATHIESApril 2020January 2026Allow6061NoNo
16823319METHODS AND COMPOSITIONS FOR GENETICALLY MODIFYING AND EXPANDING LYMPHOCYTES AND REGULATING THE ACTIVITY THEREOFMarch 2020November 2025Allow6021YesNo
16818477Conditional Modulation of Therapy Using Recombinant CellsMarch 2020August 2025Allow6051NoNo
16807254Collection, Genome Editing, And Washing Of T-Cell LymphocytesMarch 2020August 2024Allow5330YesNo
16746257TARGETED AND MODULAR EXOSOME LOADING SYSTEMJanuary 2020January 2026Abandon6051YesNo
16610883GENE THERAPY FOR CILIOPATHIESNovember 2019July 2024Allow5641YesNo
16594017Methods for the Delivery of Therapeutic Agents to Donor OrgansOctober 2019February 2026Allow6070NoNo
16498369SHRNA EXPRESSION CASSETTE, POLYNUCLEOTIDE SEQUENCE CARRYING SAME, AND APPLICATION THEREOFSeptember 2019December 2024Abandon6051NoNo
16490702METHODS FOR DETERMINING POTENCY OF ADENO-ASSOCIATED VIRUS PREPARATIONSSeptember 2019January 2026Allow6071YesNo
16537192NUCLEIC ACID MOLECULES AND USES THEREOF FOR NON-VIRAL GENE THERAPYAugust 2019July 2024Allow5941YesYes
16502859MICROFLUIDIC DEVICES, SYSTEMS, INFRASTRUCTURES, USES THEREOF AND METHODS FOR GENETIC ENGINEERING USING SAMEJuly 2019March 2025Abandon6031NoNo
16409406COMPOSITIONS FOR THE INACTIVATION OF VIRUS REPLICATION AND METHODS OF MAKING AND USING THE SAMEMay 2019May 2025Abandon6040YesNo
16405285ONCOLYTIC ADENOVIRUSES FOR TREATING CANCERMay 2019June 2024Allow6051YesNo
16336429METHODS OF ADOPTIVE CELL THERAPYMarch 2019December 2025Abandon6061NoNo
16332315DELIVERY OF NUCLEIC ACIDS, PROTEINS AND SMALL MOLECULES IN VITREOUS VESICULAR BODIESMarch 2019January 2026Allow6041NoNo
16326126METHODS AND COMPOSITIONS FOR TARGETED GENE TRANSFERFebruary 2019February 2025Abandon6061YesNo
16325679CRISPR-CAS GENOME ENGINEERING VIA A MODULAR AAV DELIVERY SYSTEMFebruary 2019February 2026Allow6091YesNo
16318965COMPOSITIONS AND METHODS FOR STUDYING THE TAT GENEJanuary 2019April 2025Allow6040YesNo

Appeals Overview

This analysis examines appeal outcomes and the strategic value of filing appeals for examiner MARVICH, MARIA.

Patent Trial and Appeal Board (PTAB) Decisions

Total PTAB Decisions
5
Examiner Affirmed
1
(20.0%)
Examiner Reversed
4
(80.0%)
Reversal Percentile
90.1%
Higher than average

What This Means

With a 80.0% reversal rate, the PTAB has reversed the examiner's rejections more often than affirming them. This reversal rate is in the top 25% across the USPTO, indicating that appeals are more successful here than in most other areas.

Strategic Value of Filing an Appeal

Total Appeal Filings
38
Allowed After Appeal Filing
11
(28.9%)
Not Allowed After Appeal Filing
27
(71.1%)
Filing Benefit Percentile
43.4%
Lower than average

Understanding Appeal Filing Strategy

Filing a Notice of Appeal can sometimes lead to allowance even before the appeal is fully briefed or decided by the PTAB. This occurs when the examiner or their supervisor reconsiders the rejection during the mandatory appeal conference (MPEP § 1207.01) after the appeal is filed.

In this dataset, 28.9% of applications that filed an appeal were subsequently allowed. This appeal filing benefit rate is below the USPTO average, suggesting that filing an appeal has limited effectiveness in prompting favorable reconsideration.

Strategic Recommendations

Appeals to PTAB show good success rates. If you have a strong case on the merits, consider fully prosecuting the appeal to a Board decision.

Filing a Notice of Appeal shows limited benefit. Consider other strategies like interviews or amendments before appealing.

Examiner MARVICH, MARIA - Prosecution Strategy Guide

Executive Summary

Examiner MARVICH, MARIA works in Art Unit 1634 and has examined 178 patent applications in our dataset. With an allowance rate of 83.1%, this examiner has an above-average tendency to allow applications. Applications typically reach final disposition in approximately 53 months.

Allowance Patterns

Examiner MARVICH, MARIA's allowance rate of 83.1% places them in the 57% percentile among all USPTO examiners. This examiner has an above-average tendency to allow applications.

Office Action Patterns

On average, applications examined by MARVICH, MARIA receive 3.41 office actions before reaching final disposition. This places the examiner in the 93% percentile for office actions issued. This examiner issues more office actions than most examiners, which may indicate thorough examination or difficulty in reaching agreement with applicants.

Prosecution Timeline

The median time to disposition (half-life) for applications examined by MARVICH, MARIA is 53 months. This places the examiner in the 3% percentile for prosecution speed. Applications take longer to reach final disposition with this examiner compared to most others.

Interview Effectiveness

Conducting an examiner interview provides a +8.7% benefit to allowance rate for applications examined by MARVICH, MARIA. This interview benefit is in the 39% percentile among all examiners. Recommendation: Interviews provide a below-average benefit with this examiner.

Request for Continued Examination (RCE) Effectiveness

When applicants file an RCE with this examiner, 20.6% of applications are subsequently allowed. This success rate is in the 23% percentile among all examiners. Strategic Insight: RCEs show lower effectiveness with this examiner compared to others. Consider whether a continuation application might be more strategic, especially if you need to add new matter or significantly broaden claims.

After-Final Amendment Practice

This examiner enters after-final amendments leading to allowance in 42.0% of cases where such amendments are filed. This entry rate is in the 64% percentile among all examiners. Strategic Recommendation: This examiner shows above-average receptiveness to after-final amendments. If your amendments clearly overcome the rejections and do not raise new issues, consider filing after-final amendments before resorting to an RCE.

Appeal Withdrawal and Reconsideration

This examiner withdraws rejections or reopens prosecution in 86.1% of appeals filed. This is in the 79% percentile among all examiners. Of these withdrawals, 80.6% occur early in the appeal process (after Notice of Appeal but before Appeal Brief). Strategic Insight: This examiner frequently reconsiders rejections during the appeal process compared to other examiners. Per MPEP § 1207.01, all appeals must go through a mandatory appeal conference. Filing a Notice of Appeal may prompt favorable reconsideration even before you file an Appeal Brief.

Petition Practice

When applicants file petitions regarding this examiner's actions, 81.8% are granted (fully or in part). This grant rate is in the 85% percentile among all examiners. Strategic Note: Petitions are frequently granted regarding this examiner's actions compared to other examiners. Per MPEP § 1002.02(c), various examiner actions are petitionable to the Technology Center Director, including prematureness of final rejection, refusal to enter amendments, and requirement for information. If you believe an examiner action is improper, consider filing a petition.

Examiner Cooperation and Flexibility

Examiner's Amendments: This examiner makes examiner's amendments in 27.0% of allowed cases (in the 99% percentile). Per MPEP § 1302.04, examiner's amendments are used to place applications in condition for allowance when only minor changes are needed. This examiner frequently uses this tool compared to other examiners, indicating a cooperative approach to getting applications allowed. Strategic Insight: If you are close to allowance but minor claim amendments are needed, this examiner may be willing to make an examiner's amendment rather than requiring another round of prosecution.

Quayle Actions: This examiner issues Ex Parte Quayle actions in 12.2% of allowed cases (in the 90% percentile). Per MPEP § 714.14, a Quayle action indicates that all claims are allowable but formal matters remain. This examiner frequently uses Quayle actions compared to other examiners, which is a positive indicator that once substantive issues are resolved, allowance follows quickly.

Prosecution Strategy Recommendations

Based on the statistical analysis of this examiner's prosecution patterns, here are tailored strategic recommendations:

  • Expect multiple rounds of prosecution: This examiner issues more office actions than average. Address potential issues proactively in your initial response and consider requesting an interview early in prosecution.
  • Appeal filing as negotiation tool: This examiner frequently reconsiders rejections during the appeal process. Filing a Notice of Appeal may prompt favorable reconsideration during the mandatory appeal conference.
  • Plan for extended prosecution: Applications take longer than average with this examiner. Factor this into your continuation strategy and client communications.
  • Examiner cooperation: This examiner frequently makes examiner's amendments to place applications in condition for allowance. If you are close to allowance, the examiner may help finalize the claims.

Relevant MPEP Sections for Prosecution Strategy

  • MPEP § 713.10: Examiner interviews - available before Notice of Allowance or transfer to PTAB
  • MPEP § 714.12: After-final amendments - may be entered "under justifiable circumstances"
  • MPEP § 1002.02(c): Petitionable matters to Technology Center Director
  • MPEP § 1004: Actions requiring primary examiner signature (allowances, final rejections, examiner's answers)
  • MPEP § 1207.01: Appeal conferences - mandatory for all appeals
  • MPEP § 1214.07: Reopening prosecution after appeal

Important Disclaimer

Not Legal Advice: The information provided in this report is for informational purposes only and does not constitute legal advice. You should consult with a qualified patent attorney or agent for advice specific to your situation.

No Guarantees: We do not provide any guarantees as to the accuracy, completeness, or timeliness of the statistics presented above. Patent prosecution statistics are derived from publicly available USPTO data and are subject to data quality limitations, processing errors, and changes in USPTO practices over time.

Limitation of Liability: Under no circumstances will IronCrow AI be liable for any outcome, decision, or action resulting from your reliance on the statistics, analysis, or recommendations presented in this report. Past prosecution patterns do not guarantee future results.

Use at Your Own Risk: While we strive to provide accurate and useful prosecution statistics, you should independently verify any information that is material to your prosecution strategy and use your professional judgment in all patent prosecution matters.